메뉴 건너뛰기




Volumn 50, Issue 2, 2012, Pages 373-384

Subchronic toxicity evaluation of potato protein isolates

Author keywords

Chaconine; Solanine; Potato protein; Protease inhibitor; Toxicity; Trypsin inhibitor

Indexed keywords

POTATO PROTEIN; UNCLASSIFIED DRUG; VEGETABLE PROTEIN;

EID: 84855271467     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.09.039     Document Type: Article
Times cited : (9)

References (42)
  • 2
    • 70349897648 scopus 로고    scopus 로고
    • Chemical composition and nutritional value of protein concentrates isolated from potato (Solanum tuberosum L.) fruit juice by precipitation with ethanol or ferric chloride
    • Bártová V., Bárta J. Chemical composition and nutritional value of protein concentrates isolated from potato (Solanum tuberosum L.) fruit juice by precipitation with ethanol or ferric chloride. J. Agric. Food Chem. 2009, 57:9028-9034.
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 9028-9034
    • Bártová, V.1    Bárta, J.2
  • 3
    • 53749099070 scopus 로고    scopus 로고
    • Changes in potassium content of different potato varieties after cooking
    • Burrowes J.D., Ramer N.J. Changes in potassium content of different potato varieties after cooking. J. Ren. Nutr. 2008, 18:530-534.
    • (2008) J. Ren. Nutr. , vol.18 , pp. 530-534
    • Burrowes, J.D.1    Ramer, N.J.2
  • 5
    • 84856216277 scopus 로고    scopus 로고
    • CIP, 2008. International Year of the Potato, Potato World. Centro Internacional de la Papa (CIP), Lima, Peru. Available from:
    • CIP, 2008. International Year of the Potato, Potato World. Centro Internacional de la Papa (CIP), Lima, Peru. Available from: http://www.potato2008.org/en/world/index.html.
  • 7
    • 0035976033 scopus 로고    scopus 로고
    • Characterization of antibody responses induced in rodents by exposure to food proteins: influence of route of exposure
    • Dearman R.J., Caddick H., Stone S., Basketter D.A., Kimber I. Characterization of antibody responses induced in rodents by exposure to food proteins: influence of route of exposure. Toxicology 2001, 167:217-231.
    • (2001) Toxicology , vol.167 , pp. 217-231
    • Dearman, R.J.1    Caddick, H.2    Stone, S.3    Basketter, D.A.4    Kimber, I.5
  • 8
    • 0036227273 scopus 로고    scopus 로고
    • Immunogenic properties of rapidly digested food proteins following gavage exposure of mice: a comparison of ovalbumin with a potato acid phosphatase preparation
    • Dearman R.J., Caddick H., Stone S., Kenna J.G., Basketter D.A., Kimber I. Immunogenic properties of rapidly digested food proteins following gavage exposure of mice: a comparison of ovalbumin with a potato acid phosphatase preparation. Food Chem. Toxicol. 2002, 40:625-633.
    • (2002) Food Chem. Toxicol. , vol.40 , pp. 625-633
    • Dearman, R.J.1    Caddick, H.2    Stone, S.3    Kenna, J.G.4    Basketter, D.A.5    Kimber, I.6
  • 10
    • 84856210853 scopus 로고    scopus 로고
    • DSHEA, 1994. Dietary Supplement Health and Education Act of 1994. U.S. Food and Drug Administration, Washington, DC. Available from:
    • DSHEA, 1994. Dietary Supplement Health and Education Act of 1994. U.S. Food and Drug Administration, Washington, DC. Available from: http://www.fda.gov/opacom/laws/dshea.html.
  • 11
    • 0030777093 scopus 로고    scopus 로고
    • Have you seen this? Inflammatory lesions in the lungs of rats
    • Elwell M.R., Mahler J.F., Rao G.N. Have you seen this? Inflammatory lesions in the lungs of rats. Toxicol. Pathol. 1997, 25:529-531.
    • (1997) Toxicol. Pathol. , vol.25 , pp. 529-531
    • Elwell, M.R.1    Mahler, J.F.2    Rao, G.N.3
  • 12
    • 33751260661 scopus 로고    scopus 로고
    • Potato glycoalkaloids and metabolites: roles in the plant and in the diet
