Copper-binding amyloid precursor protein undergoes a site-specific fragmentation in the reduction of hydrogen peroxide

Biochemistry

Volumn 37, Issue 20, 1998, Pages 7224-7230

  Multhaup, Gerd ^a   Ruppert, Thomas ^b   Schlicksupp, Andrea ^a   Hesse, Lars ^a   Bill, Eckhard ^c   Pipkorn, Rüdiger ^d   Masters, Colin L ^e,f   Beyreuther, Konrad ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c MAX PLANCK INSTITUTE FOR CHEMICAL ENERGY CONVERSION   (Germany)

^d GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^e UNIVERSITY OF MELBOURNE   (Australia)

^f FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN;

ALZHEIMER DISEASE; ARTICLE; ENZYME ACTIVE SITE; METAL BINDING; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PEROXIDATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; CHELATING AGENTS; COPPER; CYSTINE; DIMETHYL SULFOXIDE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOPEPTIDASES; FREE RADICAL SCAVENGERS; HUMANS; HYDROGEN PEROXIDE; HYDROLYSIS; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; PENTETIC ACID; PEPTIDE FRAGMENTS; PHENANTHROLINES; PROTEIN BINDING;

EID: 0032546577     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi980022m     Document Type: Article

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