GLUT4: A key player regulating glucose homeostasis? Insights from transgenic and knockout mice (Review)

Molecular Membrane Biology

Volumn 18, Issue 3, 2001, Pages 205-211

  Wallberg Henriksson, H ^a   Zierath, J R ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Exercise; Insulin; Non insulin dependent diabetes mellitus; Skeletal muscle

Indexed keywords

CARRIER PROTEIN; GLUCOSE TRANSPORTER; GLUCOSE TRANSPORTER 4; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; GLUCOSE HOMEOSTASIS; GLUCOSE TRANSPORT; HYPERGLYCEMIA; INSULIN TOLERANCE TEST; KNOCKOUT MOUSE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SKELETAL MUSCLE; TRANSGENIC MOUSE;

ANIMALS; DIABETES MELLITUS; DISEASE MODELS, ANIMAL; GENETIC COMPLEMENTATION TEST; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; HOMEOSTASIS; INSULIN RESISTANCE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MONOSACCHARIDE TRANSPORT PROTEINS; MUSCLE PROTEINS; PHYSICAL CONDITIONING, ANIMAL;

ANIMALIA; MUS MUSCULUS;

EID: 0034797496     PISSN: 09687688     EISSN: None     Source Type: Journal    
DOI: 10.1080/09687680110072131     Document Type: Review

References (60)

1. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
2. Decreased insulin-stimulated 3-O-methylglucose transport in in vitro incubated muscle strips from type II diabetic subjects
3. Exercise in transgenic mice overexpressing GLUT4 glucose transporters: Effects on substrate metabolism and glycogen regulation
4. Identification of a novel gene encoding an insulin-responsive glucose transporter protein
5. Cloning and characterization of a cDNA encoding the rat brain glucose-transporter protein
6. GLUT4 overexpression in db/db mice dose-dependently ameliorates diabetes but is not a lifelong cure
7. Regulation of cell surface GLUT4 in skeletal muscle of transgenic mice
8. Glucose transport and GLUT4 protein distribution in skeletal muscle of GLUT4 transgenic mice
9. Stimulation of glucose transport in skeletal muscle by hypoxia
10. A glucose transport protein expressed predominately in insulin-sensitive tissues
11. Exercise-induced changes in expression and activity of proteins involved in insulin signal transduction in skeletal muscle: Differential effects on insulin receptor substrates 1 and 2
12. Expression of human GLUT4 in mice results in increased insulin action
13. The triumvirate: β-cell, muscle or liver. A collusion responsible for NIDDM
14. Effects of insulin on peripheral and splanchnic glucose metabolism in non-insulin-dependent (Type II) diabetes mellitus
15. Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes
16. GLUT8, A novel member of the sugar transport facilitator family with glucose transport activity
17. Exercise induces recruitment of the 'insulin responsive' glucose transporter. Evidence for distinct intracellular insulin- and exercise-recruitable transporter pools in skeletal muscle
18. Glycemic improvement in diabetic db/db mice by overexpression of the human insulin-regulatable glucose transporter (GLUT4)
19. A substantial part of GLUT-1 in crude membranes from muscle originates from perineurial sheaths
20. Skeletal muscle glucose transport and metabolism are enhanced in transgenic mice overexpressing the GLUT4 glucose transporter
21. Exercise-induced overexpression of key regulatory proteins involved in glucose uptake and metabolism in tetraplegic persons: Molecular mechanism for improved glucose homeostasis
22. Exercise increases muscle GLUT4-levels and insulin action in subjects with impaired glucose tolerance
23. Biochemical and immunocyto-chemical localization of the GLUT5 glucose transporter in human skeletal muscle
24. GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues
25. High fat diet-induced hyperglycemia: Prevention by low level expression of a glucose transporter (GLUT4) minigene in transgenic mice
26. Effects of overexpression of human GLUT4 gene on maternal diabetes and fetal growth in spontaneous gestational diabetic C57BLKS/J Lepr(db/+) mice
27. Molecular cloning and characterization of an insulin-regulatable glucose transporter
28. Decreased in vivo glucose uptake but normal expression of GLUT1 and GLUT4 in skeletal muscle of diabetic rats
29. Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4
30. Glucose transporter levels in spontaneously obese (db/db) insulin-resistant mice
31. Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients
32. Wortmannin inhibits insulin-stimulated but not contraction-stimulated glucose transport activity in skeletal muscle
33. Improvement of insulin action in diabetic transgenic mice selectively overexpressing GLUT4 in skeletal muscle
34. Transgenic mice expressing the human GLUT4/muscle-fat facilitative glucose transporter protein exhibit efficient glycemic control
35. Contraction stimulates translocation of glucose transporter GLUT4 in skeletal muscle through a mechanism distinct from that of insulin
36. Insulin induces the translocation of GLUT4 from a unique intracellular organelle to transverse tubules in rat skeletal muscle
37. Differential effects of GLUT1 or GLUT4 overexpression on insulin responsiveness in transgenic mice
38. Sequence and structure of a human glucose transporter
39. Overexpression of GLUT4 protein in muscle increases basal and insulin-stimulated whole body glucose disposal in conscious mice
40. Exercise induces rapid increases in GLUT4 expression, glucose transport capacity, and insulin-stimulated glycogen storage in muscle
41. Improvement in glucose tolerance after 1 wk of exercise in patients with mild NIDDM
42. Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene
43. In vitro analysis of the glucose-transport system in GLUT4-null skeletal muscle
44. Post-exercise glucose uptake and glycogen synthesis in skeletal muscle from GLUT4-deficient mice
45. Human small intestine facilitative fructose/glucose transporter (GLUT5) is also present in insulin-responsive tissues and brain. Investigation of biochemical characteristics and translocation
46. Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue
47. Diverse effects of GLUT4 ablation on glucose uptake and glycogen synthesis in red and white skeletal muscle
48. GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes
49. Enhanced peripheral glucose utilization in transgenic mice expressing the human GLUT4 gene
50. Enhanced insulin action due to targeted GLUT4 overexpression exclusively in muscle
51. Amelioration of insulin resistance but not hyperinsulinemia in obese mice overexpressing GLUT4 selectively in skeletal muscle
52. Metabolic adaptations in skeletal muscle overexpressing GLUT4: Effects on muscle and physical activity
53. Muscle-specific transgenic complementation of GLUT4-deficient mice: Effects on glucose but not lipid metabolism
54. Decreased insulin activation of glycogen synthase in skeletal muscle in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus
55. Activation of glucose transport in diabetic muscle: Responses to contraction and insulin
56. The effects of wortmannin on rat skeletal muscle
57. Effects of glycemia on glucose transport in isolated skeletal muscle from patients with NIDDM: In vitro reversal of muscular insulin resistance
58. High fat feeding impairs insulin-stimulated GLUT4 recruitment in muscle via an early insulin signaling defect
59. Restoration of hypoxia-stimulated glucose uptake in GLUT4-deficient muscles by muscle-specific GLUT4 transgenic complementation
60. Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance