Comprehensive evidence-based assessment and prioritization of potential antidiabetic medicinal plants: A case study from Canadian eastern James Bay Cree traditional medicine

Evidence-based Complementary and Alternative Medicine

Volumn 2012, Issue , 2012, Pages

  Haddad, Pierre S ^a,b   Musallam, Lina ^a,b   Martineau, Louis C ^a   Harris, Cory ^a,c   Lavoie, Louis ^a   Arnason, John T ^a,d   Foster, Brian ^a,d   Bennett, Steffany ^a,d   Johns, Timothy ^a,c   Cuerrier, Alain ^a,b   Coon Come, Emma ^e   Coon Come, Rene ^e   Diamond, Josephine ^f   Etapp, Louise ^e   Etapp, Charlie ^e   George, Jimmy ^g   Husky Swallow, Charlotte ^e   Husky Swallow, Johnny ^e   Jolly, Mary ^h   Kawapit, Andrew ^g   Mamianskum, Eliza ^g   Petagumskum, John ^g   Petawabano, Smalley ^e   Petawabano, Laurie ^e   Weistche, Alex ^f   Badawi, Alaa ⁱ   more..

^a CANADIAN INSTITUTES OF HEALTH RESEARCH   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d UNIVERSITY OF OTTAWA   (Canada)

^e Cree Nation of Mistissini   (Canada)

^f Crees of Waskaganish First Nation   (Canada)

^g Whapmagoostui First Nation   (Canada)

^h Cree Nation of Nemaska   (Canada)

ⁱ PUBLIC HEALTH AGENCY OF CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA GLUCOSIDASE INHIBITOR; ANTIDIABETIC AGENT; ANTIHYPERTENSIVE AGENT; BIGUANIDE DERIVATIVE; CYTOCHROME P450; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EXENDIN 4; GLITAZONE DERIVATIVE; GLUCOSE; HERBACEOUS AGENT; INCRETIN; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; ORAL ANTIDIABETIC AGENT; PHENFORMIN; PLANT EXTRACT; ROSIGLITAZONE; SULFONYLUREA DERIVATIVE;

ABORIGINE; ADIPOGENESIS; ANTIDIABETIC ACTIVITY; ANTIGLYCATION ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; BLOOD PRESSURE REGULATION; CANADA; CARDIOVASCULAR DISEASE; DIABETES MELLITUS; DIABETIC NEUROPATHY; DIARRHEA; DRUG ACTIVITY; DRUG HYPERSENSITIVITY; DRUG MECHANISM; DRUG SAFETY; DRUG SCREENING; ENZYME INHIBITION; EVIDENCE BASED MEDICINE; EXPERIMENTAL MODEL; FLATULENCE; GLUCOSE ABSORPTION; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HUMAN; HYPERTENSION; HYPOGLYCEMIA; INSULIN RELEASE; INTESTINE ABSORPTION; LIFESTYLE MODIFICATION; LIPID DIET; LIVER METABOLISM; LIVER TOXICITY; LOW DRUG DOSE; MEDICINAL PLANT; NAUSEA; NEUROPROTECTION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; REVIEW; SIDE EFFECT; THROMBOSIS; TRADITIONAL MEDICINE; UNSPECIFIED SIDE EFFECT; WATER RETENTION; WEIGHT GAIN;

EID: 84855614331     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2012/893426     Document Type: Review

References (120)

1. Diabetes Atlas 2003 Brussels, Belgium International Diabetes Federation
2. Definition, diagnosis and classification of diabetes mellitus and its complications. Report of a WHO Consultation. Part 1: diagnosis and classification of diabetes mellitus 1999 number WHO/NCD/NCS/99.2 Geneva, Switzerland World Health Organization
3. Prevention of diabetes mellitus WHO Technical Report Series 1994 number 844 Geneva, Switzerland World Health Organization
4. Gavin J. R., Alberti K. G. M. M., Davidson M. B., DeFronzo R. A., Drash A., Gabbe S. G., Genuth S., Harris M. I., Kahn R., Keen H., Knowler W. C., Lebovitz H., Maclaren N. K., Palmer J. P., Raskin P., Rizza R. A., Stern M. P., Report of the expert committee on the diagnosis and classification of diabetes mellitus Diabetes Care 2003 26 1 S5 S20
5. Alberti K. G., Zimmet P. Z., Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation Diabetic Medicine 1998 15 7 539 553 (Pubitemid 28319935)
