A novel ability of Smad3 to regulate proteasomal degradation of a Cas family member HEF1

EMBO Journal

Volumn 19, Issue 24, 2000, Pages 6759-6769

  Liu, Xiaohong ^a   Elia, Andrew E H ^a   Law, Susan F ^b   Golemis, Erica A ^b   Farley, Jennifer ^c   Wang, Tongwen ^a,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b FOX CHASE CANCER CENTER   (United States)

^c BENAROYA RESEARCH INSTITUTE   (United States)

Author keywords

HEF1; Proteasome; Signal transduction; Smad3; TGF

Indexed keywords

ACTIVIN; PROTEASOME; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MAMMAL; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; YEAST;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CELL LINE; CYSTEINE ENDOPEPTIDASES; DNA-BINDING PROTEINS; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; LUCIFERASES; MULTIENZYME COMPLEXES; PHOSPHOPROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

MAMMALIA;

EID: 0034671642     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/19.24.6759     Document Type: Article

References (23)

1. Activation of signaling by the activin receptor complex
2. A transforming growth factor β type I receptor that signals to activated gene expression
3. Direct binding of Smad3 and Smad4 to critical TGFβ-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
4. Smads: Transcriptional activators of TGF-β responses
5. Developmental expression of four novel serine/threonine kinase receptors homologous to the activin/transforming growth factor-β type II receptor family
6. A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-β signal transduction
7. Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae
8. Cell cycle-regulated processing of HEF1 to multiple protein forms differentially targeted to multiple subcellular compartments
9. Regulation of immune responses by TGF-β
10. Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells
11. TGF-β signal transduction
12. Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in β1 integrin-mediated signaling in lymphocytes
13. Ligation of VLA-4 on T cells stimulates tyrosine phosphorylation of a 105-kD protein
14. Integrin signalling: A new Cas(t) of characters enters the stage
15. T cell receptor-mediated tyrosine phosphorylation of Cas-L, a 105-kDa Crk-associated substrate-related protein and its association of Crk and C3G
16. Differential signaling after β1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1)
17. Negative feedback regulation of TGF-β signaling by the SnoN oncoprotein
18. SnoN and Ski proto-oncoproteins are rapidly degraded in response to transforming growth factor β signaling
19. Regulation of Smad activity
20. Mechanism of activation of the TGF-β receptor
21. Mxil, a protein that specifically interacts with Max to bind Myc-Max recognition sites
22. Cytoskeleton-dependent tyrosine phosphorylation of the p130(Cas) family member HEF1 downstream of the G protein-coupled calcitonin receptor. Calcitonin induces the association of HEF1, paxillin and focal adhesion kinase