-
1
-
-
0033844944
-
Characterization of copper interactions with alzheimer amyloid beta peptides: Identification of an attomolar-affinity copper binding site on amyloid beta1-42
-
C.S. Atwood, R.C. Scarpa, X. Huang, R.D. Moir, W.D. Jones, D.P. Fairlie, R.E. Tanzi and A.I. Bush, Characterization of copper interactions with alzheimer amyloid beta peptides: identification of an attomolar-affinity copper binding site on amyloid beta1-42, J Neurochem 75 (2000), 1219-1233.
-
(2000)
J Neurochem
, vol.75
, pp. 1219-1233
-
-
Atwood, C.S.1
Scarpa, R.C.2
Huang, X.3
Moir, R.D.4
Jones, W.D.5
Fairlie, D.P.6
Tanzi, R.E.7
Bush, A.I.8
-
2
-
-
0037931743
-
Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis
-
K.J. Barnham, W.J. McKinstry, G. Multhaup, D. Galatis, C.J. Morton, C.C. Curtain, N.A. Williamson, A.R. White, M.G. Hinds, R.S.Norton, K. Beyreuther, C.L. Masters, M.W. Parker and R. Cappai, Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis, J Biol Chem 278 (2003), 17401-17407.
-
(2003)
J Biol Chem
, vol.278
, pp. 17401-17407
-
-
Barnham, K.J.1
McKinstry, W.J.2
Multhaup, G.3
Galatis, D.4
Morton, C.J.5
Curtain, C.C.6
Williamson, N.A.7
White, A.R.8
Hinds, M.G.9
Norton, R.S.10
Beyreuther, K.11
Masters, C.L.12
Parker, M.W.13
Cappai, R.14
-
3
-
-
0042858163
-
Mechanisms of biosynthesis of mammalian copper/zinc superoxide dismutase
-
T.B. Bartnikas and J.D. Gitlin, Mechanisms of biosynthesis of mammalian copper/zinc superoxide dismutase, J Biol Chem 278 (2003), 33602-33608.
-
(2003)
J Biol Chem
, vol.278
, pp. 33602-33608
-
-
Bartnikas, T.B.1
Gitlin, J.D.2
-
4
-
-
0032760270
-
It all sticks together-the APP-related family of proteins and Alzheimer's disease
-
T.A. Bayer, R. Cappai, C.L. Masters, K. Beyreuther and G. Multhaup, It all sticks together-the APP-related family of proteins and Alzheimer's disease, Mol Psychiatry 4 (1999), 524-528.
-
(1999)
Mol Psychiatry
, vol.4
, pp. 524-528
-
-
Bayer, T.A.1
Cappai, R.2
Masters, C.L.3
Beyreuther, K.4
Multhaup, G.5
-
5
-
-
10744226316
-
Dietary Cu stabilizes brain SOD-1 activity and reduces amyoid Aβ production in APP23 transgenic mice
-
T.A. Bayer, S. Schäfer, A. Simons, A. Kemmling, T. Kamer, R. Tepest, A. Eckert, K. Schüssel, O. Eikenberg, C. Sturchler-Pierrat, D. Abramowski, M. Staufenbiel and G. Multhaup, Dietary Cu stabilizes brain SOD-1 activity and reduces amyoid Aβ production in APP23 transgenic mice, PNAS 100 (2003), 14187-14192.
-
(2003)
PNAS
, vol.100
, pp. 14187-14192
-
-
Bayer, T.A.1
Schäfer, S.2
Simons, A.3
Kemmling, A.4
Kamer, T.5
Tepest, R.6
Eckert, A.7
Schüssel, K.8
Eikenberg, O.9
Sturchler-Pierrat, C.10
Abramowski, D.11
Staufenbiel, M.12
Multhaup, G.13
-
6
-
-
0033430087
-
Copper inhibits beta-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion
-
T. Borchardt, J. Camakaris, R. Cappai, C.L. Masters, K. Beyreuther and G. Multhaup, Copper inhibits beta-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion, Biochem J 344 (1999), 461-467.
