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Volumn 7, Issue 1, 2012, Pages

Postnatal changes in the expression pattern of the imprinted signalling protein XLαs underlie the changing phenotype of deficient mice

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT XLALPHAS; INSULIN; LEPTIN; MAMMALIAN TARGET OF RAPAMYCIN; S6 KINASE; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; GNAS PROTEIN, MOUSE; NEUROPEPTIDE; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

EID: 84855646813     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029753     Document Type: Article
Times cited : (19)

References (97)
  • 1
    • 0021139084 scopus 로고
    • Completion of mouse embryogenesis requires both the maternal and paternal genomes
    • McGrath J, Solter D, (1984) Completion of mouse embryogenesis requires both the maternal and paternal genomes. Cell 37: 179-183.
    • (1984) Cell , vol.37 , pp. 179-183
    • McGrath, J.1    Solter, D.2
  • 2
    • 0021237658 scopus 로고
    • Development of reconstituted mouse eggs suggests imprinting of the genome during gametogenesis
    • Surani MA, Barton SC, Norris ML, (1984) Development of reconstituted mouse eggs suggests imprinting of the genome during gametogenesis. Nature 308: 548-550.
    • (1984) Nature , vol.308 , pp. 548-550
    • Surani, M.A.1    Barton, S.C.2    Norris, M.L.3
  • 3
    • 70349104647 scopus 로고    scopus 로고
    • Genomic imprinting: employing and avoiding epigenetic processes
    • Bartolomei MS, (2009) Genomic imprinting: employing and avoiding epigenetic processes. Genes Dev 23: 2124-2133.
    • (2009) Genes Dev , vol.23 , pp. 2124-2133
    • Bartolomei, M.S.1
  • 4
    • 34250160167 scopus 로고    scopus 로고
    • Mechanisms regulating imprinted genes in clusters
    • Edwards CA, Ferguson-Smith AC, (2007) Mechanisms regulating imprinted genes in clusters. Curr Opin Cell Biol 19: 281-289.
    • (2007) Curr Opin Cell Biol , vol.19 , pp. 281-289
    • Edwards, C.A.1    Ferguson-Smith, A.C.2
  • 5
    • 0035234557 scopus 로고    scopus 로고
    • Genomic imprinting: parental influence on the genome
    • Reik W, Walter J, (2001) Genomic imprinting: parental influence on the genome. Nat Rev Genet 2: 21-32.
    • (2001) Nat Rev Genet , vol.2 , pp. 21-32
    • Reik, W.1    Walter, J.2
  • 6
    • 33847693583 scopus 로고    scopus 로고
    • Genomic imprinting, growth control and the allocation of nutritional resources: consequences for postnatal life
    • Charalambous M, da Rocha ST, Ferguson-Smith AC, (2007) Genomic imprinting, growth control and the allocation of nutritional resources: consequences for postnatal life. Curr Opin Endocrinol Diabetes Obes 14: 3-12.
    • (2007) Curr Opin Endocrinol Diabetes Obes , vol.14 , pp. 3-12
    • Charalambous, M.1    da Rocha, S.T.2    Ferguson-Smith, A.C.3
  • 8
    • 23444458380 scopus 로고    scopus 로고
    • Increased body fat in mice with a targeted mutation of the paternally expressed imprinted gene Peg3
    • Curley JP, Pinnock SB, Dickson SL, Thresher R, Miyoshi N, et al. (2005) Increased body fat in mice with a targeted mutation of the paternally expressed imprinted gene Peg3. FASEB J 19: 1302-1304.
    • (2005) FASEB J , vol.19 , pp. 1302-1304
    • Curley, J.P.1    Pinnock, S.B.2    Dickson, S.L.3    Thresher, R.4    Miyoshi, N.5
  • 9
    • 42449114088 scopus 로고    scopus 로고
    • Imprinted genes, postnatal adaptations and enduring effects on energy homeostasis
    • Frontera M, Dickins B, Plagge A, Kelsey G, (2008) Imprinted genes, postnatal adaptations and enduring effects on energy homeostasis. Ad Exp Med Biol 626: 41-61.
    • (2008) Ad Exp Med Biol , vol.626 , pp. 41-61
    • Frontera, M.1    Dickins, B.2    Plagge, A.3    Kelsey, G.4
  • 10
    • 79251578041 scopus 로고    scopus 로고
    • Distinct physiological and behavioural functions for parental alleles of imprinted Grb10
    • Garfield AS, Cowley M, Smith FM, Moorwood K, Stewart-Cox JE, et al. (2011) Distinct physiological and behavioural functions for parental alleles of imprinted Grb10. Nature 469: 534-538.
    • (2011) Nature , vol.469 , pp. 534-538
    • Garfield, A.S.1    Cowley, M.2    Smith, F.M.3    Moorwood, K.4    Stewart-Cox, J.E.5
  • 12
    • 35549001312 scopus 로고    scopus 로고
    • Genomic imprinting effects on brain development and function
    • Wilkinson LS, Davies W, Isles AR, (2007) Genomic imprinting effects on brain development and function. Nat Rev Neurosci 8: 832-843.
    • (2007) Nat Rev Neurosci , vol.8 , pp. 832-843
    • Wilkinson, L.S.1    Davies, W.2    Isles, A.R.3
  • 14
    • 0022391691 scopus 로고
    • Differential activity of maternally and paternally derived chromosome regions in mice
    • Cattanach BM, Kirk M, (1985) Differential activity of maternally and paternally derived chromosome regions in mice. Nature 315: 496-498.