6. DeFronzo R. A., Ferrannini E., Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease Diabetes Care 1991 14 3 173 194
7. Gezairy H., Guidelines for the Prevention, Management and Care of Diabetes Mellitus 2006 32 Geneva, Switzerland WHO Regional Office for the Eastern Mediterranean
8. C. D. A. C. P. G. E. Committee, Canadian diabetes association 2008 clinical practice guidelines for the prevention and management of diabetes in Canada The Canadian Journal of Diabetes 2008 32 supplement 1 S1 S201
9. Weir G. C., Laybutt D. R., Kaneto H., Bonner-Weir S., Sharma A., -cell adaptation and decompensation during the progression of diabetes Diabetes 2001 50 1 S154 S159
10. Saltiel A. R., Kahn C. R., Insulin signalling and the regulation of glucose and lipid metabolism Nature 2001 414 6865 799 806 (Pubitemid 34000783)
11. Hirabara S. M., Curi R., Maechler P., Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells Journal of Cellular Physiology 2010 222 1 187 194
12. Savage D. B., Petersen K. F., Shulman G. I., Disordered lipid metabolism and the pathogenesis of insulin resistance Physiological Reviews 2007 87 2 507 520 (Pubitemid 47084679)
13. Unger R. H., Lipid overload and overflow: metabolic trauma and the metabolic syndrome Trends in Endocrinology and Metabolism 2003 14 9 398 403 (Pubitemid 37392211)
14. Unger R. H., Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome Endocrinology 2003 144 12 5159 5165 (Pubitemid 37476041)
15. Rabuazzo A. M., Piro S., Anello M., Patan G., Purrello F., Glucotoxicity and lipotoxicity in the beta cell International Congress Series 2003 1253 115 121
16. Ceriello A., Oxidative stress and diabetes-associated complications Endocrine Practice 2006 12 1 60 62 (Pubitemid 44963614)
17. Pickup J. C., Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes Diabetes Care 2004 27 3 813 823 (Pubitemid 38280558)
18. Sonnett T. E., Levien T. L., Gates B. J., Robinson J. D., Campbell R. K., Diabetes mellitus, inflammation, obesity: proposed treatment pathways for current and future therapies Annals of Pharmacotherapy 2010 44 4 701 711
19. Krishnan S. T. M., Quattrini C., Jeziorska M., Malik R. A., Rayman G., Neurovascular factors in wound healing in the foot skin of type 2 diabetic subjects Diabetes Care 2007 30 12 3058 3062 (Pubitemid 350255246)
20. Brem H., Tomic-Canic M., Cellular and molecular basis of wound healing in diabetes Journal of Clinical Investigation 2007 117 5 1219 1222 (Pubitemid 46718408)
21. Alberti K. G. M. M., Zimmet P., Shaw J., Metabolic syndromea new world-wide definition. A consensus statement from the International Diabetes Federation Diabetic Medicine 2006 23 5 469 480
22. Alexander C. M., Landsman P. B., Teutsch S. M., Haffner S. M., NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older Diabetes 2003 52 5 1210 1214 (Pubitemid 36523358)
23. Carr D. B., Utzschneider K. M., Hull R. L., Kodama K., Retzlaff B. M., Brunzell J. D., Shofer J. B., Fish B. E., Knopp R. H., Kahn S. E., Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome Diabetes 2004 53 8 2087 2094 (Pubitemid 38970759)
24. Grundy S. M., Cleeman J. I., Daniels S. R., Donato K. A., Eckel R. H., Franklin B. A., Gordon D. J., Krauss R. M., Savage P. J., Smith S. C. Jr., Spertus J. A., Costa F., Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statement Circulation 2005 112 17 2735 2752 (Pubitemid 41532612)
25. Ahima R. S., Connecting obesity, aging and diabetes Nature Medicine 2009 15 9 996 997
26. Devlin J. T., Effects of exercise on insulin sensitivity in humans Diabetes Care 1992 15 11 1690 1693
