How does hypertension affect your eyes

Journal of Human Hypertension

Volumn 26, Issue 2, 2012, Pages 71-83

  Bhargava, M ^a   Ikram, M K ^a,b   Wong, T Y ^a,c  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

blood pressure; cardiovascular disease; retinal vascular conditions; retinopathy

Indexed keywords

ACETYLSALICYLIC ACID 3 (NITROXYMETHYL)PHENYL ESTER; ANGIOTENSIN ANTAGONIST; APOLIPOPROTEIN E; CALCIUM CHANNEL BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; FERRITIN; GLUCOSE; LIPID; LOSARTAN; STEROID; VASCULOTROPIN;

ANTIHYPERTENSIVE THERAPY; BLOOD PRESSURE REGULATION; BRAIN ATROPHY; CARDIOVASCULAR RISK; CAROTID ARTERY DISEASE; CAUCASIAN; CHINESE; CHORIORETINOPATHY; CIGARETTE SMOKING; CLINICAL TRIAL (TOPIC); CONGESTIVE HEART FAILURE; DIABETES MELLITUS; DIABETIC RETINOPATHY; DNA POLYMORPHISM; EYE DISEASE; FERRITIN BLOOD LEVEL; GENETIC ASSOCIATION; HERITABILITY; HUMAN; HYDROSTATIC PRESSURE; HYPERCHOLESTEROLEMIA; HYPERTENSION; HYPERTENSION RETINOPATHY; ISCHEMIC OPTIC NEUROPATHY; LASER COAGULATION; META ANALYSIS (TOPIC); MICROANEURYSM; MICROEMBOLISM; NEGRO; OPTIC DISK; OXIDATIVE STRESS; PREVALENCE; RACE DIFFERENCE; RETINA ARTERY OCCLUSION; RETINA BLOOD VESSEL OCCLUSION; RETINA HEMORRHAGE; RETINA MACULA AGE RELATED DEGENERATION; RETINA MACULA EDEMA; RETINA VEIN OCCLUSION; REVIEW; SEX DIFFERENCE; STROKE; SYSTOLIC BLOOD PRESSURE; VISUAL ACUITY; VISUAL FIELD DEFECT; VISUAL IMPAIRMENT; WHITE COAT HYPERTENSION;

ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; DIABETIC RETINOPATHY; EYE; HUMANS; HYPERTENSION; HYPERTENSIVE RETINOPATHY; MICROCIRCULATION; RETINAL DISEASES; RETINAL VESSELS; RISK ASSESSMENT; RISK FACTORS;

EID: 84855830571     PISSN: 09509240     EISSN: 14765527     Source Type: Journal    
DOI: 10.1038/jhh.2011.37     Document Type: Review

References (105)

1. Wong TY, Mitchell P. Hypertensive retinopathy. N Engl J Med 2004; 351: 2310-2317. (Pubitemid 39552747)
2. Gopinath B, Baur LA, Wang JJ, Teber E, Liew G, Cheung N et al. Blood pressure is associated with retinal vessel signs in preadolescent children. J Hypertens 2010; 28: 1406-1412.
3. Wong TY, Mitchell P. The eye in hypertension. Lancet 2007; 369: 425-435. (Pubitemid 46188480)
4. DellaCrocea JT, Vitale AT. Hypertension and the eye. Curr Opin Ophthalmol 2008; 19: 493-498.
5. Wang S, Xu L, Jonas JB, Wong TY, Cui T, Li YH et al. Major eye diseases and risk factors associated with systemic hypertension in an adult Chinese popula-tion: the Beijing Eye Study. Ophthalmology 2009; 116: 2373-2380.
6. Wong TY, McIntosh R. Hypertensive retinopathy signs as risk indicators of cardiovascular morbidity and mortality. Br Med Bull 2005; 73-74: 57-70. (Pubitemid 43020358)
7. Wang JJ, Mitchell P, Leung H, Rochtchina E, Wong TY, Klein R. Hypertensive retinal vessel wall signs in a general older population: the Blue Mountains Eye Study. Hypertension 2003; 42: 534-541. (Pubitemid 37237350)
8. Wong TY, Klein R, Sharret AR, Manolio TA, Hubbard LD, Marino EK et al. The prevalence and risk factors of retinal microvascular abnormalities in older people. The Cardiovascular Health Study. Ophthal-mology 2003; 110: 658-666. (Pubitemid 36520060)
9. Wang JJ, Baker ML, Hand PJ, Hankey GJ, Lindley RI, Rochtchina E et al. Transient ischemic attack and acute ischemic stroke: associations with retinal microvascular signs. Stroke 2011; 42: 404-408.
10. Ojaimi E, Nguyen TT, Klein R, Islam FM, Cotch MF, Klein BE et al. Retinopathy signs in people without diabetes. The multi-ethnic study of atherosclerosis. Ophthalmology 2011; 118: 656-662.
11. Huang OS, Lamoureux E, Tay WT, Tai ES, Wang JJ, Wong TY. Glycemic and blood pressure control in an Asian Malay population with diabetes and diabetic retinopathy. Arch Ophthalmol 2010; 128: 1185-1190.
12. Kawasaki R, Cheung N, Mosley T, Islam AF, Sharrett AR, Klein R et al. Retinal microvascular signs and 10-year risk of cerebral atrophy: the Atherosclerosis Risk in Communities (ARIC) study. Stroke 2010; 41: 1826-1828.
13. Jeganathan V, Cheung N, Tay W, Wang J, Mitchell P, Wong T. Prevalence and risk factors of retinopathy in an Asian population without diabetes: the Singapore Malay Eye Study. Arch Ophthalmol 2010; 128: 40-45.
14. Peng XY, Wang FH, Liang YB, Wang JJ, Sun LP, Peng Y et al. Retinopathy in persons without diabetes: the Handan Eye Study. Ophthalmology 2010; 117: 531-537.
15. Kawasaki R, Wang JJ, Wong TY, Kayama T, Yama-shita H. Impaired glucose tolerance, but not im-paired fasting glucose, is associated with retinopathy in Japanese population: the Funagata study. Diabetes Obes Metab 2008; 10: 514-515. (Pubitemid 351639095)
16. Wang JJ, Rochtchina E, Kaushik S, Kifley A, Wong TY, Mitchell P. Long-term incidence of isolated retinopathy lesions in older persons without dia-betes: The blue mountains eye study. Invest Opthal-mol Vis Sci 2010; 51 (e-abstract 1236).
17. Kawasaki R, Tielsch JM, Wang JJ, Wong TY, Mitchell P, Tano Y et al. The metabolic syndrome and retinal microvascular signs in a Japanese population: the Funagata study. Br J Ophthalmol 2008; 92: 161-166. (Pubitemid 351224086)
18. Leung H, Wang JJ, Rochtchina E, Wong TY, Klein R, Mitchell P. Impact of current and past blood pressure on retinal arteriolar diameter in an older population. J Hypertens 2004; 22: 1543-1549. (Pubitemid 39037606)
19. Leung H, Wang JJ, Rochtchina E, Tan AG, Wong TY, Klein R et al. Relationships between age, blood pressure and retinal vessel diameters in an older population. Invest Ophthalmol Vis Sci 2003; 44: 2900-2904. (Pubitemid 36759750)
20. Sun C, Wang JJ, Mackey DA, Wong TY. Retinal vascular caliber: systemic, environmental, and genetic associations. Surv Ophthalmol 2009; 54: 74-95.
21. Tanabe Y, Kawasaki R, Wang JJ, Wong TY, Mitchell P, Daimon M et al. Retinal arteriolar narrowing predicts 5-year risk of hypertension in Japanese people: the Funagata study. Microcirculation 2010; 17: 94-102.
22. Smith W, Wang JJ, Wong TY, Rochtchina E, Klein R, Leeder SR et al. Retinal arteriolar narrowing is associated with 5-year incident severe hypertension: the Blue Mountains Eye Study. Hypertension 2004; 44: 442-447. (Pubitemid 39281493)
23. Liew G, Sharett AR, Wang JJ, klein R, Klein BE, Mitchell P et al. Relative importance of systemic determinants of retinal aeteriolar and venular cali-ber: the atherosclerosis risk in communities study. Arch Ophthalmol 2008; 126: 1404-1410.
24. Klein R, Sharrett AR, Klein BE, Chambless LE, Cooper LS, Hubbard LD et al. Are retinal arteriolar abnormalities related to atherosclerosis?: The ather-osclerosis risk in communities study. Arterioscler Thromb Vasc Biol 2000; 20: 1644-1650. (Pubitemid 30353900)
25. Ikram MK, de Jong FJ, Vingerling JR, Witteman JC, Hofman A, Breteler MM et al. Are retinal arteriolar or venular diameters associated with markers for cardiovascular disorders? The Rotterdam Study. Invest Ophthalmol Vis Sci 2004; 45: 2129-2134. (Pubitemid 38902580)
26. Tsai WC, Li YH, Huang YY, Lin CC, Chao TH, Chen JH. Plasma vascular endothelial growth factor as a marker for early vascular damage in hypertension. Clin Sci (Lond) 2005; 109: 39-43.
27. Yilmaz MI, Sonmez A, Kilic S, Celik T, Bingol N, Pinar M et al. The association of plasma adiponectin levels with hypertensive retinopathy. Eur J Endocrinol 2005; 152: 233-240. (Pubitemid 40309570)
28. Uckaya G, Ozata M, Sonmez A, Kinalp C, Eyileten T, Bingol N et al. Is leptin associated with hyperten-sive retinopathy? J Clin Endocrinol Metab 2000; 85: 683-687.
29. Coban E, Alkan E, Altuntas S, Akar Y Serum ferritin levels correlate with hypertensive retinopathy. Med Sci Monit 2010; 16: 92-95.
30. Cheng CY, Reich D, Wong TY, Klein R, Klein BE, Patterson N et al. Admixture mapping scans identify a locus affecting retinal vascular caliber in hyper-tensive African Americans: the Atherosclerosis Risk in Communities (ARIC) study. PLoS Genet 2010; 6: e1000908.
31. Ikram M, Xueling S, Jensen R, Cotch M, Hewitt A, Ikram M et al. Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo. PLoS Genet 2010; 6: e1001184.
32. Tanabe Y, Kawasaki R, Wang JJ, Wong TY, Mitchell P, Daimon M et al. Angiotensin-converting enzyme gene and retinal arteriolar narrowing: the Funagata Study. J Hum Hypertens 2009; 23: 788-793.
33. Liew G, Wang JJ, Mitchell P, Wong TY. Retinal vascular imaging: a new tool in microvascular disease research. Circ Cardiovasc Imaging 2008; 1: 156-161.
34. Wong TY, Klein R, Klein BE, Meuer SM, Hubbard LD. Retinal vessel diameters and their associations with age and blood pressure. Invest Ophthalmol Vis Sci 2003; 44: 4644-4650. (Pubitemid 37315272)
35. Cheung CY, Hsu W, Lee ML, Wang JJ, Mitchell P, Lau Q et al. A new method to measure peripheral retinal vascular caliber over an extended area. Microcircu-lation 2010; 17: 495-503.
36. Gudmundsdottir H, Taarnhøj N, Strand A, Kjeldsen S, Høieggen A, Os I. Blood pressure development and hypertensive retinopathy: 20-year follow-up of middle-aged normotensive and hypertensive men. J Hum Hypertens 2010; 24: 505-513.
37. Liew G, Wang JJ, Cheung N, Zhang YP, Hsu W, Lee ML et al. The retinal vasculature as a fractal: methodology, reliability, and relationship to blood pressure. Ophthalmology 2008; 115: 1951-1956.
38. Witt N, Wong TY, Hughes AD, Chaturvedi N, Klein BE, Evans R et al. Abnormalities of retinal micro-vascular structure and risk of mortality from ischemic heart disease and stroke. Hypertension 2006; 47: 975-981. (Pubitemid 44297571)
39. Cheung N, Donaghue KC, Liew G, Rogers SL, Wang JJ, Lim SW et al. Quantitative assessment of early diabetic retinopathy using fractal analysis. Diabetes Care 2009; 32: 106-110.
40. Sasongko MB, Wang JJ, Donaghue KC, Cheung N, Benitez-Aguirre P, Jenkins A, et al. Alterations in retinal microvascular geometry in young type 1 diabetes. Diabetes Care 2010; 33: 1331-1336.
41. Ritt M, Schmieder RE. Wall-to-lumen ratio of retinal arterioles as a tool to assess vascular changes. Hypertension 2009; 54: 384-387.
42. Patton N, Aslam T, Macgillivray T, Dhillon B, Constable II. Asymmetry of retinal arteriolar branch widths at junctions affects ability of formulae to predict trunk arteriolar widths. Invest Ophthalmol Vis Sci 2006; 47: 1329-1333. (Pubitemid 46780737)
43. Kwa VI, van der Sande JJ, Stam J, Tijmes N, Vrooland JL, Amsterdam Vascular Medicine G Retinal arterial changes correlate with cerebral small-vessel disease. Neurology 2002; 59: 1536-1540. (Pubitemid 35387058)
44. Wong TY, Klein R, Sharrett AR, Couper DJ, Klein BE, Liao DP et al. Cerebral white matter lesions, retinopathy, and incident clinical stroke. JAMA 2002; 288: 67-74. (Pubitemid 34705520)
45. Wong TY, Klein R, Couper DJ, Cooper LS, Shahar E, Hubbard LD et al. Retinal microvascular abnormal-ities and incident stroke: the Atherosclerosis Risk in Communities Study. Lancet 2001; 358: 1134-1140. (Pubitemid 32971846)
46. Wong TY, Klein R, Sharrett AR, Nieto FJ, Boland LL, Couper DJ et al. Retinal microvascular abnormalities and cognitive impairment in middle-aged persons: the Atherosclerosis Risk in Communities Study. Stroke 2002; 33: 1487-1492. (Pubitemid 34619944)
47. Wong TY, Mosley Jr TH, Klein R, Klein BE, Sharrett AR, Couper DJ et al. Retinal microvascular changes and MRI signs of cerebral atrophy in healthy, middle-aged people. Neurology 2003; 61: 806-811. (Pubitemid 37174477)
48. Yatsuya H, Folsom AR, Wong TY, Klein R, Klein B, Sharrett AR et al. Retinal microvascular abnormal-ities and risk of lacunar stroke: Atherosclerosis Risk in Communities Study. Stroke 2010; 41: 1349-1355.
49. Wong TY, Rosamond W, Chang PP, Couper DJ, Sharrett AR, Hubbard LD et al. Retinopathy and risk of congestive heart failure. JAMA 2005; 293: 63-69. (Pubitemid 40066700)
50. Shantha GP, Srinivasan Y, Kumar AA, Salim S, Prabakhar S, Rajan AG et al. Can retinal changes predict coronary artery disease in elderly hyperten-sive patients presenting with angina? Am J Emerg Med 2010; 28: 617-621.
51. Cheung N, Bluemke DA, Klein R, Sharrett AR, Islam FM, Cotch MF et al. Retinal arteriolar narrowing and left ventricular remodeling. J Am Coll Cardiol 2007; 50: 48-55.
52. Miller RG, Prince CT, Klein R, Orchard TJ. Retinal vessel diameter and the incidence of coronary artery disease in type 1 diabetes. Am J Ophthalmol 2009; 147: 653-660.
53. Kim G-H, Youn H-J, Kang S, Choi Y-S, Moon J-I. Relation between grade II hypertensive retinopathy and coronary artery disease in treated essential hyper-tensives. Clin Exp Hypertens 2010; 32: 469-473.
