Disturbed copper bioavailability in Alzheimer's disease

International Journal of Alzheimer's Disease

Volumn , Issue , 2011, Pages

  Kaden, Daniela ^a   Bush, Ashley I ^b   Danzeisen, Ruth ^c   Bayer, Thomas A ^d   Multhaup, Gerd ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c Pipe and Fittings   (United States)

^d UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

8 QUINOLINOL DERIVATIVE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; CERULOPLASMIN; CHELATING AGENT; CLIOQUINOL; COPPER; IONOPHORE; NANOCARRIER; PLACEBO; TAU PROTEIN;

ALZHEIMER DISEASE; CELL METABOLISM; CHELATION THERAPY; COPPER BLOOD LEVEL; COPPER DEFICIENCY; DRUG BIOAVAILABILITY; HOMEOSTASIS; HUMAN; MINI MENTAL STATE EXAMINATION; NONHUMAN; PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK FACTOR; WILSON DISEASE;

EID: 84855281806     PISSN: None     EISSN: 20900252     Source Type: Journal    
DOI: 10.4061/2011/345614     Document Type: Review

References (54)

1. Lutsenko S., Human copper homeostasis: a network of interconnected pathways Current Opinion in Chemical Biology 2010 14 2 211 217
2. Harvey L. J., McArdle H. J., Biomarkers of copper status: a brief update British Journal of Nutrition 2008 99 supplement 3 S10 S13 (Pubitemid 351936561)
3. Treiber C., Simons A., Strauss M., Hafner M., Cappai R., Bayer T. A., Multhaup G., Clioquinol mediates copper uptake and counteracts copper efflux activities of the amyloid precursor protein of Alzheimer's disease Journal of Biological Chemistry 2004 279 50 51958 51964 (Pubitemid 39656565)
4. Bush A. I., Multhaup G., Moir R. D., Williamson T. G., Small D. H., Rumble B., Pollwein P., Beyreuther K., Masters C. L., A novel zinc(II) binding site modulates the function of the A4 amyloid protein precursor of Alzheimer's disease Journal of Biological Chemistry 1993 268 22 16109 16112 (Pubitemid 23229904)
5. Hesse L., Beher D., Masters C. L., Multhaup G., The A4 amyloid precursor protein binding to copper FEBS Letters 1994 349 1 109 116
6. Multhaup G., Schlicksupp A., Hesse L., Beher D., Ruppert T., Masters C. L., Beyreuther K., The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I) Science 1996 271 5254 1406 1409 (Pubitemid 26089474)
7. Multhaup G., Ruppert T., Schlicksupp A., Hesse L., Bill E., Pipkorn R., Masters C. L., Beyreuther K., Copper-binding amyloid precursor protein undergoes a site-specific fragmentation in the reduction of hydrogen peroxide Biochemistry 1998 37 20 7224 7230 (Pubitemid 28235203)
8. Acevedo K. M., Hung Y. H., Dalziel A. H., Li Q. -X., Laughton K., Wikhe K., Rembach A., Roberts B., Masters C. L., Bush A. I., Camakaris J., Copper promotes the trafficking of the amyloid precursor protein Journal of Biological Chemistry 2011 286 10 8252 8262
9. Hung Y. H., Robb E. L., Voltakis I., Ho M., Evin G., Li Q. X., Culvenor J. G., Masters C. L., Cherny R. A., Bush A. I., Paradoxical condensation of copper with elevated -amyloid in lipid rafts under cellular copper deficiency conditions. Implications for Alzheimer disease Journal of Biological Chemistry 2009 284 33 21899 21907
10. Angeletti B., Waldron K. J., Freeman K. B., Bawagan H., Hussain I., Miller C. C. J., Lau K. F., Tennan M. E., Dennison C., Robinson N. J., Dingwall C., BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper Journal of Biological Chemistry 2005 280 18 17930 17937 (Pubitemid 41389034)
11. Atwood C. S., Huang X., Moir R. D., Tanzi R. E., Bush A. I., Role of free radicals and metal ions in the pathogenesis of Alzheimer's disease Metal ions in Biological Systems 1999 36 309 364
12. Clements A., Allsop D., Walsh D. M., Williams C. H., Aggregation and metal-binding properties of mutant forms of the amyloid A peptide of Alzheimer's disease Journal of Neurochemistry 1996 66 2 740 747 (Pubitemid 26036705)
13. Dong J., Atwood C. S., Anderson V. E., Siedlak S. L., Smith M. A., Perry G., Carey P. R., Metal binding and oxidation of amyloid- within isolated senile plaque cores: raman microscopic evidence Biochemistry 2003 42 10 2768 2773 (Pubitemid 36331519)
