Covalently bound substrate at the regulatory site of yeast pyruvate decarboxylases triggers allosteric enzyme activation

Journal of Biological Chemistry

Volumn 284, Issue 18, 2009, Pages 12136-12144

  Kutter, Steffen ^a   Weiss, Manfred S ^b   Wille, Georg ^a,c   Golbik, Ralph ^a   Spinka, Michael ^a   König, Stephan ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b DESY   (Germany)

^c GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE ARCHITECTURE; ALLOSTERIC ENZYMES; ATOMIC RESOLUTION; BINDING STUDIES; COVALENT BINDING; COVALENTLY BOUND; DECARBOXYLASES; ENZYME ACTIVATION; ENZYME COMPLEXES; HISTIDINE RESIDUES; KINETIC INVESTIGATIONS; PYRUVATE; PYRUVATE DECARBOXYLASE; SIDE CHAINS; STRUCTURAL CHANGE; STRUCTURAL DATA; THREE-DIMENSIONAL STRUCTURE;

AMINES; AMINO ACIDS; LAWS AND LEGISLATION; ORGANIC ACIDS; YEAST;

ENZYMES;

CYSTEINE; FUNGAL ENZYME; HISTIDINE; PYRUVATE DECARBOXYLASE; FUNGAL PROTEIN; PYRUVIC ACID;

ALLOENZYME VARIATION; ALLOSTERISM; AMINO ACID SUBSTITUTION; ARTICLE; COVALENT BOND; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME MECHANISM; ENZYME MODIFICATION; ENZYME REGULATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; PRIORITY JOURNAL; YEAST; CHEMISTRY; ENZYMOLOGY; KINETICS; KLUYVEROMYCES; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

ALLOSTERIC REGULATION; ENZYME ACTIVATION; FUNGAL PROTEINS; KINETICS; KLUYVEROMYCES; PROTEIN STRUCTURE, TERTIARY; PYRUVATE DECARBOXYLASE; PYRUVIC ACID;

EID: 66449102566     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M806228200     Document Type: Article

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