-
1
-
-
1642282882
-
Prespecification and plasticity: shifting mechanisms of cell migration
-
Friedl P. Prespecification and plasticity: shifting mechanisms of cell migration. Curr. Opin. Cell Biol. 2004, 16:14-23.
-
(2004)
Curr. Opin. Cell Biol.
, vol.16
, pp. 14-23
-
-
Friedl, P.1
-
2
-
-
77957243835
-
The plasticity of cytoskeletal dynamics underlying neoplastic cell migration
-
Sanz-Moreno V., Marshall C.J. The plasticity of cytoskeletal dynamics underlying neoplastic cell migration. Curr. Opin. Cell Biol. 2010, 22:690-696.
-
(2010)
Curr. Opin. Cell Biol.
, vol.22
, pp. 690-696
-
-
Sanz-Moreno, V.1
Marshall, C.J.2
-
3
-
-
85045351537
-
The coordination between actin filaments and adhesion in mesenchymal migration
-
O'Neill G.M. The coordination between actin filaments and adhesion in mesenchymal migration. Cell Adh. Migr. 2009, 3:355-357.
-
(2009)
Cell Adh. Migr.
, vol.3
, pp. 355-357
-
-
O'Neill, G.M.1
-
4
-
-
54549088877
-
Rac activation and inactivation control plasticity of tumor cell movement
-
Sanz-Moreno V., Gadea G., Ahn J., Paterson H., Marra P., Pinner S., Sahai E., Marshall C.J. Rac activation and inactivation control plasticity of tumor cell movement. Cell 2008, 135:510-523.
-
(2008)
Cell
, vol.135
, pp. 510-523
-
-
Sanz-Moreno, V.1
Gadea, G.2
Ahn, J.3
Paterson, H.4
Marra, P.5
Pinner, S.6
Sahai, E.7
Marshall, C.J.8
-
5
-
-
35148825060
-
A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9
-
O'Neill G.M., Seo S., Serebriiskii I.G., Lessin S.R., Golemis E.A. A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9. Cancer Res. 2007, 67:8975-8979.
-
(2007)
Cancer Res.
, vol.67
, pp. 8975-8979
-
-
O'Neill, G.M.1
Seo, S.2
Serebriiskii, I.G.3
Lessin, S.R.4
Golemis, E.A.5
-
6
-
-
34548357152
-
Molecular basis for HEF1/NEDD9/Cas-L action as a multifunctional co-ordinator of invasion, apoptosis and cell cycle
-
Singh M., Cowell L., Seo S., O'Neill G., Golemis E. Molecular basis for HEF1/NEDD9/Cas-L action as a multifunctional co-ordinator of invasion, apoptosis and cell cycle. Cell Biochem. Biophys. 2007, 48:54-72.
-
(2007)
Cell Biochem. Biophys.
, vol.48
, pp. 54-72
-
-
Singh, M.1
Cowell, L.2
Seo, S.3
O'Neill, G.4
Golemis, E.5
-
7
-
-
31644445295
-
Cell adhesion regulates Ser/Thr phosphorylation and proteasomal degradation of HEF1
-
Zheng M., McKeown-Longo P.J. Cell adhesion regulates Ser/Thr phosphorylation and proteasomal degradation of HEF1. J. Cell Sci. 2006, 119:96-103.
-
(2006)
J. Cell Sci.
, vol.119
, pp. 96-103
-
-
Zheng, M.1
McKeown-Longo, P.J.2
-
8
-
-
43049112747
-
Protein phosphatase 2A (PP2A), a drugable tumor suppressor in Ph1(+) leukemias
-
Perrotti D., Neviani P. Protein phosphatase 2A (PP2A), a drugable tumor suppressor in Ph1(+) leukemias. Cancer Metastasis Rev. 2008, 27:159-168.
-
(2008)
Cancer Metastasis Rev.
, vol.27
, pp. 159-168
-
-
Perrotti, D.1
Neviani, P.2
-
9
-
-
2942598149
-
PhosphoSite: a bioinformatics resource dedicated to physiological protein phosphorylation
-
Hornbeck P.V., Chabra I., Kornhauser J.M., Skrzypek E., Zhang B. PhosphoSite: a bioinformatics resource dedicated to physiological protein phosphorylation. Proteomics 2004, 4:1551-1561.