    • Friedman M. Potato glycoalkaloids and metabolites: roles in the plant and in the diet. J. Agric. Food Chem. 2006, 54:8655-8881.
    • (2006) J. Agric. Food Chem. , vol.54 , pp. 8655-8881
    • Friedman, M.1
  • 13
    • 0027722955 scopus 로고
    • Pancreatic enlargement is evident in rats fed diets containing raw soybeans (Glycine max) or cowpeas (Vigna unguiculata) for 800days but not in those fed diets based on kidney beans (Phaseolus vulgaris) or lupinseed (Lupinus angustifolius)
    • Grant G., Dorward P.M., Pusztai A. Pancreatic enlargement is evident in rats fed diets containing raw soybeans (Glycine max) or cowpeas (Vigna unguiculata) for 800days but not in those fed diets based on kidney beans (Phaseolus vulgaris) or lupinseed (Lupinus angustifolius). J. Nutr. 1993, 123:2207-2215.
    • (1993) J. Nutr. , vol.123 , pp. 2207-2215
    • Grant, G.1    Dorward, P.M.2    Pusztai, A.3
  • 15
    • 0022964007 scopus 로고
    • Safety of trypsin inhibitors in the diet: effects on the rat pancreas of long-term feeding of soy flour and soy protein isolate
    • Gumbmann M.R., Spangler W.L., Dugan G.M., Rackis J.J. Safety of trypsin inhibitors in the diet: effects on the rat pancreas of long-term feeding of soy flour and soy protein isolate. Adv. Exp. Med. Biol. 1986, 199:33-79.
    • (1986) Adv. Exp. Med. Biol. , vol.199 , pp. 33-79
    • Gumbmann, M.R.1    Spangler, W.L.2    Dugan, G.M.3    Rackis, J.J.4
  • 16
    • 0024815052 scopus 로고
    • Pancreatic response in rats and mice to trypsin inhibitors from soy and potato after short- and long-term dietary exposure
    • Gumbmann M.R., Dugan G.M., Spangler W.L., Baker E.C., Rackis J.J. Pancreatic response in rats and mice to trypsin inhibitors from soy and potato after short- and long-term dietary exposure. J. Nutr. 1989, 119:1598-1609.
    • (1989) J. Nutr. , vol.119 , pp. 1598-1609
    • Gumbmann, M.R.1    Dugan, G.M.2    Spangler, W.L.3    Baker, E.C.4    Rackis, J.J.5
  • 17
    • 30744431625 scopus 로고    scopus 로고
    • Glycaemic index values for commercially available potatoes in Great Britain
    • Henry C.J., Lightowler H.J., Strik C.M., Storey M. Glycaemic index values for commercially available potatoes in Great Britain. Br. J. Nutr. 2005, 94:917-921.
    • (2005) Br. J. Nutr. , vol.94 , pp. 917-921
    • Henry, C.J.1    Lightowler, H.J.2    Strik, C.M.3    Storey, M.4
  • 18
    • 84856210854 scopus 로고    scopus 로고
    • JECFA, 1993. Toxicological evaluation of certain food additives and naturally occurring toxicants. 39th Meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), Feb. 3-12, 1992. World Health Organization (WHO), Geneva, Switzerland WHO Food Additive Series No. 30. Available from:
    • JECFA, 1993. Toxicological evaluation of certain food additives and naturally occurring toxicants. 39th Meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), Feb. 3-12, 1992. World Health Organization (WHO), Geneva, Switzerland WHO Food Additive Series No. 30. Available from: http://www.inchem.org/documents/jecfa/jecmono/v30je01.htm.
  • 19
    • 0030804462 scopus 로고    scopus 로고
    • Comparative composition of aerial and subterranean potato tubers (Solanum tuberosum)
    • Karim M.S., Percival G.C., Dixon G.R. Comparative composition of aerial and subterranean potato tubers (Solanum tuberosum). J. Sci. Food Agric. 1997, 75:251-257.
    • (1997) J. Sci. Food Agric. , vol.75 , pp. 251-257
    • Karim, M.S.1    Percival, G.C.2    Dixon, G.R.3
  • 21
    • 0346158203 scopus 로고    scopus 로고
    • Antioxidative activity and protective effect against ethanol-induced gastric mucosal damage of a potato protein hydrolysate
    • (As cited in Camire et al., 2009)