54. Cuspidi C, Meani S, Valerio C, Fusi V, Catini E, Sala C et al. Prevalence and correlates of advanced retinopathy in a large selected hypertensive popula-tion. The Evaluation of Target Organ Damage in Hypertension (ETODH) study. Blood Press 2005; 14: 25-30. (Pubitemid 40443750)
55. Cuspidi C, Negri F, Giudici V, Sala C. Retinal changes and cardiac remodelling in systemic hyper-tension. Ther Adv Cardiovasc Dis 2009; 3: 205-214.
56. Masaidi M, Cuspidi C, Giudici V, Negrib F, Sala C, Zanchetti A et al. Is retinal arteriolar-venular ratio associated with cardiac and extracardiac organ damage in essential hypertension? J Hypertens 2009; 27: 1277-1283.
57. McClintic BR, McClintic JI, Bisognano JD, Block RC. The relationship between retinal microvascular abnormalities and coronary heart disease: a review. Am JMed 2010; 123: e1-374e7.
58. Shaw LJ, Lewis JF, Hlatky MA et al. Women's Ischemic Syndrome Evaluation: current status and future research directions: report of the National Heart, Lung and Blood Institute workshop: October 2-4, 2002: Sec-tion gender-related risk factors for ischemic heart disease. Circulation 2004; 109: e56-e58.
59. Wang L, Wong TY, Sharrett AR, Klein R, Folsom AR, Jerosch-Herold M. Relationship between retinal arteriolar narrowing and myocardial perfusion: Multi-Ethnic Study of Atherosclerosis. Hypertension 2008; 51: 119-126. (Pubitemid 350307113)
60. Gunn RM. Ophthalmoscopic evidence of (1) arterial changes associated with chronic renal diseases and (2) of increased arterial tension. Trans Am Ophthal-mol Soc 1892; 12: 124-125.
61. Gunn RM. On ophthalmoscopic evidence of general arterial disease. Trans Ophthalmol Soc UK 1898; 18: 356-381.
62. Keith NM, Wagener HP, Barker NW. Some different types of essential hypertension: their course and prognosis. Am J Med Sci 1939; 197: 332-343.
63. Wong TY, McIntosh R. Systemic associations of retinal microvascular signs: a review of recent population-based studies. Ophthal Physiol Opt 2005; 25: 195-204. (Pubitemid 41702436)
64. Tso MO, J Ampol LM. Pathophysiology of hypertensive retinopathy. Ophthalmology 1982; 89: 1132-1145. (Pubitemid 12003230)
65. Wong TY, Klein R, Klein BE, Tielsch JM, Hubbard L, Nieto FJ. Retinal microvascular abnormalities and their relationship with hypertension, cardiovascular disease, and mortality. Surv Ophthalmol 2001; 46: 59-80. (Pubitemid 32781831)
66. Bock KD. Regression of retinal vascular changes by antihypertensive therapy. Hypertension 1984; 6(6 Part 2): III158-III162.
67. Dahlof B, Stenkula S, Hansson L. Hypertensive retinal vascular changes: relationship to left ventri-cular hypertrophy and arteriolar changes before and after treatment. Blood Press 1992; 1: 35-44.
68. Hughes AD, Stanton AV, Jabbar AS, Chapman N, Martinez-Perez ME, Thoma SAM. Effect of antihy-pertensive treatment on retinal microvascular changes in hypertension. J Hypertens 2008; 26: 1703-1707.
69. Thom S, Stettler C, Stanton A, Witt N, Tapp R, Chaturvedi N et al. Differential effects of antihyper-tensive treatment on the retinal microcirculation. An anglo-scandinavian cardiac outcomes trial substudy. Hypertension 2009; 54: 405-408.