27. Dishman R. K., Exercise Adherence: Its Impact on Public Health 1988 xiii Champaign, Ill, USA Human Kinetics
28. Henry R. R., Scheaffer L., Olefsky J. M., Glycemic effects of intensive caloric restriction and isocaloric refeeding in noninsulin-dependent diabetes mellitus Journal of Clinical Endocrinology and Metabolism 1985 61 5 917 925 (Pubitemid 16218491)
29. Bhattacharyya O. K., Estey E. A., Cheng A. Y. Y., Update on the Canadian Diabetes Association 2008 clinical practice guidelines The Canadian Family Physician 2009 55 1 39 43
30. Loubatires A., The discovery of hypoglycemic sulfonamides and particularly of their action mechanism Acta Diabetologica Latina 1969 6 20 56
31. Ashcroft F. M., Mechanisms of the clycaemic effects of sulfonylureas Hormone and Metabolic Research 1996 28 9 456 463 (Pubitemid 26343738)
32. Bryan J., Crane A., Vila-Carriles W. H., Babenko A. P., Aguilar-Bryan L., Insulin secretagogues, sulfonylurea receptors and KATP channels Current Pharmaceutical Design 2005 11 21 2699 2716 (Pubitemid 41051879)
33. Riddle M. C., Glycemic management of type 2 diabetes: an emerging strategy with oral agents, insulins, and combinations Endocrinology and Metabolism Clinics of North America 2005 34 1 77 98 (Pubitemid 40332504)
34. Bailey C. J., Day C., Metformin: its botanical background Practical Diabetes International 2004 21 3 115 117 (Pubitemid 38559421)
35. Witters L. A., The blooming of the French lilac Journal of Clinical Investigation 2001 108 8 1105 1107 (Pubitemid 32995367)
36. Nathan D. M., Buse J. B., Davidson M. B., Ferrannini E., Holman R. R., Sherwin R., Zinman B., Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes Clinical Diabetes 2009 32 193 203
37. Salpeter S., Greyber E., Pasternak G., Salpeter E., Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus Cochrane Database of Systematic Reviews 2006 1 CD002967
38. Bailey C. J., Turner R. C., Metformin The New England Journal of Medicine 1996 334 9 574 579 (Pubitemid 126537875)
39. Glueck C. J., Fontaine R. N., Wang P., Subbiah M. T. R., Weber K., Illig E., Streicher P., Sieve-Smith L., Tracy T. M., Lang J. E., McCullough P., Metformin reduces weight, centripetal obesity, insulin, leptin, and low-density lipoprotein cholesterol in nondiabetic, morbidly obese subjects with body mass index greater than 30 Metabolism 2001 50 7 856 861 (Pubitemid 32700469)
40. Henry R. R., Thiazolidinediones Endocrinology and Metabolism Clinics of North America 1997 26 3 553 573 (Pubitemid 27410891)
41. Lee C. H., Olson P., Evans R. M., Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors Endocrinology 2003 144 6 2201 2207 (Pubitemid 36629867)
42. Loviscach M., Rehman N., Carter L., Mudaliar S., Mohadeen P., Ciaraldi T. P., Veerkamp J. H., Henry R. R., Distribution of peroxisome proliferator-activated receptors (PPARs) in human skeletal muscle and adipose tissue: relation to insulin action Diabetologia 2000 43 3 304 311 (Pubitemid 30163473)
43. Gale S. M., Castracane V. D., Mantzoros C. S., Energy homeostasis, obesity and eating disorders: recent advances in endocrinology Journal of Nutrition 2004 134 2 295 298 (Pubitemid 38141808)
44. Hauner H., The mode of action of thiazolidinediones Diabetes/Metabolism Research and Reviews 2002 18 2 S10 S15
45. Purnell J. Q., Weyer C., Weight effect of current and experimental drugs for diabetes mellitus: from promotion to alleviation of obesity Treatments in Endocrinology 2003 2 1 33 47 (Pubitemid 37051601)
46. Bischoff H., Pharmacology of alpha-glucosidase inhibition European Journal of Clinical Investigation 1994 24 supplement 3 3 10
