Solid-state nuclear magnetic resonance studies delineate the role of the protein in activation of both aromatic rings of thiamin

Journal of the American Chemical Society

Volumn 134, Issue 1, 2012, Pages 665-672

  Balakrishnan, Anand ^a   Paramasivam, Sivakumar ^b   Chakraborty, Sumit ^a   Polenova, Tatyana ^b   Jordan, Frank ^a  

^a RUTGERS UNIVERSITY   (United States)

^b UNIVERSITY OF DELAWARE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID-BASE CATALYSTS; ACTIVE STATE; AMINOPYRIMIDINES; AROMATIC RINGS; BIFUNCTIONAL; CATALYTIC CYCLES; COFACTORS; COVALENT BOND FORMATION; ENZYME CATALYSIS; INTERMEDIATE FORMATION; NMR STUDIES; PLAUSIBLE MODEL; SOLID-STATE NMR SPECTROSCOPY; SOLID-STATE NUCLEAR MAGNETIC RESONANCE; SOLUTION NMR; SPECTRAL SIGNATURE; TAUTOMERIC FORMS; TAUTOMERIZATIONS; THIAMIN DIPHOSPHATE;

AROMATIC COMPOUNDS; CARBOXYLATION; CATALYSIS; CATALYSTS; CHEMICAL BONDS; DICHROISM; IONIZATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTONS;

ENZYMES;

AROMATIC COMPOUND; COCARBOXYLASE; PROTON; PYRIMIDINE DERIVATIVE; THIAMINE; THIAZOLE DERIVATIVE;

ARTICLE; CIRCULAR DICHROISM; COVALENT BOND; DECARBOXYLATION; ENZYME BINDING; ENZYME MECHANISM; HYDROGEN BOND; IONIZATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PKA; PROTON NUCLEAR MAGNETIC RESONANCE; PROTON TRANSPORT; SYNTHESIS; TAUTOMERIZATION;

BIOCATALYSIS; CARBOXY-LYASES; ESCHERICHIA COLI; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; SACCHAROMYCES CEREVISIAE; THIAMINE;

EID: 84855690764     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja209856x     Document Type: Article

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