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Volumn , Issue DECEMBER, 2011, Pages

The current status of neural grafting in the treatment of Huntington's disease. a review

Author keywords

Clinical studies; Huntington's disease; Neural transplantation

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN; CYCLOSPORIN A; DOPAMINE 2 RECEPTOR; IMMUNOSUPPRESSIVE AGENT; PREDNISOLONE;

EID: 84855258568     PISSN: 16625145     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnint.2011.00078     Document Type: Article
Times cited : (23)

References (78)
  • 4
    • 82255168969 scopus 로고    scopus 로고
    • Neural transplantation for the treatment of Huntington's Disease
    • Barker, R. A., and Swain, R. (2010). Neural transplantation for the treatment of Huntington's Disease. Eur. Neurol. Rev. 5, 41-45.
    • (2010) Eur. Neurol. Rev , vol.5 , pp. 41-45
    • Barker, R.A.1    Swain, R.2
  • 5
    • 18444373622 scopus 로고    scopus 로고
    • Immune problems in central nervous system cell therapy
    • Barker, R. A., and Widner, H. (2004). Immune problems in central nervous system cell therapy. NeuroRx 1, 472-481.
    • (2004) NeuroRx , vol.1 , pp. 472-481
    • Barker, R.A.1    Widner, H.2
  • 6
    • 0032836535 scopus 로고    scopus 로고
    • Behaviouralrecoveryfollowing striatal transplantation: Effects of postoperative training and Pzone volume
    • Brasted, P. J., Watts, C., Torres, E. M., Robbins, T. W., and Dunnett, S. B. (1999). Behaviouralrecoveryfollowing striatal transplantation: effects of postoperative training and Pzone volume. Exp. Brain Res. 128, 535-538.
    • (1999) Exp. Brain Res , vol.128 , pp. 535-538
    • Brasted, P.J.1    Watts, C.2    Torres, E.M.3    Robbins, T.W.4    Dunnett, S.B.5
  • 7
    • 0033940773 scopus 로고    scopus 로고
    • Behavioral recovery after transplantation into a rat model of Huntington's disease: Dependence on anatomical connectivity and extensive postoperative training
    • Brasted, P. J., Watts, C., Torres, E. M., Robbins, T. W., and Dunnett, S. B. (2000). Behavioral recovery after transplantation into a rat model of Huntington's disease: dependence on anatomical connectivity and extensive postoperative training. Behav. Neurosci. 114, 431-436.
    • (2000) Behav. Neurosci , vol.114 , pp. 431-436
    • Brasted, P.J.1    Watts, C.2    Torres, E.M.3    Robbins, T.W.4    Dunnett, S.B.5
  • 8
    • 77957230012 scopus 로고    scopus 로고
    • Neural grafting in Parkinson's disease problems and possibilities
    • Brundin, P., Barker, R. A., and Parmar, M. (2010). Neural grafting in Parkinson's disease problems and possibilities. Prog. Brain Res. 184, 265-294.
    • (2010) Prog. Brain Res , vol.184 , pp. 265-294
    • Brundin, P.1    Barker, R.A.2    Parmar, M.3
  • 9
    • 0030028145 scopus 로고    scopus 로고
    • Paucity of P-zones in striatal grafts prohibit commencement of clinical trials in Huntington's disease
    • Brundin, P., Fricker, R. A., and Nakao, N. (1996). Paucity of P-zones in striatal grafts prohibit commencement of clinical trials in Huntington's disease. Neuroscience 71, 895-897.
    • (1996) Neuroscience , vol.71 , pp. 895-897
    • Brundin, P.1    Fricker, R.A.2    Nakao, N.3
  • 10
    • 0027460630 scopus 로고
    • Characterization of GABA release from intrastriatal striatal transplants: Dependence on host-derived afferents
    • Campbell, K., Kalen, P., Wictorin, K., Lundberg, C., Mandel, R. J., and Bjorklund, A. (1993). Characterization of GABA release from intrastriatal striatal transplants: dependence on host-derived afferents. Neuroscience 53, 403-415.
    • (1993) Neuroscience , vol.53 , pp. 403-415
    • Campbell, K.1    Kalen, P.2    Wictorin, K.3    Lundberg, C.4    Mandel, R.J.5    Bjorklund, A.6
  • 13
    • 79952163901 scopus 로고    scopus 로고
    • Neuronal degeneration in striataltransplantsandHuntington's disease: Potential mechanisms and clinical implications
    • Cicchetti, F., Soulet, D., and Freeman, T. B. (2011). Neuronal degeneration in striataltransplantsandHuntington's disease: potential mechanisms and clinical implications. Brain 134(Pt 3),641-652.
    • (2011) Brain , vol.134 , Issue.Pt 3 , pp. 641-652
    • Cicchetti, F.1    Soulet, D.2    Freeman, T.B.3