-
(2004)
Proteomics
, vol.4
, pp. 1551-1561
-
-
Hornbeck, P.V.1
Chabra, I.2
Kornhauser, J.M.3
Skrzypek, E.4
Zhang, B.5
-
10
-
-
0034160011
-
Integrin signalling: a new Cas(t) of characters enters the stage
-
O'Neill G.M., Fashena S.J., Golemis E.A. Integrin signalling: a new Cas(t) of characters enters the stage. Trends Cell Biol. 2000, 10:111-119.
-
(2000)
Trends Cell Biol.
, vol.10
, pp. 111-119
-
-
O'Neill, G.M.1
Fashena, S.J.2
Golemis, E.A.3
-
11
-
-
69349084808
-
Phosphorylation of human enhancer of filamentation (HEF1) on serine 369 induces its proteasomal degradation
-
Hivert V., Pierre J., Raingeaud J. Phosphorylation of human enhancer of filamentation (HEF1) on serine 369 induces its proteasomal degradation. Biochem. Pharmacol. 2009, 78:1017-1025.
-
(2009)
Biochem. Pharmacol.
, vol.78
, pp. 1017-1025
-
-
Hivert, V.1
Pierre, J.2
Raingeaud, J.3
-
12
-
-
78650940738
-
Estradiol stabilizes the 105-kDa phospho-form of the adhesion docking protein NEDD9 and suppresses NEDD9-dependent cell spreading in breast cancer cells
-
Bradshaw L.N., Zhong J., Bradbury P., Mahmassani M., Smith J.L., Ammit A.J., O'Neill G.M. Estradiol stabilizes the 105-kDa phospho-form of the adhesion docking protein NEDD9 and suppresses NEDD9-dependent cell spreading in breast cancer cells. Biochim. Biophys. Acta, Mol. Cell Res. 2011, 1813:340-345.
-
(2011)
Biochim. Biophys. Acta, Mol. Cell Res.
, vol.1813
, pp. 340-345
-
-
Bradshaw, L.N.1
Zhong, J.2
Bradbury, P.3
Mahmassani, M.4
Smith, J.L.5
Ammit, A.J.6
O'Neill, G.M.7
-
13
-
-
0031813880
-
Cell cycle-regulated processing of HEF1 to multiple protein forms differentially targeted to multiple subcellular compartments
-
Law S.F., Zhang Y.Z., Klein-Szanto A.J., Golemis E.A. Cell cycle-regulated processing of HEF1 to multiple protein forms differentially targeted to multiple subcellular compartments. Mol. Cell. Biol. 1998, 18:3540-3551.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 3540-3551
-
-
Law, S.F.1
Zhang, Y.Z.2
Klein-Szanto, A.J.3
Golemis, E.A.4
-
14
-
-
0037131380
-
Regulation of HEF1 expression and phosphorylation by TGF-beta 1 and cell adhesion
-
Zheng M., McKeown-Longo P.J. Regulation of HEF1 expression and phosphorylation by TGF-beta 1 and cell adhesion. J. Biol. Chem. 2002, 277:39599-39608.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 39599-39608
-
-
Zheng, M.1
McKeown-Longo, P.J.2
-
15
-
-
0034671642
-
A novel ability of Smad3 to regulate proteasomal degradation of a Cas family member HEF1
-
Liu X., Elia A.E., Law S.F., Golemis E.A., Farley J., Wang T. A novel ability of Smad3 to regulate proteasomal degradation of a Cas family member HEF1. EMBO J. 2000, 19:6759-6769.
-
(2000)
EMBO J.
, vol.19
, pp. 6759-6769
-
-
Liu, X.1
Elia, A.E.2
Law, S.F.3
Golemis, E.A.4
Farley, J.5
Wang, T.6
-
16
-
-
0034959232
-
Proteolysis of the docking protein HEF1 and implications for focal adhesion dynamics
-
O'Neill G.M., Golemis E.A. Proteolysis of the docking protein HEF1 and implications for focal adhesion dynamics. Mol. Cell. Biol. 2001, 21:5094-5108.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 5094-5108
-
-
O'Neill, G.M.1
Golemis, E.A.2
-
17
-
-
28844479472
-
The Cas family docking protein, HEF1, promotes the formation of neurite-like membrane extensions
-
Bargon S.D., Gunning P.W., O'Neill G.M. The Cas family docking protein, HEF1, promotes the formation of neurite-like membrane extensions. Biochim. Biophys. Acta 2005, 1746:143-154.
-
(2005)
Biochim. Biophys. Acta
, vol.1746
, pp. 143-154
-
-
Bargon, S.D.1
Gunning, P.W.2
O'Neill, G.M.3
-
18
-
-
34147122729
-
Calyculin A, an enhancer of myosin, speeds up anaphase chromosome movement
-
Fabian L., Troscianczuk J., Forer A. Calyculin A, an enhancer of myosin, speeds up anaphase chromosome movement. Cell Chromosome 2007, 6:1.
-
(2007)
Cell Chromosome
, vol.6
, pp. 1
-
-
Fabian, L.1
Troscianczuk, J.2
Forer, A.3
-
19
-
-
0034651747
-
A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation
-
Ito A., Kataoka T.R., Watanabe M., Nishiyama K., Mazaki Y., Sabe H., Kitamura Y., Nojima H. A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation. EMBO J. 2000, 19:562-571.
-
(2000)
EMBO J.
, vol.19
, pp. 562-571
-
-
Ito, A.1
Kataoka, T.R.2
Watanabe, M.3
Nishiyama, K.4
Mazaki, Y.5
Sabe, H.6
Kitamura, Y.7
Nojima, H.8
-
20
-
-
33845947971
-
Suppression of cancer cell migration and invasion by protein phosphatase 2A through dephosphorylation of mu- and m-calpains
-
Xu L., Deng X. Suppression of cancer cell migration and invasion by protein phosphatase 2A through dephosphorylation of mu- and m-calpains. J. Biol. Chem. 2006, 281:35567-35575.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 35567-35575
-
-
Xu, L.1
Deng, X.2
-
21
-
-
0036153173
-
Dissection of HEF1-dependent functions in motility and transcriptional regulation
-
Fashena S.J., Einarson M.B., O'Neill G.M., Patriotis C., Golemis E.A. Dissection of HEF1-dependent functions in motility and transcriptional regulation. J. Cell Sci. 2002, 115:99-111.
-
(2002)
J. Cell Sci.
, vol.115
, pp. 99-111
-
-
Fashena, S.J.1
Einarson, M.B.2
O'Neill, G.M.3
Patriotis, C.4
Golemis, E.A.5
-
22
-
-
70349747017
-
NEDD9 promotes oncogenic signaling in mammary tumor development
-
Izumchenko E., Singh M.K., Plotnikova O.V., Tikhmyanova N., Little J.L., Serebriiskii I.G., Seo S., Kurokawa M., Egleston B.L., Klein-Szanto A., Pugacheva E.N., Hardy R.R., Wolfson M., Connolly D.C., Golemis E.A. NEDD9 promotes oncogenic signaling in mammary tumor development. Cancer Res. 2009, 69:7198-7206.
-
(2009)
Cancer Res.
, vol.69
, pp. 7198-7206
-
-
Izumchenko, E.1
Singh, M.K.2
Plotnikova, O.V.3
Tikhmyanova, N.4
Little, J.L.5
Serebriiskii, I.G.6
Seo, S.7
Kurokawa, M.8
Egleston, B.L.9
Klein-Szanto, A.10
Pugacheva, E.N.11
Hardy, R.R.12
Wolfson, M.13
Connolly, D.C.14
Golemis, E.A.15
-
23
-
-
80055111126
-
Homemade site directed mutagenesis of whole plasmids
-
Laible M., Boonrod K. Homemade site directed mutagenesis of whole plasmids. J. Vis. Exp. 2009, e1135.
-
(2009)
J. Vis. Exp.
-
-
Laible, M.1
Boonrod, K.2
-
24
-
-
79954578095
-
Essential role of protein phosphatase 2A in metaphase II arrest and activation of mouse eggs shown by okadaic acid, dominant negative protein phosphatase 2A, and FTY720
-
Chang H.Y., Jennings P.C., Stewart J., Verrills N.M., Jones K.T. Essential role of protein phosphatase 2A in metaphase II arrest and activation of mouse eggs shown by okadaic acid, dominant negative protein phosphatase 2A, and FTY720. J. Biol. Chem. 2011, 286:14705-14712.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 14705-14712
-
-
Chang, H.Y.1
Jennings, P.C.2
Stewart, J.3
Verrills, N.M.4
Jones, K.T.5
-
25
-
-
33845513930
-
Tamoxifen treatment promotes phosphorylation of the adhesion molecules, p130Cas/BCAR1, FAK and Src, via an adhesion-dependent pathway
-
Cowell L.N., Graham J.D., Bouton A.H., Clarke C.L., O'Neill G.M. Tamoxifen treatment promotes phosphorylation of the adhesion molecules, p130Cas/BCAR1, FAK and Src, via an adhesion-dependent pathway. Oncogene 2006, 25:7597-7607.
