Characterization of [ 3H]Lu AE60157 ([ 3H]8-(4- methylpiperazin-1-yl)-3-phenylsulfonylquinoline) binding to 5- hydroxytryptamine 6 (5-HT 6) receptors in vivo

European Journal of Pharmacology

Volumn 676, Issue 1-3, 2012, Pages 6-11

  Witten, Louise ^a   Bang Andersen, Benny ^a   Nielsen, Søren Møller ^a   Miller, Silke ^b,c   Christoffersen, Claus Tornby ^a   Stensbøl, Tine Bryan ^a   Brennum, Lise Tøttrup ^a   Arnt, Jørn ^a  

^a H LUNDBECK A S   (Denmark)

^b LUNDBECK RESEARCH USA   (United States)

^c AMGEN INC   (United States)

Author keywords

5 HT 6 receptor; Brain; In vivo binding; Occupancy; Radioligand; Striatum

Indexed keywords

3 PHENYLSULFONYL 8 (1 PIPERAZINYL)QUINOLINE; 8 (4 METHYLPIPERAZIN 1 YL) 3 PHENYLSULFONYLQUINOLINE; CLOZAPINE; HALOPERIDOL; LU AE 60157; OLANZAPINE; QUETIAPINE; RISPERIDONE; SEROTONIN 6 ANTAGONIST; SEROTONIN 6 RECEPTOR; SERTINDOLE; TRITIUM; UNCLASSIFIED DRUG; VOLINANSERIN;

AFFINITY LABELING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BRAIN REGION; CONTROLLED STUDY; DRUG PENETRATION; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; IN VIVO STUDY; ISOTOPE LABELING; LIGAND BINDING; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; SIGNAL NOISE RATIO;

ANIMALS; AUTORADIOGRAPHY; BRAIN; HUMANS; LIGANDS; MALE; MICE; PROTEIN BINDING; QUINOLINES; RATS; RECEPTORS, SEROTONIN; REPRODUCIBILITY OF RESULTS; SEROTONIN ANTAGONISTS; SUBSTRATE SPECIFICITY; SULFONES;

EID: 84855609329     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.11.029     Document Type: Article

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