Are circulating gonadotropin isoforms naturally occurring biased agonists? Basic and therapeutic implications

Reviews in Endocrine and Metabolic Disorders

Volumn 12, Issue 4, 2011, Pages 275-288

  Arey, Brian J ^a   López, Francisco J ^b  

^a BRISTOL MYERS SQUIBB   (United States)

^b Corning Incorporated ^*  (United States)

Author keywords

Biased agonist; Contraception; FSH; GPCR; Infertility. Ovulation induction; LH

Indexed keywords

8 ANILINO 1 NAPHTHALENESULFONIC ACID; CHORIONIC GONADOTROPIN; FOLLITROPIN; G PROTEIN COUPLED RECEPTOR; GLYCOPROTEIN; GONADOTROPIN; GONADOTROPIN DERIVATIVE; LUTEINIZING HORMONE; ORG 43553; PROGESTERONE; PYRAZOLE; PYRIMIDINE DERIVATIVE; QUINOLINE DERIVATIVE; RECOMBINANT CHORIONIC GONADOTROPIN; RECOMBINANT FOLLITROPIN; RECOMBINANT HORMONE; RECOMBINANT LUTEINIZING HORMONE; RECOMBINANT PROTEIN; TETRAHYDROQUINOLINE; THIAZOLE DERIVATIVE; THIAZOLIDONE; THIENOPYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

AMENORRHEA; ARTICLE; BIOLOGICAL ACTIVITY; CONTRACEPTION; CORPUS LUTEUM; DRUG EFFICACY; DRUG HALF LIFE; DRUG STRUCTURE; GLYCOSYLATION; HORMONAL THERAPY; HUMAN; INFERTILITY; LOW DRUG DOSE; NONHUMAN; OVARY HYPERSTIMULATION; OVARY POLYCYSTIC DISEASE; OVULATION INDUCTION; PLEIOTROPY; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; BIOLOGICAL AGENTS; CLINICAL TRIALS AS TOPIC; FOLLICLE STIMULATING HORMONE; GONADOTROPINS; HUMANS; MODELS, BIOLOGICAL; PROTEIN ISOFORMS; RECEPTORS, GONADOTROPIN; RESEARCH;

EID: 84855709815     PISSN: 13899155     EISSN: 15732606     Source Type: Journal    
DOI: 10.1007/s11154-011-9188-y     Document Type: Article

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