Fermented grape marc (FGM): Immunomodulating properties and its potential exploitation in the treatment of neurodegenerative diseases

Current Pharmaceutical Design

Volumn 18, Issue 1, 2012, Pages 43-50

  Marzulli, G ^a   Magrone, T ^a   Kawaguchi, K ^b   Kumazawa, Y ^b,c   Jirillo, E ^a  

^a UNIVERSITY OF BARI   (Italy)

^b IWAKI MEISEI UNIVERSITY   (Japan)

^c Vino Science Japan Inc   (Japan)

Author keywords

Cytokines; Fermented Grape Marc; Neuroinflammation; Polyphenols; T regulatory cells; Wine

Indexed keywords

BIOLOGICAL MARKER; CYTOKINE; FERMENTED GRAPE MARC; GRANZYME B; PLANT MEDICINAL PRODUCT; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DEGENERATIVE DISEASE; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FERMENTATION; FLOW CYTOMETRY; GRAPE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; IN VITRO STUDY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION;

ADULT; CYTOKINES; FERMENTATION; FORKHEAD TRANSCRIPTION FACTORS; GRANZYMES; HUMANS; IMMUNOLOGIC FACTORS; INFLAMMATION; LEUKOCYTES, MONONUCLEAR; NEURODEGENERATIVE DISEASES; VITIS; YOUNG ADULT;

EID: 84855838147     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/138161212798919011     Document Type: Article

References (34)

