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Volumn 46, Issue 1, 2012, Pages 10-17

Orexins/hypocretins acting at Gi protein-coupled OX2 receptors inhibit cyclic AMP synthesis in the primary neuronal cultures

Author keywords

Cerebral cortex; Cyclic AMP; Hypocretin; Neuronal cell culture; Orexin; Orexin receptors; PACAP; Rat; VIP

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; CYCLIC AMP; FORSKOLIN; G PROTEIN COUPLED RECEPTOR; NUCLEOTIDE; OREXIN; OREXIN 1 RECEPTOR; OREXIN 2 RECEPTOR; OREXIN A; OREXIN B; PERTUSSIS TOXIN; ADENYLATE CYCLASE; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; VASOACTIVE INTESTINAL POLYPEPTIDE;

EID: 84855742973     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-011-9526-2     Document Type: Article
Times cited : (33)

References (45)
  • 4
    • 0028868824 scopus 로고
    • Serum-free B27/neurobasal medium supports differentiated growth of neurons from the striatum, substantia nigra, septum, cerebral cortex, cerebellum, and dentate gyrus
    • Brewer GJ (1995) Serum-free B27/neurobasal medium supports differentiated growth of neurons from the striatum, substantia nigra, septum, cerebral cortex, cerebellum, and dentate gyrus. J Neurosci Res 42:674-483
    • (1995) J Neurosci Res , vol.42 , pp. 674-1483
    • Brewer, G.J.1
  • 5
    • 59349089712 scopus 로고    scopus 로고
    • The brain hypocretins and their receptors: Mediators of allostatic arousal
    • Carter ME, Borg JS, de Lecea L (2009) The brain hypocretins and their receptors: mediators of allostatic arousal. Curr Opin Pharmacol 9:39-45
    • (2009) Curr Opin Pharmacol , vol.9 , pp. 39-45
    • Carter, M.E.1    Borg, J.S.2    De Lecea, L.3
  • 7
    • 0032736148 scopus 로고    scopus 로고
    • The hypocretins/orexins: Novel hypothalamic neuropeptides involved in different physiological systems
    • de Lecea L, Sutcliffe JG (1999) The hypocretins/orexins: novel hypothalamic neuropeptides involved in different physiological systems. Cell Mol Life Sci 56:473-480
    • (1999) Cell Mol Life Sci , vol.56 , pp. 473-480
    • De Lecea, L.1    Sutcliffe, J.G.2
  • 11
    • 33947731083 scopus 로고    scopus 로고
    • Study of orexin signal transduction pathways in rat olfactory mucosa and in olfactory sensory neurons-derived cell line Odora: Multiple orexin signalling pathways
    • Gorojankina T, Grébert D, Salesse R, Tanfin Z, Caillol M (2007) Study of orexin signal transduction pathways in rat olfactory mucosa and in olfactory sensory neurons-derived cell line Odora: multiple orexin signalling pathways. Reg Peptides 141:361-369
    • (2007) Reg Peptides , vol.141 , pp. 361-369
    • Gorojankina, T.1    Grébert, D.2    Salesse, R.3    Tanfin, Z.4    Caillol, M.5
  • 12
    • 40049094368 scopus 로고    scopus 로고
    • Functions of orexins in peripheral tissues
    • DOI 10.1111/j.1748-1716.2008.01836.x
    • Heinonen MV, Purhonen AK, Mäkelä KA, Herzig KH (2008) Functions of orexins in peripheral tissues. Acta Physiol (Oxf) 192:471-485 (Pubitemid 351322731)
    • (2008) Acta Physiologica , vol.192 , Issue.4 , pp. 471-485
    • Heinonen, M.V.1    Purhonen, A.K.2    Makela, K.A.3    Herzig, K.H.4
  • 13
    • 15744381713 scopus 로고
    • Kinetic PCR analysis: Real-time monitoring of DNA amplification reactions
    • DOI 10.1038/nbt0993-1026
    • Higuchi R, Fockler C, Dollinger G, Watson R (1993) Kinetic PCR analysis: real-time monitoring of DNA amplification reactions. Biotechnology (NY) 11:1026-1030 (Pubitemid 23254023)
    • (1993) Bio/Technology , vol.11 , Issue.9 , pp. 1026-1030
    • Higuchi, R.1    Fockler, C.2    Dollinger, G.3    Watson, R.4
  • 17
    • 0034912638 scopus 로고    scopus 로고
    • Prepro-orexin and orexin receptor mRNAs are differentially expressed in peripheral tissues of male and female rats
    • DOI 10.1210/en.142.8.3324
    • Jöhren O, Neidert SJ, Kummer M, Dendorfer A, Dominiak P (2001) Prepro-orexin and orexin receptor mRNAs are differentially expressed in peripheral tissues of male and female rats. Endocrinology 142:3324-3331 (Pubitemid 32681736)
    • (2001) Endocrinology , vol.142 , Issue.8 , pp. 3324-3331
    • Johren, O.1    Neidert, S.J.2    Kummer, M.3    Dendorfer, A.4    Dominiak, P.5
