Identification of acridinyl hydrazides as potent aspartic protease inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 9, 2008, Pages 3011-3015

  Azim, M Kamran ^a   Ahmed, Waseem ^a,b   Khan, Ishtiaq A ^a   Rao, Nosheen A ^a   Khan, Khalid M ^a  

^a UNIVERSITY OF KARACHI   (Pakistan)

^b FEDERAL URDU UNIVERSITY OF ARTS   (Pakistan)

Author keywords

Acridines; Cathepsin D; Plasmepsin; Protease inhibitors; Virtual screening

Indexed keywords

ASPARTIC PROTEINASE INHIBITOR; CATHEPSIN D; HYDRAZIDE DERIVATIVE; PLASMEPSIN II;

ARTICLE; DRUG BINDING; DRUG IDENTIFICATION; ENZYME INHIBITION; IC 50; PLASMODIUM FALCIPARUM;

ACRIDINES; ALGORITHMS; ANIMALS; ANTIMALARIALS; ASPARTIC ENDOPEPTIDASES; BINDING SITES; CATALYSIS; CATHEPSIN D; HUMANS; HYDRAZINES; LIGANDS; PLASMODIUM FALCIPARUM; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

PLASMODIUM FALCIPARUM;

EID: 42949103158     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.02.060     Document Type: Article

References (22)

1. Umezawa H., Aoyagi T., Morishima H., Matsuzaki M., Hamada M., and Takeuchi T. J. Antibiot. 23 (1970) 259
2. De Clercq E. Nat. Rev. Drug Disc. 1 (2002) 13
3. Jedinak A., and Maliar T. Neoplasma 52 3 (2005) 185
4. Azim M.K., and Zaidi Z.H. Biochem. Biophys. Res. Commun. 264 (1999) 825
5. Ersmark K., Samuelsson B., and Hallberg A. Med. Res. Rev. 26 (2006) 626
6. Cooper J.D., Russell C., and Mitchison H.M. Biochim. Biophys. Acta 1762 (2006) 873
7. Ersmark K., Nervall M., Hamelink E., Janka L.K., Clemente J.C., Dunn B.M., Blackman M.J., Samuelsson B., Aqvist J., and Hallberg A. J. Med. Chem. 48 (2005) 6090
8. Hof F., Schutz A., Fah C., Mayer S., Bur D., Liu J., Goldberg D.E., and Diederich F. Angew. Chem. 45 (2006) 2138
9. Eder J., Hommel U., Cumin F., Martoglio B., and Gerhartz B. Curr. Pharm. Des. 13 (2007) 271
10. Sali A., Veerapandian B., Cooper J.B., Moss D.S., Hofmann T., and Blundell T.L. Proteins 12 (1992) 158
11. Schechter I., and Berger A. Biochem. Biophys. Res. Commun. 27 (1967) 157
12. Liu C., Jiang Z., Zhang Y., Wang Z., Zhang X., Feng F., and Wang S. Langmuir 23 (2007) 9140
13. Kirk S.R., Luedtke N.W., and Tor Y. J. Am. Chem. Soc. 122 (2000) 980
14. Murphy L., Clynes M., and Keenan J. Anticancer Res. 27 (2007) 1277
15. Ma Z., Day C.S., and Bierbach U. J. Org. Chem. 72 (2007) 5387
16. Rarey M., Kramer B., Lengauer T., and Klebe G. J. Mol. Biol. 261 (1996) 470
17. Baldwin E.T., Bhat T.N., Gulnik S., Hosur M.V., Sowder II R.C., Cachau R.E., Collins J., Silva A.M., and Erickson J.W. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 6796
18. Silva A.M., Lee A.Y., Gulnik S.V., Maier P., Collins J., Bhat T.N., Collins P.J., Cachau R.E., Luker K.E., Gluzman I.Y., Francis S.E., Oksman A., Goldberg D.E., and Erickson J.W. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 10034
19. Bohm H.-J. J. Comput. Aided Mol. Des. 8 (1994) 243
20. Haque T.S., Skillman A.G., Lee C.E., Habashita H., Gulzman I.Y., Ewing T.J.A., Goldberg D.E., Kuntz I.D., and Ellman J.A. J. Med. Chem. 42 (1999) 1428
21. Khan M.K., Rao N.A., Lodhi M.A., Perveen S., Choudhary M.I., and Voelter W. Lett. Drug Des. Disc. 4 (2007) 114
22. Molteni M., Rsenti C., Sani M., Volonterio A., and Zanda M. J. Fluorine Chem. 125 (2004) 1735