1. Schwartz C, Scholtens PA, Lalanne A, Weenen H, Niclaus S. Development of healthy eating habits early in life. Review of recent evidence and selected guidelines. Appetite 2011; [Epub ahead of print].
2. Brown L. Targets for research in the metabolic syndrome. Endocr Metab Immune Disord Drug Targets 2011; [Epub ahead of print].
3. Honda K, Takeda K. Regulatory mechanisms of immune responses to intestinal bacteria. Mucosal Immunol 2009; 2: 187-96.
4. Neish AS. Microbes in gastrointestinal health and disease: Commensal bacteria shape intestinal immune system development. Gastroenterology 2009; 136: 65-80.
5. Qia L, Flood PM, Hong J-S. Neuroinflammation is a key player in Parkinson's disease and a prime target for therapy. J Neural Transm 2010; 117: 971-9.
6. Hirsch EC, Hunot S. Neuroinflammation in Parkinson's disease. A target for neuroprotection? Lancet Neurol 2009; 8: 382-97.
7. Littlejohn D, Mangano E, Clarke M, Bobyn J, Moloney K, Hayley S. Inflammatory mechanisms of neurodegeneration in toxin-based models of Parkinson's disease. Parkinsons Dis 2010; 2011: 713517.
8. Tufekci KU, Genc S, Genc K. The endotoxin-induced neuroinflammation model of Parkinson's disease. Parkinsons Dis 2011; 2011: 487-50.
9. Lehnardt S. Innate immunity and neuroinflammation in the CNS: The role of microglia in Toll-like receptor-mediated neuronal injury. Glia 2010; 58: 253-63.
10. Okun E, Griffionen KJ, Lathia JD, Tang S-C, Mattson P, Arumugam V. Toll-like receptors in neurodegeneration. Brain Res Rev 2009; 59: 278-92.
11. Magrone T, Marzulli G, Jirillo E. Immunopathogenesis of neurodegenerative diseases: current therapeutic models of neuroprotection with special reference to natural products. Curr Pharm Des 2012, 18: 34-42.
12. Magrone T, Tafaro A, Jirillo F, et al. Red wine consumption and prevention of atherosclerosis: an in vitro model using human peripheral blood mononuclear cells. Curr Pharm Des 2007; 13: 3718-25.
13. Magrone T, Tafaro A, Jirillo F, Amati L, Jirillo E, Covelli V. Elicitation of immune responsiveness against antigenic challenge in age-related diseases: effects of red wine polyphenols. Curr Pharm Des 2008; 14: 2749-57.
14. Magrone T, Panaro MA, Jirillo E, Covelli V. Molecular effects elicited in vitro by red wine on human healthy peripheral blood mononuclear cells: potential therapeutical application of polyphenols to diet-related chronic diseases. Curr Pharm Des 2008; 14: 2758-66.
15. Kawaguchi K, Matsumoto T, Kumazawa Y. Effects of antioxidant polyphenols on TNF-alpha-related diseases. Curr Top Med Chem 2011; 11: 1767-79.
16. Kaneko M, Kanesaka M, Yoneyama M, Tominaga T, Jirillo E, Kumazawa Y. Inhibitory effects of fermented grape marc from Vitis vinifera Negroamaro on antigen-induced degranulation. Immunopharmacol Immunotoxicol 2010; 32: 454-61.
17. Tominaga T, Kawaguchi K, Kanesaka M, Kawauchi H, Jirillo E, Kumazawa Y. Suppression of type-I allergic responses by oral administration of grape marc fermented with Lactobacillus plantarum. Immunopharmacol Immunotoxicol 2010; 32: 593-9.
18. Couper KN, Blount DG, Riley EM. IL-10: the master regulator of immunity to infection. J Immunol 2008; 180: 5771-7.
19. Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ T regulatory cells. Nat Immunol 2003; 4: 330-6.
20. Vignali DA, Collison LW, Workman CJ. How regulatory T cells work. Nat Rev Immunol 2008; 8: 523-32.
21. Kim JM, Rasmussen JP, Rudensky AY. Regulatory T cells prevent catastrophic autoimmunity through the life span of mice. Nat Immunol 2007; 8: 191-7.
22. Mellor AM, Munn DH. Physiologic control of the functional status of Foxp3+ regulatory T cells. J Immunol 2011; 186: 4535-40.
23. Andrade F. Non-cytotoxic antiviral activities of granzymes in the context of the immune antiviral state. Immunol Rev 2010; 235: 128-46
24. Haque A, Best SE, Unosson K, et al. Granzyme B expression by CD8+ T cells is required for the development of experimental cerebral malaria. J Immunol 2011;186: 6148-56.
25. Kryczek I, Wu E, Zhao E, et al. IL-17+ regulatory T cells in the microenvironments of chronic inflammation and cancer. J Immunol 2011; 186: 4388-95.
26. Kebir H, Kreymborg K, Ifergan I, et al. Human Th17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat Med 2007; 13: 1173-5.
27. Neumann H, Medana I, Bauer J, Lassmann H. Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases. Trend Neurosci 2002; 25: 313-9.
28. Wang T, Allie R, Conant K, et al. Granzyme B mediates neurotoxicity through a G-protein coupled receptor. FASEB J 2003; 20: 122-30.
29. Haile Y, Pasychniyk D, Turner D, Bleackley RC, Giuliani F. CD4+CD25+CD127dimFoxP3+T cells are cytotoxic for human neurons. J Leukoc Biol 2011; 89: 927-34.
30. Addey C, White M, Dou L, Coe D, Dyson J, Chai J-G. Functional plasticity of antigen-specific regulatory T cells in context of tumor. J Immunol 2011; 186: 4557-64.
31. Cabrera C, Artacho R, Gimenez R. Beneficial effects of green tea-a review. J Am Coll Nutr 2006; 25: 79-99.
32. Qin S, Alcorn JF, Craigo JK, et al. Epigallocatechin-3. gallate reduces airway inflammation in mice through binding to proinflammatory chemokines and inhibiting inflammatory cell recruitment. J Immunol 2011; 186: 3693-700.
33. Chaturvedi V, Collison LW, Guy CS, Workman CJ, Vignali DAA. Cutting edge: Human regulatory T cells require IL-35 to mediate suppression and infectious tolerance. J Immunol 2011; 186: 6661-6.
34. Morlacchi S, Dal Secco V, Soldani C, Glaichenhaus N, Viola A, Sarukhan A. Regulatory T cells target chemokine secretion by dendritic cells independently of their capacity to regulate T cell proliferation. J Immunol 2011; 186: 6807-14.