47. Hanefeld M., The role of acarbose in the treatment of non-insulin-dependent diabetes mellitus Journal of Diabetes and its Complications 1998 12 4 228 237 (Pubitemid 28284754)
48. Harrigan R. A., Nathan M. S., Beattie P., Oral agents for the treatment of type 2 diabetes mellitus: pharmacology, toxicity, and treatment Annals of Emergency Medicine 2001 38 1 68 78 (Pubitemid 32606034)
49. Burcelin R., Serino M., Cabou C., A role for the gut-to-brain GLP-1 dependent axis in the control of metabolism Current Opinion in Pharmacology 2009 9 6 744 752
50. Hansotia T., Drucker D. J., GIP and GLP-1 as incretin hormones: Lessons from single and double incretin receptor knockout mice Regulatory Peptides 2005 128 2 125 134 (Pubitemid 40380913)
51. Verspohl E. J., Novel therapeutics for type 2 diabetes: incretin hormone mimetics (glucagon-like peptide-1 receptor agonists) and dipeptidyl peptidase-4 inhibitors Pharmacology and Therapeutics 2009 124 1 113 138
52. Ekoe J. M., Thouez J. P., Petitclerc C., Foggin P. M., Ghadirian P., Epidemiology of obesity in relationship to some chronic medical conditions among Inuit and Cree Indian populations in New Quebec, Canada Diabetes Research and Clinical Practice 1990 10 supplement 1 S17 S27
53. Garriguet D., Obesity and the eating habits of the Aboriginal population Health Reports 2008 19 1 21 35
54. Kuzmina E. L., Dannenbaum D., Torrie J., Cree Diabetes Information System (CDIS): 2009 Annual Update 2010 Chisasibi, Québec, Canada Cree Board of Health and Social Services of James Bay Public Health Report Series 3 on Diabetes. http://www.creehealth.org/clinical-protocols/cree-diabetes- information-system-cdis-2009-annual-report
55. Thouez J. P., Ekoe J. M., Foggin P. M., Verdy M., Nadeau M., Laroche P., Rannou A., Ghadirian P., Obesity, hypertension, hyperuricemia and diabetes mellitus among the Cree and Inuit of northern Québec Arctic Medical Research 1990 49 4 180 188
56. Hanley A. J., Harris S. B., Mamakeesick M., Goodwin K., Fiddler E., Hegele R. A., McLaughlin J. R., Zinman B., Complications of type 2 siabetes among aboriginal canadians: increasing the understanding of prevalence and risk factors The Canadian Journal of Diabetes 2003 27 4 455 463 (Pubitemid 38101354)
57. Hanley A. J. G., Harris S. B., Mamakeesick M., Goodwin K., Fiddler E., Hegele R. A., Spence J. D., House A. A., Brown E., Schoales B., Mclaughlin J. R., Klein R., Zinman B., Complications of type 2 diabetes among aboriginal Canadians: prevalence and associated risk factors Diabetes Care 2005 28 8 2054 2057 (Pubitemid 41060990)
58. Efrat S., Fusco-DeMane D., Lemberg H., Emran O. A., Wang X., Conditional transformation of a pancreatic -cell line derived from transgenic mice expressing a tetracycline-regulated oncogene Proceedings of the National Academy of Sciences of the United States of America 1995 92 8 3576 3580
59. Benhaddou-Andaloussi A., Martineau L. C., Vallerand D., Haddad Y., Afshar A., Settaf A., Haddad P. S., Multiple molecular targets underlie the antidiabetic effect of Nigella sativa seed extract in skeletal muscle, adipocyte and liver cells Diabetes, Obesity and Metabolism 2010 12 2 148 157
60. Martineau L. C., Couture A., Spoor D., Benhaddou-Andaloussi A., Harris C., Meddah B., Leduc C., Burt A., Vuong T., Mai Le P., Prentki M., Bennett S. A., Arnason J. T., Haddad P. S., Anti-diabetic properties of the Canadian lowbush blueberry Vaccinium angustifolium Ait Phytomedicine 2006 13 9-10 612 623 (Pubitemid 44773715)
