Anti-IL-2 treatment impairs the expansion of treg cell population during acute malaria and enhances the Th1 cell response at the chronic disease

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  ZagoClá, Cláudia A ^a   Bortoluci, Karina R ^a,b   Sardinha, Luiz R ^c   Pretel, Fernando D ^a   Castillo Méndez, Sheyla I ^a   do Rosário, Ana Paula ^a   Hiyane, Meire I ^a   Muxel, Sandra M ^a   Rodriguez MálagaSé, Sérgio M ^a   Abrahamsohn, Ises A ^a   Álvarez, José M ^a   D'Império Lima, Maria Regina ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c HOSPITAL ISRAELITA ALBERT EINSTEIN   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CYTOKINE ANTIBODY; GAMMA INTERFERON; IMMUNOGLOBULIN G2A ANTIBODY; INTERLEUKIN 2; INTERLEUKIN 2 ANTIBODY; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 2 RECEPTOR ALPHA; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY JES6 1; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

ACUTE DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SPECIFICITY; ARTICLE; CD4+ CD25+ FOXP3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL ACTIVITY; CELL EXPANSION; CELL POPULATION; CELLULAR IMMUNITY; CHRONIC DISEASE; CYTOKINE RELEASE; HUMORAL IMMUNITY; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PLASMODIUM CHABAUDI INFECTION; PROTEIN EXPRESSION; RECEPTOR AFFINITY; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL;

MUS; PLASMODIUM CHABAUDI;

EID: 84855857551     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029894     Document Type: Article

References (46)