  • 14
    • 0027300349 scopus 로고
    • Synaptic relationships between cortical and dopaminergic inputs and intrinsic GABAergic systems within intrastriatal striatal grafts
    • Clarke, D. J., and Dunnett, S. B. (1993). Synaptic relationships between cortical and dopaminergic inputs and intrinsic GABAergic systems within intrastriatal striatal grafts. J. Chem. Neuroanat. 6, 147-158.
    • (1993) J. Chem. Neuroanat , vol.6 , pp. 147-158
    • Clarke, D.J.1    Dunnett, S.B.2
  • 15
    • 0023945243 scopus 로고
    • Striatal grafts in rats with unilateral neostriatal lesions I. Ultrastructural evidence of afferent synaptic inputs from the host nigrostriatal pathway
    • Clarke, D. J., Dunnett, S. B., Isacson, O., Sirinathsinghji, D. J., and Bjorklund, A. (1988). Striatal grafts in rats with unilateral neostriatal lesions I. Ultrastructural evidence of afferent synaptic inputs from the host nigrostriatal pathway. Neuroscience 24,791-801.
    • (1988) Neuroscience , vol.24 , pp. 791-801
    • Clarke, D.J.1    Dunnett, S.B.2    Isacson, O.3    Sirinathsinghji, D.J.4    Bjorklund, A.5
  • 16
    • 0017167057 scopus 로고
    • Lesion of striatal neurones with kainic acid provides a model for Huntington's chorea
    • Coyle, J. T., and Schwarcz, R. (1976). Lesion of striatal neurones with kainic acid provides a model for Huntington's chorea. Nature 263, 244-246.
    • (1976) Nature , vol.263 , pp. 244-246
    • Coyle, J.T.1    Schwarcz, R.2
  • 17
    • 0025363346 scopus 로고
    • Excitotoxic injury of the neostriatum: A model for Huntington's disease
    • DiFiglia, M. (1990). Excitotoxic injury of the neostriatum: a model for Huntington's disease. Trends Neurosci. 13, 286-289.
    • (1990) Trends Neurosci , vol.13 , pp. 286-289
    • Difiglia, M.1
  • 18
    • 0032589199 scopus 로고    scopus 로고
    • Striatal reconstruction by striatal grafts
    • Dunnett, S. B. (1999). Striatal reconstruction by striatal grafts. J. Neural Transm. Suppl. 55, 115-129.
    • (1999) J. Neural Transm. Suppl , vol.55 , pp. 115-129
    • Dunnett, S.B.1
  • 20
    • 0023919424 scopus 로고
    • Striatal grafts in rats with unilateral neostriatal lesions III. Recovery from dopamine-dependent motor asymmetry and deficits in skilled paw reaching
    • Dunnett, S. B., Isacson, O., Sirinathsinghji, D. J., Clarke, D. J., and Bjorklund, A. (1988). Striatal grafts in rats with unilateral neostriatal lesions III. Recovery from dopamine-dependent motor asymmetry and deficits in skilled paw reaching. Neuroscience 24, 813-820.
    • (1988) Neuroscience , vol.24 , pp. 813-820
    • Dunnett, S.B.1    Isacson, O.2    Sirinathsinghji, D.J.3    Clarke, D.J.4    Bjorklund, A.5
  • 21
    • 33846462480 scopus 로고    scopus 로고
    • Stem cell transplantation for Huntington's disease
    • Dunnett, S. B., and Rosser, A. E. (2007). Stem cell transplantation for Huntington's disease. Exp. Neurol. 203, 279-292.
    • (2007) Exp. Neurol , vol.203 , pp. 279-292
    • Dunnett, S.B.1    Rosser, A.E.2
  • 22
    • 0027396021 scopus 로고
    • Excitotoxin lesions in primates as a model for Huntington's disease: Histopathologic and neurochemicalcharacterization
    • Ferrante, R. J., Kowall, N. W., Cipolloni, P. B., Storey, E., and Beal, M. F. (1993). Excitotoxin lesions in primates as a model for Huntington's disease: histopathologic and neurochemicalcharacterization. Exp.Neurol. 119, 46-71.
    • (1993) Exp.Neurol , vol.119 , pp. 46-71
    • Ferrante, R.J.1    Kowall, N.W.2    Cipolloni, P.B.3    Storey, E.4    Beal, M.F.5
  • 24
    • 78650956995 scopus 로고    scopus 로고
    • Technical factors that influence neural transplant safety in Huntington's disease
    • Freeman, T. B., Cicchetti, F., BachoudLevi, A. C., and Dunnett, S. B. (2011). Technical factors that influence neural transplant safety in Huntington's disease. Exp. Neurol. 227,1-9.
    • (2011) Exp. Neurol , vol.227 , pp. 1-9
    • Freeman, T.B.1    Cicchetti, F.2    Bachoudlevi, A.C.3    Dunnett, S.B.4
  • 26
    • 0028856119 scopus 로고
    • Development of the human striatum: Implications for fetal striatal transplantation in the treatment of Huntington's disease