    • (1985) Nature , vol.315 , pp. 496-498
    • Cattanach, B.M.1    Kirk, M.2
  • 15
    • 0032544019 scopus 로고    scopus 로고
    • The human GNAS1 gene is imprinted and encodes distinct paternally and biallelically expressed G proteins
    • Hayward BE, Kamiya M, Strain L, Moran V, Campbell R, et al. (1998) The human GNAS1 gene is imprinted and encodes distinct paternally and biallelically expressed G proteins. Proc Natl Acad Sci U S A 95: 10038-10043.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 10038-10043
    • Hayward, B.E.1    Kamiya, M.2    Strain, L.3    Moran, V.4    Campbell, R.5
  • 16
    • 77955876027 scopus 로고    scopus 로고
    • Imprinting on chromosome 20: tissue-specific imprinting and imprinting mutations in the GNAS locus
    • Kelsey G, (2010) Imprinting on chromosome 20: tissue-specific imprinting and imprinting mutations in the GNAS locus. Am J Med Genet C Semin Med Genet 154C: 377-386.
    • (2010) Am J Med Genet C Semin Med Genet , vol.154 C , pp. 377-386
    • Kelsey, G.1
  • 17
    • 39749113991 scopus 로고    scopus 로고
    • Control of imprinting at the Gnas cluster
    • Peters J, Williamson CM, (2007) Control of imprinting at the Gnas cluster. Epigenetics 2: 207-213.
    • (2007) Epigenetics , vol.2 , pp. 207-213
    • Peters, J.1    Williamson, C.M.2
  • 18
    • 0033616719 scopus 로고    scopus 로고
    • A cluster of oppositely imprinted transcripts at the Gnas locus in the distal imprinting region of mouse chromosome 2
    • Peters J, Wroe SF, Wells CA, Miller HJ, Bodle D, et al. (1999) A cluster of oppositely imprinted transcripts at the Gnas locus in the distal imprinting region of mouse chromosome 2. Proc Natl Acad Sci U S A 96: 3830-3835.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 3830-3835
    • Peters, J.1    Wroe, S.F.2    Wells, C.A.3    Miller, H.J.4    Bodle, D.5
  • 19
    • 39749100503 scopus 로고    scopus 로고
    • Physiological functions of the imprinted Gnas locus and its protein variants Gαs and XLαs in human and mouse
    • Plagge A, Kelsey G, Germain-Lee EL, (2008) Physiological functions of the imprinted Gnas locus and its protein variants Gαs and XLαs in human and mouse. J Endocrinol 196: 193-214.
    • (2008) J Endocrinol , vol.196 , pp. 193-214
    • Plagge, A.1    Kelsey, G.2    Germain-Lee, E.L.3
  • 20
    • 74249123592 scopus 로고    scopus 로고
    • The role of GNAS and other imprinted genes in the development of obesity
    • Weinstein LS, Xie T, Qasem A, Wang J, Chen M, (2010) The role of GNAS and other imprinted genes in the development of obesity. Int J Obes (Lond) 34: 6-17.
    • (2010) Int J Obes (Lond) , vol.34 , pp. 6-17
    • Weinstein, L.S.1    Xie, T.2    Qasem, A.3    Wang, J.4    Chen, M.5
  • 22
    • 0036020511 scopus 로고    scopus 로고
    • Receptor-mediated adenylyl cyclase activation through XLαs, the extra-large variant of the stimulatory G protein α-subunit
    • Bastepe M, Gunes Y, Perez-Villamil B, Hunzelman J, Weinstein LS, et al. (2002) Receptor-mediated adenylyl cyclase activation through XLαs, the extra-large variant of the stimulatory G protein α-subunit. Mol Endocrinol 16: 1912-1919.
    • (2002) Mol Endocrinol , vol.16 , pp. 1912-1919
    • Bastepe, M.1    Gunes, Y.2    Perez-Villamil, B.3    Hunzelman, J.4    Weinstein, L.S.5
  • 23
    • 66049136160 scopus 로고    scopus 로고
    • Central nervous system imprinting of the G protein Gsα and its role in metabolic regulation
    • Chen M, Wang J, Dickerson KE, Kelleher J, Xie T, et al. (2009) Central nervous system imprinting of the G protein Gsα and its role in metabolic regulation. Cell Metab 9: 548-555.
    • (2009) Cell Metab , vol.9 , pp. 548-555
    • Chen, M.1    Wang, J.2    Dickerson, K.E.3    Kelleher, J.4    Xie, T.5
  • 24
    • 0035982094 scopus 로고    scopus 로고
    • Paternal imprinting of Gαs in the human thyroid as the basis of TSH resistance in Pseudohypoparathyroidism type 1a
    • Germain-Lee EL, Ding CL, Deng Z, Crane JL, Saji M, et al. (2002) Paternal imprinting of Gαs in the human thyroid as the basis of TSH resistance in Pseudohypoparathyroidism type 1a. Biochem Biophys Res Commun 296: 67-72.
    • (2002) Biochem Biophys Res Commun , vol.296 , pp. 67-72
    • Germain-Lee, E.L.1    Ding, C.L.2    Deng, Z.3    Crane, J.L.4    Saji, M.5
  • 25
    • 26844542000 scopus 로고    scopus 로고
    • A mouse model of Albright Hereditary Osteodystrophy generated by targeted disruption of exon 1 of the Gnas gene
    • Germain-Lee EL, Schwindinger W, Crane JL, Zewdu R, Zweifel LS, et al. (2005) A mouse model of Albright Hereditary Osteodystrophy generated by targeted disruption of exon 1 of the Gnas gene. Endocrinology 146: 4697-4709.
    • (2005) Endocrinology , vol.146 , pp. 4697-4709
    • Germain-Lee, E.L.1    Schwindinger, W.2    Crane, J.L.3    Zewdu, R.4    Zweifel, L.S.5
  • 27
    • 0036771614 scopus 로고    scopus 로고
    • The Gsα gene: predominant maternal origin of transcription in human thyroid gland and gonads
    • Mantovani G, Ballare E, Giammona E, Beck-Peccoz P, Spada A, (2002) The Gsα gene: predominant maternal origin of transcription in human thyroid gland and gonads. J Clin Endocrinol Metab 87: 4736-4740.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 4736-4740
    • Mantovani, G.1    Ballare, E.2    Giammona, E.3    Beck-Peccoz, P.4    Spada, A.5
  • 28
    • 0041631077 scopus 로고    scopus 로고
    • Epigenetic properties and identification of an imprint mark in the Nesp-Gnasxl domain of the mouse Gnas imprinted locus
    • Coombes C, Arnaud P, Gordon E, Dean W, Coar EA, et al. (2003) Epigenetic properties and identification of an imprint mark in the Nesp-Gnasxl domain of the mouse Gnas imprinted locus. Mol Cell Biol 23: 5475-5488.
    • (2003) Mol Cell Biol , vol.23 , pp. 5475-5488
    • Coombes, C.1    Arnaud, P.2    Gordon, E.3    Dean, W.4    Coar, E.A.5
  • 29
    • 0034721880 scopus 로고    scopus 로고
    • Characterization of the extra-large G protein α-subunit XLαs. I. Tissue distribution and subcellular localization
    • Pasolli HA, Klemke M, Kehlenbach RH, Wang Y, Huttner WB, (2000) Characterization of the extra-large G protein α-subunit XLαs. I. Tissue distribution and subcellular localization. J Biol Chem 275: 33622-33632.
    • (2000) J Biol Chem , vol.275 , pp. 33622-33632
    • Pasolli, H.A.1    Klemke, M.2    Kehlenbach, R.H.3    Wang, Y.4    Huttner, W.B.5
  • 30
    • 3543036987 scopus 로고    scopus 로고
    • The imprinted signaling protein XLαs is required for postnatal adaptation to feeding
    • Plagge A, Gordon E, Dean W, Boiani R, Cinti S, et al. (2004) The imprinted signaling protein XLαs is required for postnatal adaptation to feeding. Nat Genet 36: 818-826.
    • (2004) Nat Genet , vol.36 , pp. 818-826
    • Plagge, A.1    Gordon, E.2    Dean, W.3    Boiani, R.4    Cinti, S.5
  • 31
    • 17244363516 scopus 로고    scopus 로고
    • Identification of the control region for tissue-specific imprinting of the stimulatory G protein α-subunit
    • Liu J, Chen M, Deng C, Bourc'his D, Nealon JG, et al. (2005) Identification of the control region for tissue-specific imprinting of the stimulatory G protein α-subunit. Proc Natl Acad Sci U S A 102: 5513-5518.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 5513-5518
    • Liu, J.1    Chen, M.2    Deng, C.3    Bourc'his, D.4    Nealon, J.G.5
  • 32
    • 3543006557 scopus 로고    scopus 로고
    • A cis-acting control region is required exclusively for the tissue-specific imprinting of Gnas
    • Williamson CM, Ball ST, Nottingham WT, Skinner JA, Plagge A, et al. (2004) A cis-acting control region is required exclusively for the tissue-specific imprinting of Gnas. Nat Genet 36: 894-899.
    • (2004) Nat Genet , vol.36 , pp. 894-899
    • Williamson, C.M.1    Ball, S.T.2    Nottingham, W.T.3    Skinner, J.A.4    Plagge, A.5
  • 33
    • 33644617486 scopus 로고    scopus 로고
    • Identification of an imprinting control region affecting the expression of all transcripts in the Gnas cluster
    • Williamson CM, Turner MD, Ball ST, Nottingham WT, Glenister P, et al. (2006) Identification of an imprinting control region affecting the expression of all transcripts in the Gnas cluster. Nat Genet 38: 350-355.
    • (2006) Nat Genet , vol.38 , pp. 350-355
    • Williamson, C.M.1    Turner, M.D.2    Ball, S.T.3    Nottingham, W.T.4    Glenister, P.5
  • 34
    • 11244353640 scopus 로고    scopus 로고
    • Deletion of the NESP55 differentially methylated region causes loss of maternal GNAS imprints and Pseudohypoparathyroidism type Ib
    • Bastepe M, Frohlich LF, Linglart A, Abu-Zahra HS, Tojo K, et al. (2005) Deletion of the NESP55 differentially methylated region causes loss of maternal GNAS imprints and Pseudohypoparathyroidism type Ib. Nat Genet 37: 25-27.
    • (2005) Nat Genet , vol.37 , pp. 25-27
    • Bastepe, M.1    Frohlich, L.F.2    Linglart, A.3    Abu-Zahra, H.S.4    Tojo, K.5
  • 35
    • 58149506281 scopus 로고    scopus 로고
    • Transcription is required for establishment of germline methylation marks at imprinted genes
    • Chotalia M, Smallwood SA, Ruf N, Dawson C, Lucifero D, et al. (2009) Transcription is required for establishment of germline methylation marks at imprinted genes. Genes Dev 23: 105-117.
    • (2009) Genes Dev , vol.23 , pp. 105-117
    • Chotalia, M.1    Smallwood, S.A.2    Ruf, N.3    Dawson, C.4    Lucifero, D.5
  • 36
    • 79953733907 scopus 로고    scopus 로고
    • Uncoupling antisense-mediated silencing and DNA methylation in the imprinted Gnas cluster
    • Williamson CM, Ball ST, Dawson C, Mehta S, Beechey CV, et al. (2011) Uncoupling antisense-mediated silencing and DNA methylation in the imprinted Gnas cluster. PLoS Genet 7: e1001347.
    • (2011) PLoS Genet , vol.7
    • Williamson, C.M.1    Ball, S.T.2    Dawson, C.3    Mehta, S.4    Beechey, C.V.5
  • 37
    • 0035970852 scopus 로고    scopus 로고
    • Expression of the extra-large G protein α-subunit XLαs in neuroepithelial cells and young neurons during development of the rat nervous system
    • Pasolli HA, Huttner WB, (2001) Expression of the extra-large G protein α-subunit XLαs in neuroepithelial cells and young neurons during development of the rat nervous system. Neurosci Lett 301: 119-122.
    • (2001) Neurosci Lett , vol.301 , pp. 119-122
    • Pasolli, H.A.1    Huttner, W.B.2
  • 38
    • 79953178944 scopus 로고    scopus 로고
    • Transgenic overexpression of the extra-large Gsα variant XLαs enhances Gsα-mediated responses in the mouse renal proximal tubule in vivo
    • Liu Z, Segawa H, Aydin C, Reyes M, Erben RG, et al. (2011) Transgenic overexpression of the extra-large Gsα variant XLαs enhances Gsα-mediated responses in the mouse renal proximal tubule in vivo. Endocrinology 152: 1222-1233.
    • (2011) Endocrinology , vol.152 , pp. 1222-1233
    • Liu, Z.1    Segawa, H.2    Aydin, C.3    Reyes, M.4    Erben, R.G.5
  • 39
    • 33745806530 scopus 로고    scopus 로고
    • The alternative stimulatory G Protein α-subunit XLαs is a critical regulator of energy and glucose metabolism and sympathetic nerve activity in adult mice
    • Xie T, Plagge A, Gavrilova O, Pack S, Jou W, et al. (2006) The alternative stimulatory G Protein α-subunit XLαs is a critical regulator of energy and glucose metabolism and sympathetic nerve activity in adult mice. J Biol Chem 281: 18989-18999.
    • (2006) J Biol Chem , vol.281 , pp. 18989-18999
    • Xie, T.1    Plagge, A.2    Gavrilova, O.3    Pack, S.4    Jou, W.5
  • 41
    • 21044439497 scopus 로고    scopus 로고
    • Alternative Gnas gene products have opposite effects on glucose and lipid metabolism
    • Chen M, Gavrilova O, Liu J, Xie T, Deng C, et al. (2005) Alternative Gnas gene products have opposite effects on glucose and lipid metabolism. Proc Natl Acad Sci U S A 102: 7386-7391.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 7386-7391
    • Chen, M.1    Gavrilova, O.2    Liu, J.3    Xie, T.4    Deng, C.5
  • 42
    • 67349156681 scopus 로고    scopus 로고
    • A missense mutation in the non-neural G-protein α-subunit isoforms modulates susceptibility to obesity
    • Kelly ML, Moir L, Jones L, Whitehill E, Anstee QM, et al. (2009) A missense mutation in the non-neural G-protein α-subunit isoforms modulates susceptibility to obesity. Int J Obes (Lond) 33: 507-518.
    • (2009) Int J Obes (Lond) , vol.33 , pp. 507-518
    • Kelly, M.L.1    Moir, L.2    Jones, L.3    Whitehill, E.4    Anstee, Q.M.5
  • 43
    • 0036426326 scopus 로고    scopus 로고
    • The imprinted oedematous-small mutation on mouse chromosome 2 identifies new roles for Gnas and Gnasxl in development
    • Skinner JA, Cattanach BM, Peters J, (2002) The imprinted oedematous-small mutation on mouse chromosome 2 identifies new roles for Gnas and Gnasxl in development. Genomics 80: 373-375.
    • (2002) Genomics , vol.80 , pp. 373-375
    • Skinner, J.A.1    Cattanach, B.M.2    Peters, J.3
  • 44
    • 0035898609 scopus 로고    scopus 로고
    • Two overlapping reading frames in a single exon encode interacting proteins-a novel way of gene usage
    • Klemke M, Kehlenbach RH, Huttner WB, (2001) Two overlapping reading frames in a single exon encode interacting proteins-a novel way of gene usage. Embo J 20: 3849-3860.
    • (2001) Embo J , vol.20 , pp. 3849-3860
    • Klemke, M.1    Kehlenbach, R.H.2    Huttner, W.B.3
  • 45
    • 0034041160 scopus 로고    scopus 로고
    • High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP
    • Rodriguez CI, Buchholz F, Galloway J, Sequerra R, Kasper J, et al. (2000) High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP. Nat Genet 25: 139-140.
    • (2000) Nat Genet , vol.25 , pp. 139-140
    • Rodriguez, C.I.1    Buchholz, F.2    Galloway, J.3    Sequerra, R.4    Kasper, J.5
  • 46
    • 0032842478 scopus 로고    scopus 로고
    • Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety
    • Tronche F, Kellendonk C, Kretz O, Gass P, Anlag K, et al. (1999) Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet 23: 99-103.
    • (1999) Nat Genet , vol.23 , pp. 99-103
    • Tronche, F.1    Kellendonk, C.2    Kretz, O.3    Gass, P.4    Anlag, K.5
  • 47
    • 0029566108 scopus 로고
    • A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells
    • Schwenk F, Baron U, Rajewsky K, (1995) A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res 23: 5080-5081.
    • (1995) Nucleic Acids Res , vol.23 , pp. 5080-5081
    • Schwenk, F.1    Baron, U.2    Rajewsky, K.3
  • 48
    • 0026708177 scopus 로고
    • Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
    • Li E, Bestor TH, Jaenisch R, (1992) Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69: 915-926.
    • (1992) Cell , vol.69 , pp. 915-926
    • Li, E.1    Bestor, T.H.2    Jaenisch, R.3
  • 49
    • 0029988995 scopus 로고    scopus 로고
    • A modular set of Flp, FRT and lacZ fusion vectors for manipulating genes by site-specific recombination
    • Dymecki SM, (1996) A modular set of Flp, FRT and lacZ fusion vectors for manipulating genes by site-specific recombination. Gene 171: 197-201.
    • (1996) Gene , vol.171 , pp. 197-201
    • Dymecki, S.M.1
  • 50
    • 0032541483 scopus 로고    scopus 로고
    • Role of nucleotide sequences of loxP spacer region in Cre-mediated recombination
    • Lee G, Saito I, (1998) Role of nucleotide sequences of loxP spacer region in Cre-mediated recombination. Gene 216: 55-65.
    • (1998) Gene , vol.216 , pp. 55-65
    • Lee, G.1    Saito, I.2
  • 51
    • 33748655865 scopus 로고    scopus 로고
    • Nestin-Cre transgenic mouse line Nes-Cre1 mediates highly efficient Cre/loxP mediated recombination in the nervous system, kidney, and somite-derived tissues
    • Dubois NC, Hofmann D, Kaloulis K, Bishop JM, Trumpp A, (2006) Nestin-Cre transgenic mouse line Nes-Cre1 mediates highly efficient Cre/loxP mediated recombination in the nervous system, kidney, and somite-derived tissues. Genesis 44: 355-360.
    • (2006) Genesis , vol.44 , pp. 355-360
    • Dubois, N.C.1    Hofmann, D.2    Kaloulis, K.3    Bishop, J.M.4    Trumpp, A.5
  • 52
    • 0037657915 scopus 로고    scopus 로고
    • A directional strategy for monitoring Cre-mediated recombination at the cellular level in the mouse
    • Schnutgen F, Doerflinger N, Calleja C, Wendling O, Chambon P, et al. (2003) A directional strategy for monitoring Cre-mediated recombination at the cellular level in the mouse. Nat Biotechnol 21: 562-565.
    • (2003) Nat Biotechnol , vol.21 , pp. 562-565
    • Schnutgen, F.1    Doerflinger, N.2    Calleja, C.3    Wendling, O.4    Chambon, P.5
  • 53
    • 58449116590 scopus 로고    scopus 로고
    • Pedunculopontine and laterodorsal tegmental nuclei contain distinct populations of cholinergic, glutamatergic and GABAergic neurons in the rat
    • Wang HL, Morales M, (2009) Pedunculopontine and laterodorsal tegmental nuclei contain distinct populations of cholinergic, glutamatergic and GABAergic neurons in the rat. Eur J Neurosci 29: 340-358.
    • (2009) Eur J Neurosci , vol.29 , pp. 340-358
    • Wang, H.L.1    Morales, M.2
  • 54
    • 0031427482 scopus 로고    scopus 로고
    • Identification of rat brainstem multisynaptic connections to the oral motor nuclei in the rat using pseudorabies virus. II. Facial muscle motor systems
    • Fay RA, Norgren R, (1997) Identification of rat brainstem multisynaptic connections to the oral motor nuclei in the rat using pseudorabies virus. II. Facial muscle motor systems. Brain Res Brain Res Rev 25: 276-290.
    • (1997) Brain Res Brain Res Rev , vol.25 , pp. 276-290
    • Fay, R.A.1    Norgren, R.2
  • 55
    • 23444461401 scopus 로고    scopus 로고
    • Modulation of hypoglossal motoneuron excitability by intracellular signal transduction cascades
    • Feldman JL, Neverova NV, Saywell SA, (2005) Modulation of hypoglossal motoneuron excitability by intracellular signal transduction cascades. Respir Physiol Neurobiol 147: 131-143.
    • (2005) Respir Physiol Neurobiol , vol.147 , pp. 131-143
    • Feldman, J.L.1    Neverova, N.V.2    Saywell, S.A.3
  • 57
    • 79960518168 scopus 로고    scopus 로고
    • Molecular and neuroanatomical characterization of single neurons in the mouse medullary gigantocellular reticular nucleus
    • Martin E, Devidze N, Shelley D, Westberg L, Fontaine C, et al. (2011) Molecular and neuroanatomical characterization of single neurons in the mouse medullary gigantocellular reticular nucleus. J Comp Neurol 519: 2574-2593.
    • (2011) J Comp Neurol , vol.519 , pp. 2574-2593
    • Martin, E.1    Devidze, N.2    Shelley, D.3    Westberg, L.4    Fontaine, C.5
  • 58
    • 23244432007 scopus 로고    scopus 로고
    • An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance
    • Aston-Jones G, Cohen JD, (2005) An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. Annu Rev Neurosci 28: 403-450.
    • (2005) Annu Rev Neurosci , vol.28 , pp. 403-450
    • Aston-Jones, G.1    Cohen, J.D.2
  • 59
    • 78349312826 scopus 로고    scopus 로고
    • GABAergic actions on cholinergic laterodorsal tegmental neurons: implications for control of behavioral state
    • Kohlmeier KA, Kristiansen U, (2010) GABAergic actions on cholinergic laterodorsal tegmental neurons: implications for control of behavioral state. Neuroscience 171: 812-829.
    • (2010) Neuroscience , vol.171 , pp. 812-829
    • Kohlmeier, K.A.1    Kristiansen, U.2
  • 61
    • 51149096739 scopus 로고    scopus 로고
    • Melanocortin-4 receptor mRNA expressed in sympathetic outflow neurons to brown adipose tissue: neuroanatomical and functional evidence
    • Song CK, Vaughan CH, Keen-Rhinehart E, Harris RB, Richard D, et al. (2008) Melanocortin-4 receptor mRNA expressed in sympathetic outflow neurons to brown adipose tissue: neuroanatomical and functional evidence. Am J Physiol Regul Integr Comp Physiol 295: R417-428.
    • (2008) Am J Physiol Regul Integr Comp Physiol , vol.295
    • Song, C.K.1    Vaughan, C.H.2    Keen-Rhinehart, E.3    Harris, R.B.4    Richard, D.5
  • 62
    • 66149094635 scopus 로고    scopus 로고
    • Microinjections of α-melanocyte stimulating hormone into the nucleus ambiguus of the rat elicit vagally mediated bradycardia
    • Chitravanshi VC, Bhatt S, Sapru HN, (2009) Microinjections of α-melanocyte stimulating hormone into the nucleus ambiguus of the rat elicit vagally mediated bradycardia. Am J Physiol Regul Integr Comp Physiol 296: R1402-1411.
    • (2009) Am J Physiol Regul Integr Comp Physiol , vol.296
    • Chitravanshi, V.C.1    Bhatt, S.2    Sapru, H.N.3
  • 63
    • 2542455688 scopus 로고    scopus 로고
    • Minireview: Leptin and development of hypothalamic feeding circuits
    • Bouret SG, Simerly RB, (2004) Minireview: Leptin and development of hypothalamic feeding circuits. Endocrinology 145: 2621-2626.
    • (2004) Endocrinology , vol.145 , pp. 2621-2626
    • Bouret, S.G.1    Simerly, R.B.2
  • 65
    • 34147119799 scopus 로고    scopus 로고
    • The hormonal control of food intake
    • Coll AP, Farooqi IS, O'Rahilly S, (2007) The hormonal control of food intake. Cell 129: 251-262.
    • (2007) Cell , vol.129 , pp. 251-262
    • Coll, A.P.1    Farooqi, I.S.2    O'Rahilly, S.3
  • 66
    • 64949116079 scopus 로고    scopus 로고
    • The nucleus tractus solitarius: a portal for visceral afferent signal processing, energy status assessment and integration of their combined effects on food intake
    • Grill HJ, Hayes MR, (2009) The nucleus tractus solitarius: a portal for visceral afferent signal processing, energy status assessment and integration of their combined effects on food intake. Int J Obes (Lond) 33 (Suppl 1): S11-15.
    • (2009) Int J Obes (Lond) , vol.33 , Issue.SUPPL. 1
    • Grill, H.J.1    Hayes, M.R.2
  • 67
    • 35448971402 scopus 로고    scopus 로고
    • Thermogenesis activated by central melanocortin signaling is dependent on neurons in the rostral raphe pallidus (rRPa) area
    • Fan W, Morrison SF, Cao WH, Yu P, (2007) Thermogenesis activated by central melanocortin signaling is dependent on neurons in the rostral raphe pallidus (rRPa) area. Brain Res 1179: 61-69.
    • (2007) Brain Res , vol.1179 , pp. 61-69
    • Fan, W.1    Morrison, S.F.2    Cao, W.H.3    Yu, P.4
  • 68
    • 0037139340 scopus 로고    scopus 로고
    • The neurochemical characterisation of hypothalamic pathways projecting polysynaptically to brown adipose tissue in the rat
    • Oldfield BJ, Giles ME, Watson A, Anderson C, Colvill LM, et al. (2002) The neurochemical characterisation of hypothalamic pathways projecting polysynaptically to brown adipose tissue in the rat. Neuroscience 110: 515-526.
    • (2002) Neuroscience , vol.110 , pp. 515-526
    • Oldfield, B.J.1    Giles, M.E.2    Watson, A.3    Anderson, C.4    Colvill, L.M.5
  • 69
    • 79955026978 scopus 로고    scopus 로고
    • Central neural pathways for thermoregulation
    • Morrison SF, Nakamura K, (2011) Central neural pathways for thermoregulation. Front Biosci 16: 74-104.
    • (2011) Front Biosci , vol.16 , pp. 74-104
    • Morrison, S.F.1    Nakamura, K.2
  • 70
  • 71
    • 79551512119 scopus 로고    scopus 로고
    • Leptin-receptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits
    • Zhang Y, Kerman IA, Laque A, Nguyen P, Faouzi M, et al. (2011) Leptin-receptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits. J Neurosci 31: 1873-1884.
    • (2011) J Neurosci , vol.31 , pp. 1873-1884
    • Zhang, Y.1    Kerman, I.A.2    Laque, A.3    Nguyen, P.4    Faouzi, M.5
  • 74
    • 79551555006 scopus 로고    scopus 로고
    • Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis
    • Rossi J, Balthasar N, Olson D, Scott M, Berglund E, et al. (2011) Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis. Cell Metab 13: 195-204.
