Pharmacokinetics and disposition of rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, in rat

Xenobiotica

Volumn 32, Issue 8, 2002, Pages 715-727

  Nezasa, K ^a   Takao, A ^b   Kimura, K ^b   Takaichi, M ^b   Inazawa, K ^a   Koike, M ^a  

^a SHIONOGI AND CO LTD   (Japan)

^b DAIICHI PURE CHEMICALS CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ROSUVASTATIN;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; AUTORADIOGRAPHY; BILE; BILE DUCT; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG DISTRIBUTION; FEMALE; ISOTOPE LABELING; MALE; NONHUMAN; RADIATION DOSE; RADIOACTIVITY; RAT; URINE;

ANIMALS; AREA UNDER CURVE; BILE; CARBON RADIOISOTOPES; FEMALE; FLUOROBENZENES; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MODELS, CHEMICAL; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; SULFONAMIDES; TIME FACTORS; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 0036690999     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/00498250210144820     Document Type: Article

References (15)

1. The interaction of diltiazem with lovastatin and pravastatin
2. HMG-CoA reductase inhibitors: Assessing differences in drug interactions and safety profiles
3. Carrier-mediated uptake of cerivastatin in primary cultured rat hepatocyres
4. Effect of itraconazole on the pharmacokinetics of atorvastatin
5. Tissue selectivity of pravastatin sodium, lovastain and simvastatin
6. Disposition and metabolism of pravastatin sodium in rats, dogs and monkeys
7. Carrier-mediated uptake of pravastatin by rat hepatocytes in primary culture
8. ZD4522 - An HMG-CoA reductase inhibitor free of metabolically mediated drug interactions: Metabolic studies in human in vitro systems
9. Preclinical and clinical pharmacology of rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor
10. Increase in cerivastatin systemic exposure after single and multiple dosing in cyclosporine-treated kidney transplant recipients
11. Cellular uptake of fluvastatin, an inhibitor of HMG-CoA reductase, by rat cultured hepatocytes and human aortic endothelial cells
12. Statin therapy and reductions in low-density lipoprotein cholesterol: Initial clinical data on the potent new statin rosuvastatin
13. Tissue selectivity of hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors
14. Disposition of fluvastatin, an inhibitor of HMG-CoA reductase, in mouse, rat, dog, and monkey
15. Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors