Cholesterol synthesis is associated with hepatic lipid content and dependent on fructose/glucose intake in healthy humans

Experimental Diabetes Research

Volumn 2012, Issue , 2012, Pages

  Silbernagel, Guenther ^a   Lütjohann, Dieter ^b   MacHann, Juergen ^a   Meichsner, Sabrina ^b   Kantartzis, Konstantinos ^a   Schick, Fritz ^a   Häring, Hans Ulrich ^a   Stefan, Norbert ^a   Fritsche, Andreas ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPESTEROL; CHOLESTEROL; DESMOSTEROL; LANOSTEROL; LIPID; SITOSTEROL; FRUCTOSE; GLUCOSE; INSULIN; STEROL;

ABSORPTION; ADULT; ARTICLE; BODY MASS; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; FOLLOW UP; GLUCOSE INTAKE; HOMEOSTASIS; HUMAN; INTERVENTION STUDY; LIPID LIVER LEVEL; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTON NUCLEAR MAGNETIC RESONANCE; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; BIOSYNTHESIS; BLOOD; CHEMISTRY; CLINICAL TRIAL; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; DIET; INTRAABDOMINAL FAT; LIVER; METABOLISM;

ADULT; BODY MASS INDEX; CHOLESTEROL; COHORT STUDIES; DIET; FEMALE; FRUCTOSE; GLUCOSE; HUMANS; INSULIN; INTRA-ABDOMINAL FAT; LIPIDS; LIVER; MALE; STEROLS;

EID: 84855602265     PISSN: 16875214     EISSN: 16875303     Source Type: Journal    
DOI: 10.1155/2012/361863     Document Type: Article

References (42)

