Modulatory efficacy of hesperetin (citrus flavanone) on xenobiotic-metabolizing enzymes during 1,2-dimethylhydrazine-induced colon carcinogenesis

Chemico-Biological Interactions

Volumn 180, Issue 2, 2009, Pages 254-261

  Aranganathan, S ^a   Panneer Selvam, J ^a   Sangeetha, N ^a   Nalini, N ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Aberrant crypt foci; Dimethylhydrazine; Hesperetin; Xenobiotics

Indexed keywords

1,2 DIMETHYLHYDRAZINE; CYTOCHROME B5; CYTOCHROME B5 REDUCTASE; CYTOCHROME P450; CYTOCHROME P450 2E1; GLUTATHIONE TRANSFERASE; HESPERETIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; COLON CANCER; COLON MUCOSA; CONTROLLED STUDY; DRUG EFFICACY; DYSPLASIA; ENZYME ACTIVITY; ENZYME REGULATION; INTESTINE CRYPT; LIVER; MALE; NONHUMAN; RAT; SUPPLEMENTATION;

1,2-DIMETHYLHYDRAZINE; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARCINOGENS; CITRUS; COLON; COLONIC NEOPLASMS; HESPERIDIN; MALE; RATS;

CITRUS; RATTUS; RATTUS NORVEGICUS;

EID: 67349197661     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2009.03.005     Document Type: Article

References (46)

1. Jemal A., Murray T., Ward E., Samuels A., Tiwari R.C., Ghafoor A., Feuer E.J., and Thun M.J. Cancer statistics. CA Cancer J. Clin. 55 (2005) 10-30
2. Fodde R., Smits R., and Clevers H. APC, signal transduction and genetic instability in colorectal cancer. Nat. Rev. Cancer 1 (2001) 55-67
3. Srikhande S.V., Saoji R.R., Barreto S.G., Kakade A.C., Waterford S.D., Ahire S.B., Goliwale F.M., and Shykla P.J. Outcomes of resection for rectal cancer in India: the impact of the double stapling technique. World J. Surg. Oncol. 5 (2007) 35-40
4. Giovannucci E. Modifiable risk factors for colon cancer. Gastroenterol. Clin. North Am. 31 (2002) 925-943
5. Teny P., Giovannucci F., Michela K.B., Bergkvist L., Hansen H., Holmberg L., and Wolk A. Fruit, vegetables, dietary fiber and risk of colorectal cancer. J. Natl. Cancer Inst. 93 (2001) 525-533
6. Cho K.R., and Vogelstein B. Genetic alterations in the adenoma carcinoma sequence. Cancer 70 (1992) 1727-1731
7. Harbach P.R., and Swenberg J.A. Effects of selenium on 1,2-dimethylhydrazine metabolism and DNA alkylation. Carcinogenesis 2 (1981) 575-580
8. Tanaka T., Kawabata K., Kakumoto K., Makita H., Matsunaga K., Mori H., Satoh K., Hara A., Murakami A., Koshimizu K., and Ohigashi H. Chemoprevention of azoxymethane-induced rat colon carcinogenesis by a xanthine oxidase inhibitor, 1-acatoxychavicol acetate. Jpn. J. Cancer Res. 88 (1997) 821-830
9. Steinkellner H., Rabot S., Freywald C., Nobis E., Scharf G., Chabicousky M., Knasmuller S., and Kassie F. Effects of cruciferous vegetables and their constituents on drug metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens. Mutat. Res. 480 (2001) 285-297
10. Rodrigues M.A.M., Silva L.A.G., Salvadori D.M.F., de Camargo J.L.V., and Montenegro M.R. Aberrant crypt foci and colon cancer: comparison between a short- and medium-term bioassay for colon carcinogenesis using dimethylhydrazine in Wistar rats. Brazilian J. Med. Biol. Res. 35 (2002) 351-355
11. Chen C., and Lai M.D. Aberrant crypt foci as microscopic precancerous of colorectal cancer. World J. Gastroenterol. 9 (2003) 2642-2649
12. Roncucci L., Pedroni M., Vaccina F., Benatti P., Marzona L., and Pol A.D. Aberrant crypt foci in colorectal carcinogenesis. Cell and crypt dynamics. Cell Prolifer. 33 (2003) 1-8
13. Kohno H., Yamaguch K., Taima M., and Tanaka T. Prevention of colonic aberrant crypt foci by dietary feeding of chalcone and 2-hydroxy chalocone in male F344 rats. J. Toxicol. Pathol. 15 (2002) 137-143
14. Singh R.P., Banerjee S., Kumar P.V.S., Raversha K.A., and Rao A.R. Tinospora cardifolia induces enzymes of carcinogen/drug metabolism and antioxidant system, and inhibit lipid peroxidation in mice. Phytomedicine 13 (2006) 74-84
15. Choi G.S., Lee S., Jeong T.S., Lee M.K., Lee J.S., Jung U.J., Kim H.J., Park Y.B., Bok S.H., and Choi M.S. Evaluation of hesperetin 7-O-lauryl ether as lipid lowering agent in high-cholesterol fed rats. Bioorg. Med. Chem. 12 (2004) 3599-3605
16. Cai Y.Z., Luo Q., Sun M., and Corke H. Antioxidant activity and phenolic compounds of 112 traditional. Life Sci. 74 (2004) 2157-2184
17. Kim J.Y., Jung K.J., Choi J.S., and Chung H.Y. Modulation of the age-related nuclear factor-κB (NF-κB) pathway by hesperetin. Ageing Cell 5 (2006) 401-411
18. Omura T., and Sato R. The carbon monoxide binding pigment of the liver. J. Biol Chem. 239 (1964) 2370-2378
19. Omura T., and Takasue S. A new method for simultaneous purification of cytochrome b5 and NADPH-cytochrome c reductase from rat liver microsomes. J. Biochem. 67 (1970) 249-257
20. Watt K.C., Plopper C.G., and Buckpitt A.R. Measurement of cytochrome P450 2E1 activity in rat tracheobronchial airways using high-performance liquid chromatography with electrochemical detection. Anal. Biochem. 248 (1997) 26-30
21. Mihara K., and Sato R. Partial purification of cytochrome b5 reductase from rabbit liver microsomes with detergent and its properties. J. Biochem. 71 (1972) 725-735
22. Ernster L., Danielson L., and Ljunggren M. DT-diaphorse purification from the soluble fraction of at liver cytoplasm. Biochem. Biophys. Acta 582 (1979) 67-78
23. Habig W.H., Pabst M.J., and Jokoby W.B. Glutathione S-transferases-the first step in mercapturic acid formation. J. Biol Chem. 249 (1974) 7130-7139