14. Lovell M. A., Robertson J. D., Teesdale W. J., Campbell J. L., Markesbery W. R., Copper, iron and zinc in Alzheimer's disease senile plaques Journal of the Neurological Sciences 1998 158 1 47 52 (Pubitemid 28277534)
15. Bush A. I., Pettingell W. H., Multhaup G., Paradis D. M., Vonsattel J. P., Gusella J. F., Beyreuther K., Masters C. L., Tanzi R. E., Rapid induction of Alzheimer A amyloid formation by zinc Science 1994 265 5177 1464 1467 (Pubitemid 24306803)
16. Walsh D. M., Klyubin I., Fadeeva J. V., Cullen W. K., Anwyl R., Wolfe M. S., Rowan M. J., Selkoe D. J., Naturally secreted oligomers of amyloid protein potently inhibit hippocampal long-term potentiation in vivo Nature 2002 416 6880 535 539 (Pubitemid 34288854)
17. Harmeier A., Wozny C., Rost B. R., Munter L. M., Hua H., Georgiev O., Beyermann M., Hildebrand P. W., Weise C., Schaffner W., Schmitz D., Multhaup G., Role of amyloid- glycine 33 in oligomerization, toxicity, and neuronal plasticity Journal of Neuroscience 2009 29 23 7582 7590
18. Jin M., Shepardson N., Yang T., Chen G., Walsh D., Selkoe D. J., Soluble amyloid -protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration Proceedings of the National Academy of Sciences of the United States of America 2011 108 14 5819 5824
19. Zhou L. X., Du J. T., Zeng Z. Y., Wu W. H., Zhao Y. F., Kanazawa K., Ishizuka Y., Nemoto T., Nakanishi H., Li Y. M., Copper (II) modulates in vitro aggregation of a tau peptide Peptides 2007 28 11 2229 2234 (Pubitemid 47600415)
20. Soragni A., Zambelli B., Mukrasch M. D., Biernat J., Jeganathan S., Griesinger C., Ciurli S., Mandelkow E., Zweckstetter M., Structural characterization of binding of Cu(II) to Tau protein Biochemistry 2008 47 41 10841 10851
21. Huang X., Atwood C. S., Hartshorn M. A., Multhaup G., Goldstein L. E., Scarpa R. C., Cuajungco M. P., Gray D. N., Lim J., Moir R. D., Tanzi R. E., Bush A. I., The A peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction Biochemistry 1999 38 24 7609 7616 (Pubitemid 29289332)
22. Innocenti M., Salvietti E., Guidotti M., Casini A., Bellandi S., Foresti M. L., Gabbiani C., Pozzi A., Zatta P., Messori L., Trace copper(II) or zinc(II) ions drastically modify the aggregation behavior of Amyloid- 1-42: an AFM study Journal of Alzheimer's Disease 2010 19 4 1323 1329
23. Bolognin S., Messori L., Drago D., Gabbiani C., Cendron L., Zatta P., Aluminum, copper, iron and zinc differentially alter amyloid-A 142 aggregation and toxicity International Journal of Biochemistry and Cell Biology 2011 43 6 877 885
24. Maynard C. J., Cappai R., Volitakis I., Cherny R. A., White A. R., Beyreuther K., Masters C. L., Bush A. I., Li Q. X., Overexpression of Alzheimer's disease amyloid- opposes the age-dependent elevations of brain copper and iron Journal of Biological Chemistry 2002 277 47 44670 44676 (Pubitemid 36159056)
25. White A. R., Reyes R., Mercer J. F. B., Camakaris J., Zheng H., Bush A. I., Multhaup G., Beyreuther K., Masters C. L., Cappai R., Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice Brain Research 1999 842 2 439 444 (Pubitemid 29475178)
26. Bayer T. A., Schfer S., Simons A., Kemmling A., Kamer T., Tepest R., Eckert A., Schssel K., Eikenberg O., Sturchler-Pierrat C., Abramowski D., Staufenbiel M., Multhaup G., Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid A production in APP23 transgenic mice Proceedings of the National Academy of Sciences of the United States of America 2003 100 2 14187 14192 (Pubitemid 37499212)
27. Cherny R. A., Atwood C. S., Xilinas M. E., Gray D. N., Jones W. D., McLean C. A., Barnham K. J., Volitakis I., Fraser F. W., Kim Y. S., Huang X., Goldstein L. E., Moir R. D., Lim J. T., Beyreuther K., Zheng H., Tanzi R. E., Masters C. L., Bush A. I., Treatment with a copper-zinc chelator markedly and rapidly inhibits -amyloid accumulation in Alzheimer's disease transgenic mice Neuron 2001 30 3 665 676 (Pubitemid 32607332)
