메뉴 건너뛰기




Volumn 14, Issue 7, 2006, Pages 1155-1163

Visceral obesity is associated with high levels of serum squalene

Author keywords

Cholesterol synthesis; Insulin resistance; Intra abdominal obesity; Squalene synthase; Type 2 diabetes

Indexed keywords

BIOLOGICAL MARKER; CHOLESTEROL; INSULIN; SQUALENE; SQUALENE SYNTHASE;

EID: 33846884414     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2006.132     Document Type: Article
Times cited : (27)

References (35)
  • 1
    • 0026572747 scopus 로고
    • Pathogenesis of type 2 (non-insulin dependent) diabetes mellitus: A balanced overview
    • DeFronzo RA. Pathogenesis of type 2 (non-insulin dependent) diabetes mellitus: a balanced overview. Diabetologia. 1992;35:389-97.
    • (1992) Diabetologia , vol.35 , pp. 389-397
    • DeFronzo, R.A.1
  • 2
    • 0027319430 scopus 로고
    • Cardiovascular disease risk factors as predictors of type 2 (non-insulin- dependent) diabetes mellitus in elderly subjects
    • Mykkänen L, Kuusisto J, Pyörälä K, Laakso M. Cardiovascular disease risk factors as predictors of type 2 (non-insulin- dependent) diabetes mellitus in elderly subjects. Diabetologia. 1993;36:553-9.
    • (1993) Diabetologia , vol.36 , pp. 553-559
    • Mykkänen, L.1    Kuusisto, J.2    Pyörälä, K.3    Laakso, M.4
  • 3
    • 0036726421 scopus 로고    scopus 로고
    • Diabetes contributes to cholesterol metabolism regardless of obesity
    • Simonen PP, Gylling HK, Miettinen TA. Diabetes contributes to cholesterol metabolism regardless of obesity. Diabetes Care. 2002;25:1511-5.
    • (2002) Diabetes Care , vol.25 , pp. 1511-1515
    • Simonen, P.P.1    Gylling, H.K.2    Miettinen, T.A.3
  • 4
    • 1542723726 scopus 로고    scopus 로고
    • Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men
    • Pihlajamäki J, Gylling H, Miettinen TA, Laakso M. Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men. J Lipid Res. 2004;45:507-12.
    • (2004) J Lipid Res , vol.45 , pp. 507-512
    • Pihlajamäki, J.1    Gylling, H.2    Miettinen, T.A.3    Laakso, M.4
  • 5
    • 0034800255 scopus 로고    scopus 로고
    • Mechanisms of hepatic very low-density lipoprotein overproduction in insulin resistance
    • Adeli K, Taghibiglou C, Van Iderstine SC, Lewis GF. Mechanisms of hepatic very low-density lipoprotein overproduction in insulin resistance. Trends Cardiovasc Med. 2001;11:170-6.
    • (2001) Trends Cardiovasc Med , vol.11 , pp. 170-176
    • Adeli, K.1    Taghibiglou, C.2    Van Iderstine, S.C.3    Lewis, G.F.4
  • 6
    • 0037155935 scopus 로고    scopus 로고
    • Liver x receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis
    • Tobin KA, Ulven SM, Schuster GU, et al. Liver x receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis. J Biol Chem. 2002;277:10691-7.
    • (2002) J Biol Chem , vol.277 , pp. 10691-10697
    • Tobin, K.A.1    Ulven, S.M.2    Schuster, G.U.3
  • 7
    • 0018664832 scopus 로고
    • Effects of weight reduction on squalene, methyl sterols and cholesterol and on their synthesis in human adipose tissue
    • Tilvis R, Miettinen TA. Effects of weight reduction on squalene, methyl sterols and cholesterol and on their synthesis in human adipose tissue. Eur J Clin Invest. 1979;9:155-60.
    • (1979) Eur J Clin Invest , vol.9 , pp. 155-160
    • Tilvis, R.1    Miettinen, T.A.2
  • 8
    • 0020458671 scopus 로고
    • Metabolism of squalene in human fat cells: Demonstration of a two-pool system
    • Tilvis R, Kovanen PT, Miettinen TA. Metabolism of squalene in human fat cells: demonstration of a two-pool system. J Biol Chem. 1982;257:10300-5.
    • (1982) J Biol Chem , vol.257 , pp. 10300-10305
    • Tilvis, R.1    Kovanen, P.T.2    Miettinen, T.A.3
  • 9
    • 0025156823 scopus 로고
    • Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population
    • Miettinen TA, Tilvis RS, Kesäniemi YA. Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population. Am J Epidemiol. 1990;131:20-31.
    • (1990) Am J Epidemiol , vol.131 , pp. 20-31
    • Miettinen, T.A.1    Tilvis, R.S.2    Kesäniemi, Y.A.3
  • 10
    • 0023804159 scopus 로고
    • Effects of hypocaloric diet and insulin therapy on metabolic control and mechanisms of hyperglycemia in obese non-insulin-dependent diabetic subjects
    • Laakso M, Uusitupa M, Takala J, Majander H, Reijonen T, Penttilä I. Effects of hypocaloric diet and insulin therapy on metabolic control and mechanisms of hyperglycemia in obese non-insulin-dependent diabetic subjects. Metabolism. 1988;37:1092-100.
    • (1988) Metabolism , vol.37 , pp. 1092-1100
    • Laakso, M.1    Uusitupa, M.2    Takala, J.3    Majander, H.4    Reijonen, T.5    Penttilä, I.6
  • 11
    • 11144346107 scopus 로고    scopus 로고
    • Multiple abnormalities in glucose and energy metabolism in offspring of patients with type 2 diabetes
    • Salmenniemi U, Ruotsalainen E, Pihlajamäki J, Laakso M. Multiple abnormalities in glucose and energy metabolism in offspring of patients with type 2 diabetes. Circulation. 2004;110:3842-48.
    • (2004) Circulation , vol.110 , pp. 3842-3848
    • Salmenniemi, U.1    Ruotsalainen, E.2    Pihlajamäki, J.3    Laakso, M.4
  • 12
    • 0031851293 scopus 로고    scopus 로고
    • Definition, diagnosis and classification of diabetes mellitus and its complications: I. Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation
    • Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications: I. Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15:539-53.
    • (1998) Diabet Med , vol.15 , pp. 539-553
    • Alberti, K.G.1    Zimmet, P.Z.2
  • 13
    • 0026474342 scopus 로고
    • A simple method for quantitation of insulin sensitivity and insulin release from an intravenous glucose tolerance test
    • Galvin P, Ward G, Walters J, et al. A simple method for quantitation of insulin sensitivity and insulin release from an intravenous glucose tolerance test. Diabet Med. 1992;9:921-8.
    • (1992) Diabet Med , vol.9 , pp. 921-928
    • Galvin, P.1    Ward, G.2    Walters, J.3
  • 14
    • 0018520840 scopus 로고
    • Glucose clamp technique: A method for quantifying insulin secretion and resistance
    • DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol. 1979;237:E214-23.
    • (1979) Am J Physiol , vol.237
    • DeFronzo, R.A.1    Tobin, J.D.2    Andres, R.3
  • 15
    • 0022485185 scopus 로고
    • Determination of total adipose tissue and body fat in women by computed tomography, 40k, and tritium
    • Sjöström L, Kvist H, Cederblad A, Tylen U. Determination of total adipose tissue and body fat in women by computed tomography, 40k, and tritium. Am J Physiol. 1986;250:E736-45.
    • (1986) Am J Physiol , vol.250
    • Sjöström, L.1    Kvist, H.2    Cederblad, A.3    Tylen, U.4
  • 16
    • 0025364118 scopus 로고
    • Insulin resistance is associated with lipid and lipoprotein abnormalities in subjects with varying degrees of glucose tolerance
    • Laakso M, Sarlund H, Mykkänen L. Insulin resistance is associated with lipid and lipoprotein abnormalities in subjects with varying degrees of glucose tolerance. Arteriosclerosis. 1990;10:223-31.
    • (1990) Arteriosclerosis , vol.10 , pp. 223-231
    • Laakso, M.1    Sarlund, H.2    Mykkänen, L.3
  • 17
    • 0036739547 scopus 로고    scopus 로고
    • Inheritance of cholesterol metabolism of probands with high or low cholesterol absorption
    • Gylling H, Miettinen TA. Inheritance of cholesterol metabolism of probands with high or low cholesterol absorption. J Lipid Res. 2002;43:1472-6.
    • (2002) J Lipid Res , vol.43 , pp. 1472-1476
    • Gylling, H.1    Miettinen, T.A.2
  • 18
    • 0002702529 scopus 로고
    • Non-cholesterol sterols and bile acid production in hypercholesterolaemic patients with ileal bypass
    • Miettinen TA, Koivisto P. Non-cholesterol sterols and bile acid production in hypercholesterolaemic patients with ileal bypass. Bile Acids Cholesterol Health Disease. 1983;183-87.
    • (1983) Bile Acids Cholesterol Health Disease , pp. 183-187
    • Miettinen, T.A.1    Koivisto, P.2
  • 19
    • 0034672674 scopus 로고    scopus 로고
    • Structure and regulation of mammalian squalene synthase
    • Tansey TR, Shechter I. Structure and regulation of mammalian squalene synthase. Biochim Biophys Acta. 2000;1529:49-62.
    • (2000) Biochim Biophys Acta , vol.1529 , pp. 49-62
    • Tansey, T.R.1    Shechter, I.2
  • 20
    • 0029100908 scopus 로고
    • Molecular cloning and functional analysis of the promoter of the human squalene synthase gene
    • Guan G, Jiang G, Koch RL, Shechter I. Molecular cloning and functional analysis of the promoter of the human squalene synthase gene. J Biol Chem. 1995;270:21958-65.
    • (1995) J Biol Chem , vol.270 , pp. 21958-21965
    • Guan, G.1    Jiang, G.2    Koch, R.L.3    Shechter, I.4
  • 21
    • 13444269543 scopus 로고    scopus 로고
    • Haploview: Analysis and visualization of Id and haplotype maps
    • Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of Id and haplotype maps. Bioinformatics. 2005;21:263-5.
    • (2005) Bioinformatics , vol.21 , pp. 263-265
    • Barrett, J.C.1    Fry, B.2    Maller, J.3    Daly, M.J.4
  • 22
    • 0015145933 scopus 로고
    • Cholesterol production in obesity
    • Miettinen TA. Cholesterol production in obesity. Circulation. 1971;44:842-50.
    • (1971) Circulation , vol.44 , pp. 842-850
    • Miettinen, T.A.1
  • 24
    • 0033790554 scopus 로고    scopus 로고
    • Cholesterol absorption efficiency and sterol metabolism in obesity
    • Miettinen TA, Gylling H. Cholesterol absorption efficiency and sterol metabolism in obesity. Atherosclerosis. 2000;153:241-8.
    • (2000) Atherosclerosis , vol.153 , pp. 241-248
    • Miettinen, T.A.1    Gylling, H.2
  • 25
    • 0242721947 scopus 로고    scopus 로고
    • Synthesis and absorption markers of cholesterol in serum and lipoproteins during a large dose of statin treatment
    • Miettinen TA, Gylling H. Synthesis and absorption markers of cholesterol in serum and lipoproteins during a large dose of statin treatment. Eur J Clin Invest. 2003;33:976-82.
    • (2003) Eur J Clin Invest , vol.33 , pp. 976-982
    • Miettinen, T.A.1    Gylling, H.2
  • 26
    • 0018186703 scopus 로고
    • Plasma squalene: Lipoprotein distribution and kinetic analysis
    • Saudek CD, Frier BM, Liu GC. Plasma squalene: lipoprotein distribution and kinetic analysis. J Lipid Res. 1978;19:827-35.
    • (1978) J Lipid Res , vol.19 , pp. 827-835
    • Saudek, C.D.1    Frier, B.M.2    Liu, G.C.3
  • 27
    • 0033812005 scopus 로고    scopus 로고