70. Karter Y, Curgunlu A, Altinisik S, Ertürk N, Vehid S, Mihmanli I et al. Target organ damage and changes in arterial compliance in white coat hypertension. Is white coat innocent? Blood Press 2003; 12: 307-313. (Pubitemid 38139221)
71. Grosso A, Veglio F, Porta M, Grignolo FM, Wong TY. Hypertensive retinopathy revisited: some answers, more questions. Br J Ophthalmol 2005; 89: 1646-1654. (Pubitemid 41729914)
72. Klein R, Marino EK, Kuller LH, Polak JF, Tracy RP, Gottdiener JS et al. The relation of atherosclerotic cardiovascular disease to retinopathy in people with diabetes in the Cardiovascular Health Study. Br JOphthalmol 2002; 86: 84-90. (Pubitemid 34074891)
73. Cheung N, Mitchell P, Wong TY. Diabetic retino-pathy. RevLancet 2010; 376: 124-136.
74. Matthews DR, Stratton IM, Aldington SJ, Holman RR, Kohner EM, Group UKPDS. Risks of progression of retinopathy and vision loss related to tight blood pressure control in type 2 diabetes mellitus: UKPDS 69. Arch Ophthalmol 2004; 122: 1631-1640. (Pubitemid 39473407)
75. Wong T, Mwamburi M, Klein R, Larsen M, Flynn H, Hernandez-Medina M et al. Rates of progression in diabetic retinopathy during different time periods: a systematic review and meta-analysis. Diabetes Care 2009; 32: 2307-2313.
76. Chaturvedi N, Porta M, Klein R, Orchard T, Fuller J, Parving HH et al. Effect of candesartan on preven-tion (DIRECT-Prevent 1) and progression (DIRECT-Protect 1) of retinopathy in type 1 diabetes: rando-mised, placebo-controlled trials. Lancet 2008; 372: 1394-1402.
77. Sjolie A, Klein R, Porta M, Orchard T, Fuller J, Parving HH et al. Effect of candesartan on progres-sion and regression of retinopathy in type 2 diabetes (DIRECT-Protect 2): a randomised placebo-con-trolled trial. Lancet 2008; 372: 1385-1393.
78. Mauer M, Zinman B, Gardiner R, Suissa S, Sinaiko A, Strand T et al. Renal and retinal effects of enalapril and losartan in type 1 diabetes. N Engl J Med 2009; 361: 40-51.
79. Klein R, Myers CE, Klein BEK, Zinman B, Gardiner R, Suissa S et al. Relationship of blood pressure to retinal vessel diameter in type 1 diabetes mellitus. Arch Ophthalmol 2010; 128: 198-205.
80. Mirshahi A, Feltgen N, Hansen LL, Hattenbach L-O. Retinal vascular occlusions: review article]. Dtsch Arztebl Int 2008; 105: 474-479.
81. Hayreh SS. Prevalent misconceptions about acute retinal vascular occlusive disorders. Prog Retin Eye Res 2005; 24: 493-519. (Pubitemid 40544632)
82. Scott IU, Ip MS, VanVeldhuisen PC, Oden NL, Blodi BA, Fisher M et al. A randomized trial comparing the efficacy and safety of intravitreal triamcinolone with standard care to treat vision loss associated with macular edema secondary to branch retinal vein occlusion: the standard care vs corticosteroid for retinal vein occlusion (SCORE)Study Report 6. Arch Ophthalmol 2009; 127: 1115-1128.
83. Haller JA, Bandello F, Belfort RJ, Blumenkranz MS, Gillies M, Heier J et al. Randomized, sham-con-trolled trial of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion. Ophthalmology2010; 117: 1134-1146 .e3.
84. Hayreh SS, Podhajsky PA, Zimmerman MB. Retinal artery occlusion: associated systemic and ophthalmic abnormalities. Ophthalmology 2009; 116: 1928-1936.
85. Arnold M, Koerner U, Remonda L, Nedeltchev K, Mattle HP, Schroth G et al. Comparison of intra-arterial thrombolysis with conventional treatment in patients with acute central retinal artery occlusion. J Neurol Neurosurg Psychiatry 2005; 76: 196-199. (Pubitemid 40143707)
86. Cheung N, Klein R, Wang JJ, Cotch MF, Islam AF, Klein BE et al. Traditional and novel cardiovascular risk factors for retinal vein occlusion: the multi-ethnic study of atherosclerosis. Invest Ophthalmol Vis Sci 2008; 49: 4297-4302.
