메뉴 건너뛰기




Volumn 58, Issue 2, 2011, Pages 133-142

Wogonin suppresses arrhythmias, inflammatory responses, and apoptosis induced by myocardial ischemia/reperfusion in rats

Author keywords

apoptosis; arrhythmias; monocyte chemoattractant protein 1; myocardial ischemia reperfusion injury; nuclear factor B; p38 mitogen activated protein kinase; wogonin

Indexed keywords

ANTIARRHYTHMIC AGENT; ANTIINFLAMMATORY AGENT; APOPTOSIS INHIBITOR; CASPASE 3; CREATINE KINASE; I KAPPA B ALPHA; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; SUPEROXIDE; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR; WOGONIN;

EID: 80051791387     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0b013e31821a5078     Document Type: Article
Times cited : (53)

References (46)
  • 1
    • 35748946613 scopus 로고    scopus 로고
    • Regulation of ion channels and arrhythmias in the ischemic heart
    • Akar JG, Akar FG. Regulation of ion channels and arrhythmias in the ischemic heart. J Electrocardiol. 2007;40:S37-S41.
    • (2007) J Electrocardiol. , vol.40
    • Akar, J.G.1    Akar, F.G.2
  • 2
    • 20344401109 scopus 로고    scopus 로고
    • Mechanisms, management and future directions for reperfusion injury after acute myocardial infarction
    • Cannon RO III. Mechanisms, management and future directions for reperfusion injury after acute myocardial infarction. Natl Clin Pract Cardiovasc Med. 2005;2:88-94.
    • (2005) Natl Clin Pract Cardiovasc Med. , vol.2 , pp. 88-94
    • Cannon III, R.O.1
  • 3
    • 3042819287 scopus 로고    scopus 로고
    • The role of the chemokines in myocardial ischemia and reperfusion
    • Frangogiannis NG. The role of the chemokines in myocardial ischemia and reperfusion. Curr Vasc Pharmacol. 2004;2:163-174.
    • (2004) Curr Vasc Pharmacol. , vol.2 , pp. 163-174
    • Frangogiannis, N.G.1
  • 4
    • 0037352329 scopus 로고    scopus 로고
    • Role of nuclear factor-kappa B activation in acute ischaemia-reperfusion injury in myocardium
    • Kis A, Yellon DM, Baxter GF. Role of nuclear factor-kappa B activation in acute ischaemia-reperfusion injury in myocardium. Br J Pharmacol. 2003;138:894-900.
    • (2003) Br J Pharmacol. , vol.138 , pp. 894-900
    • Kis, A.1    Yellon, D.M.2    Baxter, G.F.3
  • 5
    • 0030855813 scopus 로고    scopus 로고
    • In vivo transfection of cis element ''decoy'' against nuclear factor-kappaB binding site prevents myocardial infarction
    • Morishita R, Sugimoto T, Aoki M, et al. In vivo transfection of cis element ''decoy'' against nuclear factor-kappaB binding site prevents myocardial infarction. Natl Med. 1997;3:894-899.
    • (1997) Natl Med. , vol.3 , pp. 894-899
    • Morishita, R.1    Sugimoto, T.2    Aoki, M.3
  • 6
    • 0037370653 scopus 로고    scopus 로고
    • Proteasome inhibition ablates activation of NF-kB in myocardial reperfusion and reduces reperfusion injury
    • Pye J, Ardeshirpour F, McCain A, et al. Proteasome inhibition ablates activation of NF-kB in myocardial reperfusion and reduces reperfusion injury. Am J Physiol Heart Circ Physiol. 2003;284:H919-H926.
    • (2003) Am J Physiol Heart Circ Physiol. , vol.284
    • Pye, J.1    Ardeshirpour, F.2    McCain, A.3
  • 7
    • 0036847858 scopus 로고    scopus 로고
    • Apoptosis in myocardial ischemia and infarction
    • Krijnen PA, Nijmeijer R, Meijer CJ, et al. Apoptosis in myocardial ischemia and infarction. J Clin Pathol. 2002;55:801-811.
