Pharmacological heterogeneity of NMDA receptors: Characterization of NR1a/NR2D heteromers expressed in Xenopus oocytes

European Journal of Pharmacology

Volumn 320, Issue 1, 1997, Pages 87-94

  Buller, Amy L ^a   Monaghan, Daniel T ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Glutamate receptor; Ligand gated ion channel; NMDA receptor; Xenopus oocyte

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 4 (3 PHOSPHONOALLYL) 2 PIPERAZINECARBOXYLIC ACID; 4 (4 PHENYLBENZOYL)PIPERAZINE 2,3 DICARBOXYLIC ACID; ALPHA AMINO 5 (PHOSPHONOMETHYL)(1,1' BIPHENYL) 3 PROPIONIC ACID; ALPHA AMINO 5 (PHOSPHONOMETHYL)[1,1' BIPHENYL] 3 PROPANOIC ACID; DECAHYDRO 6 (2H TETRAZOL 5 YLMETHYL) 3 ISOQUINOLINECARBOXYLIC ACID; DICARBOXYLIC ACID DERIVATIVE; ION CHANNEL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT; PROPIONIC ACID DERIVATIVE; QUINOLINIC ACID DERIVATIVE; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FEMALE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; XENOPUS LAEVIS;

2-AMINO-5-PHOSPHONOVALERATE; ANIMALS; BIPHENYL COMPOUNDS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; ISOQUINOLINES; OOCYTES; PIPERAZINES; PROPIONIC ACIDS; QUINOLINIC ACIDS; RECEPTORS, N-METHYL-D-ASPARTATE; RECOMBINANT PROTEINS; TETRAZOLES; TRANSFECTION; XENOPUS LAEVIS;

EID: 0031046379     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00880-1     Document Type: Article

References (44)