    • Freeman, T. B., Sanberg, P. R., and Isacson, O. (1995). Development of the human striatum: implications for fetal striatal transplantation in the treatment of Huntington's disease. Cell Transplant. 4, 539-545.
    • (1995) Cell Transplant , vol.4 , pp. 539-545
    • Freeman, T.B.1    Sanberg, P.R.2    Isacson, O.3
  • 31
    • 77954424684 scopus 로고    scopus 로고
    • How vital is sleep in Huntington's disease
    • Goodman, A. O., and Barker, R. A. (2010). How vital is sleep in Huntington's disease? J. Neurol. 257, 882-897.
    • (2010) J. Neurol , vol.257 , pp. 882-897
    • Goodman, A.O.1    Barker, R.A.2
  • 34
    • 0024439946 scopus 로고
    • Intrastriatal grafts derivedfromfetalstriatalprimordia. I. Phenotypy and modular organization
    • Graybiel, A. M., Liu, F. C., and Dunnett, S. B. (1989). Intrastriatal grafts derivedfromfetalstriatalprimordia. I. Phenotypy and modular organization. J. Neurosci. 9, 3250-3271.
    • (1989) J. Neurosci , vol.9 , pp. 3250-3271
    • Graybiel, A.M.1    Liu, F.C.2    Dunnett, S.B.3
  • 36
    • 67651176147 scopus 로고    scopus 로고
    • Health-related quality of life in Huntington's disease: Which factors matter most?
    • Ho, A. K., Gilbert, A. S., Mason, S. L., Goodman, A. O., and Barker, R. A. (2009). Health-related quality of life in Huntington's disease: which factors matter most? Mov. Disord. 24, 574-578.
    • (2009) Mov. Disord , vol.24 , pp. 574-578
    • Ho, A.K.1    Gilbert, A.S.2    Mason, S.L.3    Goodman, A.O.4    Barker, R.A.5
  • 37
    • 85009226418 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease
    • Huntington Study Group
    • Huntington Study Group. (2001). A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease. Neurology 57, 397-404.
    • (2001) Neurology , vol.57 , pp. 397-404
  • 38
    • 61449249687 scopus 로고    scopus 로고
    • Randomized controlled trial of ethyleicosapentaenoic acid in Huntington disease: The TREND-HD study
    • Huntington Study Group TRENDHD Investigators
    • Huntington Study Group TRENDHD Investigators. (2008). Randomized controlled trial of ethyleicosapentaenoic acid in Huntington disease: the TREND-HD study. Arch. Neurol. 65, 1582-1589.
    • (2008) Arch. Neurol , vol.65 , pp. 1582-1589
  • 39
    • 0021226160 scopus 로고
    • Functional neuronal replacement by grafted striatal neurones in the ibotenic acid-lesioned rat striatum
    • Isacson, O., Brundin, P., Kelly, P. A., Gage, F. H., and Bjorklund, A. (1984). Functional neuronal replacement by grafted striatal neurones in the ibotenic acid-lesioned rat striatum. Nature 311, 458-460.
    • (1984) Nature , vol.311 , pp. 458-460
    • Isacson, O.1    Brundin, P.2    Kelly, P.A.3    Gage, F.H.4    Bjorklund, A.5
  • 42
    • 0031777250 scopus 로고    scopus 로고
    • Functional integration of striatal allografts in a primate model of Huntington's disease
    • Kendall, A. L., Rayment, F. D., Torres, E. M., Baker, H. F., Ridley, R. M., and Dunnett, S. B. (1998). Functional integration of striatal allografts in a primate model of Huntington's disease. Nat. Med. 4, 727-729.
    • (1998) Nat. Med , vol.4 , pp. 727-729
    • Kendall, A.L.1    Rayment, F.D.2    Torres, E.M.3    Baker, H.F.4    Ridley, R.M.5    Dunnett, S.B.6
  • 43
    • 0031887047 scopus 로고    scopus 로고
    • Safety of intrastriatal neurotransplantation for Huntington's disease patients
    • Kopyov, O. V., Jacques, S., Lieberman, A., Duma, C. M., and Eagle, K. S. (1998). Safety of intrastriatal neurotransplantation for Huntington's disease patients. Exp. Neurol. 149, 97-108.
    • (1998) Exp. Neurol , vol.149 , pp. 97-108
    • Kopyov, O.V.1    Jacques, S.2    Lieberman, A.3    Duma, C.M.4    Eagle, K.S.5
  • 45
    • 55249107197 scopus 로고    scopus 로고
    • Alloimmunisation to donor antigens and immune rejection following foetal neural grafts to the brain in patients with Huntington's disease
    • doi:10.1371/journal.pone.0000166
    • Krystkowiak, P., Gaura, V., Labalette, M., Rialland, A., Remy, P., Peschanski, M., and Bachoud-Levi, A. C. (2007). Alloimmunisation to donor antigens and immune rejection following foetal neural grafts to the brain in patients with Huntington's disease. PLoS ONE 2, e166. doi:10.1371/journal.pone.0000166
    • (2007) PLoS ONE , vol.2
    • