X-ray and NMR crystallography in an enzyme active site: The indoline quinonoid intermediate in tryptophan synthase

Journal of the American Chemical Society

Volumn 133, Issue 1, 2011, Pages 4-7

  Lai, Jinfeng ^a   Niks, Dimitri ^a   Wang, Yachong ^a   Domratcheva, Tatiana ^b   Barends, Thomas R M ^b   Schwarz, Friedrich ^b   Olsen, Ryan A ^a   Elliott, Douglas W ^a   Fatmi, M Qaiser ^a   Chang, Chia En A ^a   Schlichting, Ilme ^b   Dunn, Michael F ^a   Mueller, Leonard J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AB INITIO; ACTIVE SITE; CATALYTIC RESIDUE; CHEMICAL ENVIRONMENT; ENZYME ACTIVE SITES; ENZYME MECHANISM; HIGH RESOLUTION; NMR CRYSTALLOGRAPHY; NMR SPECTROSCOPY; PROTONATION STATE; QUINONOID INTERMEDIATES; REACTIVE SUBSTRATES; SENSITIVE PROBE; SIDE-CHAIN; SOLID-STATE NMR SPECTROSCOPY; TAUTOMERIC FORMS; THREE-DIMENSIONAL STRUCTURE; TRYPTOPHAN SYNTHASE;

AMINO ACIDS; CHEMICAL SHIFT; COMPLEXATION; COMPUTATIONAL CHEMISTRY; ENZYMES; MINERALOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTONATION; SELF ASSEMBLY; SUBSTRATES; X RAY CRYSTALLOGRAPHY; X RAYS;

CRYSTAL STRUCTURE;

CARBON 13; INDOLE DERIVATIVE; NITROGEN 15; QUINONE DERIVATIVE; TRYPTOPHAN SYNTHASE;

AB INITIO CALCULATION; ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME MECHANISM; ISOMER; PROTON NUCLEAR MAGNETIC RESONANCE; PROTON TRANSPORT; SOLID STATE; THREE DIMENSIONAL IMAGING; X RAY CRYSTALLOGRAPHY;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; INDOLES; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; TRYPTOPHAN SYNTHASE; VITAMIN B 6;

EID: 78650973762     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja106555c     Document Type: Article

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