Facile synthesis of oxo-/thioxopyrimidines and tetrazoles C-C linked to sugars as novel non-toxic antioxidant acetylcholinesterase inhibitors

Carbohydrate Research

Volumn 347, Issue 1, 2012, Pages 47-54

  Figueiredo, J A ^a   Ismael, M I ^a   Pinheiro, J M ^a   Silva, A M S ^b   Justino, J ^c   Silva, F V M ^c   Goulart, M ^c   Mira, D ^c   Araujo M E M ^d   Campoy, R ^d   Rauter, A P ^d  

^a UNIVERSITY OF BEIRA INTERIOR   (Portugal)

^b UNIVERSITY OF AVEIRO   (Portugal)

^c POLYTECHNIC INSTITUTE OF SANTARÉM   (Portugal)

^d UNIVERSITY OF LISBON   (Portugal)

Author keywords

Acetylcholinesterase inhibitors; Antioxidant activity; Oxo thioxopyrimidine; Sugar linked heterocycles; Tetrazole

Indexed keywords

ACETYLCHOLINESTERASE; ACETYLCHOLINESTERASE INHIBITION; ALZHEIMER'S DISEASE; ANTIOXIDANT ACTIVITIES; BIOACTIVE COMPOUNDS; CHROMOSOMAL ABERRATION; CONVENTIONAL HEATING; CONVENTIONAL METHODS; COPPER SULFATE; CYTOTOXIC EFFECTS; DICYCLOHEXYLCARBODIIMIDE; FACILE SYNTHESIS; FORMYL GROUP; GALLIC ACIDS; GENOTOXICITIES; HETEROCYCLES; HIGH YIELD; HUMAN LYMPHOCYTES; HYDROXYLAMINE HYDROCHLORIDE; IN-VITRO; KETO ESTER; MICROWAVE ASSISTED SYNTHESIS; MTT METHOD; OXO-/THIOXOPYRIMIDINE; PYRANOSE; SODIUM AZIDE; TARGET MOLECULE; TETRAZOLES; TRIETHYLAMINES;

CYANIDES; CYTOTOXICITY; DISEASE CONTROL; IRRADIATION; MICROWAVE IRRADIATION; REACTION INTERMEDIATES; SODIUM; SODIUM SULFATE; SUGARS; THIOUREAS; UREA;

SYNTHESIS (CHEMICAL);

5 [3 O BENZYL 1,2 O ISOPROPYLIDENETETROFURANOS 4 YL]TETRAZOLE; ANTIOXIDANT; BETA CAROTENE; CARBON; CHOLINESTERASE INHIBITOR; COPPER SULFATE; DICYCLOHEXYLCARBODIIMIDE; ETHYL 3 O BENZYL 1,2 O ISOPROPYLIDENE 2 OXOPYRIMIDINE 5 CARBOXYLATE; ETHYL 3 O BENZYL 1,2 O ISOPROPYLIDENE TETROFURANOS 4 YL] 1,2,3,4 TETRAHYDRO 6 METHYL 2 OXOPYRIMIDINE 5 CARBOXYLATE; ETHYL 3 O BENZYL 1,2 O ISOPROPYLIDENE TETROFURANOS 4 YL] 1,2,3,4 TETRAHYDRO 6 METHYL 2 THIOXO PYRIMIDINE 5 CARBOXYLATE; ETHYL 3 O BENZYL 1,2:3,4 DI O ISOPROPYLIDENE TETROFURANOS 4 YL] 1,2,3,4 TETRAHYDRO 6 METHYL 2 OXOPYRIMIDINE 5 CARBOXYLATE; GALLIC ACID; HYDROXYLAMINE; LINOLEIC ACID; NITRILE; OXOPYRIMIDINE DERIVATIVE; SODIUM AZIDE; SUGAR; TETRAZOLE DERIVATIVE; THIOXOPYRIMIDINE DERIVATIVE; TRIETHYLAMINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; ARTICLE; CHROMOSOME ABERRATION; CONCENTRATION (PARAMETERS); CYTOTOXICITY; DRUG SYNTHESIS; GENOTOXICITY; HUMAN; HUMAN CELL; LYMPHOCYTE; MICROWAVE IRRADIATION; PRIORITY JOURNAL; REACTION TIME;

ACETYLCHOLINESTERASE; ANIMALS; ANTIOXIDANTS; BETA CAROTENE; CARBOHYDRATES; CATTLE; CELL LINE; CELL SURVIVAL; CHEMISTRY TECHNIQUES, SYNTHETIC; CHOLINESTERASE INHIBITORS; HUMANS; LINOLEIC ACID; PYRIMIDINES; TETRAZOLES;

EID: 84855591332     PISSN: 00086215     EISSN: 1873426X     Source Type: Journal    
DOI: 10.1016/j.carres.2011.11.006     Document Type: Article

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