Antiproliferative effects of mitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on human glioma and neuroblastoma cell lines

Phytomedicine

Volumn 14, Issue 4, 2007, Pages 280-284

  Garcia Prado E ^a   Garcia Gimenez M D ^a   De la Puerta Vazquez R ^a   Espartero Sanchez J L ^a   Saenz Rodriguez M T ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

Author keywords

Antiproliferative activity; Glioma; Neuroblastoma; Oxindole alkaloid; Uncaria tomentosa

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CYCLOPHOSPHAMIDE; MITRAPHYLLINE; OXINDOLE; UNCARIA TOMENTOSA EXTRACT; UNCLASSIFIED DRUG; VINCRISTINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL VIABILITY; COLORIMETRY; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG STRUCTURE; GLIOMA CELL; HUMAN; HUMAN CELL; IC 50; INFLAMMATION; NEUROBLASTOMA CELL; PRIORITY JOURNAL; TRADITIONAL MEDICINE; UNCARIA TOMENTOSA;

ALKALOIDS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAT'S CLAW; CELL LINE, TUMOR; CELL SURVIVAL; GLIOMA; HUMANS; INDOLE ALKALOIDS; INDOLES; INHIBITORY CONCENTRATION 50; NEUROBLASTOMA; PHYTOTHERAPY; PLANT BARK; PLANT EXTRACTS;

UNCARIA TOMENTOSA;

EID: 33847703663     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2006.12.023     Document Type: Article

References (19)

1. Aguilar J.L., Rojas P., Marcelo A., Plaza A., Bauer R., and Reininger E. Anti-inflammatory activity of two different extracts of Uncaria tomentosa (Rubiaceae). J. Ethnopharmacol. 81 (2002) 271-276
2. Akesson C., Pero R.W., and Ivars F. C-Med 100, a hot water extract of Uncaria tomentosa, prolongs lymphocyte survival in vivo. Phytomedicine 10 (2003) 23-33
3. Aquino R., De Simone F., Vincieri F.F., and Pizza C. New polyhydroxylated triterpenes from Uncaria tomentosa. J. Nat. Prod. 53 (1990) 559-564
4. Bacher N., Tiefenthaler M., Sturm S., Stuppner H., Ausserlechner M., and Kofler R. Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells. Br. J. Haematol. 132 (2006) 615-622
5. De Matta S.M., Monache F.D., Ferrari F., and Marini-Bettolo G.B. Alkaloids and procyanidins of a Uncaria sp. from Peru. Pharmacology 31 (1976) 527-535
6. Ganzera M., Muhannad I., Khan R.A., and Khan I.A. Improved method for determination of oxindole alkaloids Uncaria tomentosa by high performance liquid chromatography. Planta Med. 67 (2001) 447-450
7. Heitzman M.E., Neto C.C., Winiarz E., Vaisberg A.J., and Hammond G.B. Ethnobotany, phytochemistry and pharmacology of Uncaria (Rubiaceae). Phytochemistry 66 (2005) 5-29
8. Kitajima M., Hashimoto K., Yokoya M., Takayama H., Sandoval M., and Aimi N. Two new nor-triterpene gycosides from Peruvian "Uña de gato" (Uncaria tomentosa). J. Nat. Prod. 66 (2003) 320-323
9. Kitajima M., Yokoya M., Takayama H., and Aimi N. Synthesis and absolute configuration of a new 3,4-dihydro-β-carboline-type alkaloid, 3,4-dehydro-5(S)-5-carboxystrictosidine, isolated from Peruvian uña de gato (Uncaria tomentosa). Chem. Pharm. Bull. 50 (2002) 1376-1378
10. Laus G., Brössner D., and Keplinger K. Alkaloids of peruvian Uncaria tomentosa. Phytochemistry 45 (1997) 855-860
11. Montoro P., Carbone V., Quiroz J., De Simone F., and Pizza C. Identification and quantification of comonents in extracts of Uncaria tomentosa by HPLC-ES/MS. Phytochemistry 15 (2004) 55-64
12. Muhammad I., Dunbar D.C., Khan R.A., Ganzera M., and Khan I.A. Investigation of Uña de Gato 1,7-Deoxyloganic acid and 15NNMR spectroscopic studies on pentacyclic oxindole alkaloids from Uncaria tomentosa. Phytochemistry 57 (2001) 781-785
13. Muhammad I., Khan I.A., Fischer N.H., and Fronczek F.R. Two steroisomeric pentacyclic oxindole alkaloids from Uncaria tomentosa: uncarine C and uncarine E. Acta Crystallogr. C 57 (2001) 480-482
14. Muñoz M., Rosso M., Pérez A., Coveñas R., Rosso R., Zamarriego C., and Piruat J.I. The NK1 receptor is involved in the antitumoral actino of L-733,060 and in the mitogenic action of substance P on neuroblastoma and glioma cell lines. Neuropeptides 39 (2005) 427-432
15. Philp R.B. Herbal-Drug Interaction and Adverse Effects. An Evidence-based Quick Reference Guide (2004), McGraw-Hill, New York pp. 63-65
16. Sandoval M., Charbonne R.M., and Okuhama N.N. Cat's claw inhibits TNF-alpha production and scavenges free radicals: role in cytoprotection. Free Rad. Biol. Med. 29 (2000) 71-78
17. Seki H., Takayama H., Aimi N., Sakai S., and Ponglux D. A nuclear manetic resonance study on the eleven stereoisomers of heteroyohimbine-type oxindole alkaloids. Chem. Pharm. Bull. 41 12 (1993) 2077-2086
18. Wagner H., Kreutzkamp B., and Jurcic K. Die alkaloide von Uncaria tomentosa und ihre phagozytose-steigernde Wirkung. Planta Med. (1985) 419-423
19. Wurm M., Kacani L., Laus G., Keplinger K., and Dierich M.P. Pentacyclic oxindole alkaloids from Uncaria tomentosa induce human endothelial cells to release a lymphocyte-proliferation regulating factor. Planta Med. 64 (1998) 701-704