-
(2006)
Oncogene
, vol.25
, pp. 7597-7607
-
-
Cowell, L.N.1
Graham, J.D.2
Bouton, A.H.3
Clarke, C.L.4
O'Neill, G.M.5
-
26
-
-
44949179470
-
A novel Cas family member, HEPL, regulates FAK and cell spreading
-
Singh M.K., Dadke D., Nicolas E., Serebriiskii I.G., Apostolou S., Canutescu A., Egleston B.L., Golemis E.A. A novel Cas family member, HEPL, regulates FAK and cell spreading. Mol. Biol. Cell 2008, 19:1627-1636.
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 1627-1636
-
-
Singh, M.K.1
Dadke, D.2
Nicolas, E.3
Serebriiskii, I.G.4
Apostolou, S.5
Canutescu, A.6
Egleston, B.L.7
Golemis, E.A.8
-
27
-
-
0033934340
-
The docking protein HEF1 is an apoptotic mediator at focal adhesion sites
-
Law S.F., O'Neill G.M., Fashena S.J., Einarson M.B., Golemis E.A. The docking protein HEF1 is an apoptotic mediator at focal adhesion sites. Mol. Cell. Biol. 2000, 20:5184-5195.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 5184-5195
-
-
Law, S.F.1
O'Neill, G.M.2
Fashena, S.J.3
Einarson, M.B.4
Golemis, E.A.5
-
28
-
-
33846101533
-
Regulation of cell adhesion by PP2A and SV40 small tumor antigen: an important link to cell transformation
-
Sontag J.M., Sontag E. Regulation of cell adhesion by PP2A and SV40 small tumor antigen: an important link to cell transformation. Cell. Mol. Life Sci. 2006, 63:2979-2991.
-
(2006)
Cell. Mol. Life Sci.
, vol.63
, pp. 2979-2991
-
-
Sontag, J.M.1
Sontag, E.2
-
29
-
-
35748971432
-
The PP2A-associated protein alpha4 plays a critical role in the regulation of cell spreading and migration
-
Kong M., Bui T.V., Ditsworth D., Gruber J.J., Goncharov D., Krymskaya V.P., Lindsten T., Thompson C.B. The PP2A-associated protein alpha4 plays a critical role in the regulation of cell spreading and migration. J. Biol. Chem. 2007, 282:29712-29720.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 29712-29720
-
-
Kong, M.1
Bui, T.V.2
Ditsworth, D.3
Gruber, J.J.4
Goncharov, D.5
Krymskaya, V.P.6
Lindsten, T.7
Thompson, C.B.8
-
30
-
-
0034238109
-
Phosphorylation of the [beta]1 integrin cytoplasmic domain: toward an understanding of function and mechanism
-
Mulrooney J., Foley K., Vineberg S., Barreuther M., Grabel L. Phosphorylation of the [beta]1 integrin cytoplasmic domain: toward an understanding of function and mechanism. Exp. Cell Res. 2000, 258:332-341.
-
(2000)
Exp. Cell Res.
, vol.258
, pp. 332-341
-
-
Mulrooney, J.1
Foley, K.2
Vineberg, S.3
Barreuther, M.4
Grabel, L.5
-
31
-
-
1342282948
-
Modulation of Thr phosphorylation of integrin beta1 during muscle differentiation
-
Kim S.M., Kwon M.S., Park C.S., Choi K.R., Chun J.S., Ahn J., Song W.K. Modulation of Thr phosphorylation of integrin beta1 during muscle differentiation. J. Biol. Chem. 2004, 279:7082-7090.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 7082-7090
-
-
Kim, S.M.1
Kwon, M.S.2
Park, C.S.3
Choi, K.R.4
Chun, J.S.5
Ahn, J.6
Song, W.K.7
-
32
-
-
0035921772
-
Protein phosphatase 2A interacts with the Src kinase substrate p130(CAS)
-
Yokoyama N., Miller W.T. Protein phosphatase 2A interacts with the Src kinase substrate p130(CAS). Oncogene 2001, 20:6057-6065.
-
(2001)
Oncogene
, vol.20
, pp. 6057-6065
-
-
Yokoyama, N.1
Miller, W.T.2
-
33
-
-
1642586962
-
FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly
-
Webb D.J., Donais K., Whitmore L.A., Thomas S.M., Turner C.E., Parsons J.T., Horwitz A.F. FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat. Cell Biol. 2004, 6:154-161.
