A high throughput in vitro mrp2 assay to predict in vivo biliary excretion

Xenobiotica

Volumn 42, Issue 2, 2012, Pages 157-163

  Colombo, Federico ^a   Armstrong, Catherine ^a   Duan, Jianmin ^a   Rioux, Nathalie ^a  

^a BOEHRINGER INGELHEIM CANADA LTD   (Canada)

Author keywords

Biliary excretion; Drugdrug interaction; MRP2; Rats

Indexed keywords

5(6) CARBOXY 2',7' DICHLOROFLUORESCEIN; BENZBROMARONE; CYCLOSPORIN A; DIGOXIN; FLUORESCEIN DERIVATIVE; MULTIDRUG RESISTANCE PROTEIN 2; TAUROCHOLIC ACID; UNCLASSIFIED DRUG; VERLUKAST;

ANIMAL EXPERIMENT; ARTICLE; BILIARY EXCRETION; DRUG UPTAKE; HIGH THROUGHPUT SCREENING; IC 50; IN VIVO STUDY; MALE; MEMBRANE VESICLE; NONHUMAN; PROTEIN DETERMINATION; RAT;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BENZBROMARONE; BILE CANALICULI; BILIARY TRACT; BIOLOGICAL TRANSPORT; CYCLOSPORINE; DIGOXIN; DRUG EVALUATION, PRECLINICAL; DRUG INTERACTIONS; FLUORESCEINS; HIGH-THROUGHPUT SCREENING ASSAYS; METABOLIC CLEARANCE RATE; PROPIONATES; QUINOLINES; RATS; TAUROCHOLIC ACID; TRANSPORT VESICLES;

RATTUS;

EID: 84855445008     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2011.614021     Document Type: Article

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