Diabetes contributes to cholesterol metabolism regardless of obesity

Diabetes Care

Volumn 25, Issue 9, 2002, Pages 1511-1515

  Simonen, Piia P ^a   Gylling, Helena K ^b   Miettinen, Tatu A ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; ISOTOPE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; AGE; ARTICLE; BILIARY EXCRETION; BODY MASS; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; LIPID ABSORPTION; MALE; MODULATION; OBESITY; POPULATION RESEARCH; TRIACYLGLYCEROL BLOOD LEVEL; TURNOVER TIME; WEIGHT; BLOOD; CHOLESTEROL INTAKE; COHORT ANALYSIS; CROSS-SECTIONAL STUDY; METABOLISM; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS;

CHOLESTEROL, DIETARY; COHORT STUDIES; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; MALE; MIDDLE AGED; OBESITY; TRIGLYCERIDES;

EID: 0036726421     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.25.9.1511     Document Type: Article

References (32)

1. Abrams JJ, Ginsberg H, Grundy SM: Metabolism of cholesterol and plasma triglycerides in nonketotic diabetes mellitus. Diabetes 31:903-910, 1982
2. Andersen E, Hellström P, Hellström K: Cholesterol and bile acid metabolism in middle-aged diabetics. Diabete Metab 12:261-266, 1986
3. Naoumova RP, Cummings MH, Watts GF, Rendell NB, Taylor GW, Sōnksen PH, Thompson GR: Acute hyperinsulinaemia decreases cholesterol synthesis less in subjects with non-insulin-dependent diabetes mellitus than in non-diabetic subjects. Eur J Clin Invest 26:332-340, 1996
4. Gylling H, Miettinen TA: Cholesterol absorption, synthesis and low and high density lipoprotein metabolism in non-insulin-dependent diabetes mellitus. Diabetes Care 20:90-95, 1997
5. Bennion LJ, Grundy SM: Effects of diabetes mellitus on cholesterol metabolism in man. N Engl J Med 296:1365-1371, 1977
6. Scoppola A, Testa G, Frontoni S, Maddaloni E, Gambardella S, Menzinger G, Lala A: Effects of insulin on cholesterol synthesis in type II diabetes patients. Diabetes Care 18:1362-1369, 1995
7. Briones ER, Steiger DL, Palumbo PJ, O'Fallon WM, Langworthy AL, Zimmerman BR, Kottke BA: Sterol excretion and cholesterol absorption in diabetics and nondiabetics with and without hyperlipidemia. Am J Clin Nutr 44:353-361, 1986
8. Tilvis RS, Miettinen TA: Serum plant sterols and their relation to cholesterol absorption. Am J Clin Nutr 43:92-97, 1986
9. Miettinen TA, Tilvis RS, Kesäniemi YA: Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population. Am J Epidemiol 131:20-31, 1990
10. Sutherland WH, Scott RS, Lintott CJ, Robertson MC, Stapely SA, Cox C: Plasma non-cholesterol sterols in patients with non-insulin dependent diabetes mellitus. Horm Metab Res 24:172-175, 1992
11. Strandberg TE, Salomaa V, Vanhanen H, Miettinen TA: Associations of fasting blood glucose with cholesterol absorption and synthesis in nondiabetic middle-aged men. Diabetes 45:755-761, 1996
12. Nestel PJ, Whyte HM, Goodman DS: Distribution and turnover of cholesterol in humans. J Clin Invest 48:982-991, 1969
13. Miettinen TA: Cholesterol production in obesity. Circulation 44:842-847, 1971
14. Nestel PJ, Schreibman PH, Ahrens EH Jr: Cholesterol metabolism in human obesity. J Clin Invest 52:2389-2397, 1973
15. Miettinen TA, Gylling H: Cholesterol absorption efficiency and sterol metabolism in obesity. Atherosclerosis 153:241-248, 2000
16. Simonen P, Gylling H, Howard AN, Miettinen TA: Introducing a new component of the metabolic syndrome: low cholesterol absorption. Am J Clin Nutr 72:82-88, 2000
17. Rajaratnam RA, Gylling H, Miettinen TA: Independent association of serum squalene and noncholesterol sterols with coronary artery disease in postmenopausal women. J Am Coll Cardiol 35:1185-1191, 2000
18. Knuts L-R, Rastas M, Haapala P: Micro-Nutrica. Version 1.0. Helsinki, Kansaneläkelaitos (National Pensions Institute) 1991
19. Lipid Research Clinics Program: Manual of Laboratory Operations, Lipid Research Clinic Program. Washington, DC, 1974, p. 51-59 (DHEW publ. no. NIH 75-628)
20. Havekes LM, de Knijff P, Beisiegel U, Havinga J, Smit M, Klasen E: A rapid micromethod for apolipoprotein E phenotyping directly in serum. J Lipid Res 28:455-463, 1987
21. Miettinen TA: Gas-liquid chromatographic determination of fecal neutral sterols using a capillary column. Clin Chim Acta 124:245-248, 1982
22. Miettinen TA, Ahrens EH Jr, Grundy SM: Quantitative isolation and gas-liquid chromatographic analysis of total dietary and fecal neutral steroids. J Lipid Res 6:411-424, 1965
23. Grundy SM, Ahrens EH Jr, Miettinen TA: Quantitative isolation and gas-liquid chromatographic analysis of total fecal bile acids. J Lipid Res 6:397-410, 1965
24. 3) when used as an index substance. Science 116:634-635, 1952
25. Crouse JR, Grundy SM: Evaluation of a continuous isotope feeding method for measurement of cholesterol absorption in man. J Lipid Res 19:967-971, 1978
26. American Diabetes Association: Detection and management of lipid disorders in diabetes (Consensus Statement). Diabetes Care 5:828-835, 1993
27. Miettinen TA, Kesāniemi YA: Cholesterol absorption: regulation of cholesterol synthesis and elimination and within-population variations of serum cholesterol levels. Am J Clin Nutr 49:629-635, 1989
28. Bosner MS, Lange LG, Stenson WF, Ostlund RE: Percent cholesterol absorption in normal women and men quantified with dual stable isotopic tracers and negative ion mass spectrometry. J Lipid Res 40:302-308, 1999
29. Horton JD, Shimomura I: Sterol regulatory, element-binding proteins: activators of cholesterol and fatty acid biosynthesis. Curr Opin Lipidol 10:143-150, 1999
30. Sehayek E, Ono JG, Shefer S: Biliary cholesterol excretion: a novel mechanism that regulates dietary cholesterol absorption. Proc Natl Acad Sci USA 95:10194-10199, 1998
31. Berge KE, Tian H, Graf GA: Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science 290:1771-1775, 2000
32. Miettinen TA: Phytosterolemia, xanthomatosis and premature atherosclerotic arterial disease: a case with high plant sterol absorption, impaired sterol elimination and low cholesterol synthesis. Eur J Clin Invest 10:27-35, 1980