61. Benhaddou-Andaloussi A., Martineau L. C., Spoor D., Vuong T., Leduc C., Joly E., Burt A., Meddah B., Settaf A., Arnason J. T., Prentki M., Haddad P. S., Antidiabetic activity of Nigella sativa seed extract in cultured pancreatic -cells, skeletal muscle cells, and adipocytes Pharmaceutical Biology 2008 46 1-2 96 104 (Pubitemid 351196226)
62. Wallberg-Henriksson H., Zierath J. R., GLUT4: a key player regulating glucose homeostasis? Insights from transgenic and knockout mice (review) Molecular Membrane Biology 2001 18 3 205 211 (Pubitemid 32971217)
63. Kurth-Kraczek E. J., Hirshman M. F., Goodyear L. J., Winder W. W., 5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle Diabetes 1999 48 8 1667 1671 (Pubitemid 29356879)
64. Berti L., Gammeltoft S., Leptin stimulates glucose uptake in C2C12 muscle cells by activation of ERK2 Molecular and Cellular Endocrinology 1999 157 1-2 121 130 (Pubitemid 29505133)
65. Calderhead D. M., Kitagawa K., Tanner L. I., Holman G. D., Lienhard G. E., Insulin regulation of the two glucose transporters in 3T3-L1 adipocytes Journal of Biological Chemistry 1990 265 23 13800 13808
66. Galante P., Mosthaf L., Kellerer M., Berti L., Tippmer S., Bossenmaier B., Fujiwara T., Okuno A., Horikoshi H., Haring H. U., Acute hyperglycemia provides an insulin-independent inducer for GLUT4 translocation in C2C12 myotubes and rat skeletal muscle Diabetes 1995 44 6 646 651
67. Sarabia V., Ramlal T., Klip A., Glucose uptake in human and animal muscle cells in culture Biochemistry and Cell Biology 1990 68 2 536 542 (Pubitemid 20251774)
68. Rosen O. M., Smith C. J., Fung C., Rubin C. S., Development of hormone receptors and hormone responsiveness in vitro. Effect of prolonged insulin treatment on hexose uptake in 3T3-L1 adipocytes Journal of Biological Chemistry 1978 253 20 7579 7583 (Pubitemid 9045252)
69. Harmon A. W., Harp J. B., Differential effects of flavonoids on 3T3-L1 adipogenesis and lipolysis The American Journal of PhysiologyCell Physiology 2001 280 4 C807 C813
70. Ljung B., Bamberg K., Dahllof B., Kjellstedt A., Oakes N. D., stling J., Svensson L., Camejo G., AZ 242, a novel PPAR / agonist with beneficial effects on insulin resistance and carbohydrate and lipid metabolism in ob/ob mice and obese zucker rats Journal of Lipid Research 2002 43 11 1855 1863 (Pubitemid 35315803)
71. Norisada N., Masuzaki H., Fujimoto M., Inoue G., Hosoda K., Hayashi T., Watanabe M., Muraoka S., Yoneda F., Nakao K., Antidiabetic and adipogenic properties in a newly synthesized thiazolidine derivative, FPFS-410 Metabolism 2004 53 12 1532 1537 (Pubitemid 39556365)
72. Tontonoz P., Hu E., Spiegelman B. M., Regulation of adipocyte gene expression and differentiation by peroxisome proliferator activated receptor Current Opinion in Genetics and Development 1995 5 5 571 576
73. Harbilas D., Martineau L. C., Harris C. S., Adeyiwola-Spoor D. C. A., Saleem A., Lambert J., Caves D., Johns T., Prentki M., Cuerrier A., Arnason J. T., Bennett S. A. L., Haddad P. S., Evaluation of the antidiabetic potential of selected medicinal plant extracts from the Canadian boreal forest used to treat symptoms of diabetes: part II Canadian Journal of Physiology and Pharmacology 2009 87 6 479 492
74. Martineau L. C., Herve J., Muhamad A., Saleem A., Harris C. S., Arnason J. T., Haddad P. S., Anti-adipogenic activities of Alnus incana and Populus balsamifera bark extracts, part I: sites and mechanisms of action Planta Medica 2010 76 13 1439 1446
