CTF/NF1 transcription factors act as potent genetic insulators for integrating gene transfer vectors

Gene Therapy

Volumn 19, Issue 1, 2012, Pages 15-24

  Gaussin, A ^a,b   Modlich, U ^c   Bauche, C ^d   Niederlander N J ^a   Schambach, A ^c   Duros, C ^d   Artus, A ^d   Baum, C ^c   Cohen Haguenauer, O ^d,e   Mermod, N ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b EPFL   (Switzerland)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d Ecole Normale Superieure de Cachan   (France)

^e UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

CTCF; CTF NF1; genome integration; genotoxicity; insulators; oncogene

Indexed keywords

NUCLEAR FACTOR I; RETROVIRUS VECTOR; TRANSCRIPTION FACTOR CTCF;

ARTICLE; BINDING SITE; BONE MARROW CELL; CELL EXPANSION; CELL IMMORTALIZATION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE TRANSFER; GENE VECTOR; GENETIC VARIABILITY; GENOTOXICITY; HUMAN; HUMAN CELL; INSULATOR ELEMENT; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

ANIMALS; BINDING SITES; BONE MARROW CELLS; DNA-BINDING PROTEINS; ENHANCER ELEMENTS, GENETIC; FRIEND MURINE LEUKEMIA VIRUS; GENE SILENCING; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HELA CELLS; HUMANS; INSULATOR ELEMENTS; MICE; MICE, INBRED C57BL; NFI TRANSCRIPTION FACTORS; PLASMIDS; PROTO-ONCOGENES; REPRESSOR PROTEINS; RNA, SMALL INTERFERING; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION; TRANSGENES; VIRUS INTEGRATION;

EID: 84855465127     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2011.70     Document Type: Article

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