    • Kudoh K., Matsumoto M., Onodera S., Takeda Y., Ando K., Shiomi N. Antioxidative activity and protective effect against ethanol-induced gastric mucosal damage of a potato protein hydrolysate. J. Nutr. Sci. Vitaminol. 2003, 49:451-455. (As cited in Camire et al., 2009).
    • (2003) J. Nutr. Sci. Vitaminol. , vol.49 , pp. 451-455
    • Kudoh, K.1    Matsumoto, M.2    Onodera, S.3    Takeda, Y.4    Ando, K.5    Shiomi, N.6
  • 22
    • 38049145913 scopus 로고    scopus 로고
    • Glycaemic and satiating properties of potato products
    • Leeman M., Ostman E., Björck I. Glycaemic and satiating properties of potato products. Eur. J. Clin. Nutr. 2008, 62:87-95.
    • (2008) Eur. J. Clin. Nutr. , vol.62 , pp. 87-95
    • Leeman, M.1    Ostman, E.2    Björck, I.3
  • 23
    • 84985402643 scopus 로고
    • The effect of either raw or boiled liquid extract from potato (Solanum tuberosum) on the digestibility of a diet based on barley in pigs
    • Livingstone R.M., Baird B.A., Atkinson T., Crofts R.M.J. The effect of either raw or boiled liquid extract from potato (Solanum tuberosum) on the digestibility of a diet based on barley in pigs. J. Sci. Food Agric. 1980, 31:695-700.
    • (1980) J. Sci. Food Agric. , vol.31 , pp. 695-700
    • Livingstone, R.M.1    Baird, B.A.2    Atkinson, T.3    Crofts, R.M.J.4
  • 24
    • 0023907044 scopus 로고
    • Molecular characterization of the patatin multigene family of potato
    • Mignery G.A., Pikaard C.S., Park W.D. Molecular characterization of the patatin multigene family of potato. Gene 1988, 62:27-44.
    • (1988) Gene , vol.62 , pp. 27-44
    • Mignery, G.A.1    Pikaard, C.S.2    Park, W.D.3
  • 25
    • 84984526138 scopus 로고
    • Plant inhibitors of proteolytic enzymes
    • Mossor G., Skupin J., Romanowska B. Plant inhibitors of proteolytic enzymes. Nahrung 1984, 28:93-122.
    • (1984) Nahrung , vol.28 , pp. 93-122
    • Mossor, G.1    Skupin, J.2    Romanowska, B.3
  • 26
    • 84856216279 scopus 로고    scopus 로고
    • OECD, 2002. Consensus document on compositional considerations for new varieties of potatoes: key food and feed nutrients, anti-nutrients and toxicants, Organization for Economic Co-operation and Development (OECD), Paris, France. Available from:
    • OECD, 2002. Consensus document on compositional considerations for new varieties of potatoes: key food and feed nutrients, anti-nutrients and toxicants, Organization for Economic Co-operation and Development (OECD), Paris, France. Available from: http://www.oecd.org.
  • 28
    • 51349087938 scopus 로고    scopus 로고
    • Occurrence and physico-chemical properties of protease inhibitors from potato tuber (Solanum tuberosum).
    • Ph. D. Thesis. Wageningen University, Wageningen, The Netherlands. Available from:
    • Pouvreau, L., 2004. Occurrence and physico-chemical properties of protease inhibitors from potato tuber (Solanum tuberosum). Ph. D. Thesis. Wageningen University, Wageningen, The Netherlands. Available from: http://edepot.wur.nl/35450.
    • (2004)
    • Pouvreau, L.1
  • 30
    • 77954942974 scopus 로고    scopus 로고
    • The effect on glucagon, glucagon-like peptide-1, total and acyl-ghrelin of dietary fats ingested with and without potato
    • Radulescu A., Gannon M.C., Nuttall F.Q. The effect on glucagon, glucagon-like peptide-1, total and acyl-ghrelin of dietary fats ingested with and without potato. J. Clin. Endocrinol. Metab. 2010, 95:3385-3391.
    • (2010) J. Clin. Endocrinol. Metab. , vol.95 , pp. 3385-3391
    • Radulescu, A.1    Gannon, M.C.2    Nuttall, F.Q.3
  • 33
    • 0032948251 scopus 로고    scopus 로고
    • Identification of patatin as a novel allergen for children with positive skin prick test responses to raw potato
    • Seppälä U., Alenius H., Turjanmaa K., Reunala T., Palosuo T., Kalkkinen N. Identification of patatin as a novel allergen for children with positive skin prick test responses to raw potato. J. Allergy Clin. Immunol. 1999, 103:165-171.