1. von Bergmann K., Sudhop T., Ltjohann D., Cholesterol and plant sterol absorption: recent insights American Journal of Cardiology 2005 96 1 10D 14D (Pubitemid 40898164)
2. Weingrtner O., Ltjohann D., Bhm M., Laufs U., Relationship between cholesterol synthesis and intestinal absorption is associated with cardiovascular risk Atherosclerosis 2010 210 2 362 365
3. Berge K. E., Tian H., Graf G. A., Yu L., Grishin N. V., Schultz J., Kwiterovich P., Shan B., Barnes R., Hobbs H. H., Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters Science 2000 290 5497 1771 1775 (Pubitemid 32004809)
4. Lee M. H., Lu K., Hazard S., Yu H., Shulenin S., Hidaka H., Kojima H., Allikmets R., Sakuma N., Pegoraro R., Srivastava A. K., Salen G., Dean M., Patel S. B., Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption Nature Genetics 2001 27 1 79 83 (Pubitemid 32044523)
5. Altmann S. W., Davis H. R. Jr., Zhu L. J., Yao X., Hoos L. M., Tetzloff G., Iyer S. P. N., Maguire M., Golovko A., Zeng M., Wang L., Murgolo N., Graziano M. P., Niemann-pick C1 like 1 protein is critical for intestinal cholesterol absorption Science 2004 303 5661 1201 1204 (Pubitemid 38233587)
6. Simonen P., Gylling H., Howard A. N., Miettinen T. A., Introducing a new component of the metabolic syndrome: low cholesterol absorption American Journal of Clinical Nutrition 2000 72 1 82 88 (Pubitemid 30441661)
7. Silbernagel G., Fauler G., Hoffmann M. M., Ltjohann D., Winkelmann B. R., Boehm B. O., Mrz W., The associations of cholesterol metabolism and plasma plant sterols with all-cause and cardiovascular mortality Journal of Lipid Research 2010 51 8 2384 2393
8. Silbernagel G., Fauler G., Renner W., Landl E. M., Hoffmann M. M., Winkelmann B. R., Boehm B. O., Mrz W., The relationships of cholesterol metabolism and plasma plant sterols with the severity of coronary artery disease Journal of Lipid Research 2009 50 2 334 341
9. Pihlajamki J., Gylling H., Miettinen T. A., Laakso M., Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men Journal of Lipid Research 2004 45 3 507 512 (Pubitemid 38337997)
10. Simonen P. P., Gylling H. K., Miettinen T. A., Diabetes contributes to cholesterol metabolism regardless of obesity Diabetes Care 2002 25 9 1511 1515 (Pubitemid 41071103)
11. Hoenig M. R., Sellke F. W., Insulin resistance is associated with increased cholesterol synthesis, decreased cholesterol absorption and enhanced lipid response to statin therapy Atherosclerosis 2010 211 1 260 265
12. Peltola P., Pihlajamki J., Koutnikova H., Ruotsalainen E., Salmenniemi U., Vauhkonen I., Kainulainen S., Gylling H., Miettinen T. A., Auwerx J., Laakso M., Visceral obesity is associated with high levels of serum squalene Obesity 2006 14 7 1155 1163 (Pubitemid 46219681)
13. Hoenig M. R., Cowin G., Buckley R., McHenery C., Coulthard A., Low density lipoprotein cholesterol is inversely correlated with abdominal visceral fat area: a magnetic resonance imaging study Lipids in Health and Disease 2011 10, article 12
14. Stefan N., Kantartzis K., Hring H. U., Causes and metabolic consequences of fatty liver Endocrine Reviews 2008 29 7 939 960
15. Fabbrini E., Magkos F., Mohammed B. S., Pietka T., Abumrad N. A., Patterson B. W., Okunade A., Klein S., Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity Proceedings of the National Academy of Sciences of the United States of America 2009 106 36 15430 15435
16. Cohen J. C., Horton J. D., Hobbs H. H., Human fatty liver disease: old questions and new insights Science 2011 332 6037 1519 1523
17. Stefan N., Haring H. U., The metabolically benign and malignant fatty liver Diabetes 2011 60 8 2011 2017
18. Simonen P., Kotronen A., Hallikainen M., Sevastianova K., Makkonen J., Hakkarainen A., Lundbom N., Miettinen T. A., Gylling H., Yki-Jrvinen H., Cholesterol synthesis is increased and absorption decreased in non-alcoholic fatty liver disease independent of obesity Journal of Hepatology 2011 54 1 153 159
19. Silbernagel G., Machann J., Unmuth S., Schick F., Stefan N., Hring H. U., Fritsche A., Effects of 4-week very-high-fructose/glucose diets on insulin sensitivity, visceral fat and intrahepatic lipids: an exploratory trial British Journal of Nutrition 2011 106 1 79 86
20. Tappy L., L K. A., Metabolic effects of fructose and the worldwide increase in obesity Physiological Reviews 2010 90 1 23 46
21. L K. A., Faeh D., Stettler R., Ith M., Kreis R., Vermathen P., Boesch C., Ravussin E., Tappy L., A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans American Journal of Clinical Nutrition 2006 84 6 1374 1379 (Pubitemid 44912820)