    • (2002) J Clin Pathol. , vol.55 , pp. 801-811
    • Krijnen, P.A.1    Nijmeijer, R.2    Meijer, C.J.3
  • 8
    • 0032750323 scopus 로고    scopus 로고
    • Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi
    • Gao Z, Huang K, Yang X, et al. Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. Biochim Biophys Acta. 1999;1472:643-650.
    • (1999) Biochim Biophys Acta. , vol.1472 , pp. 643-650
    • Gao, Z.1    Huang, K.2    Yang, X.3
  • 9
    • 0032814249 scopus 로고    scopus 로고
    • Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships
    • Kim HK, Cheon BS, Kim YH, et al. Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships. Biochem Pharmacol. 1999;58:759-765.
    • (1999) Biochem Pharmacol. , vol.58 , pp. 759-765
    • Kim, H.K.1    Cheon, B.S.2    Kim, Y.H.3
  • 10
    • 0034693253 scopus 로고    scopus 로고
    • Wogonin inhibits inducible prostaglandin E2 production in macrophages
    • Wakabayashi I, Yasui K. Wogonin inhibits inducible prostaglandin E2 production in macrophages. Eur J Pharmacol. 2000;406:477-481.
    • (2000) Eur J Pharmacol. , vol.406 , pp. 477-481
    • Wakabayashi, I.1    Yasui, K.2
  • 11
    • 0034876980 scopus 로고    scopus 로고
    • Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells
    • Chang YL, Shen JJ, Wung BS, et al. Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells. Mol Pharmacol. 2001;60:507-513.
    • (2001) Mol Pharmacol. , vol.60 , pp. 507-513
    • Chang, Y.L.1    Shen, J.J.2    Wung, B.S.3
  • 12
    • 0038166129 scopus 로고    scopus 로고
    • Effects of baicalin, baicalein, and wogonin on interleukin-6 and interleukin-8 expression, and nuclear factor-kB binding activities induced by interleukin-1 in human retinal pigment epithelial cell line
    • Nakamura N, Hayasaka S, Zhang XY, et al. Effects of baicalin, baicalein, and wogonin on interleukin-6 and interleukin-8 expression, and nuclear factor-kB binding activities induced by interleukin-1 in human retinal pigment epithelial cell line. Exp Eye Res. 2003;77:195-202.
    • (2003) Exp Eye Res. , vol.77 , pp. 195-202
    • Nakamura, N.1    Hayasaka, S.2    Zhang, X.Y.3
  • 13
    • 0035839226 scopus 로고    scopus 로고
    • Inhibition of TPA-induced cyclooxygenase- 2 expression and skin inflammation in mice by wogonin, a plant flavone from Scutellaria radix
    • Park BK, Heo MY, Park H, et al. Inhibition of TPA-induced cyclooxygenase- 2 expression and skin inflammation in mice by wogonin, a plant flavone from Scutellaria radix. Eur J Pharmacol. 2001;425:153-157.
    • (2001) Eur J Pharmacol. , vol.425 , pp. 153-157
    • Park, B.K.1    Heo, M.Y.2    Park, H.3
  • 14
    • 0037141773 scopus 로고    scopus 로고
    • In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production
    • Shen SC, Lee WR, Lin HY, et al. In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production. Eur J Pharmacol. 2002;446:187-194.
    • (2002) Eur J Pharmacol. , vol.446 , pp. 187-194
    • Shen, S.C.1    Lee, W.R.2    Lin, H.Y.3
  • 15
    • 0018898050 scopus 로고
    • The effects of prolonged oral administration of a new antidysrhythmic drug (Org 6001) on coronary artery ligation dysrhythmias in conscious and anesthetized rats
    • Kane KA, Leprán I, McDonald FM, et al. The effects of prolonged oral administration of a new antidysrhythmic drug (Org 6001) on coronary artery ligation dysrhythmias in conscious and anesthetized rats. J Cardiovasc Pharmacol. 1980;2:411-423.