    • (2011) Cell Metab , vol.13 , pp. 195-204
    • Rossi, J.1    Balthasar, N.2    Olson, D.3    Scott, M.4    Berglund, E.5
  • 75
    • 71949093692 scopus 로고    scopus 로고
    • Hypothalamic and hindbrain melanocortin receptors contribute to the feeding, thermogenic, and cardiovascular action of melanocortins
    • Skibicka KP, Grill HJ, (2009) Hypothalamic and hindbrain melanocortin receptors contribute to the feeding, thermogenic, and cardiovascular action of melanocortins. Endocrinology 150: 5351-5361.
    • (2009) Endocrinology , vol.150 , pp. 5351-5361
    • Skibicka, K.P.1    Grill, H.J.2
  • 76
    • 33947387967 scopus 로고    scopus 로고
    • Role of the central melanocortin circuitry in adaptive thermogenesis of brown adipose tissue
    • Voss-Andreae A, Murphy JG, Ellacott KL, Stuart RC, Nillni EA, et al. (2007) Role of the central melanocortin circuitry in adaptive thermogenesis of brown adipose tissue. Endocrinology 148: 1550-1560.
    • (2007) Endocrinology , vol.148 , pp. 1550-1560
    • Voss-Andreae, A.1    Murphy, J.G.2    Ellacott, K.L.3    Stuart, R.C.4    Nillni, E.A.5
  • 78
    • 23244451186 scopus 로고    scopus 로고
    • Melanocortin-4 receptor-deficient mice are not hypertensive or salt-sensitive despite obesity, hyperinsulinemia and hyperleptinemia
    • Tallam LS, Stec DE, Willis MA, da Silva AA, Hall JE, (2005) Melanocortin-4 receptor-deficient mice are not hypertensive or salt-sensitive despite obesity, hyperinsulinemia and hyperleptinemia. Hypertension 46: 326-332.
    • (2005) Hypertension , vol.46 , pp. 326-332
    • Tallam, L.S.1    Stec, D.E.2    Willis, M.A.3    da Silva, A.A.4    Hall, J.E.5
  • 80
    • 72249092928 scopus 로고    scopus 로고
    • Recent advances in understanding leptin signaling and leptin resistance
    • Morris DL, Rui L, (2009) Recent advances in understanding leptin signaling and leptin resistance. Am J Physiol Endocrinol Metab 297: E1247-1259.
    • (2009) Am J Physiol Endocrinol Metab , vol.297
    • Morris, D.L.1    Rui, L.2
  • 81
    • 57849105425 scopus 로고    scopus 로고
    • Enhanced orexin receptor-2 signaling prevents diet-induced obesity and improves leptin sensitivity
    • Funato H, Tsai AL, Willie JT, Kisanuki Y, Williams SC, et al. (2009) Enhanced orexin receptor-2 signaling prevents diet-induced obesity and improves leptin sensitivity. Cell Metab 9: 64-76.
    • (2009) Cell Metab , vol.9 , pp. 64-76
    • Funato, H.1    Tsai, A.L.2    Willie, J.T.3    Kisanuki, Y.4    Williams, S.C.5
  • 82
    • 33747451335 scopus 로고    scopus 로고
    • Corticotropin releasing factor increases in brown adipose tissue thermogenesis and heart rate through dorsomedial hypothalamus and medullary raphe pallidus
    • Cerri M, Morrison SF, (2006) Corticotropin releasing factor increases in brown adipose tissue thermogenesis and heart rate through dorsomedial hypothalamus and medullary raphe pallidus. Neuroscience 140: 711-721.
    • (2006) Neuroscience , vol.140 , pp. 711-721
    • Cerri, M.1    Morrison, S.F.2
  • 83
    • 9444264434 scopus 로고    scopus 로고
    • Postnatal regression of hypothalamic dopaminergic neurons in prolactin-deficient Snell dwarf mice
    • Phelps CJ, (2004) Postnatal regression of hypothalamic dopaminergic neurons in prolactin-deficient Snell dwarf mice. Endocrinology 145: 5656-5664.
    • (2004) Endocrinology , vol.145 , pp. 5656-5664
    • Phelps, C.J.1
  • 84
    • 79952104568 scopus 로고    scopus 로고
    • mTOR couples cellular nutrient sensing to organismal metabolic homeostasis
    • Howell JJ, Manning BD, (2011) mTOR couples cellular nutrient sensing to organismal metabolic homeostasis. Trends Endocrinol Metab 22: 94-102.
    • (2011) Trends Endocrinol Metab , vol.22 , pp. 94-102
    • Howell, J.J.1    Manning, B.D.2
  • 85
    • 33646582664 scopus 로고    scopus 로고
    • Hypothalamic mTOR signaling regulates food intake
    • Cota D, Proulx K, Smith KA, Kozma SC, Thomas G, et al. (2006) Hypothalamic mTOR signaling regulates food intake. Science 312: 927-930.
    • (2006) Science , vol.312 , pp. 927-930
    • Cota, D.1    Proulx, K.2    Smith, K.A.3    Kozma, S.C.4    Thomas, G.5
  • 86
    • 4544220704 scopus 로고    scopus 로고
    • Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
    • Um SH, Frigerio F, Watanabe M, Picard F, Joaquin M, et al. (2004) Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 431: 200-205.
    • (2004) Nature , vol.431 , pp. 200-205
    • Um, S.H.1    Frigerio, F.2    Watanabe, M.3    Picard, F.4    Joaquin, M.5
  • 87
    • 0028057681 scopus 로고
    • Independent regulatory elements in the nestin gene direct transgene expression to neural stem cells or muscle precursors
    • Zimmerman L, Parr B, Lendahl U, Cunningham M, McKay R, et al. (1994) Independent regulatory elements in the nestin gene direct transgene expression to neural stem cells or muscle precursors. Neuron 12: 11-24.
    • (1994) Neuron , vol.12 , pp. 11-24
    • Zimmerman, L.1    Parr, B.2    Lendahl, U.3    Cunningham, M.4    McKay, R.5
  • 88
    • 61849139073 scopus 로고    scopus 로고
    • Vascular wall resident progenitor cells: a review
    • Pacilli A, Pasquinelli G, (2009) Vascular wall resident progenitor cells: a review. Exp Cell Res 315: 901-914.
    • (2009) Exp Cell Res , vol.315 , pp. 901-914
    • Pacilli, A.1    Pasquinelli, G.2
  • 89
    • 65949097938 scopus 로고    scopus 로고
    • Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity
    • Nogueiras R, Perez-Tilve D, Veyrat-Durebex C, Morgan DA, Varela L, et al. (2009) Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity. J Neurosci 29: 5916-5925.
    • (2009) J Neurosci , vol.29 , pp. 5916-5925
    • Nogueiras, R.1    Perez-Tilve, D.2    Veyrat-Durebex, C.3    Morgan, D.A.4    Varela, L.5
  • 90
    • 79958696694 scopus 로고    scopus 로고
    • The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling
    • Hsu PP, Kang SA, Rameseder J, Zhang Y, Ottina KA, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332: 1317-1322.
    • (2011) Science , vol.332 , pp. 1317-1322
    • Hsu, P.P.1    Kang, S.A.2    Rameseder, J.3    Zhang, Y.4    Ottina, K.A.5
  • 91
    • 79958696336 scopus 로고    scopus 로고
    • Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling
    • Yu Y, Yoon SO, Poulogiannis G, Yang Q, Ma XM, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332: 1322-1326.
    • (2011) Science , vol.332 , pp. 1322-1326
    • Yu, Y.1    Yoon, S.O.2    Poulogiannis, G.3    Yang, Q.4    Ma, X.M.5
  • 92
    • 34547888298 scopus 로고    scopus 로고
    • Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life
    • Smith FM, Holt LJ, Garfield AS, Charalambous M, Koumanov F, et al. (2007) Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life. Mol Cell Biol 27: 5871-5886.
    • (2007) Mol Cell Biol , vol.27 , pp. 5871-5886
    • Smith, F.M.1    Holt, L.J.2    Garfield, A.S.3    Charalambous, M.4    Koumanov, F.5
  • 93
    • 0037335439 scopus 로고    scopus 로고
    • Absence of Ndn, encoding the Prader-Willi syndrome-deleted gene necdin, results in congenital deficiency of central respiratory drive in neonatal mice
    • Ren J, Lee S, Pagliardini S, Gerard M, Stewart CL, et al. (2003) Absence of Ndn, encoding the Prader-Willi syndrome-deleted gene necdin, results in congenital deficiency of central respiratory drive in neonatal mice. J Neurosci 23: 1569-1573.
    • (2003) J Neurosci , vol.23 , pp. 1569-1573
    • Ren, J.1    Lee, S.2    Pagliardini, S.3    Gerard, M.4    Stewart, C.L.5
  • 94
    • 78649454993 scopus 로고    scopus 로고
    • A single postnatal injection of oxytocin rescues the lethal feeding behaviour in mouse newborns deficient for the imprinted Magel2 gene
    • Schaller F, Watrin F, Sturny R, Massacrier A, Szepetowski P, et al. (2010) A single postnatal injection of oxytocin rescues the lethal feeding behaviour in mouse newborns deficient for the imprinted Magel2 gene. Hum Mol Genet 19: 4895-4905.
    • (2010) Hum Mol Genet , vol.19 , pp. 4895-4905
    • Schaller, F.1    Watrin, F.2    Sturny, R.3    Massacrier, A.4    Szepetowski, P.5
  • 95
    • 77649083119 scopus 로고    scopus 로고
    • The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating Arc
    • Greer PL, Hanayama R, Bloodgood BL, Mardinly AR, Lipton DM, et al. (2010) The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating Arc. Cell 140: 704-716.
    • (2010) Cell , vol.140 , pp. 704-716
    • Greer, P.L.1    Hanayama, R.2    Bloodgood, B.L.3    Mardinly, A.R.4    Lipton, D.M.5
  • 96
    • 77955299096 scopus 로고    scopus 로고
    • High-resolution analysis of parent-of-origin allelic expression in the mouse brain
    • Gregg C, Zhang J, Weissbourd B, Luo S, Schroth GP, et al. (2010) High-resolution analysis of parent-of-origin allelic expression in the mouse brain. Science 329: 643-648.
    • (2010) Science , vol.329 , pp. 643-648
    • Gregg, C.1    Zhang, J.2    Weissbourd, B.3    Luo, S.4    Schroth, G.P.5
  • 97
    • 0034120279 scopus 로고    scopus 로고
    • A proline-rich region and nearby cysteine residues target XLαs to the Golgi complex region
    • Ugur O, Jones TL, (2000) A proline-rich region and nearby cysteine residues target XLαs to the Golgi complex region. Mol Biol Cell 11: 1421-1432.
    • (2000) Mol Biol Cell , vol.11 , pp. 1421-1432
    • Ugur, O.1    Jones, T.L.2


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