  • 18
    • 35048821410 scopus 로고    scopus 로고
    • Effects of PACAP, VIP and related peptides on cyclic AMP formation in rat neuronal and astrocyte cultures and cerebral cortical slices
    • Jozwiak-Bebenista M, Dejda A, Nowak JZ (2007) Effects of PACAP, VIP and related peptides on cyclic AMP formation in ratneuronal and astrocyte cultures and cerebral cortical slices. Pharmacol Rep 59:414-420 (Pubitemid 47554821)
    • (2007) Pharmacological Reports , vol.59 , Issue.4 , pp. 414-420
    • Jozwiak-Bebenista, M.1    Dejda, A.2    Nowak, J.Z.3
  • 19
    • 75749083285 scopus 로고    scopus 로고
    • Interaction of orexins/hypocretins with adrenocortical functions
    • Kagerer SM, Jöhren O (2010) Interaction of orexins/hypocretins with adrenocortical functions. Acta Physiol (Oxf) 198:361-371
    • (2010) Acta Physiol (Oxf) , vol.198 , pp. 361-371
    • Kagerer, S.M.1    Jöhren, O.2
  • 20
    • 0141920775 scopus 로고    scopus 로고
    • Orexin receptors and G-protein coupling: Evidence for another "promiscuous" seven transmembrane domain receptor
    • DOI 10.1254/jphs.93.126
    • Karteris E, Randeva HS (2003) Orexin receptors and G-protein coupling: evidence for another "promiscuous" seven transmembrane domain receptor. J Pharmacol Sci 93:126-128 (Pubitemid 37254278)
    • (2003) Journal of Pharmacological Sciences , vol.93 , Issue.1 , pp. 126-128
    • Karteris, E.1    Randeva, H.S.2
  • 21
    • 77954570581 scopus 로고    scopus 로고
    • Chemistry and biology of orexin signaling
    • Kodatek T, Cai D (2010) Chemistry and biology of orexin signaling. Mol Biosyst 6:1366-1375
    • (2010) Mol Biosyst , vol.6 , pp. 1366-1375
    • Kodatek, T.1    Cai, D.2
  • 22
    • 33646415110 scopus 로고    scopus 로고
    • Intracellular signal pathways utilized by the hypocretin/orexin receptors
    • de Lecea L, Sutcliffe JG (eds) Springer Science Business Media, Berlin
    • Kukkonen JP, Åkerman KE (2005) Intracellular signal pathways utilized by the hypocretin/orexin receptors. In: de Lecea L, Sutcliffe JG (eds) Hypocretins as integrators of physiological signals. Springer Science Business Media, Berlin, pp 221-231
    • (2005) Hypocretins As Integrators of Physiological Signals , pp. 221-231
    • Kukkonen, J.P.1    Åkerman, K.E.2
  • 24
    • 0033529520 scopus 로고    scopus 로고
    • The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene
    • DOI 10.1016/S0092-8674(00)81965-0
    • Lin L, Faraco J, Li R, Kadotani H, Rogers W, Lin X, Qiu X, de Jong PJ, Nishino S, Mignot E (1999) The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98:365-376 (Pubitemid 29380571)
    • (1999) Cell , vol.98 , Issue.3 , pp. 365-376
    • Lin, L.1    Faraco, J.2    Li, R.3    Kadotani, H.4    Rogers, W.5    Lin, X.6    Qiu, X.7    De Jong, P.J.8    Nishino, S.9    Mignot, E.10
  • 26
    • 43849100266 scopus 로고    scopus 로고
    • Orexins and orexin receptors: From molecules to integrative physiology
    • Matsuki T, Sakurai T (2008) Orexins and orexin receptors: from molecules to integrative physiology. Results Probl Cell Differ 46:27-55
    • (2008) Results Probl Cell Differ , vol.46 , pp. 27-55
    • Matsuki, T.1    Sakurai, T.2
  • 29
    • 34548404227 scopus 로고    scopus 로고
    • Effects of PACAP and VIP on cyclic AMP formation in rat neuronal and astrocyte cultures under normoxic and hypoxic condition
    • DOI 10.1016/j.peptides.2007.04.007, PII S0196978107001283
    • Nowak JZ, Jozwiak-Bebenista M, Bednarek K (2007) Effects of PACAP and VIP on cyclic AMP formation in rat neuronal and astrocyte cultures under normoxic and hypoxic condition. Peptides 28:1706-1712 (Pubitemid 47361419)
    • (2007) Peptides , vol.28 , Issue.9 , pp. 1706-1712
    • Nowak, J.Z.1    Jozwiak-Bebenista, M.2    Bednarek, K.3
  • 30
    • 52749084662 scopus 로고    scopus 로고
    • Role of orexin in central regulation of gastrointestinal functions
    • Okumura T, Takakusaki K (2008) Role of orexin in central regulation of gastrointestinal functions. J Gastroenterol 43:652-660
    • (2008) J Gastroenterol , vol.43 , pp. 652-660
    • Okumura, T.1    Takakusaki, K.2
  • 32
    • 70349263987 scopus 로고    scopus 로고