87. Cugati S, WangJJ, Rochtchina E, Mitchell P. Ten-year incidence of retinal emboli in an older population. Stroke 2006; 37: 908-910. (Pubitemid 43731931)
88. Rogers SL, McIntosh RL, Lim L, Mitchell P, Cheung N, Kowalski JW et al. Natural history of branch retinal vein occlusion: an evidence-based systematic review. Ophthalmology 2010; 117: 1094-1101.
89. McIntosh RL, Rogers SL, Lim L, Cheung N, Wang JJ, Mitchell P et al. Natural history of central retinal vein occlusion: an evidence-based systematic re-view. Ophthalmology 2010; 117(6): 1113-1123.
90. Rogers S, McIntosh RL, Cheung N, Lim L, Wang JJ, Mitchell P et al. The prevalence of retinal vein occlusion: pooled data from population studies from the United States, Europe, Asia, and Australia. Ophthalmology 2010; 117(2): 313-319.
91. Karia N. Retinal vein occlusion: pathophysiology and treatment options. Clin Ophthalmol 2010; 4: 809-816.
92. Sodi A, Giambene B, Marcucci R, Sofi F, Fedi S, Abbate R, et al. Atherosclerotic and thrombo-philic risk factors in patients with ischemic central retinal vein occlusion. Retina 2010; (e-pub ahead of print 21 December 2010).
93. Patel PJ, Zaheer I, Karia N. Intravitreal triamcinolone acetonide for macular edema owing to retinal vein occlusion. Eye 2008; 22: 60-64.
94. Prager F, Michels S, Kriechbaum K, Georgopoulos M, Funk M, Geitzenauer W et al. Intravitreal bevacizu-mab (Avastin) for macular edema secondary to retinal vein occlusion:12-month results of a pro-spective clinical trial. Br J Ophthalmol 2009; 93: 452-456.
95. Wong TY, Klein R. Retinal arteriolar emboli: epide-miology and risk of stroke. Curr Opin Ophthalmol 2002; 13: 142-146. (Pubitemid 34518197)
96. Klein R, Klein BE, Moss SE, Meuer SM. Retinal emboli and cardiovascular disease: the Beaver Dam Eye Study. Arch Ophthalmol 2003; 121: 1446-1451. (Pubitemid 37243746)
97. Wang JJ, Cugati S, Knudtson MD, Rochtchina E, Klein R, Klein BEK et al. Retinal arteriolar emboli and long-term mortality pooled data analysis from two older populations. Stroke 2006; 37: 1833-1836. (Pubitemid 44297738)
98. Wong TY, Larsen EK, Klein R, Mitchell P, Couper DJ, Klein BE et al. Cardiovascular risk factors for retinal vein occlusion and arteriolar emboli: the athero-sclerosis risk in communities & cardiovascular health studies. Ophthalmology 2005; 112: 540-547. (Pubitemid 41108850)
99. Panton RW, Goldberg MF, Farber MD. Retinal arterial macroaneurysms: risk factors and natural history. Br J Ophthalmol 1990; 74: 595-600. (Pubitemid 20302792)
100. Brown DM, Sobol WM, FolkJC, Weingeist TA. Retinal arteriolar macroaneurysms: long-term visual out-come. Br J Ophthalmol 1994; 78: 534-538. (Pubitemid 24213011)
101. Rabb MF, Gagliano DA, Teske MP. Retinal arterial macroaneurysms. Surv Ophthalmol 1988; 33: 73-96.
102. Hayreh SS. Management of ischemic optic neuro-pathies. Indian J Ophthalmol 2011; 59: 123-136.
103. Hayreh SS. Blood flow in the optic nerve head and factors that may influence it. Prog Retin Eye Res 2001; 20: 595-624. (Pubitemid 32720393)
104. Rucker JC, Biousse V, Newman NJ. Ischemic optic neuropathies. Curr Opin Neurol 2004; 17: 27-35. (Pubitemid 38316776)
105. Hattenhauer MG, LeavittJA, Hodge DO, Grill R, Gray DT. Incidence of nonarteritic anterior ischemic optic neuropathy. Am J Ophthalmol 1997; 123: 103-107. (Pubitemid 27044568)