    • (1999) J. Allergy Clin. Immunol. , vol.103 , pp. 165-171
    • Seppälä, U.1    Alenius, H.2    Turjanmaa, K.3    Reunala, T.4    Palosuo, T.5    Kalkkinen, N.6
  • 34
    • 0034114799 scopus 로고    scopus 로고
    • IgE reactivity to patatin-like latex allergen, Hev b 7, and to patatin of potato tuber, Sol t 1, in adults and children allergic to natural rubber latex
    • Seppälä U., Palosuo T., Seppälä U., Kalkkinen N., Ylitalo L., Reunala T., Turjanmaa K., Reunala T. IgE reactivity to patatin-like latex allergen, Hev b 7, and to patatin of potato tuber, Sol t 1, in adults and children allergic to natural rubber latex. Allergy 2000, 55:266-273.
    • (2000) Allergy , vol.55 , pp. 266-273
    • Seppälä, U.1    Palosuo, T.2    Seppälä, U.3    Kalkkinen, N.4    Ylitalo, L.5    Reunala, T.6    Turjanmaa, K.7    Reunala, T.8
  • 35
    • 51649109469 scopus 로고    scopus 로고
    • LC-MS analysis of solanidane glycoalkaloid diversity among tubers of four wild potato species and three cultivars (Solanum tuberosum)
    • Shakya R., Navarre D.A. LC-MS analysis of solanidane glycoalkaloid diversity among tubers of four wild potato species and three cultivars (Solanum tuberosum). J. Agric. Food Chem. 2008, 56:6949-6958.
    • (2008) J. Agric. Food Chem. , vol.56 , pp. 6949-6958
    • Shakya, R.1    Navarre, D.A.2
  • 36
    • 0041922392 scopus 로고    scopus 로고
    • Tuber storage proteins
    • Shewry P.R. Tuber storage proteins. Ann. Bot. 2003, 91:755-769.
    • (2003) Ann. Bot. , vol.91 , pp. 755-769
    • Shewry, P.R.1
  • 37
    • 77949916603 scopus 로고    scopus 로고
    • Introduction
    • Elsevier Academic Press, Burlington, MA, J. Singh, L. Kaur (Eds.)
    • Singh J., Kaur L. Introduction. Advances in Potato Chemistry and Technology 2009, Elsevier Academic Press, Burlington, MA. J. Singh, L. Kaur (Eds.).
    • (2009) Advances in Potato Chemistry and Technology
    • Singh, J.1    Kaur, L.2
  • 38
    • 0024404991 scopus 로고
    • Hypertrophy and hyperplasia of the rat pancreas produced by short-term dietary administration of soya-derived protein and soybean trypsin inhibitor
    • Smith J.C., Wilson F.D., Allen P.V., Berry D.L. Hypertrophy and hyperplasia of the rat pancreas produced by short-term dietary administration of soya-derived protein and soybean trypsin inhibitor. J. Appl. Toxicol. 1989, 9:175-179.
    • (1989) J. Appl. Toxicol. , vol.9 , pp. 175-179
    • Smith, J.C.1    Wilson, F.D.2    Allen, P.V.3    Berry, D.L.4
  • 40
    • 0020957621 scopus 로고
    • Effects on the monkey, pig and rat pancreas of soy products with varying levels of trypsin inhibitor and comparison with the administration of cholecystokinin
    • Struthers B.J., MacDonald J.R., Dahlgren R.R., Hopkins D.T. Effects on the monkey, pig and rat pancreas of soy products with varying levels of trypsin inhibitor and comparison with the administration of cholecystokinin. J. Nutr. 1983, 113:86-97.
    • (1983) J. Nutr. , vol.113 , pp. 86-97
    • Struthers, B.J.1    MacDonald, J.R.2    Dahlgren, R.R.3    Hopkins, D.T.4
  • 41
    • 84856225457 scopus 로고    scopus 로고
    • U.S. FDA, 2002. Agency Response Letter GRAS Notice No. GRN 000086. U.S. Food and Drug Administration (U.S. FDA), Center for Food Safety & Applied Nutrition (CFSAN), College Park, MD. Available from:
    • U.S. FDA, 2002. Agency Response Letter GRAS Notice No. GRN 000086. U.S. Food and Drug Administration (U.S. FDA), Center for Food Safety & Applied Nutrition (CFSAN), College Park, MD. Available from: http://www.fda.gov/Food/FoodIngredientsPackaging/GenerallyRecognizedasSafeGRAS/GRASListings/ucm154603.htm.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.