1. WHO (2008) World Health Organization Malaria, other vectorborne and parasitic diseases: Regional trend in cases and deaths.
2. Langhorne J, Ndungu FM, Sponaas AM, Marsh K, (2008) Immunity to malaria: more questions than answers. Nat Immunol 9: 725-732.
3. Doolan DL, Dobano C, Baird JK, (2009) Acquired immunity to malaria. Clin Microbiol Rev 22: 13-36 Table of Contents.
4. Schofield L, Grau GE, (2005) Immunological processes in malaria pathogenesis. Nat Rev Immunol 5: 722-735.
5. Hansen DS, Schofield L, (2010) Natural regulatory T cells in malaria: host or parasite allies? PLoS Pathog 6 (4): e1000771.
6. Langhorne J, Kim KJ, Asofsky R, (1985) Distribution of immunoglobulin isotypes in the nonspecific B-cell response induced by infection with Plasmodium chabaudi adami and Plasmodium yoelii. Cell Immunol 90: 251-257.
7. Falanga PB, D'Imperio Lima MR, Coutinho A, Pereira da Silva L, (1987) Isotypic pattern of the polyclonal B cell response during primary infection by Plasmodium chabaudi and in immune-protected mice. Eur J Immunol 17: 599-603.
8. D'Imperio Lima MR, Alvarez JM, Furtado GC, Kipnis TL, Coutinho A, et al. (1996) Ig-isotype patterns of primary and secondary B cell responses to Plasmodium chabaudi chabaudi correlate with IFN-gamma and IL-4 cytokine production with CD45RB expression by CD4+ spleen cells. Scand J Immunol 43: 263-270.
9. Stevenson MM, Tam MF, Belosevic M, van der Meide PH, Podoba JE, (1990) Role of endogenous gamma interferon in host response to infection with blood-stage Plasmodium chabaudi AS. Infect Immun 58: 3225-3232.
10. Mota MM, Brown KN, Holder AA, Jarra W, (1998) Acute Plasmodium chabaudi chabaudi malaria infection induces antibodies which bind to the surfaces of parasitized erythrocytes and promote their phagocytosis by macrophages in vitro. Infect Immun 66: 4080-4086.
11. Franklin BS, Rodrigues SO, Antonelli LR, Oliveira RV, Goncalves AM, et al. (2007) MyD88-dependent activation of dendritic cells and CD4(+) T lymphocytes mediates symptoms, but is not required for the immunological control of parasites during rodent malaria. Microbes Infect 9: 881-890.
12. Helmby H, Jonsson G, Troye-Blomberg M, (2000) Cellular changes and apoptosis in the spleens and peripheral blood of mice infected with blood-stage Plasmodium chabaudi chabaudi AS. Infect Immun 68: 1485-1490.
13. Muxel SM, Freitas do Rosario AP, Zago CA, Castillo-Mendez SI, Sardinha LR, et al. (2011) The spleen CD4+ T cell response to blood-stage Plasmodium chabaudi malaria develops in two phases characterized by different properties. PLoS One 6: e22434.
14. Achtman AH, Stephens R, Cadman ET, Harrison V, Langhorne J, (2007) Malaria-specific antibody responses and parasite persistence after infection of mice with Plasmodium chabaudi chabaudi. Parasite Immunol 29: 435-444.
15. Freitas do Rosario AP, Muxel SM, Rodriguez-Malaga SM, Sardinha LR, Zago CA, et al. (2008) Gradual decline in malaria-specific memory T cell responses leads to failure to maintain long-term protective immunity to Plasmodium chabaudi AS despite persistence of B cell memory and circulating antibody. J Immunol 181: 8344-8355.
16. Hoyer KK, Dooms H, Barron L, Abbas AK, (2008) Interleukin-2 in the development and control of inflammatory disease. Immunol Rev 226: 19-28.
17. Malek TR, Bayer AL, (2004) Tolerance, not immunity, crucially depends on IL-2. Nat Rev Immunol 4: 665-674.
18. Thornton AM, Shevach EM, (1998) CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 188: 287-296.
19. Morgan DA, Ruscetti FW, Gallo R, (1976) Selective in vitro growth of T lymphocytes from normal human bone marrows. Science 193: 1007-1008.
20. Refaeli Y, Van Parijs L, London CA, Tschopp J, Abbas AK, (1998) Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis. Immunity 8: 615-623.
21. Almeida AR, Legrand N, Papiernik M, Freitas AA, (2002) Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J Immunol 169: 4850-4860.
22. Malek TR, Yu A, Vincek V, Scibelli P, Kong L, (2002) CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. Immunity 17: 167-178.
23. Boyman O, Kovar M, Rubinstein MP, Surh CD, Sprent J, (2006) Selective stimulation of T cell subsets with antibody-cytokine immune complexes. Science 311: 1924-1927.
24. Haque A, Best SE, Amante FH, Mustafah S, Desbarrieres L, et al. (2010) CD4+ natural regulatory T cells prevent experimental cerebral malaria via CTLA-4 when expanded in vivo. PLoS Pathog 6 (12): e1001221.
