메뉴 건너뛰기




Volumn 44, Issue 2, 2012, Pages 257-261

Hepatocytes: The powerhouse of biotransformation

Author keywords

Biotransformation enzymes; Hepatocytes; Phase I metabolism; Phase II metabolism

Indexed keywords

CYTOCHROME P450; XENOBIOTIC AGENT;

EID: 84855573973     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2011.11.011     Document Type: Short Survey
Times cited : (57)

References (37)
  • 1
    • 0037346969 scopus 로고    scopus 로고
    • The hepatocyte: Heterogeneity and plasticity of liver cells
    • DOI 10.1016/S1357-2725(02)00182-6, PII S1357272502001826
    • S. Sell The hepatocyte: heterogeneity and plasticity of liver cells The International Journal of Biochemistry & Cell Biology 35 2003 267 271 (Pubitemid 36084445)
    • (2003) International Journal of Biochemistry and Cell Biology , vol.35 , Issue.3 , pp. 267-271
    • Sell, S.1
  • 2
    • 0025903396 scopus 로고
    • Four forms of cytochrome P-450 in human fetal liver: Purification and their capacity to activate promutagens
    • M. Kitada, M. Taneda, K. Itahashi, and T. Kamataki Four forms of cytochrome P-450 in human fetal liver: purification and their capacity to activate promutagens Japanese Journal of Cancer Research 82 4 1991 426 432
    • (1991) Japanese Journal of Cancer Research , vol.82 , Issue.4 , pp. 426-432
    • Kitada, M.1    Taneda, M.2    Itahashi, K.3    Kamataki, T.4
  • 4
    • 43049154812 scopus 로고    scopus 로고
    • The ontogeny of drug metabolism enzymes and implications for adverse drug events
    • R.N. Hines The ontogeny of drug metabolism enzymes and implications for adverse drug events Pharmacology & Therapeutics 118 2008 250 267
    • (2008) Pharmacology & Therapeutics , vol.118 , pp. 250-267
    • Hines, R.N.1
  • 6
    • 0024244103 scopus 로고
    • Human ethanol-inducible P450IIE1: Complete gene sequence, promoter characterization, chromosome mapping and cDNA-directed expression
    • M. Umeno, O.W. McBride, C.S. Yang, H.V. Gelboin, and F.J. Gonzalez Human ethanol-inducible P450IIE1: complete gene sequence, promoter characterization, chromosome mapping and cDNA-directed expression Biochemistry 04 1988 9006 90013
    • (1988) Biochemistry , vol.4 , pp. 9006-90013
    • Umeno, M.1    McBride, O.W.2    Yang, C.S.3    Gelboin, H.V.4    Gonzalez, F.J.5
  • 7
    • 78651165715 scopus 로고
    • The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature
    • T. Omura, and R. Sato The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature The Journal of Biological Chemistry 239 7 1964 2370 2378
    • (1964) The Journal of Biological Chemistry , vol.239 , Issue.7 , pp. 2370-2378
    • Omura, T.1    Sato, R.2
  • 8
    • 50449100139 scopus 로고
    • The carbon monoxide-binding pigment of liver microsomes. II. Solubilization, purification, and properties
    • T. Omura, and R. Sato The carbon monoxide-binding pigment of liver microsomes. II. Solubilization, purification, and properties The Journal of Biological Chemistry 239 7 1964 2379 2385
    • (1964) The Journal of Biological Chemistry , vol.239 , Issue.7 , pp. 2379-2385
    • Omura, T.1    Sato, R.2
  • 9
    • 84855587041 scopus 로고    scopus 로고
    • 2006 [cited September 28th 2009]. Available from
    • -2006 [cited September 28th 2009]. Available from: http://cpd.ibmh.msk. su.
  • 10
  • 15
    • 34247259568 scopus 로고    scopus 로고
    • Drug-induced liver injury
    • G. Abboud, and N. Kaplowitz Drug-induced liver injury Drug Safety 30 2007 277 294 (Pubitemid 46624528)
    • (2007) Drug Safety , vol.30 , Issue.4 , pp. 277-294
    • Abboud, G.1    Kaplowitz, N.2
  • 16
    • 0041342015 scopus 로고    scopus 로고
    • Drug-induced hepatotoxicity
    • DOI 10.1056/NEJMra021844
    • W.M. Lee Drug-induced hepatotoxicity New England Journal of Medicine 31 2003 474 485 (Pubitemid 36910027)
    • (2003) New England Journal of Medicine , vol.349 , Issue.5 , pp. 474-485
    • Lee, W.M.1
  • 17
    • 0033199820 scopus 로고    scopus 로고
    • Characterization of drug metabolizing activities in pig hepatocytes for use in bioartificial liver devices: Comparison with other hepatic cellular models
    • DOI 10.1016/S0168-8278(99)80049-X
    • M.T. Donato, J.V. Castell, and M.J. Gómez-Lechón Characterization of drug metabolizing activities in pig hepatocytes for use in bioartificial liver devices: comparison with other hepatic cellular models Journal of Hepatology 31 3 1999 542 549 (Pubitemid 29408740)
    • (1999) Journal of Hepatology , vol.31 , Issue.3 , pp. 542-549
    • Donato, M.T.1    Castell, J.V.2    Gomez-Lechon, M.J.3
  • 18
    • 0036301269 scopus 로고    scopus 로고
    • Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: Molecular mechanisms that determine lower expression in cultured cells
    • DOI 10.1080/00498250210128675
    • C. Rodríguez-Antona, M.T. Donato, A.R. Boobis, R.J. Edwards, P.S. Watts, and J.V. Castell Cytcochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells Xenobiotica 32 6 2002 505 520 (Pubitemid 34743622)
    • (2002) Xenobiotica , vol.32 , Issue.6 , pp. 505-520
    • Rodriguez-Antona, C.1    Donato, M.T.2    Boobis, A.3    Edwards, R.J.4    Watts, P.S.5    Castell, J.V.6    Gomez-Lechon, M.-J.7
  • 19
    • 0034964158 scopus 로고    scopus 로고
    • Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation
    • E.L. LeCluyse Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation European Journal of Pharmaceutical Sciences 13 2001 343 368
    • (2001) European Journal of Pharmaceutical Sciences , vol.13 , pp. 343-368
    • Lecluyse, E.L.1
  • 20
    • 0029033092 scopus 로고
    • Effect of model inducers on cytochrome P450 activities of human hepatocytes in primary culture
    • M.T. Donato, J.V. Castell, and M.J. Gómez-Lechón Effect of model inducers on cytochrome P450 activities of human hepatocytes in primary culture Drug Metabolism and Disposition 23 5 1995 553 558
    • (1995) Drug Metabolism and Disposition , vol.23 , Issue.5 , pp. 553-558
    • Donato, M.T.1    Castell, J.V.2    Gómez-Lechón, M.J.3
  • 21
    • 4644341747 scopus 로고    scopus 로고
    • Human hepatocytes in primary culture: The choice to investigate drug metabolism in man
    • DOI 10.2174/1389200043335414
    • M.J. Gómez-Lechón, M.T. Donato, J.V. Castell, and R. Jover Human hepatocytes in primary culture: the choice to investigate drug metabolism in man Current Drug Metabolism 5 5 2004 443 462 (Pubitemid 39276606)
    • (2004) Current Drug Metabolism , vol.5 , Issue.5 , pp. 443-462
    • Gomez-Lechon, M.J.1    Donato, M.T.2    Castell, J.V.3    Jover, R.4
  • 22
    • 34247510665 scopus 로고    scopus 로고
    • Hepatocytes-the choice to investigate drug metabolism and toxicity in man: In vitro variability as a reflection of in vivo
    • DOI 10.1016/j.cbi.2006.10.013, PII S0009279706003243
    • M.J. Gomez-Lechon, J.V. Castell, and M.T. Donato Hepatocytes - the choice to investigate drug metabolism and toxicity in man: in vitro variability as a reflection of in vivo Chemico-Biological Interactions 168 1 2007 May 30 50 (Pubitemid 46659918)
    • (2007) Chemico-Biological Interactions , vol.168 , Issue.1 , pp. 30-50
    • Gomez-Lechon, M.J.1    Castell, J.V.2    Donato, M.T.3
  • 23
    • 0031171612 scopus 로고    scopus 로고
    • Time-dependent expression of cytochrome P450 genes in primary cultures of well-differentiated human hepatocytes
    • J. George, B. Goodwin, C. Liddle, M. Tapner, and G.C. Farrell Time-dependent expression of cytochrome P450 genes in primary cultures of well-differentiated human hepatocytes Journal of Laboratory and Clinical Medicine 129 6 1997 638 648 (Pubitemid 27288667)
    • (1997) Journal of Laboratory and Clinical Medicine , vol.129 , Issue.6 , pp. 638-648
    • George, J.1    Goodwin, B.2    Liddle, C.3    Tapner, M.4    Farrell, G.C.5
  • 24
    • 77950020144 scopus 로고    scopus 로고
    • Stem cell-derived hepatocytes and their use in toxicology
    • C. Guguen-Guillouzo, A. Corlu, and A. Guillouzo Stem cell-derived hepatocytes and their use in toxicology Toxicology 270 2010 3 9
    • (2010) Toxicology , vol.270 , pp. 3-9
    • Guguen-Guillouzo, C.1    Corlu, A.2    Guillouzo, A.3
  • 25
    • 0242668517 scopus 로고
    • Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug
    • DOI 10.1073/pnas.84.2.551
    • P.H. Beaune, P.M. Dansette, D. Mansuy, L. Kiffel, M. Finck, and C. Amar Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug Proceedings of the National Academy of Sciences of the United States of America 84 2 1987 551 555 (Pubitemid 17006233)
    • (1987) Proceedings of the National Academy of Sciences of the United States of America , vol.84 , Issue.2 , pp. 551-555
    • Beaune, Ph.1    Dansette, P.M.2    Mansuy, D.3
  • 29
    • 0043027091 scopus 로고    scopus 로고
    • A transgenic mouse model with a luciferase reporter for studying in vivo transcriptional regulation of the human CYP3A4 gene
    • DOI 10.1124/dmd.31.8.1054
    • W. Zhang, A.F. Purchio, K. Chen, J. Wu, L. Lu, and R. Coffee A transgenic mouse model with a luciferase reporter for studying in vivo transcriptional regulation of the human CYP3A4 gene Drug Metabolism and Disposition 31 8 2003 1054 1064 (Pubitemid 36975677)
    • (2003) Drug Metabolism and Disposition , vol.31 , Issue.8 , pp. 1054-1064
    • Zhang, W.1    Purchio, A.F.2    Chen, K.3    Wu, J.4    Lu, L.5    Coffee, R.6    Contag, P.R.7    West, D.B.8
  • 34
    • 77954290036 scopus 로고    scopus 로고
    • Assessment of chimeric mice with humanized liver as a tool for prediciting circulating human metabolites
    • H. Kamimura, N. Nakada, K. Suzuki, A. Mera, K. Souda, and Y. Murakami Assessment of chimeric mice with humanized liver as a tool for prediciting circulating human metabolites Drug Metabolism and Pharmacokinetics 25 3 2010 223 235
    • (2010) Drug Metabolism and Pharmacokinetics , vol.25 , Issue.3 , pp. 223-235
    • Kamimura, H.1    Nakada, N.2    Suzuki, K.3    Mera, A.4    Souda, K.5    Murakami, Y.6
  • 35
    • 78049374383 scopus 로고    scopus 로고
    • Chimeric mice with humanized liver: Tools for the study of drug metabolism, excretion, and toxicity
    • P. Maurel, 1st ed. Humana Press New York
    • S.C. Strom, J. Davila, and M. Grompe Chimeric mice with humanized liver: tools for the study of drug metabolism, excretion, and toxicity P. Maurel, Hepatocytes, methods in molecular biology 1st ed. 2010 Humana Press New York
    • (2010) Hepatocytes, Methods in Molecular Biology
    • Strom, S.C.1    Davila, J.2    Grompe, M.3
  • 36
    • 77950438544 scopus 로고    scopus 로고
    • Microfluidic cell culture systems for drug research
    • M-H. Wu, S-B. Huang, and G-B. Lee Microfluidic cell culture systems for drug research Lab on a Chip 10 2010 939 956
    • (2010) Lab on A Chip , vol.10 , pp. 939-956
    • Wu, M.-H.1    Huang, S.-B.2    Lee, G.-B.3
  • 37
    • 62749110786 scopus 로고    scopus 로고
    • Characterization of drug metabolites and cytotoxicity assay simultaneously using an integrated microfuidic device
    • B. Ma, G. Zhang, J. Qin, and B. Lin Characterization of drug metabolites and cytotoxicity assay simultaneously using an integrated microfuidic device Lab on a Chip 9 2009 232 238
    • (2009) Lab on A Chip , vol.9 , pp. 232-238
    • Ma, B.1    Zhang, G.2    Qin, J.3    Lin, B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.