75. Martineau L. C., Muhammad A., Saleem A., Hervé J., Harris C. S., Arnason J. T., Haddad P. S., Anti-adipogenic activities of Alnus incana and Populus balsamifera bark extracts, part II: bioassay-guided identification of actives salicortin and oregonin Planta Medica 2010 76 14 1519 1524
76. Postic C., Dentin R., Girard J., Role of the liver in the control of carbohydrate and lipid homeostasis Diabetes and Metabolism 2004 30 5 398 408 (Pubitemid 39648006)
77. Wu C., Okar D. A., Kang J., Lange A. J., Reduction of hepatic glucose production as a therapeutic target in the treatment of diabetes Current Drug Targets: Immune, Endocrine and Metabolic Disorders 2005 5 1 51 59 (Pubitemid 40394303)
78. Klover P. J., Mooney R. A., Hepatocytes: critical for glucose homeostasis International Journal of Biochemistry and Cell Biology 2004 36 5 753 758 (Pubitemid 38299389)
79. Magnusson I., Rothman D. L., Katz L. D., Shulman R. G., Shulman G. I., Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study Journal of Clinical Investigation 1992 90 4 1323 1327
80. Wajngot A., Chandramouli V., Schumann W. C., Ekberg K., Jones P. K., Efendic S., Landau B. R., Quantitative contribution of gluconeogenesis to glucose production during fasting in type 2 diabetes mellitus Metabolism 2001 50 1 47 52 (Pubitemid 32058548)
81. Lawrence J. C., Roach P. J., New insights into the role and mechanism of glycogen synthase activation by insulin Diabetes 1997 46 4 541 547 (Pubitemid 27143368)
82. Thomas J. A., Schlender K. K., Larner J., A rapid filter paper assay for UDPglucose-glycogen glucosyltransferase, including an improved biosynthesis of UDP-14C-glucose Analytical Biochemistry 1968 25 C 486 499
83. Vedavanam K., Srijayanta S., O'Reilly J., Raman A., Wiseman H., Antioxidant action and potential antidiabetic properties of an isoflavonoid-containing soyabean phytochemical extract (SPE) Phytotherapy Research 1999 13 7 601 608 (Pubitemid 29520939)
84. Shimizu M., Kobayashi Y., Suzuki M., Satsu H., Miyamoto Y., Regulation of intestinal glucose transport by tea catechins BioFactors 2000 13 14 61 65 (Pubitemid 32107346)
85. Johnston K., Sharp P., Clifford M., Morgan L., Dietary polyphenols decrease glucose uptake by human intestinal Caco-2 cells FEBS Letters 2005 579 7 1653 1657 (Pubitemid 40341538)
86. Arakawa K., Ishihara T., Oku A., Nawano M., Ueta K., Kitamura K., Matsumoto M., Saito A., Improved diabetic syndrome in C57BL/KsJ-db/db mice by oral administration of the Na(+)-glucose cotransporter inhibitor T-1095 The British Journal of Pharmacology 2001 132 2 578 586 (Pubitemid 32142370)
87. Wagman A. S., Nuss J. M., Current therapies and emerging targets for the treatment of diabetes Current Pharmaceutical Design 2001 7 6 417 450 (Pubitemid 32409729)
88. Asano T., Ogihara T., Katagiri H., Sakoda H., Ono H., Fujishiro M., Anai M., Kurihara H., Uchijima Y., Glucose transporter and Na+/glucose cotransporter as molecular targets of anti-diabetic drugs Current Medicinal Chemistry 2004 11 20 2717 2724 (Pubitemid 39255559)
89. Ueta K., Ishihara T., Matsumoto Y., Oku A., Nawano M., Fujita T., Saito A., Arakawa K., Long-term treatment with the Na+-glucose cotransporter inhibitor T-1095 causes sustained improvement in hyperglycemia and prevents diabetic neuropathy in Goto-Kakizaki Rats Life Sciences 2005 76 23 2655 2668 (Pubitemid 40404055)
90. Katzung B. M., Trevor S. B., Drug biotransformation Basic and Clinical Pharmacology 2009 chapter 1.4 New York, NY, USA The McGraw-Hill