    • (1980) J Cardiovasc Pharmacol. , vol.2 , pp. 411-423
    • Kane, K.A.1    Leprán, I.2    McDonald, F.M.3
  • 16
    • 0018817635 scopus 로고
    • Coronary artery ligation in anesthetized rats as a method for the production of experimental dysrhythmias and for the determination of infarct size
    • Clark C, Foreman MI, Kane KA, et al. Coronary artery ligation in anesthetized rats as a method for the production of experimental dysrhythmias and for the determination of infarct size. J Pharmacol Methods. 1980;3:357-368.
    • (1980) J Pharmacol Methods. , vol.3 , pp. 357-368
    • Clark, C.1    Foreman, M.I.2    Kane, K.A.3
  • 17
    • 0021690255 scopus 로고
    • Ischemia and reperfusion-induced arrhythmias in the rat. Effects of xanthine oxidase inhibition with allopurinol
    • Manning AS, Coltart DJ, Hearse DJ. Ischemia and reperfusion-induced arrhythmias in the rat. Effects of xanthine oxidase inhibition with allopurinol. Circ Res. 1984;55:545-548.
    • (1984) Circ Res. , vol.55 , pp. 545-548
    • Manning, A.S.1    Coltart, D.J.2    Hearse, D.J.3
  • 18
    • 0023199330 scopus 로고
    • Models for the study of arrhythmias in myocardial ischaemia and infarction: The use of the rat
    • Curtis MJ, Macleod BA, Walker MJ. Models for the study of arrhythmias in myocardial ischaemia and infarction: The use of the rat. J Mol Cell Cardiol. 1987;19:399-419.
    • (1987) J Mol Cell Cardiol. , vol.19 , pp. 399-419
    • Curtis, M.J.1    Macleod, B.A.2    Walker, M.J.3
  • 19
    • 74549197632 scopus 로고    scopus 로고
    • Cardioprotective effects of longterm treatment with raloxifene, a selective estrogen receptor modulator, on myocardial ischemia/reperfusion injury in ovariectomized rats
    • Chung MT, Cheng PY, Lam KK, et al. Cardioprotective effects of longterm treatment with raloxifene, a selective estrogen receptor modulator, on myocardial ischemia/reperfusion injury in ovariectomized rats. Menopause. 2010;17:127-134.
    • (2011) Menopause. , vol.17 , pp. 127-134
    • Chung, M.T.1    Cheng, P.Y.2    Lam, K.K.3
  • 20
    • 85047679058 scopus 로고
    • The Lambeth Conventions: Guidelines for the study of arrhythmias in ischaemia infarction, and reperfusion
    • Walker MJ, Curtis MJ, Hearse DJ, et al. The Lambeth Conventions: Guidelines for the study of arrhythmias in ischaemia infarction, and reperfusion. Cardiovasc Res. 1988;22:447-455.
    • (1988) Cardiovasc Res. , vol.22 , pp. 447-455
    • Walker, M.J.1    Curtis, M.J.2    Hearse, D.J.3
  • 21
    • 0020680631 scopus 로고
    • Effects of aspirin and prostacyclin on arrhythmias resulting from coronary artery ligation and on infarct size
    • Johnston KM, MacLeod BA, Walker MJ. Effects of aspirin and prostacyclin on arrhythmias resulting from coronary artery ligation and on infarct size. Br J Pharmacol. 1983;78:29-37.
    • (1983) Br J Pharmacol. , vol.78 , pp. 29-37
    • Johnston, K.M.1    MacLeod, B.A.2    Walker, M.J.3
  • 22
    • 0024508802 scopus 로고
    • Ischaemia-induced and reperfusion-induced arrhythmias differ in their sensitivity to potassium: Implications for mechanisms of initiation and maintenance of ventricular fibrillation
    • Curtis MJ, Hearse DJ. Ischaemia-induced and reperfusion-induced arrhythmias differ in their sensitivity to potassium: Implications for mechanisms of initiation and maintenance of ventricular fibrillation. J Mol Cell Cardiol. 1989;21:21-40.