1. Aebischer, B., P. Frey, H.P. Haerter, P.L. Herrling, W.A. Mueller, H.J. Olverman and J.C. Watkins, 1989, Synthesis and NMDA antagonist properties of the enantiomers of (E)-4-(3-phosphonopropyl)-piperazine-2-carboxylic acid (CPP) and of the unsaturated analogue (E)-4-(3-phosphonopoprop-2-enyl)piperazine-2-carboxylic acid (CPP-ene), Helv. Chim. Acta 72, 1043.
2. Anantharam, V., R.G. Panchal, A. Wilson, V. Koltchine and S.N. Treistman, 1992, Combinatorial RNA splicing alters the surface charge on the NMDA receptor, FEBS Lett. 305, 27.
3. Andaloro, V.J., D.E. Jane, J.C. Watkins and D.T. Monaghan, 1996, Pharmacology of NMDA receptor subtypes, Soc. Neurosci. 22, 1529.
4. Bear, M.F. and R.C. Malenka, 1994, Synaptic plasticity: LTP and LTD, Current Opin. Neurobiol. 4, 389.
5. Beaton, J.A., K. Stemsrud and D.T. Monaghan, 1992, Identification of a novel N-methyl-D-aspartate receptor population in the rat medial thalamus, J. Neurochem. 59, 754.
6. Buller, A.L., H.C. Larson, B.E. Schneider, J.A. Beaton, R.A. Morrisett and D.T. Monaghan, 1994, The molecular basis of NMDA receptor subtypes: native receptor diversity is predicted by subunit composition, J. Neurosci. 14, 5471.
7. Buller, A.L., H.C. Larson, R.A. Morrisett and D.T. Monaghan, 1995, Glycine modulates ethanol inhibition of heteromeric N-methyl-D-aspartate receptors expressed in Xenopus oocytes, Mol. Pharmacol. 48, 717.
8. Chazot, P.L., S.K. Coleman, M. Cik and F.A. Stephenson, 1994, Molecular characterization of N-methyl-D-aspartate receptors expressed in mammalian cells yields evidence for the co-existence of three subunit types within a discrete receptor molecule, J. Biol. Chem. 269, 24403.
9. Davies, J. and J.C. Watkins, 1982, Actions of D and L forms of 2-amino-5-phosphonovalerate (2APV) and 2-amino-4-phosphonobutyrate in the cat spinal cord, Brain Res. 235, 378.
10. Durand, G.M., P. Gregor, X. Zheng, G.R. Uhl and R.S. Zukin, 1992, Cloning of an apparent splice variant of the rat N-methyl-D-aspartate NMDAR1 with altered sensitivity to polyamines and activators of protein kinase C, Proc. Natl. Acad. Sci. USA 89, 9359.
11. Durand, G.M., M.V.L. Bennett and R.S. Zukin, 1993, Splice variants of the N-methyl-D-aspartate receptor NR1 identify domains involved in the regulation by polyamines and protein kinase C, Proc. Natl. Acad. Sci. USA 90, 6731.
12. Ebert, B., E.H.F. Wong and P. Krogsgaard-Larson, 1991, Identification of a novel NMDA receptor in rat cerebellum, Eur. J. Pharmacol. Mol. Pharmacol. Sect. 208, 49.
13. Hollmann, M., J. Boulter, C. Maron, L. Beasley, J. Sullivan, G. Pecht and S. Heinemann, 1993, Zinc potentiates agonist-induced currents at certain splice variants of the NMDA receptor, Neuron 10, 943.
14. Ikeda, K.M., H. Nagasawa, K. Mori, K. Sakimura, Y. Watanabe, Inoue and M. Mishina, 1992, Cloning and expression of the ∈4 subunit of the NMDA receptor channel, FEBS Lett. 313, 34.
15. Ishii, T., H. Moriyoshi, K. Sugihara, K. Sakurada, H. Kadotani, M. Yokoi, R. Akazawa, R. Shigemoto, N. Mizuno, M. Masu and S. Nakanishi, 1993, Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits, J. Biol. Chem. 268, 2836.
16. Kutsuwada, T., H. Kashiwabuchi, H. Mori, K. Sakimura, E. Kushiya, K. Araki, H. Meguro, H. Masaki, T. Kumanishi, M. Arakawa and M. Mishina, 1992, Molecular diversity of the NMDA receptor channel, Nature 358, 36.
17. Laurie, D.J. and P.H. Seeburg, 1994a, Regional and developmental heterogeneity in splicing of the rat brain NMDAR1 mRNA, J. Neurosci. 14, 3180.
18. Laurie, D.J. and P.H. Seeburg, 1994b, Ligand affinities at recombinant N-methyl-D-aspartate receptors depend on subunit composition, Eur. J. Pharmacol. 268, 335.
19. Leonard, J.P. and S.R. Kelso, 1990, Apparent desensitization of NMDA responses in Xenopus oocytes involves calcium-dependent chloride current, Neuron 2, 53.
20. Lipton, S.A. and P.A. Rosenberg, 1994, Excitatory amino acids as a final common pathway for neurological disorders, New Engl. J. Med. 330, 613.
21. Meguro, H., H. Mori, K. Araki, E. Kushiya, T. Kutsuwada, M. Yamazaki, T. Kumanishi, M. Arakawa, T. Sakimura and M. Mishina, 1992, Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs, Nature 357, 70.