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 154-161
-
-
Webb, D.J.1
Donais, K.2
Whitmore, L.A.3
Thomas, S.M.4
Turner, C.E.5
Parsons, J.T.6
Horwitz, A.F.7
-
34
-
-
34547926839
-
LKB1 modulates lung cancer differentiation and metastasis
-
Ji H., Ramsey M.R., Hayes D.N., Fan C., McNamara K., Kozlowski P., Torrice C., Wu M.C., Shimamura T., Perera S.A., Liang M.C., Cai D., Naumov G.N., Bao L., Contreras C.M., Li D., Chen L., Krishnamurthy J., Koivunen J., Chirieac L.R., Padera R.F., Bronson R.T., Lindeman N.I., Christiani D.C., Lin X., Shapiro G.I., Janne P.A., Johnson B.E., Meyerson M., Kwiatkowski D.J., Castrillon D.H., Bardeesy N., Sharpless N.E., Wong K.K. LKB1 modulates lung cancer differentiation and metastasis. Nature 2007, 448:807-810.
-
(2007)
Nature
, vol.448
, pp. 807-810
-
-
Ji, H.1
Ramsey, M.R.2
Hayes, D.N.3
Fan, C.4
McNamara, K.5
Kozlowski, P.6
Torrice, C.7
Wu, M.C.8
Shimamura, T.9
Perera, S.A.10
Liang, M.C.11
Cai, D.12
Naumov, G.N.13
Bao, L.14
Contreras, C.M.15
Li, D.16
Chen, L.17
Krishnamurthy, J.18
Koivunen, J.19
Chirieac, L.R.20
Padera, R.F.21
Bronson, R.T.22
Lindeman, N.I.23
Christiani, D.C.24
Lin, X.25
Shapiro, G.I.26
Janne, P.A.27
Johnson, B.E.28
Meyerson, M.29
Kwiatkowski, D.J.30
Castrillon, D.H.31
Bardeesy, N.32
Sharpless, N.E.33
Wong, K.K.34
more..
-
35
-
-
34648832173
-
FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia
-
Neviani P., Santhanam R., Oaks J.J., Eiring A.M., Notari M., Blaser B.W., Liu S., Trotta R., Muthusamy N., Gambacorti-Passerini C., Druker B.J., Cortes J., Marcucci G., Chen C.S., Verrills N.M., Roy D.C., Caligiuri M.A., Bloomfield C.D., Byrd J.C., Perrotti D. FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia. J. Clin. Invest. 2007, 117:2408-2421.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 2408-2421
-
-
Neviani, P.1
Santhanam, R.2
Oaks, J.J.3
Eiring, A.M.4
Notari, M.5
Blaser, B.W.6
Liu, S.7
Trotta, R.8
Muthusamy, N.9
Gambacorti-Passerini, C.10
Druker, B.J.11
Cortes, J.12
Marcucci, G.13
Chen, C.S.14
Verrills, N.M.15
Roy, D.C.16
Caligiuri, M.A.17
Bloomfield, C.D.18
Byrd, J.C.19
Perrotti, D.20
more..
-
36
-
-
77954376747
-
Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers
-
Roberts K.G., Smith A.M., McDougall F., Carpenter H., Horan M., Neviani P., Powell J.A., Thomas D., Guthridge M.A., Perrotti D., Sim A.T., Ashman L.K., Verrills N.M. Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers. Cancer Res. 2010, 70:5438-5447.
-
(2010)
Cancer Res.
, vol.70
, pp. 5438-5447
-
-
Roberts, K.G.1
Smith, A.M.2
McDougall, F.3
Carpenter, H.4
Horan, M.5
Neviani, P.6
Powell, J.A.7
Thomas, D.8
Guthridge, M.A.9
Perrotti, D.10
Sim, A.T.11
Ashman, L.K.12
Verrills, N.M.13
-
37
-
-
66149126544
-
Cas-L was overexpressed in imatinib-resistant gastrointestinal stromal tumor cells
-
Thao le B., Vu H.A., Yasuda K., Taniguchi S., Yagasaki F., Taguchi T., Watanabe T., Sato Y. Cas-L was overexpressed in imatinib-resistant gastrointestinal stromal tumor cells. Cancer Biol. Ther. 2009, 8:683-688.
-
(2009)
Cancer Biol. Ther.
, vol.8
, pp. 683-688
-
-
Thao le, B.1
Vu, H.A.2
Yasuda, K.3
Taniguchi, S.4
Yagasaki, F.5
Taguchi, T.6
Watanabe, T.7
Sato, Y.8
|