Microphthalmia-associated transcription factor acts through PEDF to regulate RPE cell migration

Experimental Cell Research

Volumn 318, Issue 3, 2012, Pages 251-261

  Ma, Xiaoyin ^a   Pan, Li ^a   Jin, Xi ^a,b   Dai, Xiaodan ^a,b   Li, Huirong ^a,b   Wen, Bin ^a,b   Chen, Yu ^a,b   Ma, Aobo ^a   Qu, Jia ^b   Hou, Ling ^a,b,c  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b State Key Laboratory Cultivation Base   (China)

^c Zhejiang Provincial Key Laboratory for Technology and Application of Model Organisms   (China)

Author keywords

Microtubule assembly; Pigment cells; Retinal degenerative disease; Signaling; Transcription factor

Indexed keywords

BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; PIGMENT EPITHELIUM DERIVED FACTOR;

ARTICLE; CELL FUNCTION; CELL MATURATION; CELL MIGRATION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MICROTUBULE ASSEMBLY; PIGMENT EPITHELIUM; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REGULATORY MECHANISM; UPREGULATION;

EID: 84855835939     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2011.11.002     Document Type: Article

References (58)

1. Longbottom R., Fruttiger M., Douglas R.H., Martinez-Barbera J.P., Greenwood J., Moss S.E. Genetic ablation of retinal pigment epithelial cells reveals the adaptive response of the epithelium and impact on photoreceptors. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:18728-18733.
2. Raymond S.M., Jackson I.J. The retinal pigmented epithelium is required for development and maintenance of the mouse neural retina. Curr. Biol. 1995, 5:1286-1295.
3. Simo R., Villarroel M., Corraliza L., Hernandez C., Garcia-Ramirez M. The retinal pigment epithelium: something more than a constituent of the blood-retinal barrier-implications for the pathogenesis of diabetic retinopathy. J. Biomed. Biotechnol. 2010, 2010:190724.
4. Becerra S.P. Focus on Molecules: pigment epithelium-derived factor (PEDF). Exp. Eye Res. 2006, 82:739-740.
5. Tombran-Tink J., Shivaram S.M., Chader G.J., Johnson L.V., Bok D. Expression, secretion, and age-related downregulation of pigment epithelium-derived factor, a serpin with neurotrophic activity. J. Neurosci. 1995, 15:4992-5003.
6. Ablonczy Z., Prakasam A., Fant J., Fauq A., Crosson C., Sambamurti K. Pigment epithelium-derived factor maintains retinal pigment epithelium function by inhibiting vascular endothelial growth factor-R2 signaling through gamma-secretase. J. Biol. Chem. 2009, 284:30177-30186.
7. He S., Kumar S.R., Zhou P., Krasnoperov V., Ryan S.J., Gill P.S., Hinton D.R. Soluble EphB4 inhibition of PDGF-induced RPE migration in vitro. Invest. Ophthalmol. Vis. Sci. 2010, 51:543-552.
8. Tombran-Tink J., Barnstable C.J. PEDF: a multifaceted neurotrophic factor. Nat. Rev. Neurosci. 2003, 4:628-636.
9. Kirchhof B., Kirchhof E., Ryan S.J., Sorgente N. Vitreous modulation of migration and proliferation of retinal pigment epithelial cells in vitro. Invest. Ophthalmol. Vis. Sci. 1989, 30:1951-1957.
10. Li R., Maminishkis A., Wang F.E., Miller S.S. PDGF-C and -D induced proliferation/migration of human RPE is abolished by inflammatory cytokines. Invest. Ophthalmol. Vis. Sci. 2007, 48:5722-5732.
11. Matsunaga N., Chikaraishi Y., Izuta H., Ogata N., Shimazawa M., Matsumura M., Hara H. Role of soluble vascular endothelial growth factor receptor-1 in the vitreous in proliferative diabetic retinopathy. Ophthalmology 2008, 115:1916-1922.
12. Murugeswari P., Shukla D., Rajendran A., Kim R., Namperumalsamy P., Muthukkaruppan V. Proinflammatory cytokines and angiogenic and anti-angiogenic factors in vitreous of patients with proliferative diabetic retinopathy and eales' disease. Retina 2008, 28:817-824.
13. Binder S., Stanzel B.V., Krebs I., Glittenberg C. Transplantation of the RPE in AMD. Prog. Retin. Eye Res. 2007, 26:516-554.
14. Mangan B.G., Al-Yahya K., Chen C.T., Gionfriddo J.R., Powell C.C., Dubielzig R.R., Ehrhart E.J., Madl J.E. Retinal pigment epithelial damage, breakdown of the blood-retinal barrier, and retinal inflammation in dogs with primary glaucoma. Vet. Ophthalmol. 2007, 10(Suppl. 1):117-124.
15. Ogata N., Matsuoka M., Imaizumi M., Arichi M., Matsumura M. Decreased levels of pigment epithelium-derived factor in eyes with neuroretinal dystrophic diseases. Am. J. Ophthalmol. 2004, 137:1129-1130.
16. Pons M., Marin-Castano M.E. Cigarette smoke-related hydroquinone dysregulates MCP-1, VEGF and PEDF expression in retinal pigment epithelium in vitro and in vivo. PLoS One 2011, 6:e16722.
17. Hiscott P., Gray R., Grierson I., Gregor Z. Cytokeratin-containing cells in proliferative diabetic retinopathy membranes. Br. J. Ophthalmol. 1994, 78:219-222.
18. Gartner S., Henkind P. Pathology of retinitis pigmentosa. Ophthalmology 1982, 89:1425-1432.
19. Schuman S.G., Koreishi A.F., Farsiu S., Jung S.H., Izatt J.A., Toth C.A. Photoreceptor layer thinning over drusen in eyes with age-related macular degeneration imaged in vivo with spectral-domain optical coherence tomography. Ophthalmology 2009, 116. (488-496 e482).
20. Arnheiter H. The discovery of the microphthalmia locus and its gene, Mitf. Pigment Cell Melanoma Res. 2010, 23:729-735.
21. Hou L., Pavan W.J. Transcriptional and signaling regulation in neural crest stem cell-derived melanocyte development: do all roads lead to Mitf?. Cell Res. 2008, 18:1163-1176.
22. Bharti K., Nguyen M.T., Skuntz S., Bertuzzi S., Arnheiter H. The other pigment cell: specification and development of the pigmented epithelium of the vertebrate eye. Pigment Cell Res. 2006, 19:380-394.
23. Tassabehji M., Newton V.E., Read A.P. Waardenburg syndrome type 2 caused by mutations in the human microphthalmia (MITF) gene. Nat. Genet. 1994, 8:251-255.
24. Amiel J., Watkin P.M., Tassabehji M., Read A.P., Winter R.M. Mutation of the MITF gene in albinism-deafness syndrome (Tietz syndrome). Clin. Dysmorphol. 1998, 7:17-20.
25. Hou L., Panthier J.J., Arnheiter H. Signaling and transcriptional regulation in the neural crest-derived melanocyte lineage: interactions between KIT and MITF. Development 2000, 127:5379-5389.
26. Hou L., Arnheiter H., Pavan W.J. Interspecies difference in the regulation of melanocyte development by SOX10 and MITF. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:9081-9085.
27. Wen B., Chen Y., Li H., Wang J., Shen J., Ma A., Qu J., Bismuth K., Debbache J., Arnheiter H., Hou L. Allele-specific genetic interactions between Mitf and Kit affect melanocyte development. Pigment Cell Melanoma Res. 2010, 23:441-447.
28. Johnson S.L., Nguyen A.N., Lister J.A. mitfa is required at multiple stages of melanocyte differentiation but not to establish the melanocyte stem cell. Dev. Biol. 2011, 350:405-413.
29. Levy C., Khaled M., Robinson K.C., Veguilla R.A., Chen P.H., Yokoyama S., Makino E., Lu J., Larue L., Beermann F., Chin L., Bosenberg M., Song J.S., Fisher D.E. Lineage-specific transcriptional regulation of DICER by MITF in melanocytes. Cell 2010, 141:994-1005.
30. McGill G.G., Horstmann M., Widlund H.R., Du J., Motyckova G., Nishimura E.K., Lin Y.L., Ramaswamy S., Avery W., Ding H.F., Jordan S.A., Jackson I.J., Korsmeyer S.J., Golub T.R., Fisher D.E. Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell 2002, 109:707-718.
31. Carreira S., Goodall J., Aksan I., La Rocca S.A., Galibert M.D., Denat L., Larue L., Goding C.R. Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression. Nature 2005, 433:764-769.
32. Loercher A.E., Tank E.M., Delston R.B., Harbour J.W. MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A. J. Cell Biol. 2005, 168:35-40.
33. Hodgkinson C.A., Moore K.J., Nakayama A., Steingrimsson E., Copeland N.G., Jenkins N.A., Arnheiter H. Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein. Cell 1993, 74:395-404.
34. Nguyen M., Arnheiter H. Signaling and transcriptional regulation in early mammalian eye development: a link between FGF and MITF. Development 2000, 127:3581-3591.
35. Rowan S., Chen C.M., Young T.L., Fisher D.E., Cepko C.L. Transdifferentiation of the retina into pigmented cells in ocular retardation mice defines a new function of the homeodomain gene Chx10. Development 2004, 131:5139-5152.
36. Steingrimsson E., Nii A., Fisher D.E., Ferre-D'Amare A.R., McCormick R.J., Russell L.B., Burley S.K., Ward J.M., Jenkins N.A., Copeland N.G. The semidominant Mi(b) mutation identifies a role for the HLH domain in DNA binding in addition to its role in protein dimerization. EMBO J. 1996, 15:6280-6289.
37. Smith S.B., Bora N., McCool D., Kutty G., Wong P., Kutty R.K., Wiggert B. Photoreceptor cells in the vitiligo mouse die by apoptosis. TRPM-2/clusterin expression is increased in the neural retina and in the retinal pigment epithelium. Invest. Ophthalmol. Vis. Sci. 1995, 36:2193-2201.
38. Bumsted K.M., Barnstable C.J. Dorsal retinal pigment epithelium differentiates as neural retina in the microphthalmia (mi/mi) mouse. Invest. Ophthalmol. Vis. Sci. 2000, 41:903-908.
39. Planque N., Raposo G., Leconte L., Anezo O., Martin P., Saule S. Microphthalmia transcription factor induces both retinal pigmented epithelium and neural crest melanocytes from neuroretina cells. J. Biol. Chem. 2004, 279:41911-41917.
40. Masuda T., Esumi N. SOX9, through interaction with microphthalmia-associated transcription factor (MITF) and OTX2, regulates BEST1 expression in the retinal pigment epithelium. J. Biol. Chem. 2010, 285:26933-26944.
41. Anderson M.G., Smith R.S., Hawes N.L., Zabaleta A., Chang B., Wiggs J.L., John S.W. Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice. Nat. Genet. 2002, 30:81-85.
42. Spritz R.A., Strunk K.M., Giebel L.B., King R.A. Detection of mutations in the tyrosinase gene in a patient with type IA oculocutaneous albinism. N. Engl. J. Med. 1990, 322:1724-1728.
43. Zhao C., Yasumura D., Li X., Matthes M., Lloyd M., Nielsen G., Ahern K., Snyder M., Bok D., Dunaief J.L., LaVail M.M., Vollrath D. mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice. J. Clin. Invest. 2011, 121:369-383.
44. Yamauchi J., Miyamoto Y., Chan J.R., Tanoue A. ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration. J. Cell Biol. 2008, 181:351-365.
45. Chien J., Ota T., Aletti G., Shridhar R., Boccellino M., Quagliuolo L., Baldi A., Shridhar V. Serine protease HtrA1 associates with microtubules and inhibits cell migration. Mol. Cell. Biol. 2009, 29:4177-4187.
46. Bernard A., Gao-Li J., Franco C.A., Bouceba T., Huet A., Li Z. Laminin receptor involvement in the anti-angiogenic activity of pigment epithelium-derived factor. J. Biol. Chem. 2009, 284:10480-10490.
47. Yang H., Grossniklaus H.E. Constitutive overexpression of pigment epithelium-derived factor inhibition of ocular melanoma growth and metastasis. Invest. Ophthalmol. Vis. Sci. 2010, 51:28-34.
48. Dallol A., Agathanggelou A., Tommasi S., Pfeifer G.P., Maher E.R., Latif F. Involvement of the RASSF1A tumor suppressor gene in controlling cell migration. Cancer Res. 2005, 65:7653-7659.
49. Wu X., Kodama A., Fuchs E. ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity. Cell 2008, 135:137-148.
50. Gao J., Huo L., Sun X., Liu M., Li D., Dong J.T., Zhou J. The tumor suppressor CYLD regulates microtubule dynamics and plays a role in cell migration. J. Biol. Chem. 2008, 283:8802-8809.
51. Siegrist S.E., Doe C.Q. Microtubule-induced cortical cell polarity. Genes Dev. 2007, 21:483-496.
52. Hall A. The cytoskeleton and cancer. Cancer Metastasis Rev. 2009, 28:5-14.
53. Cao W., Tombran-Tink J., Chen W., Mrazek D., Elias R., McGinnis J.F. Pigment epithelium-derived factor protects cultured retinal neurons against hydrogen peroxide-induced cell death. J. Neurosci. Res. 1999, 57:789-800.
54. Dawson D.W., Volpert O.V., Gillis P., Crawford S.E., Xu H., Benedict W., Bouck N.P. Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science 1999, 285:245-248.
55. Ogata N., Tombran-Tink J., Jo N., Mrazek D., Matsumura M. Upregulation of pigment epithelium-derived factor after laser photocoagulation. Am. J. Ophthalmol. 2001, 132:427-429.
56. Cayouette M., Smith S.B., Becerra S.P., Gravel C. Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations. Neurobiol. Dis. 1999, 6:523-532.
57. Park K., Jin J., Hu Y., Zhou K., Ma J.X. Overexpression of pigment epithelium-derived factor inhibits retinal inflammation and neovascularization. Am. J. Pathol. 2011, 178:688-698.
58. Huang Q., Wang S., Sorenson C.M., Sheibani N. PEDF-deficient mice exhibit an enhanced rate of retinal vascular expansion and are more sensitive to hyperoxia-mediated vessel obliteration. Exp. Eye Res. 2008, 87:226-241.