28. Adlard P. A., Cherny R. A., Finkelstein D. I., Gautier E., Robb E., Cortes M., Volitakis I., Liu X., Smith J. P., Perez K., Laughton K., Li Q. X., Charman S. A., Nicolazzo J. A., Wilkins S., Deleva K., Lynch T., Kok G., Ritchie C. W., Tanzi R. E., Cappai R., Masters C. L., Barnham K. J., Bush A. I., Rapid restoration of cognition in Alzheimer's transgenic mice with 8-Hydroxy quinoline analogs is associated with decreased interstitial A Neuron 2008 59 1 43 55 (Pubitemid 351905863)
29. Faux N. G., Ritchie C. W., Gunn A., Rembach A., Tsatsanis A., Bedo J., Harrison J., Lannfelt L., Blennow K., Zetterberg H., Ingelsson M., Masters C. L., Tanzi R. E., Cummings J. L., Herd C. M., Bush A. I., PBT2 rapidly improves cognition in alzheimer's disease: additional phase II analyses Journal of Alzheimer's Disease 2010 20 2 509 516
30. Adlard P. A., Bica L., White A. R., Nurjono M., Filiz G., Crouch P. J., Donnelly P. S., Cappai R., Finkelstein D. I., Bush A. I., Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease PLoS One 2011 6 3
31. Schfer S., Pajonk F. G., Multhaup G., Bayer T. A., Copper and clioquinol treatment in young APP transgenic and wild-type mice: effects on life expectancy, body weight, and metal-ion levels Journal of Molecular Medicine 2007 85 4 405 413 (Pubitemid 46452257)
32. Sparks D. L., Schreurs B. G., Trace amounts of copper in water induce -amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease Proceedings of the National Academy of Sciences of the United States of America 2003 100 19 11065 11069 (Pubitemid 37140153)
33. Sparks D. L., Friedland R., Petanceska S., Schreurs B. G., Shi J., Perry G., Smith M. A., Sharma A., Derosa S., Ziolkowski C., Stankovic G., Trace copper levels in the drinking water, but not zinc or aluminum influence CNS Alzheimer-like pathology Journal of Nutrition, Health and Aging 2006 10 4 247 254 (Pubitemid 44351819)
34. Sparks D. L., Ziolkowski C., Lawmaster T., Martin T., Influence of water quality on cholesterol-induced tau pathology: preliminary data International Journal of Alzheimer's Disease 2011 2011 7
35. Marquer C., Devauges V., Cossec J. -C., Liot G., Lécart S., Saudou F., Duyckaerts C., Lévque-Fort S., Potier M. -C., Local cholesterol increase triggers amyloid precursor protein-Bace1 clustering in lipid rafts and rapid endocytosis Federation of American Societies for Experimental Biology Journal 2011 25 4 1295 1305
36. Kessler H., Pajonk F. G., Bach D., Schneider-Axmann T., Falkai P., Herrmann W., Multhaup G., Wiltfang J., Schfer S., Wirths O., Bayer T. A., Effect of copper intake on CSF parameters in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial Journal of Neural Transmission 2008 115 12 1651 1659
37. Kessler H., Bayer T. A., Bach D., Schneider-Axmann T., Supprian T., Herrmann W., Haber M., Multhaup G., Falkai P., Pajonk F. G., Intake of copper has no effect on cognition in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial Journal of Neural Transmission 2008 115 8 1181 1187
38. Kessler H., Pajonk F. G., Meisser P., Schneider-Axmann T., Hoffmann K. H., Supprian T., Herrmann W., Obeid R., Multhaup G., Falkai P., Bayer T. A., Cerebrospinal fluid diagnostic markers correlate with lower plasma copper and ceruloplasmin in patients with Alzheimer's disease Journal of Neural Transmission 2006 113 11 1763 1769 (Pubitemid 44657672)
39. Pajonk F. G., Kessler H., Supprian T., Hamzei P., Bach D., Schweickhardt J., Herrmann W., Obeid R., Simons A., Falkai P., Multhaup G., Bayer T. A., Cognitive decline correlates with low plasma concentrations of copper in patients with mild to moderate Alzheimer's disease Journal of Alzheimer's Disease 2005 8 1 23 27 (Pubitemid 41267320)
40. Ritchie C. W., Bush A. I., Mackinnon A., Macfarlane S., Mastwyk M., MacGregor L., Kiers L., Cherny R., Li Q. X., Tammer A., Carrington D., Mavros C., Volitakis I., Xilinas M., Ames D., Davis S., Beyreuther K., Tanzi R. E., Masters C. L., Metal-protein attenuation with Iodochlorhydroxyquin (Clioquinol) targeting A amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial Archives of Neurology 2003 60 12 1685 1691 (Pubitemid 37521621)
41. Lannfelt L., Blennow K., Zetterberg H., Batsman S., Ames D., Harrison J., Masters C. L., Targum S., Bush A. I., Murdoch R., Wilson J., Ritchie C. W., Safety, efficacy, and biomarker findings of PBT2 in targeting A as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial The Lancet Neurology 2008 7 9 779 786
42. Squitti R., Lupoi D., Pasqualetti P., Dal Forno G., Vernieri F., Chiovenda P., Rossi L., Cortesi M., Cassetta E., Rossini P. M., Elevation of serum copper levels in Alzheimer's disease Neurology 2002 59 8 1153 1161 (Pubitemid 35192384)
43. Squitti R., Pasqualetti P., Cassetta E., Dal Forno G., Cesaretti S., Pedace F., Finazzi-Agr A., Rossini P. M., Elevation of serum copper levels discriminates Alzheimer's disease from vascular dementia Neurology 2003 60 12 2013 2014 (Pubitemid 36736031)
44. Squitti R., Pasqualetti P., Dal Forno G., Moffa F., Cassetta E., Lupoi D., Vernieri F., Rossi L., Baldassini M., Rossini P. M., Excess of serum copper not related to ceruloplasmin in Alzheimer disease Neurology 2005 64 6 1040 1046 (Pubitemid 40388458)
45. Squitti R., Barbati G., Rossi L., Ventriglia M., Dal Forno G., Cesaretti S., Moffa F., Caridi I., Cassetta E., Pasqualetti P., Calabrese L., Lupoi D., Rossini P. M., Excess of nonceruloplasmin serum copper in AD correlates with MMSE, CSF -amyloid, and h-tau Neurology 2006 67 1 76 82 (Pubitemid 44305465)
46. Arnal N., Cristalli D. O., de Alaniz M. J. T., Marra C. A., Clinical utility of copper, ceruloplasmin, and metallothionein plasma determinations in human neurodegenerative patients and their first-degree relatives Brain Research 2010 1319 C 118 130
47. Brewer G. J., Kanzer S. H., Zimmerman E. A., Celmins D. F., Heckman S. M., Dick R., Copper and ceruloplasmin abnormalities in Alzheimers disease American Journal of Alzheimer's Disease and other Dementias 2010 25 6 490 497
48. Harris Z. L., Durley A. P., Man T. K., Gitlin J. D., Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux Proceedings of the National Academy of Sciences of the United States of America 1999 96 19 10812 10817 (Pubitemid 29442226)
49. Bucossi S., Ventriglia M., Panetta V., Salustri C., Pasqualetti P., Mariani S., Siotto M., Rossini P. M., Squitti R., Copper in alzheimer's disease: a meta-analysis of serum,plasma, and cerebrospinal fluid studies Journal of Alzheimer's Disease 2011 24 1 175 185
50. Cuajungco M. P., Fagét K. Y., Huang X., Tanzi R. E., Bush A. I., Metal chelation as a potential therapy for Alzheimer's disease Annals of the New York Academy of Sciences 2000 920 292 304 (Pubitemid 32056584)
51. Treiber C., Quadir M. A., Voigt P., Radowski M., Xu S., Munter L. M., Bayer T. A., Schaefer M., Haag R., Multhaup G., Cellular copper import by nanocarrier systems, intracellular availability, and effects on amyloid peptide secretion Biochemistry 2009 48 20 4273 4284
52. Borchardt T., Camakaris J., Cappai R., Masters C. L., Beyreuther K., Multhaup G., Copper inhibits -amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion Biochemical Journal 1999 344 2 461 467 (Pubitemid 30011603)
53. Phinney A. L., Drisaldi B., Schmidt S. D., Lugowski S., Coronado V., Liang Y., Horne P., Yang J., Sekoulidis J., Coomaraswamy J., Chishti M. A., Cox D. W., Mathews P. M., Nixon R. A., Carlson G. A., St. George-Hyslop P. P., Westaway D., In vivo reduction of amyloid- by a mutant copper transporter Proceedings of the National Academy of Sciences of the United States of America 2003 100 24 14193 14198 (Pubitemid 37499213)
54. Cater M. A., McInnes K. T., Li Q. X., Volitakis I., Fontaine S. L. A., Mercer J. F. B., Bush A. I., Intracellular copper deficiency increases amyloid- secretion by diverse mechanisms Biochemical Journal 2008 412 1 141 152 (Pubitemid 351678344)