    • (1989) J Mol Cell Cardiol. , vol.21 , pp. 21-40
    • Curtis, M.J.1    Hearse, D.J.2
  • 23
    • 0025939769 scopus 로고
    • Influence of tedisamil on the initiation and maintenance of ventricular fibrillation: Chemical defibrillation by Ito blockade?
    • Tsuchihashi K, Curtis MJ. Influence of tedisamil on the initiation and maintenance of ventricular fibrillation: Chemical defibrillation by Ito blockade? J Cardiovasc Pharmacol. 1991;18:445-456.
    • (1991) J Cardiovasc Pharmacol. , vol.18 , pp. 445-456
    • Tsuchihashi, K.1    Curtis, M.J.2
  • 24
    • 35348970307 scopus 로고    scopus 로고
    • IKKb inhibition attenuates myocardial injury and dysfunction following acute ischemia-reperfusion injury
    • Moss NC, Stansfield WE, Willis MS, et al. IKKb inhibition attenuates myocardial injury and dysfunction following acute ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2007;293:H2248-H2253.
    • (2007) Am J Physiol Heart Circ Physiol. , vol.293
    • Moss, N.C.1    Stansfield, W.E.2    Willis, M.S.3
  • 25
    • 33749318469 scopus 로고    scopus 로고
    • Tetramethylpyrazine induces heme oxygenase-1 expression and attenuates myocardial ischemia/reperfusion injury in rats
    • Chen SY, Hsiao G, Hwang HR, et al. Tetramethylpyrazine induces heme oxygenase-1 expression and attenuates myocardial ischemia/reperfusion injury in rats. J Biomed Sci. 2006;13:731-740.
    • (2006) J Biomed Sci. , vol.13 , pp. 731-740
    • Chen, S.Y.1    Hsiao, G.2    Hwang, H.R.3
  • 26
    • 24644499108 scopus 로고    scopus 로고
    • Atrial fibrillation increases production of superoxide by the left atrium and left atrial appendage: Role of the NADPH and xanthine oxidases
    • Dudley SC Jr, Hoch NE, McCann LA, et al. Atrial fibrillation increases production of superoxide by the left atrium and left atrial appendage: Role of the NADPH and xanthine oxidases. Circulation. 2005;112:1266-1273.
    • (2005) Circulation. , vol.112 , pp. 1266-1273
    • Dudley Jr., S.C.1    Hoch, N.E.2    McCann, L.A.3
  • 27
    • 33747882756 scopus 로고    scopus 로고
    • Heart rate: A risk factor for cardiac diseases and outcomes? Pathophysiology of cardiac diseases and the potential role of heart rate slowing
    • Lanza GA, Fox K, Crea F. Heart rate: A risk factor for cardiac diseases and outcomes? Pathophysiology of cardiac diseases and the potential role of heart rate slowing. Adv Cardiol. 2006;43:1-16.
    • (2006) Adv Cardiol. , vol.43 , pp. 1-16
    • Lanza, G.A.1    Fox, K.2    Crea, F.3
  • 28
    • 34548463341 scopus 로고    scopus 로고
    • Antioxidants and cardioprotection
    • Hamilton KL. Antioxidants and cardioprotection. Med Sci Sports Exerc. 2007;39:1544-1553.
    • (2007) Med Sci Sports Exerc. , vol.39 , pp. 1544-1553
    • Hamilton, K.L.1
  • 29
    • 0038746702 scopus 로고    scopus 로고
    • Redox regulation following cardiac ischemia and reperfusion
    • Marczin N, Bundy RE, Hoare GS, et al. Redox regulation following cardiac ischemia and reperfusion. Coron Artery Dis. 2003;14:123-133.
    • (2003) Coron Artery Dis. , vol.14 , pp. 123-133
    • Marczin, N.1    Bundy, R.E.2    Hoare, G.S.3
  • 30
    • 0028214238 scopus 로고
    • The microcirculation and inflammation: Modulation of leukocyte- endothelial cell adhesion
    • Granger DN, Kubes P. The microcirculation and inflammation: Modulation of leukocyte-endothelial cell adhesion. J Leukoc Biol. 1994;55:662-675.