24. Bird R.P. Role of ACF in understanding the pathogenesis of colon cancer. Cancer Lett. 93 (1995) 55-71
25. Yagi K. Lipid peroxides and human disease. Chem. Phys. Lipids 337 (1978) 51
26. Donnan S.K. The thiobarbituricacid test applied to tissues from rats treated in various ways. J. Biol. Chem. 182 (1950) 415-419
27. Rao K.S., and Recknagel R.O. Early onset of lipid peroxidation in rat liver after carbon tetrachloride administration. Exp. Mol. Pathol. 9 (1968) 271-278
28. Jiang Z.Y., Hunt J.V., and Wolf S.P. Detection of lipid hydroperoxides using Fox method. Anal. Biochem. 202 (1992) 384-389
29. Sinha K.A. Colorimetric assay of catalase. Anal. Biochem. 47 (1972) 389-394
30. Kakkar P.S., Das B., and Viswanathan P.N. A modified spectrophotometric assay of superoxide dismutase. Indian J. Biochem. Biophys. 21 (1984) 130-132
31. Aranganathan S., Panneer Selvam J., and Nalini N. Hesperetin exerts dose dependent chemopreventive effect against 1,2-dimethylhydrazine induced rat colon carcinogenesis. Invest. New Drugs 27 (2008) 203-213
32. Manju V., and Nalini N. Chemopreventive efficacy of ginger, a naturally occurring anticarcinogen during the initiation, post-initiation stages of 1,2 dimethylhydrazine-induced colon cancer. Clin. Chem. Acta 358 (2005) 60-67
33. Pollard S.E., Whiteman M., and Spencer J.P. Modulation of peroxynitrite-induced fibroblast injury by hesperetin: a role for intracellular scavenging and modulation of ERK signaling. Biochem. Biophys. Res. Commun. 347 (2006) 916-923
34. Scott M.D., Lubin B.H., Linzuo F.A., and Kuypers. Erythrocyte defense against hydrogen peroxide, preeminent importance of catalase. J. Lab. Clin. Med. 118 (1991) 7-16
35. Lee S.M., and Lee W.K. Inhibitory effects of lactic acid bacteria (LAB) on the azooxymethane-induced colonic preneoplastic lesion. J. Microbiol. 38 (2000) 169-175
36. Mori M., Hata K., Yamada Y., Kuno T., and Hara A. Significance and role of early-lesions in experimental colorectal carcinogenesis. Chemico-Biol. Interact. 155 (2005) 1-9
37. Agner D., Bazo A.P., Riberio L.R., and Salvadori M.F.D. DNA damage and aberrant crypt foci as putative biomarker to evaluate the chemopreventive effect of annatto (Bixa orellana L.) in rat colon carcinogenesis. Mutat. Res. 582 (2005) 146-154
38. Baijal P.K., Fitzpatrick D.W., and Bird R.P. Phenobarbital and 3-methylcholanthrene treatment alters phase I and II enzymes and the sensitivity of the rat colon to the carcinogenic activity of azoxymethane. Food Chem. Toxicol. 35 (1997) 789-798
39. Sohn O.S., Ishizaki H., Yang C.S., and Fiala E.S. Metabolism of azoxymethane, methazoxymethanol and N-nitrosodimethylamine by cytochrome P450IIEI. Carcinogenesis 12 (1991) 127-131
40. Nebert D.W., and Russele D.E. Clinical importance of the cytochrome P450. Lancet 360 (2002) 1155-1162
41. Shen S.C., Lin C.W., Lee H.M., Chien L.L., and Chen Y.C. Lipopolysaccharide plus 12-o-tetradecanoylphorbol 13-acetate induction of migration and invasion of glioma cells in vitro and in vivo: differential inhibitory effects of flavonoids. Neuroscience 140 (2006) 477-489
42. Dasgupta R.K., Adamson P.J., Davies F.E., Rollinson S., Roddam P.L., et al. Polymorphic variation in GSTP1 modulates outcome following therapy for multiple myeloma. Blood 102 (2003) 2345-2350
43. Flora S.D., and Ramel C. Mechanisms of inhibitors of mutagenesis and carcinogenesis. Classification and overview. Mutat. Res. 202 (1998) 285-306
44. Yannai S., Day A.J., Williamson G., and Rhodes M.J. Characterization of flavonoids as monofunctional or bifunctional inducers of quinone reductase in murine hepatoma cell lines. Food. Chem. Toxicol. 36 (1998) 623-630
45. Helsby N., Williams J., Kerr D., Gescher A., and Chipman J. The isoflavones equol and genistein do not induce xenobiotic metabolizing enzymes in mouse and in human cells. Xenobiotics 27 (1997) 587-596
46. Tanaka T., Kawabata K., Kakumoto M., et al. Citrus auraptene exerts dose-dependent chemopreventive activity in rat large bowel tumourogensis: the inhibition correlates with suppression of cell proliferation and lipid peroxidation and with induction of phase II drug metabolizing enzymes. Cancer Res. 58 (1998) 2550-2556