A missense mutation in the non-neural G-protein α-subunit isoforms modulates susceptibility to obesity

International Journal of Obesity

Volumn 33, Issue 5, 2009, Pages 507-518

  Kelly, M L ^a   Moir, L ^a   Jones, L ^a   Whitehill, E ^a   Anstee, Q M ^b   Goldin, R D ^b   Hough, A ^a   Cheeseman, M ^a,c   Jansson, J O ^d   Peters, J ^a   Cox, R D ^a,e  

^a Diabetes Group   (United Kingdom)

^b ST MARY S HOSPITAL   (United Kingdom)

^c Medical Research Council Harwell Institute   (United Kingdom)

^d SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^e MRC MAMMALIAN GENETICS UNIT   (United Kingdom)

Author keywords

camp; Genetics; Gnas; Metabolism; Mouse

Indexed keywords

FAT; GLUCOSE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALORIMETRY; DISEASE PREDISPOSITION; DUAL ENERGY X RAY ABSORPTIOMETRY; EXON; EXTRACHROMOSOMAL INHERITANCE; FEMALE; FOOD INTAKE; GENETIC CORRELATION; GLUCOSE TOLERANCE TEST; HERITABILITY; LEAN BODY WEIGHT; LIPID DIET; LIVER HISTOLOGY; MALE; METABOLIC RATE; MISSENSE MUTATION; MOUSE; MOUSE STRAIN; NONHUMAN; OBESITY; OED SML MOUSE; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN VARIANT; SPECIES COMPARISON; WEIGHT;

ANIMALS; BIOLOGICAL MARKERS; BODY COMPOSITION; DIETARY FATS; DISEASE MODELS, ANIMAL; ENERGY METABOLISM; GTP-BINDING PROTEIN ALPHA SUBUNITS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HYPERGLYCEMIA; MALE; MICE; MUTATION, MISSENSE; OBESITY; POINT MUTATION; PROTEIN ISOFORMS;

MUS;

EID: 67349156681     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2009.30     Document Type: Article

References (21)

1. Holmes R, Williamson C, Peters J, Denny P, Wells C. A comprehensive transcript map of the mouse Gnas imprinted complex. Genome Res 2003; 13: 1410-1415.
2. Plagge A, Gordon E, Dean W, Boiani R, Cinti S, Peters J et al. The imprinted signaling protein XL alpha s is required for postnatal adaptation to feeding. Nat Genet 2004; 36: 818-826.
3. Peters J, Holmes R, Monk D, Beechey CV, Moore GE, Williamson CM. Imprinting control within the compact Gnas locus. Cytogenet Genome Res 2006; 113: 194-201.
4. Weinstein LS, Yu S, Warner DR, Liu J. Endocrine manifestations of stimulatory G protein. Endocr Rev 2001; 22: 675-705.
5. Peters J, Wroe SF, Wells CA, Miller HJ, Bodle D, Beechey CV et al. A cluster of oppositely imprinted transcripts at the Gnas locus in the distal imprinting region of mouse chromosome 2. Proc Natl Acad Sci USA 1999; 96: 3830-3835.
6. Pasolli HA, Klemke M, Kehlenbach RH, Wang Y, Huttner WB. Characterization of the extra-large G protein alpha -subunit xlalpha s. I. Tissue distribution and subcellular localization. J Biol Chem 2000; 275: 33622-33632.
7. Klemke M, Pasolli HA, Kehlenbach RH, Offermanns S, Schultz G, Huttner WB. Characterization of the extra-large G protein alphasubunit XLalpha s. II. Signal transduction properties. J Biol Chem 2000; 275: 33633-33640.
8. Chen M, Gavrilova O, Liu J, Xie T, Deng C, Nguyen AT et al. Alternative Gnas gene products have opposite effects on glucose and lipid metabolism. Proc Natl Acad Sci USA 2005; 102: 7386-7391.
9. Xie T, Plagge A, Gavrilova O, Pack S, Jou W, Lai EW et al. The alternative stimulatory G protein alpha-subunit XLalphas is a critical regulator of energy and glucose metabolism and sympathetic nerve activity in adult mice. J Biol Chem 2006; 281: 18989-18999.
10. Klemke M, Kehlenbach RH, Huttner WB. Two overlapping reading frames in a single exon encode interacting proteins - a novel way of gene usage. EMBO J 2001; 20: 3849-3860.
11. Yu S, Castle A, Chen M, Lee R, Takeda K, Weinstein LS. Increased insulin sensitivity in Gsalpha knockout mice. J Biol Chem 2001; 276: 19994-19998.
12. Yu S, Gavrilova O, Chen H, Lee R, Liu J, Pacak K et al. Paternal versus maternal transmission of a stimulatory G-protein {alpha} subunit knockout produces opposite effects on energy metabolism. J Clin Invest 2000; 105: 615-623.
13. Yu S, Yu D, Lee E, Eckhaus M, Lee R, Corria Z et al. Variable and tissue-specific hormone resistance in heterotrimeric Gs protein alpha-subunit (Gsalpha) knockout mice is due to tissue-specific imprinting of the Gsalpha gene. Proc Natl Acad Sci USA 1998; 95: 8715-8720.
14. Cattanach BM, Peters J, Ball S, Rasberry C. Two imprinted gene mutations: three phenotypes. Hum Mol Genet 2000; 9: 2263-2273.
15. Skinner JA, Cattanach BM, Peters J. The imprinted oedematoussmall mutation on mouse chromosome 2 identifies new roles for Gnas and Gnasxl in development. Genomics 2002; 80: 373-375.
16. Williamson CM, Ball ST, Nottingham WT, Skinner JA, Plagge A, Turner MD et al. A cis-acting control region is required exclusively for the tissue-specific imprinting of Gnas. Nat Genet 2004; 36: 894-899.
17. Schmidt-Nielsen K. Energy metabolism, metabolic rate and body size. Animal Physiology 1990. 4th edn. Cambridge University Press: Cambridge, UK, pp 192-201.
18. Chen M, Gavrilova O, Liu J, Xie T, Deng C, Nguyen AT et al. Alternative Gnas gene products have opposite effects on glucose and lipid metabolism. Proc Natl Acad Sci USA 2005; 102: 7386-7391.
19. Chen M, Gavrilova O, Zhao WQ, Nguyen A, Lorenzo J, Shen L et al. Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gs alpha deficiency. J Clin Invest 2005; 115: 3217-3227.
20. Long DN, McGuire S, Levine MA, Weinstein LS, Germain-Lee EL. Body mass index differences in pseudohypoparathyroidism type1a versus pseudopseudohypoparathyroidism may implicate paternal imprinting of Galpha(s) in the development of human obesity. J Clin Endocrinol Metab 2007; 92: 1073-1079.
21. Frontera M, Dickins B, Plagge A, Kelsey G. Imprinted genes, postnatal adaptations and enduring effects on energy homeostasis. Adv Exp Med Biol 2008; 626: 41-61.