Gradual decline in malaria-specific memory T cell responses leads to failure to maintain long-term protective immunity to Plasmodium chabaudi AS despite persistence of B cell memory and circulating antibody

Journal of Immunology

Volumn 181, Issue 12, 2008, Pages 8344-8355

  Freitas Do Rosário, Ana Paula ^a   Muxel, Sandra Márcia ^a   Rodríguez Málaga, Sérgio Marcelo ^a   Sardinha, Luiz Roberto ^a   Zago, Cláudia Augusta ^a   Castillo Méndez, Sheyla Inés ^a   Álvarez, José Mariá ^a   D'Império Lima, Maria Regina ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2A ANTIBODY; PARASITE ANTIGEN; PROTOZOON ANTIBODY;

ADOLESCENT; ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIBODY TITER; ANTIGEN RECOGNITION; APOPTOSIS; ARTICLE; B LYMPHOCYTE; C57BL 6 MOUSE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; FEMALE; HOST RESISTANCE; IMMUNE RESPONSE; IMMUNOLOGICAL MEMORY; MALARIA; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PARASITEMIA; PLASMODIUM CHABAUDI; PRIORITY JOURNAL; T LYMPHOCYTE; ANIMAL; BIOSYNTHESIS; BLOOD; C57BL MOUSE; DRUG EFFECT; ERYTHROCYTE; GENETICS; IMMUNOLOGY; INNATE IMMUNITY; MOUSE MUTANT; PARASITOLOGY; T LYMPHOCYTE SUBPOPULATION; TIME;

ANIMALS; ANTIBODIES, PROTOZOAN; B-LYMPHOCYTE SUBSETS; ERYTHROCYTES; FEMALE; IMMUNITY, INNATE; IMMUNOLOGIC MEMORY; MALARIA; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PARASITEMIA; PLASMODIUM CHABAUDI; T-LYMPHOCYTE SUBSETS; TIME FACTORS;

EID: 58849157347     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.12.8344     Document Type: Article

References (36)

