Long-term treatment with the Na+-glucose cotransporter inhibitor T-1095 causes sustained improvement in hyperglycemia and prevents diabetic neuropathy in Goto-Kakizaki Rats

Life Sciences

Volumn 76, Issue 23, 2005, Pages 2655-2668

  Ueta, Kiichiro ^a   Ishihara, Tomomi ^a   Matsumoto, Yukio ^a   Oku, Akira ^a   Nawano, Masao ^a   Fujita, Takuya ^a   Saito, Akira ^a   Arakawa, Kenji ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Antidiabetic agent; GK rat; Insulin resistance; Na+ glucose cotransporter; Neuropathy; T 1095; Type 2 diabetes

Indexed keywords

(BENZO[B]FURAN 5 YL) 2',6' DIHYDROXY 4' METHYLPROPIOPHENONE 2' O (6 O METHOXYCARBONYL BETA DEXTRO GLYCOPYRANOSIDE); 3 (5 BENZOFURANYL) 1 [2 HYDROXY 6 [6 O (METHOXYCARBONYL) BETA DEXTRO GLUCOPYRANOSYL] 4 METHYLPHENYL] 1 PROPANONE; GLUCOSE; HEMOGLOBIN A1C; INSULIN; PROTEIN INHIBITOR; SODIUM GLUCOSE COTRANSPORTER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DIET; DISEASE COURSE; DISEASE DURATION; DISEASE MODEL; DISEASE SEVERITY; DRUG ACTIVITY; DRUG EFFECT; DRUG SCREENING; FEMALE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLUCOSE URINE LEVEL; GLUCOSURIA; HEAT; HOMEOSTASIS; HYPERGLYCEMIA; HYPOGLYCEMIA; INSULIN RELEASE; INSULIN RESISTANCE; LONG TERM CARE; MALE; MODEL; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; ORAL GLUCOSE TOLERANCE TEST; RAT; RAT STRAIN; STRAIN DIFFERENCE; TAIL FLICK TEST; WEIGHT GAIN;

RATTUS NORVEGICUS;

EID: 15544383811     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2004.09.038     Document Type: Article

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