91. Tam T. W., Liu R., Arnason J. T., Krantis A., Staines W. A., Haddad P. S., Foster B. C., Actions of ethnobotanically selected Cree anti-diabetic plants on human cytochrome P450 isoforms and flavin-containing monooxygenase 3 Journal of Ethnopharmacology 2009 126 1 119 126
92. Lubna P., Hsiao-Pai C., Jun S., Ilir T., Nanette S., George K., In vitro evidence of glucose-induced toxicity in GnRH secreting neurons: high glucose concentrations influence GnRH secretion, impair cell viability, and induce apoptosis in the GT1-1 neuronal cell line Fertility and Sterility 2007 88 4 1143 1149
93. Russell J. W., Sullivan K. A., Windebank A. J., Herrmann D. N., Feldman E. L., Neurons undergo apoptosis in animal and cell culture models of diabetes Neurobiology of Disease 1999 6 5 347 363 (Pubitemid 29496214)
94. Harris C. S., Lambert J., Saleem A., Coonishish J., Martineau L. C., Cuerrier A., Haddad P. S., Arnason J. T., Bennett S. A. L., Antidiabetic activity of extracts from needle, bark, and cone of Picea glauca: organ-specific protection from glucose toxicity and glucose deprivation Pharmaceutical Biology 2008 46 1-2 126 134 (Pubitemid 351196230)
95. Spoor D. C., Martineau L. C., Leduc C., Benhaddou-Andaloussi A., Meddah B., Harris C., Burt A., Fraser M. H., Coonishish J., Joly E., Cuerrier A., Bennett S. A. L., Johns T., Prentki M., Arnason J. T., Haddad P. S., Selected plant species from the Cree pharmacopoeia of northern Quebec possess anti-diabetic potential The Canadian Journal of Physiology and Pharmacology 2006 84 8-9 847 858 (Pubitemid 46132209)
96. Baynes J. W., Role of oxidative stress in development of complications in diabetes Diabetes 1991 40 4 405 412
97. Sudha G., Ravishankar G. A., Involvement and interaction of various signaling compounds on the plant metabolic events during defense response, resistance to stress factors, formation of secondary metabolites and their molecular aspects Plant Cell, Tissue and Organ Culture 2002 71 3 181 212 (Pubitemid 35249969)
98. Wu X., Beecher G. R., Holden J. M., Haytowitz D. B., Gebhardt S. E., Prior R. L., Lipophilic and hydrophilic antioxidant capacities of common foods in the United States Journal of Agricultural and Food Chemistry 2004 52 12 4026 4037
99. Wang H., Cao G., Prior R. L., Total antioxidant capacity of fruits Journal of Agricultural and Food Chemistry 1996 44 3 701 705 (Pubitemid 126468422)
100. Ou B., Huang D., Hampsch-Woodill M., Flanagan J. A., Deemer E. K., Analysis of antioxidant activities of common vegetables employing oxygen radical absorbance capacity (ORAC) and ferric reducing antioxidant power (FRAP) assays: a comparative study Journal of Agricultural and Food Chemistry 2002 50 11 3122 3128 (Pubitemid 34533610)
101. Bondet V., Brand-Williams W., Berset C., Kinetics and mechanisms of antioxidant activity using the DPPH free radical method Lebensmittel- Wissenschaft und-Technologie 1997 30 6 609 615 (Pubitemid 127163582)
102. T. I. E. Committee, Utility of the TBARS assay in detecting oxidative stress in white sucker (Catostomus commersoni) populations exposed to pulp mill effluent Aquatic Toxicology 2003 63 4 447 463
103. Nathan D. M., International expert committee report on the role of the A1C assay in the diagnosis of diabetes Diabetes Care 2009 32 7 1327 1334
104. Harris C. S., Beaulieu L. P., Fraser M. H., Inhibition of advanced glycation end product formation by medicinal plant extracts correlates with phenolic metabolites and antioxidant activity Planta Medica 2010 77 2 196 204
105. Schreyer S. A., Chua S. C., Leboeuf R. C., Obesity and diabetes in TNF- receptor-deficient mice Journal of Clinical Investigation 1998 102 2 402 411 (Pubitemid 28335200)
106. Ma J., Chen T., Mandelin J., Ceponis A., Miller N. E., Hukkanen M., Ma G. F., Konttinen Y. T., Regulation of macrophage activation Cellular and Molecular Life Sciences 2003 60 11 2334 2346 (Pubitemid 37487255)
107. Haddad Y., Vallerand D., Brault A., Haddad P. S., Antioxidant and hepatoprotective effects of silibinin in a rat model of nonalcoholic steatohepatitis Evidence-Based Complementary and Alternative Medicine 2011 2011 10
108. Vianna R., Brault A., Martineau L. C., Couture R., Arnason J. T., Haddad P. S., In vivo anti-diabetic activity of the ethanolic crude extract of sorbus decora C.K.Schneid. (Rosacea): a medicinal plant used by canadian James Bay Cree Nations to treat symptoms related to diabetes Evidence-Based Complementary and Alternative Medicine 2011 2011 7
109. Schreyer S. A., Wilson D. L., Leboeuf R. C., C57BL/6 mice fed high fat diets as models for diabetes-accelerated atherosclerosis Atherosclerosis 1998 136 1 17 24 (Pubitemid 28341437)
110. Winzell M. S., Ahren B., The high-fat diet-fed mouse: a model for studying mechanisms and treatment of impaired glucose tolerance and type 2 diabetes Diabetes 2004 53 3 S215 S219
111. Parekh P. I., Petro A. E., Tiller J. M., Feinglos M. N., Surwit R. S., Reversal of diet-induced obesity and diabetes in C57BL/6J mice Metabolism 1998 47 9 1089 1096 (Pubitemid 28428014)
112. Surwit R. S., Wang S., Petro A. E., Sanchis D., Raimbault S., Ricquier D., Collins S., Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice Proceedings of the National Academy of Sciences of the United States of America 1998 95 7 4061 4065 (Pubitemid 28173254)
113. Collins S., Daniel K. W., Petro A. E., Surwit R. S., Strain-specific response to 3-adrenergic receptor agonist treatment of diet-induced obesity in mice Endocrinology 1997 138 1 405 413 (Pubitemid 27009450)
114. Reuter T. Y., Diet-induced models for obesity and type 2 diabetes Drug Discovery Today: Disease Models 2007 4 1 3 8 (Pubitemid 350286528)
115. Ahren B., Holst J. J., Martensson H., Balkan B., Improved glucose tolerance and insulin secretion by inhibition of dipeptidyl peptidase IV in mice European Journal of Pharmacology 2000 404 1-2 239 245
116. Hildebrandt A. L., Kelly-Sullivan D. M., Black S. C., Antiobesity effects of chronic cannabinoid CB1 receptor antagonist treatment in diet-induced obese mice European Journal of Pharmacology 2003 462 13 125 132 (Pubitemid 36183743)
117. Leduc C., Coonishish J., Haddad P., Cuerrier A., Plants used by the Cree Nation of Eeyou Istchee (Quebec, Canada) for the treatment of diabetes: a novel approach in quantitative ethnobotany Journal of Ethnopharmacology 2006 105 1-2 55 63
118. de Sousa Arajo T. A., Alencar N. L., de Amorim E. L. C., de Albuquerque U. P., A new approach to study medicinal plants with tannins and flavonoids contents from the local knowledge Journal of Ethnopharmacology 2008 120 1 72 80
119. Fraser M. H., Cuerrier A., Haddad P. S., Arnason J. T., Owen P. L., Johns T., Medicinal plants of Cree communities (Quebec, Canada): antioxidant activity of plants used to treat type 2 diabetes symptoms The Canadian Journal of Physiology and Pharmacology 2007 85 11 1200 1214 (Pubitemid 351196418)
120. Nistor Baldea L. A., Martineau L. C., Benhaddou-Andaloussi A., Arnason J. T., Levy E., Haddad P. S., Inhibition of intestinal glucose absorption by anti-diabetic medicinal plants derived from the James Bay Cree traditional pharmacopeia Journal of Ethnopharmacology 2010 132 2 473 482