1. Roll Back Malaria. World Health Organization and UNICEF. 2005. World Malaria Report 2005 (http://www.rbm.who.int/wmr2005/html/exsummary-en.htm).
2. Cox, J., S. Semoff, and M. Hommel. 1987. Plasmodium chabaudi: a rodent malaria model for in vivo and in vitro cytoadherence of malaria parasites in the absence of knobs. Parasite Immunol. 9: 543-561.
3. Falanga, P. B., M. R. D'Império Lima, A. Coutinho, and L. Pereira da Silva. 1987. Isotypic pattern of the polyclonal B cell response during primary infection by Plasmodium chabaudi in normal and immune-protected mice. Eur. J. Immunol. 17: 599-603.
4. D'Império Lima, M. R., A. Bandeira, P. Falanga, A. A. Freitas, T. L. Kipnis, L. Pereira da Silva, and A. Coutinho. 1991. Clonal analysis of B lymphocyte responses to Plasmodium chabaudi infection of normal and immunoprotected mice. Int. Immunol. 3: 1207-1216.
5. + spleen cells. Scand. J. Immunol. 43: 263-270. (Pubitemid 126424048)
6. + T cells reactive with Plasmodium chabaudi chabaudi: distinct response kinetics for cells with Th1 and Th2 characteristics during infection. Int. Immunol. 1: 416-424.
7. Stevenson, M. M., M. F. Tam, M. Belosevic, P. H. van der Meide, and J. E. Podoba. 1990. Role of endogenous interferon in host response to infection with blood-stage Plasmodium chabaudi AS. Infect. Immun. 58: 3225-3232.
8. + T-cell clones reactive to the murine malaria parasite Plasmodium chabaudi. Immunology. 77: 99-105.
9. Helmby, H., G. Jonsson, and M. Troye-Blomberg. 2000. Cellular changes and apoptosis in the spleens and peripheral blood of mice infected with blood-stage Plasmodium chabaudi chabaudi AS. Infect. Immun. 68: 1485-1490. (Pubitemid 30108548)
10. + T cells undergo extensive apoptosis s during a Plasmodium chabaudi chabaudi AS infection. Parasite Immunol. 23: 617-626.
11. Cavacini, L. A., C. A. Long, and W. P. Weidanz. 1986. T-cell immunity in murine malaria: adoptive transfer of resistance to Plasmodium chabaudi adami in nude mice with splenic T cells. Infect. Immun. 52: 637-643.
12. Süss, G., K. Eichmann, E. Kury, A. Linke, and J. Langhorne. 1988. Roles of CD4- and CD8-bearing T lymphocytes in the immune response to the erythrocytic stages of Plasmodium chabaudi. Infect. Immun. 56: 3081-3088. (Pubitemid 18278635)
13. + T cells and B cells are necessary for the transfer of protective immunity to Plasmodium chabaudi chabaudi. Eur. J. Immunol. 21: 1433-1438.
14. + T lymphocytes both contribute to acquired immunity to blood-stage Plasmodium chabaudi AS. Infect. Immun. 59: 51-58.
15. Struik, S. S., and E. M. Riley. 2004. Does malaria suffer from lack of memory? Immunol. Rev. 201: 268-290.
16. Wykes, M., and M. F. Good. 2006. Memory B cell responses and malaria. Parasite Immunol. 28: 31-34.
17. + T cell memory; lessons for malaria. Parasite Immunol. 28: 25-30.
18. Touré-Baldé, A., J. L. Sarthou, G. Aribot, P. Michel, J. F. Trape, C. Rogier, and C. Roussilhon. 1996. Plasmodium falciparum induces apoptosis in human mononuclear cells. Infect. Immun. 64: 744-750.
19. + T cells adoptively transferred into recipient mice after challenge with homologous parasite. Proc. Natl. Acad. Sci. USA 95: 1715-1720.
20. Wipasa, J., H. Xu, A. Stowers, and M. F. Good. 2001. Apoptotic deletion of Th cells specific for the 19-kDa carboxyl-terminal fragment of merozoite surface protein 1 during malaria infection. J. Immunol. 167: 3903-3909. (Pubitemid 32910835)
21. + T cells in malaria infection. J. Exp. Med. 195: 881-892. (Pubitemid 34286759)
22. Dunachie, S. J., and A. V. Hill. 2003. Prime-boost strategies for malaria vaccine development. J. Exp. Biol. 206: 3771-3779. (Pubitemid 37365459)
23. Achtman, A. H., R. Stephens, E. T. Cadman, V. Harrison, and J. Langhorne. 2007. Malaria-specific antibody responses and parasite persistence after infection of mice with Plasmodium chabaudi chabaudi. Parasite Immunol. 29: 435-444.
24. Kundig, T. M., A. Shahinian, K. Kawai, H. W. Mittrucker, E. Sebzda, M. F. Bachmann, T. W. Mak, and P. S. Ohashi. 1996. Duration of TCR stimulation determines costimulatory requirement of T cells. Immunity. 5: 41-52.
25. Cavinato, R. A., K. R. B. Bastos, L. R. Sardinha, R. M. Elias, J. M. Alvarez, and M. R. D'Império Lima. 2001. Susceptibility of the different blood forms of Plasmodium chabaudi chabaudi to hyperimmune serum, IgG1, IgG2a and F(ab')2 fragments. Parasite Immunol. 23: 587-597.
26. Su, Z., and M. M. Stevenson. 2002. IL-12 is required for antibody-mediated protective immunity against blood-stage Plasmodium chabaudi AS malaria infection in mice. J. Immunol. 168: 1348-1355. (Pubitemid 34094505)
27. Barkan, D., H. Ginsburg, and J. Golenser. 2000. Optimisation of flow cytometric measurement of parasitaemia in Plasmodium-infected mice. Int. J. Parasitol. 30: 649-653. (Pubitemid 30209951)
28. Elias, R. M., L. R. Sardinha, K. R. Bastos, C. A. Zago, A. P. da Silva, J. M. Alvarez, and M. R. Lima. 2005. Role of CD28 in polyclonal and specific T and B cell responses required for protection against blood stage malaria. J. Immunol. 174: 790-799.
29. Phillips, R. S., L. R. Brannan, P. Balmer, and P. Neuville. 1997. Antigenic variation during malaria infection: the contribution from the murine parasite Plasmodium chabaudi. Parasite Immunol. 19: 427-434.
30. Elliott, S. R., R. D. Kuns, and M. F. Good. 2005. Heterologous immunity in the absence of variant-specific antibodies after exposure to subpatent infection with blood-stage malaria. Infect. Immun. 73: 2478-2485.
31. Pombo, D. J., G. Lawrence, C. Hirunpetcharat, C. Rzepczyk, M. Bryden, N. Cloonan, K. Anderson, Y. Mahakunkijcharoen, L. B. Martin, D. Wilson, et al. 2002. Immunity to malaria after administration of ultra-low doses of red cells infected with Plasmodium falciparum. Lancet 360: 610-617.
32. Favila-Castillo, L., A. Monroy-Ostria, and D. Garcia-Tapia. 1999. Plasmodium chabaudi chabaudi: effect of low parasitemias on immunity in CB6F1 mice. Exp. Parasitol. 92: 73-80. (Pubitemid 29370084)
33. Ravetch, J. V., and S. Bolland. 2001. IgG Fc receptors. Annu. Rev. Immunol. 19: 275-290.
34. Radbruch, A., G. Muehlinghaus, E. O. Luger, A. Inamine, K. G. C. Smith, T. Dorner, and F. Hiepe. 2006. Competence and competition: the challenge of becoming a long-lived plasma cell. Nat. Rev. Immunol. 6: 741-750. (Pubitemid 44453460)
35. Bystry, R. S., V. Aluvihare, K. A. Welch, M. Kallikourdis, and A. G. Bertz. 2001. B cells and professional APCs recruit regulatory T cells via CCL4. Nature 2: 1126-1132.
36. Ocaña-Morgner, C., M. M. Mota, and A. Rodriguez. 2003. Malaria blood stage suppression of liver stage immunity by dendritic cells. J. Exp. Med. 197: 137-141.