25. Ho M, Webster HK, Green B, Looareesuwan S, Kongchareon S, et al. (1988) Defective production of and response to IL-2 in acute human falciparum malaria. J Immunol 141: 2755-2759.
26. Winkler S, Willheim M, Baier K, Schmid D, Aichelburg A, et al. (1998) Reciprocal regulation of Th1- and Th2-cytokine-producing T cells during clearance of parasitemia in Plasmodium falciparum malaria. Infect Immun 66: 6040-6044.
27. Berretta F, St-Pierre J, Piccirillo CA, Stevenson MM, (2011) IL-2 contributes to maintaining a balance between CD4+Foxp3+ regulatory T cells and effector CD4+ T cells required for immune control of blood-stage malaria infection. J Immunol 186: 4862-4871.
28. Depper JM, Leonard WJ, Robb RJ, Waldmann TA, Greene WC, (1983) Blockade of the interleukin-2 receptor by anti-Tac antibody: inhibition of human lymphocyte activation. J Immunol 131: 690-696.
29. Malek TR, Ortega G, Jakway JP, Chan C, Shevach EM, (1984) The murine IL 2 receptor. II. Monoclonal anti-IL 2 receptor antibodies as specific inhibitors of T cell function in vitro. J Immunol 133: 1976-1982.
30. Cao X, Shores EW, Hu-Li J, Anver MR, Kelsall BL, et al. (1995) Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain. Immunity 2: 223-238.
31. Razi-Wolf Z, Hollander GA, Reiser H, (1996) Activation of CD4+ T lymphocytes form interleukin 2-deficient mice by costimulatory B7 molecules. Proc Natl Acad Sci U S A 93: 2903-2908.
32. Van Parijs L, Sethna MP, Schweitzer AN, Borriello F, Sharpe AH, et al. (1997) Functional consequences of dysregulated B7-1 (CD80) and B7-2 (CD86) expression in B or T lymphocytes of transgenic mice. J Immunol 159: 5336-5344.
33. Khoruts A, Mondino A, Pape KA, Reiner SL, Jenkins MK, (1998) A natural immunological adjuvant enhances T cell clonal expansion through a CD28-dependent, interleukin (IL)-2-independent mechanism. J Exp Med 187: 225-236.
34. Batchelder JM, Burns JM Jr, Cigel FK, Lieberg H, Manning DD, et al. (2003) Plasmodium chabaudi adami: interferon-gamma but not IL-2 is essential for the expression of cell-mediated immunity against blood-stage parasites in mice. Exp Parasitol 105: 159-166.
35. Kundig TM, Schorle H, Bachmann MF, Hengartner H, Zinkernagel RM, et al. (1993) Immune responses in interleukin-2-deficient mice. Science 262: 1059-1061.
36. Vanhaesebroeck B, Vogt PK, Rommel C, (2010) PI3K: from the bench to the clinic and back. Curr Top Microbiol Immunol 347: 1-19.
37. Vu MD, Xiao X, Gao W, Degauque N, Chen M, et al. (2007) OX40 costimulation turns off Foxp3+ Tregs. Blood 110: 2501-2510.
38. Cambos M, Belanger B, Jacques A, Roulet A, Scorza T, (2008) Natural regulatory (CD4(+)CD25(+)FOXP(+)) T cells control the production of pro-inflammatory cytokines during Plasmodium chabaudi adami infection and do not contribute to immune evasion. Int J Parasitol 38: 229-238 Epub 2007 Jul 2026.
39. Couper KN, Blount DG, Wilson MS, Hafalla JC, Belkaid Y, et al. (2008) IL-10 from CD4CD25Foxp3CD127 adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection. PLoS Pathog 4: e1000004.
40. Lyddane C, Gajewska BU, Santos E, King PD, Furtado GC, et al. (2006) Cutting Edge: CD28 controls dominant regulatory T cell activity during active immunization. J Immunol 176: 3306-3310.
41. Kinter AL, Godbout EJ, McNally JP, Sereti I, Roby GA, et al. (2008) The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands. J Immunol 181: 6738-6746.
42. Rudd CE, Taylor A, Schneider H, (2009) CD28 and CTLA-4 coreceptor expression and signal transduction. Immunol Rev 229: 12-26.
43. Dooms H, Kahn E, Knoechel B, Abbas AK, (2004) IL-2 induces a competitive survival advantage in T lymphocytes. J Immunol 172: 5973-5979.
44. Vignali DA, Collison LW, Workman CJ, (2008) How regulatory T cells work. Nat Rev Immunol 8: 523-532.
45. Elias RM, Sardinha LR, Bastos KR, Zago CA, da Silva AP, et al. (2005) Role of CD28 in polyclonal and specific T and B cell responses required for protection against blood stage malaria. J Immunol 174: 790-799.
46. Cavinato RA, Bastos KR, Sardinha LR, Elias RM, Alvarez JM, et al. (2001) Susceptibility of the different developmental stages of the asexual (schizogonic) erythrocyte cycle of Plasmodium chabaudi chabaudi to hyperimmune serum, immunoglobulin (Ig)G1, IgG2a and F(ab′)2 fragments. Parasite Immunol 23: 587-597.