    • Ym-53601, a novel squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in several animal species
    • Ugawa T, Kakuta H, Moritani H, et al. Ym-53601, a novel squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in several animal species. Br J Pharmacol. 2000;131:63-70.
    • (2000) Br J Pharmacol , vol.131 , pp. 63-70
    • Ugawa, T.1    Kakuta, H.2    Moritani, H.3
  • 29
    • 11144356074 scopus 로고    scopus 로고
    • Activated liver x receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor gamma expression
    • Seo JB, Moon HM, Kim WS, et al. Activated liver x receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor gamma expression. Mol Cell Biol. 2004;24:3430-44.
    • (2004) Mol Cell Biol , vol.24 , pp. 3430-3444
    • Seo, J.B.1    Moon, H.M.2    Kim, W.S.3
  • 30
    • 0030885520 scopus 로고    scopus 로고
    • The orphan nuclear receptor LXRalpha is positively and negatively regulated by distinct products of mevalonate metabolism
    • Forman BM, Ruan B, Chen J, Schroepfer GJ Jr., Evans RM. The orphan nuclear receptor LXRalpha is positively and negatively regulated by distinct products of mevalonate metabolism. Proc NatlAcad Sci USA. 1997;94:10588-93.
    • (1997) Proc NatlAcad Sci USA , vol.94 , pp. 10588-10593
    • Forman, B.M.1    Ruan, B.2    Chen, J.3    Schroepfer Jr., G.J.4    Evans, R.M.5
  • 31
    • 0036251153 scopus 로고    scopus 로고
    • Srebps: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • Horton JD, Goldstein JL, Brown MS. Srebps: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest. 2002;109:1125-31.
    • (2002) J Clin Invest , vol.109 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 32
    • 0032793068 scopus 로고    scopus 로고
    • Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: Implications for adipocyte differentiation and metabolism
    • Fajas L, Schoonjans K, Gelman L, et al. Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism. Mol Cell Biol. 1999;19:5495-503.
    • (1999) Mol Cell Biol , vol.19 , pp. 5495-5503
    • Fajas, L.1    Schoonjans, K.2    Gelman, L.3
  • 33
    • 0032516081 scopus 로고    scopus 로고
    • Add1/srebpl activates PPARgamma through the production of endogenous ligand
    • Kim JB, Wright HM, Wright M, Spiegelman BM. Add1/srebpl activates PPARgamma through the production of endogenous ligand. Proc Natl Acad Sci USA. 1998;95:4333-7.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 4333-4337
    • Kim, J.B.1    Wright, H.M.2    Wright, M.3    Spiegelman, B.M.4
  • 34
    • 0037243080 scopus 로고    scopus 로고
    • Squalene synthase inhibitors suppress triglyceride biosynthesis through the farnesol pathway in rat hepatocytes
    • Hiyoshi H, Yanagimachi M, Ito M, et al. Squalene synthase inhibitors suppress triglyceride biosynthesis through the farnesol pathway in rat hepatocytes. J Lipid Res. 2003;44:128-35.
    • (2003) J Lipid Res , vol.44 , pp. 128-135
    • Hiyoshi, H.1    Yanagimachi, M.2    Ito, M.3
  • 35
    • 0030892083 scopus 로고    scopus 로고
    • Multiple sequence elements are involved in the transcriptional regulation of the human squalene synthase gene
    • Guan G, Dai PH, Osborne TF, Kim JB, Shechter I. Multiple sequence elements are involved in the transcriptional regulation of the human squalene synthase gene. J Biol Chem. 1997;272:10295-302.
    • (1997) J Biol Chem , vol.272 , pp. 10295-10302
    • Guan, G.1    Dai, P.H.2    Osborne, T.F.3    Kim, J.B.4    Shechter, I.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.