22. L K. A., Ith M., Kreis R., Faeh D., Bortolotti M., Tran C., Boesch C., Tappy L., Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes American Journal of Clinical Nutrition 2009 89 6 1760 1765
23. Stanhope K. L., Schwarz J. M., Keim N. L., Griffen S. C., Bremer A. A., Graham J. L., Hatcher B., Cox C. L., Dyachenko A., Zhang W., McGahan J. P., Seibert A., Krauss R. M., Chiu S., Schaefer E. J., Ai M., Otokozawa S., Nakajima K., Nakano T., Beysen C., Hellerstein M. K., Berglund L., Havel P. J., Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans Journal of Clinical Investigation 2009 119 5 1322 1334
24. Miettinen T. A., Tilvis R. S., Kesaniemi Y. A., Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population American Journal of Epidemiology 1990 131 1 20 31 (Pubitemid 20014696)
25. Matthan N. R., Lichtenstein A. H., Approaches to measuring cholesterol absorption in humans Atherosclerosis 2004 174 2 197 205 (Pubitemid 38597076)
26. Silbernagel G., Mrz W., Plant sterols: cardiovascular risk factors? Journal of Laboratory and Clinical Medicine 2008 32 4 209 218
27. Weingrtner O., Pinsdorf T., Rogacev K. S., Blmer L., Grenner Y., Grber S., Ulrich C., Girndt M., Bhm M., Fliser D., Laufs U., Ltjohann D., Heine G. H., The relationships of markers of cholesterol homeostasis with carotid intima-media thickness PLoS One 2010 5 10
28. Matsuda M., DeFronzo R. A., Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp Diabetes Care 1999 22 9 1462 1470 (Pubitemid 29418240)
29. Machann J., Thamer C., Schnoedt B., Haap M., Haring H. U., Claussen C. D., Stumvoll M., Fritsche A., Schick F., Standardized assessment of whole body adipose tissue topography by MRI Journal of Magnetic Resonance Imaging 2005 21 4 455 462 (Pubitemid 40446442)
30. Fabbrini E., Conte C., Magkos F., Methods for assessing intrahepatic fat content and steatosis Current Opinion in Clinical Nutrition and Metabolic Care 2009 12 5 474 481
31. Schwenzer N. F., Springer F., Schraml C., Stefan N., Machann J., Schick F., Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance Journal of Hepatology 2009 51 3 433 445
32. Schulz K. F., Altman D. G., Moher D., CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials British Medical Journal 2010 340, article 32 c332
33. Brown M. S., Goldstein J. L., The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor Cell 1997 89 3 331 340 (Pubitemid 27220877)
34. Horton J. D., Goldstein J. L., Brown M. S., SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver Journal of Clinical Investigation 2002 109 9 1125 1131 (Pubitemid 34496588)
35. Caballero F., Fernndez A., De Lacy A. M., Fernndez-Checa J. C., Caballera J., Garca-Ruiz C., Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH Journal of Hepatology 2009 50 4 789 796
36. Szendroedi J., Anderwald C., Krssak M., Bayerle-Eder M., Esterbauer H., Pfeiler G., Brehm A., Nowotny P., Hofer A., Waldhausl W., Roden M., Effects of high-dose simvastatin therapy on glucose metabolism and ectopic lipid deposition in nonobese type 2 diabetic patients Diabetes Care 2009 32 2 209 214
37. Chan D. C., Watts G. F., Gan S. K., Ooi E. M., Barrett P. H., Effect of ezetimibe on hepatic fat, inflammatory markers, and apolipoprotein B-100 kinetics in insulin-resistant obese subjects on a weight loss diet Diabetes Care 2010 33 5 1134 1139
38. Katan M. B., Grundy S. M., Jones P., Law M., Miettinen T., Paoletti R., Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels Mayo Clinic Proceedings 2003 78 8 965 978 (Pubitemid 36936128)
39. Tobin K. A., Ulven S. M., Schuster G. U., Steineger H. H., Andresen S. M., Gustafsson J. A., Nebb H. I., Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis Journal of Biological Chemistry 2002 277 12 10691 10697 (Pubitemid 34975649)
40. Magkos F., Mohammed B. S., Mittendorfer B., Effect of obesity on the plasma lipoprotein subclass profile in normoglycemic and normolipidemic men and women International Journal of Obesity 2008 32 11 1655 1664
41. Kantartzis K., Rittig K., Cegan A., Machann J., Schick F., Balletshofer B., Fritsche A., Schleicher E., Hring H. U., Stefan N., Fatty liver is independently associated with alterations in circulating HDL2 and HDL3 subfractions Diabetes Care 2008 31 2 366 368 (Pubitemid 351213353)
42. Hoenig M. R., Implications of the obesity epidemic for lipid-lowering therapy: non-HDL cholesterol should replace LDL cholesterol as the primary therapeutic target Vascular Health and Risk Management 2008 4 1 143 156 (Pubitemid 351460855)