    • Orexin-stimulated MAP kinase cascades are activated through multiple G-protein signalling pathways in human H295R adrenocortical cells: Diverse roles for orexins A and B
    • Ramanjaneya M, Conner AC, Chen J, Kumar P, Brown JE, Jöhren O, Lehnert H, Stanfield PR, Randeva HS (2009) Orexin-stimulated MAP kinase cascades are activated through multiple G-protein signalling pathways in human H295R adrenocortical cells: diverse roles for orexins A and B. J Endocrinol 202:249-261
    • (2009) J Endocrinol , vol.202 , pp. 249-261
    • Ramanjaneya, M.1    Conner, A.C.2    Chen, J.3    Kumar, P.4    Brown, J.E.5    Jöhren, O.6    Lehnert, H.7    Stanfield, P.R.8    Randeva, H.S.9
  • 33
    • 0034750656 scopus 로고    scopus 로고
    • Expression of orexin-a and functional orexin type 2 receptors in the human adult adrenals: Implications for adrenal function and energy homeostasis
    • DOI 10.1210/jc.86.10.4808
    • Randeva HS, Karteris E, Grammatopoulos D, Hillhouse EW (2001) Expression of orexin-A and functional orexin type 2 receptors in the human adult adrenals: implications for adrenal function and energy homeostasis. J Clin Endocrinol Metab 86:4808-4813 (Pubitemid 33020524)
    • (2001) Journal of Clinical Endocrinology and Metabolism , vol.86 , Issue.10 , pp. 4808-4813
    • Randeva, H.S.1    Karteris, E.2    Grammatopoulos, D.3    Hillhouse, E.W.4
  • 36
    • 0016374975 scopus 로고
    • A highly sensitive adenylate cyclase assay
    • Salomon Y, Londos C, Rodbell M (1974) A highly sensitive adenylate cyclase assay. Analyt Biochem 58:541-548
    • (1974) Analyt Biochem , vol.58 , pp. 541-548
    • Salomon, Y.1    Londos, C.2    Rodbell, M.3
  • 37
    • 0014625412 scopus 로고
    • A radioisotopic method for measuring the formation of adenosine 3′,5′-monophosphate in incubated slices of brain
    • Shimizu H, Daly JW, Creveling CR (1969) A radioisotopic method for measuring the formation of adenosine 3′,5′-monophosphate in incubated slices of brain. J Neurochem 16:1609-1619
    • (1969) J Neurochem , vol.16 , pp. 1609-1619
    • Shimizu, H.1    Daly, J.W.2    Creveling, C.R.3
  • 38
  • 40
    • 0043128708 scopus 로고    scopus 로고
    • Pattern of hypocretin (orexin) soma and axon loss, and gliosis, in human narcolepsy
    • Thannickal TC, Siegel JM, Nienhuis R, Moore RY (2003) Pattern of hypocretin (orexin) soma and axon loss, and gliosis, in human narcolepsy. Brain Pathol 13:340-351 (Pubitemid 36975824)
    • (2003) Brain Pathology , vol.13 , Issue.3 , pp. 340-351
    • Thannickal, T.C.1    Siegel, J.M.2    Nienhuis, R.3    Moore, R.Y.4
  • 41
    • 0032189780 scopus 로고    scopus 로고
    • Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin
    • van den Pol AN, Gao XB, Obrietan K, Kilduff TS, Belousov AB (1998) Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/ orexin. J Neurosci 18:7962-7971 (Pubitemid 28441034)
    • (1998) Journal of Neuroscience , vol.18 , Issue.19 , pp. 7962-7971
    • Van Den, P.A.N.1    Gao, X.-B.2    Obrietan, K.3    Kilduff, T.S.4    Belousov, A.B.5
  • 44
    • 80051512547 scopus 로고    scopus 로고
    • Activation of orexin/hypocretin type 1-like receptors stimulates cAMP synthesis in primary cultures of rat astrocytes
    • in press
    • Woldan-Tambor A, Biegańska K, Wiktorowska-Owczarek A, Zawilska JB (2011) Activation of orexin/hypocretin type 1-like receptors stimulates cAMP synthesis in primary cultures of rat astrocytes. Pharmacol Rep 63 (in press)
    • (2011) Pharmacol Rep , vol.63
    • Woldan-Tambor, A.1    Biegańska, K.2    Wiktorowska-Owczarek, A.3    Zawilska, J.B.4
  • 45
    • 0042565939 scopus 로고    scopus 로고
    • Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins
    • Zhu Y, Miwa Y, Yamanaka A, Yada T, Shibahara M, Abe Y, Samurai T, Goto K (2003) Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type- 2 couples to both pertussis toxin-sensitive and -insensitive Gproteins. J Pharmacol Sci 92:259-266 (Pubitemid 36992313)
    • (2003) Journal of Pharmacological Sciences , vol.92 , Issue.3 , pp. 259-266
    • Zhu, Y.1    Miwa, Y.2    Yamanaka, A.3    Yada, T.4    Shibahara, M.5    Abe, Y.6    Sakurai, T.7    Goto, K.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.