    • (1994) J Leukoc Biol. , vol.55 , pp. 662-675
    • Granger, D.N.1    Kubes, P.2
  • 31
    • 33748557190 scopus 로고    scopus 로고
    • Regulating the regulator: NF-kB signaling in heart
    • Hall G, Hasday JD, Rogers TB. Regulating the regulator: NF-kB signaling in heart. J Mol Cell Cardiol. 2006;41:580-591.
    • (2006) J Mol Cell Cardiol. , vol.41 , pp. 580-591
    • Hall, G.1    Hasday, J.D.2    Rogers, T.B.3
  • 32
    • 0043236476 scopus 로고    scopus 로고
    • Gene transfer of IkappaBalpha limits infarct size in a mouse model of myocardial ischemia-reperfusion injury
    • Squadrito F, Deodato B, Squadrito G, et al. Gene transfer of IkappaBalpha limits infarct size in a mouse model of myocardial ischemia-reperfusion injury. Lab Invest. 2003;83:1097-1104.
    • (2003) Lab Invest. , vol.83 , pp. 1097-1104
    • Squadrito, F.1    Deodato, B.2    Squadrito, G.3
  • 33
    • 59649117807 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1: A key mediator in inflammatory processes
    • Melgarejo E, Medina MA, Sanchez-Jimenes F, et al. Monocyte chemoattractant protein-1: A key mediator in inflammatory processes. Int J Biochem Cell Biol. 2009;41:998-1001.
    • (2009) Int J Biochem Cell Biol. , vol.41 , pp. 998-1001
    • Melgarejo, E.1    Medina, M.A.2    Sanchez-Jimenes, F.3
  • 34
    • 16844387569 scopus 로고    scopus 로고
    • Induction of monocyte chemoattractant protein-1 in the small veins of the ischemic and reperfused canine myocardium
    • Kumar AG, Ballantyne CM, Michael LH, et al. Induction of monocyte chemoattractant protein-1 in the small veins of the ischemic and reperfused canine myocardium. Circulation. 1997;95:693-700.
    • (1997) Circulation. , vol.95 , pp. 693-700
    • Kumar, A.G.1    Ballantyne, C.M.2    Michael, L.H.3
  • 35
    • 0032984889 scopus 로고    scopus 로고
    • Prevention of myocardial reperfusion injury in rats by an antibody against monocyte chemotactic and activating factor/monocyte chemoattractant protein-1
    • Ono K, Matsumori A, Furukawa Yet al. Prevention of myocardial reperfusion injury in rats by an antibody against monocyte chemotactic and activating factor/monocyte chemoattractant protein-1. Lab Invest. 1999;79:195-203.
    • (1999) Lab Invest. , vol.79 , pp. 195-203
    • Ono, K.1    Matsumori, A.2    Furukawa, Y.3
  • 36
    • 0036378606 scopus 로고    scopus 로고
    • Enhanced MCP-1 expression during ischemia/reperfusion injury is mediated by oxidative stress and NF-kB
    • Sung FL, Zhu TY, Au-Yeung KKW, et al. Enhanced MCP-1 expression during ischemia/reperfusion injury is mediated by oxidative stress and NF-kB. Kidney Int. 2002;62:1160-1170.
    • (2002) Kidney Int. , vol.62 , pp. 1160-1170
    • Sung, F.L.1    Zhu, T.Y.2    Au-Yeung, K.K.W.3
  • 37
    • 0038757610 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases: A new therapeutic target in cardiac pathology
    • Ravingerova T, Barancik M, Strniskova M. Mitogen-activated protein kinases: A new therapeutic target in cardiac pathology. Mol Cell Biochem. 2003;247:127-138.
    • (2003) Mol Cell Biochem. , vol.247 , pp. 127-138
    • Ravingerova, T.1    Barancik, M.2    Strniskova, M.3
  • 38
    • 19644367000 scopus 로고    scopus 로고
    • Activation and signaling of the p38 MAP kinase pathway
    • Zarubin T, Han J. Activation and signaling of the p38 MAP kinase pathway. Cell Res. 2005;15:11-18.
    • (2005) Cell Res. , vol.15 , pp. 11-18
    • Zarubin, T.1    Han, J.2
  • 39
    • 0033528695 scopus 로고    scopus 로고
    • Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischemia and reperfusion
    • Ma XL, Kumar S, Gao F, et al. Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischemia and reperfusion. Circulation. 1999;99: 1685-1691.
    • (1999) Circulation. , vol.99 , pp. 1685-1691
    • Ma, X.L.1    Kumar, S.2    Gao, F.3
  • 40
    • 0035008371 scopus 로고    scopus 로고
    • Inhibition of p38 MAPK alpha/ beta reduces ischemic injury and does not block protective effects of preconditioning
    • Schneider S, Chen W, Hou J, et al. Inhibition of p38 MAPK alpha/ beta reduces ischemic injury and does not block protective effects of preconditioning. Am J Physiol Heart Circ Physiol. 2001;280:H499-H508.
    • (2001) Am J Physiol Heart Circ Physiol. , vol.280
    • Schneider, S.1    Chen, W.2    Hou, J.3
  • 41
    • 11044236031 scopus 로고    scopus 로고
    • Ischemia/reperfusion injury at the intersection with cell death
    • Logue SE, Gustaffson AB, Samali A, et al. Ischemia/reperfusion injury at the intersection with cell death. J Mol Cell Cardiol. 2005;38:21-33.
    • (2005) J Mol Cell Cardiol. , vol.38 , pp. 21-33
    • Logue, S.E.1    Gustaffson, A.B.2    Samali, A.3
  • 42
    • 0035708509 scopus 로고    scopus 로고
    • Roles of caspases in the programmed cell death of motoneurons in vivo
    • Yaginuma H, Sato N, Homma S, et al. Roles of caspases in the programmed cell death of motoneurons in vivo. Arch Histol Cytol. 2001; 64:461-474.
    • (2001) Arch Histol Cytol. , vol.64 , pp. 461-474
    • Yaginuma, H.1    Sato, N.2    Homma, S.3
  • 43
    • 0036023614 scopus 로고    scopus 로고
    • Myocardial apoptosis and ischemic preconditioning
    • Zhao ZQ, Vinten-Johansen J. Myocardial apoptosis and ischemic preconditioning. Cardiovasc Res. 2002;55:438-455.
    • (2002) Cardiovasc Res. , vol.55 , pp. 438-455
    • Zhao, Z.Q.1    Vinten-Johansen, J.2
  • 44
    • 34249067378 scopus 로고    scopus 로고
    • Comparative effects of flavonoids on oxidant scavenging and ischemia-reperfusion injury in cardiomyocytes
    • Chang WT, Shao ZH, Yin JJ, et al. Comparative effects of flavonoids on oxidant scavenging and ischemia-reperfusion injury in cardiomyocytes. Eur J Pharmacol. 2007;566:58-66.
    • (2007) Eur J Pharmacol. , vol.566 , pp. 58-66
    • Chang, W.T.1    Shao, Z.H.2    Yin, J.J.3
  • 45
    • 1642553221 scopus 로고    scopus 로고
    • Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia
    • Lee H, Kim YO, Kim H, et al. Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia. FASEB J. 2003;17:1943-1944.
    • (2003) FASEB J. , vol.17 , pp. 1943-1944
    • Lee, H.1    Kim, Y.O.2    Kim, H.3
  • 46
    • 21644489720 scopus 로고    scopus 로고
    • Wogonin inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusion
    • Cho J, Lee HK. Wogonin inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusion. Biol Pharm Bull. 2004;27: 1561-1564.
    • (2004) Biol Pharm Bull. , vol.27 , pp. 1561-1564
    • Cho, J.1    Lee, H.K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.