Piperazine-2,3-dicarboxylic acid derivatives as dual antagonists of NMDA and GluK1-containing kainate receptors

Journal of Medicinal Chemistry

Volumn 55, Issue 1, 2012, Pages 327-341

  Irvine, Mark W ^a   Costa, Blaise M ^c   Dlaboga, Daniel ^a   Culley, Georgia R ^a   Hulse, Richard ^b   Scholefield, Caroline L ^a   Atlason, Palmi ^a   Fang, Guangyu ^a   Eaves, Richard ^a   Morley, Richard ^a   Mayo Martin, Maria B ^a   Amici, Mascia ^a   Bortolotto, Zuner A ^a   Donaldson, Lucy ^b   Collingridge, Graham L ^a   Molnár, Elek ^a   Monaghan, Daniel T ^c   Jane, David E ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (6 IODONAPHTHALENE 2 CARBONYL)PIPERAZINE 2,3 DICARBOXYLIC ACID; 1 (6 PHENYLNAPHTHALENE 2 CARBONYL)PIPERAZINE 2,3 DICARBOXYLIC ACID; 1 (9 BROMOPHENANTHRENE 3 CARBONYL)PIPERAZINE 2,3 DICARBOXYLIC ACID; 1 (9 IODOPHENANTHRENE 3 CARBONYL)PIPERAZINE 2,3 DICARBOXYLIC ACID; 1 (PHENANTHRENE 2 CARBONYL)PIPERAZINE 2,3 DICARBOXYLIC ACID; AMPA RECEPTOR; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; IC 50; MALE; NERVE INJURY; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANALGESICS; ANIMALS; BINDING SITES; EXCITATORY POSTSYNAPTIC POTENTIALS; FEMALE; HEK293 CELLS; HIPPOCAMPUS; HUMANS; MALE; MODELS, MOLECULAR; NEURALGIA; OOCYTES; PATCH-CLAMP TECHNIQUES; PERIPHERAL NERVE INJURIES; PHENANTHRENES; PIPERAZINES; POINT MUTATION; PROTEIN SUBUNITS; RATS; RATS, WISTAR; RECEPTORS, KAINIC ACID; RECEPTORS, N-METHYL-D-ASPARTATE; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS;

EID: 84855829537     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201230z     Document Type: Article

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