22. 3H]MK801 binding to subpopulations of NMDA receptors, Neurosci. Lett. 122, 21.
23. Monaghan, D.T. and J.A. Beaton, 1991, Quinolinate differentiates between forebrain and cerebellar NMDA receptors, Eur. J. Pharmacol. 194, 124.
24. Monaghan, D.T. and J.A. Beaton, 1992, Pharmacologically-distinct NMDA receptor populations of the cerebellum, medial thalamic nuclei and forebrain, Mol. Neuropharmacol. 2, 71.
25. Monaghan, D.T., H.J. Olverman, L. Nguyen, J.C. Watkins and C.W. Cotman, 1988, Two classes of N-methyl-D-aspartate recognition sites: differential distribution and differential regulation by glycine, Proc. Natl. Acad. Sci. USA 85, 9836.
26. Monaghan, D.T., R.J. Bridges and C.W. Cotman, 1989, The excitatory amino acid receptors: their classes, pharmacology and distinct properties in the central nervous system, Annu. Rev. Pharmacol. Toxicol. 29, 365.
27. Monyer, H., R. Sprengel, R. Schoepfer, A. Herb, M. Higuchi, H. Lomeli, N. Burnashev, B. Sakmann and P.H. Seeburg, 1992, Heteromeric NMDA receptors: molecular and functional distinction of subtypes, Nature 256, 1217.
28. Monyer, H., N. Burnashev, D.J. Laurie, B. Sakmann and P.H. Seeburg, 1994, Developmental and regional expression in the rat brain and functional properties of four NMDA receptors, Neuron 12, 529.
29. Moriyoshi, K., M. Masu, T. Ishii, R. Shigemoto, N. Mizuno and S. Nakanishi, 1991, Molecular cloning and characterization of the rat NMDA receptor, Nature 354, 31.
30. Müller, W., D.A. Lowe, H. Neijt, S. Urwylerm, P.L. Herrling, D. Blaser and D. Seebach, 1992, Synthesis and N-methyl-D-aspartate (NMDA) antagonist properties of the enantiomers of α-amino-5-(phosphonomethyl)[1,1′-biphenyl]-3-propanoic acid. Use of a new chiral glycine derivative, Helv. Chim. Acta 75, 855.
31. Nakanishi, N., R. Axel and N.A. Schneider, 1992, Alternative splicing generates functionally distinct N-methyl-D-aspartate receptors, Proc. Natl. Acad. Sci. USA 89, 5552.
32. Ornstein, P.L., D.D. Schoepp, J.D. Leander and D. Lodge, 1991, The development of novel competitive N-methyl-D-aspartate antagonists as useful therapeutic agents: discovery of LY274614 and LY233536, in: Excitatory Amino Acids, eds. B.S. Meldrum, F. Moroni, R.P. Simon and J.H. Woods (Raven Press, New York, NY) p. 415.
33. 3H]glutamate, Exp. Brain Res. 86, 652.
34. Perkins, M.N. and T.W. Stone, 1983, Quinolinic acid: regional variations in neuronal sensitivity, Brain Res. 259, 172.
35. 3H]MK801 binding in rat brain, J. Neurochem. 60, 1344.
36. Sekiguchi, M., K. Okamoto and Y. Sakai, 1990, Glycine-insensitive NMDA-sensitive receptor expressed in Xenopus oocytes by guinea pig mRNA, J. Neurosci. 10, 2148.
37. Stone, T.W., 1984, Excitant activity of methyl derivatives of quinolinic acid on rat cortical neurones, Br. J. Pharmacol. 81, 175.
38. Sugihara, H., T. Moriyoshi, T. Ishii, M. Masu and S. Nakanishi, 1992, Structure and properties of seven isoforms of the NMDA receptor generated by alternative splicing, Biochem. Biophys. Res. Commun. 185, 826.
39. Wafford, K.A., C.J. Bain, B. LeBourdelles, P.J. Whiting and J.A. Kemp, 1993, Preferential co-assembly of recombinant NMDA receptors composed of three different subunits, NeuroReport 4, 1347.
40. Watanabe, M., Y. Inoue, K. Sakimura and M. Mishina, 1992, Developmental changes in distribution of NMDA receptor channel subunit mRNAs, NeuroReport 3, 1138.
41. Watanabe, M.Y. Inoue, K. Sakimura and M. Mishina, 1993, Distinct distributors of five N-methyl-D-aspartate receptor channel subunit mRNAs in the forebrain, J. Comp. Neurol. 338, 377.
42. Williams, K., 1994, Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors, Mol. Pharmacol. 44, 851.
43. Williams, K., S.L. Russell, Y.M. Shen and P.B. Molinoff, 1993, Developmental switch in the expression of NMDA receptors occurs in vivo and in vitro, Neuron 10, 267.
44. Yamazaki, M., H. Mori, K. Araki, K. Mori and M. Mishina, 1992, Cloning, expression and modulation of a mouse NMDA receptor subunit, FEBS Lett. 300, 39.