-
(1999)
Biochem J
, vol.344
, pp. 461-467
-
-
Borchardt, T.1
Camakaris, J.2
Cappai, R.3
Masters, C.L.4
Beyreuther, K.5
Multhaup, G.6
-
7
-
-
0037386086
-
The metallobiology of Alzheimer's disease
-
A.I. Bush, The metallobiology of Alzheimer's disease, Trends Neurosci 26 (2003), 207-214.
-
(2003)
Trends Neurosci
, vol.26
, pp. 207-214
-
-
Bush, A.I.1
-
8
-
-
0034964390
-
Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits beta-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice
-
R.A. Cherny, C.S. Atwood, M.E. Xilinas, D.N. Gray, W.D. Jones, C.A. McLean, K.J. Barnham, I. Volitakis, F.W. Fraser, Y. Kim, X. Huang, L.E. Goldstein, R.D. Moir, J.T. Lim, K. Beyreuther, H. Zheng, R.E. Tanzi, C.L. Masters and A.I. Bush, Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits beta-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice, Neuron 30 (2001), 665-676.
-
(2001)
Neuron
, vol.30
, pp. 665-676
-
-
Cherny, R.A.1
Atwood, C.S.2
Xilinas, M.E.3
Gray, D.N.4
Jones, W.D.5
McLean, C.A.6
Barnham, K.J.7
Volitakis, I.8
Fraser, F.W.9
Kim, Y.10
Huang, X.11
Goldstein, L.E.12
Moir, R.D.13
Lim, J.T.14
Beyreuther, K.15
Zheng, H.16
Tanzi, R.E.17
Masters, C.L.18
Bush, A.I.19
-
9
-
-
0030297178
-
Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer's disease: Possible relation to oxidative stress
-
M.A. Deibel, W.D. Ehmann and W.R. Markesbery, Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer's disease: possible relation to oxidative stress, J Neurol Sci 143 (1996), 137-142.
-
(1996)
J Neurol Sci
, vol.143
, pp. 137-142
-
-
Deibel, M.A.1
Ehmann, W.D.2
Markesbery, W.R.3
-
10
-
-
0028177269
-
The beta A4 amyloid precursor protein binding to copper
-
L. Hesse, D. Beher, C.L. Masters and G. Multhaup, The beta A4 amyloid precursor protein binding to copper, Febs Lett 349 (1994), 109-116.
-
(1994)
Febs Lett
, vol.349
, pp. 109-116
-
-
Hesse, L.1
Beher, D.2
Masters, C.L.3
Multhaup, G.4
-
11
-
-
0037160028
-
Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron
-
C.J. Maynard, R. Cappai, I. Volitakis, R.A. Cherny, A.R. White, K. Beyreuther, C.L. Masters, A.I. Bush and Q.X. Li, Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron, J Biol Chem 277 (2002), 44670-44676.
-
(2002)
J Biol Chem
, vol.277
, pp. 44670-44676
-
-
Maynard, C.J.1
Cappai, R.2
Volitakis, I.3
Cherny, R.A.4
White, A.R.5
Beyreuther, K.6
Masters, C.L.7
Bush, A.I.8
Li, Q.X.9
-
12
-
-
0021271971
-
Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
-
G. McKhann, D. Drachman, M. Folstein, R. Katzman, D. Price and E.M. Stadlan, Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease, Neurology 34 (1984), 939-944.
-
(1984)
Neurology
, vol.34
, pp. 939-944
-
-
McKhann, G.1
Drachman, D.2
Folstein, M.3
Katzman, R.4
Price, D.5
Stadlan, E.M.6
-
13
-
-
0029935396
-
The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I)
-
G. Multhaup, A. Schlicksupp, L. Hesse, D. Beher, T. Ruppert, C.L. Masters and K. Beyreuther, The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I), Science 271 (1996), 1406-1409.
-
(1996)
Science
, vol.271
, pp. 1406-1409
-
-
Multhaup, G.1
Schlicksupp, A.2
Hesse, L.3
Beher, D.4
Ruppert, T.5
Masters, C.L.6
Beyreuther, K.7
-
14
-
-
10744228112
-
In vivo reduction of amyloid Aβ by a mutant copper transporter
-
A.L. Phinney, B.Drisaldi, S. Lugowski, S. Schmidt, H. Bonek, Y. Liang, P. Home, L. Yang, J. Sekoulidis, J. Coomaraswarmy, D. Cox, P.M. Mathews, R.A. Nixon, G.A. Carlson, P. St George-Hyslop and D. Westaway, In vivo reduction of amyloid Aβ by a mutant copper transporter, PNAS 100 (2003), 14193-14198.
-
(2003)
PNAS
, vol.100
, pp. 14193-14198
-
-
Phinney, A.L.1
Drisaldi, B.2
Lugowski, S.3
Schmidt, S.4
Bonek, H.5
Liang, Y.6
Home, P.7
Yang, L.8
Sekoulidis, J.9
Coomaraswarmy, J.10
Cox, D.11
Mathews, P.M.12
Nixon, R.A.13
Carlson, G.A.14
St George-Hyslop, P.15
Westaway, D.16
-
15
-
-
10744224267
-
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: A pilot phase 2 clinical trial
-
C.W. Ritchie, A.I. Bush, A. Mackinnon, S. Macfarlane, M. Mastwyk, L. MacGregor, L. Kiers, R. Cherny, Q.X. Li, A. Tammer, D. Carrington, C. Mavros, I. Volitakis, M. Xilinas, D. Ames, S. Davis, K. Beyreuther, R.E. Tanzi and C.L. Masters, Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial, Arch Neurol 60 (2003), 1685-1691.
-
(2003)
Arch Neurol
, vol.60
, pp. 1685-1691
-
-
Ritchie, C.W.1
Bush, A.I.2
Mackinnon, A.3
Macfarlane, S.4
Mastwyk, M.5
MacGregor, L.6
Kiers, L.7
Cherny, R.8
Li, Q.X.9
Tammer, A.10
Carrington, D.11
Mavros, C.12
Volitakis, I.13
Xilinas, M.14
Ames, D.15
Davis, S.16
Beyreuther, K.17
Tanzi, R.E.18
Masters, C.L.19
-
16
-
-
3042683018
-
Trace elements and cognitive impairment: An elderly cohort study
-
C. Smorgon, E. Mari, A.R. Atti, E. Dalla Nora, P.F. Zamboni, F. Calzoni, A. Passaro and R. Fellin, Trace elements and cognitive impairment: an elderly cohort study, Arch Gerontol Geriatr Suppl (2004), 393-402.
-
(2004)
Arch Gerontol Geriatr Suppl
, pp. 393-402
-
-
Smorgon, C.1
Mari, E.2
Atti, A.R.3
Dalla Nora, E.4
Zamboni, P.F.5
Calzoni, F.6
Passaro, A.7
Fellin, R.8
-
17
-
-
0031847561
-
Copper, ceruloplasmin and superoxide dismutase in patients with Alzheimer's disease. A case-control study
-
J. Snaedal, J. Kristinsson, S. Gunnarsdottir, Olafsdottir, M. Baldvinsson and T. Johannesson, Copper, ceruloplasmin and superoxide dismutase in patients with Alzheimer's disease. A case-control study, Dement Geriatr Cogn Disord 9 (1998), 239-242.
-
(1998)
Dement Geriatr Cogn Disord
, vol.9
, pp. 239-242
-
-
Snaedal, J.1
Kristinsson, J.2
Gunnarsdottir, S.3
Olafsdottir4
Baldvinsson, M.5
Johannesson, T.6
-
18
-
-
2442621522
-
Copper perturbation in 2 monozygotic twins discordant for degree of cognitive impairment
-
R. Squitti, E. Cassetta, G. Dal Forno, D. Lupoi, G. Lippolis, F. Pauri, F. Vernieri, A. Cappa and P.M. Rossini, Copper perturbation in 2 monozygotic twins discordant for degree of cognitive impairment, Arch Neurol 61 (2004), 738-743.
-
(2004)
Arch Neurol
, vol.61
, pp. 738-743
-
-
Squitti, R.1
Cassetta, E.2
Dal Forno, G.3
Lupoi, D.4
Lippolis, G.5
Pauri, F.6
Vernieri, F.7
Cappa, A.8
Rossini, P.M.9
-
19
-
-
0037159210
-
Elevation of serum copper levels in Alzheimer's disease
-
R. Squitti, D. Lupoi, P. Pasqualetti, G. Dal Forno, F. Vernieri, P. Chiovenda, L. Rossi, M. Cortesi, E. Cassetta and P.M. Rossini, Elevation of serum copper levels in Alzheimer's disease, Neurology 59 (2002), 1153-1161.
-
(2002)
Neurology
, vol.59
, pp. 1153-1161
-
-
Squitti, R.1
Lupoi, D.2
Pasqualetti, P.3
Dal Forno, G.4
Vernieri, F.5
Chiovenda, P.6
Rossi, L.7
Cortesi, M.8
Cassetta, E.9
Rossini, P.M.10
-
20
-
-
0037700234
-
Elevation of serum copper levels discriminates Alzheimer's disease from vascular dementia
-
R. Squitti, P. Pasqualetti, E. Cassetta, G. Dal Forno, S. Cesaretti, F. Pedace, A. Finazzi-Agro and P.M. Rossini, Elevation of serum copper levels discriminates Alzheimer's disease from vascular dementia, Neurology 60 (2003), 2013-2014.
-
(2003)
Neurology
, vol.60
, pp. 2013-2014
-
-
Squitti, R.1
Pasqualetti, P.2
Cassetta, E.3
Dal Forno, G.4
Cesaretti, S.5
Pedace, F.6
Finazzi-Agro, A.7
Rossini, P.M.8
-
21
-
-
10644280708
-
Clioquinol Mediates Copper Uptake and Counteracts Copper Efflux Activities of the Amyloid Precursor Protein of Alzheimer's Disease
-
C. Treiber, A. Simons, M. Strauss, M. Hafner, R. Cappai, T.A. Bayer and G. Multhaup, Clioquinol Mediates Copper Uptake and Counteracts Copper Efflux Activities of the Amyloid Precursor Protein of Alzheimer's Disease, J. Biol. Chem. 279 (2004), 51958-51964.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 51958-51964
-
-
Treiber, C.1
Simons, A.2
Strauss, M.3
Hafner, M.4
Cappai, R.5
Bayer, T.A.6
Multhaup, G.7
-
22
-
-
3042847439
-
Long-term high copper intake: Effects on indexes of copper status, antioxidant status, and immune function in young men
-
J.R. Turnlund, R.A. Jacob, C.L. Keen, J.J. Strain, D.S. Kelley, J.M. Domek, W.R. Keyes, J.L. Ensunsa, J. Lykkesfeldt and J. Coulter, Long-term high copper intake: effects on indexes of copper status, antioxidant status, and immune function in young men, Am J Clin Nutr 79 (2004), 1037-1044.
-
(2004)
Am J Clin Nutr
, vol.79
, pp. 1037-1044
-
-
Turnlund, J.R.1
Jacob, R.A.2
Keen, C.L.3
Strain, J.J.4
Kelley, D.S.5
Domek, J.M.6
Keyes, W.R.7
Ensunsa, J.L.8
Lykkesfeldt, J.9
Coulter, J.10
-
23
-
-
0032830357
-
Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice
-
A.R. White, R. Reyes, J.F. Mercer, J. Camakaris, H. Zheng, A.I. Bush, G. Multhaup, K. Beyreuther, C.L. Masters and R. Cappai, Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice, Brain Res 842 (1999), 439-444.
-
(1999)
Brain Res
, vol.842
, pp. 439-444
-
-
White, A.R.1
Reyes, R.2
Mercer, J.F.3
Camakaris, J.4
Zheng, H.5
Bush, A.I.6
Multhaup, G.7
Beyreuther, K.8
Masters, C.L.9
Cappai, R.10
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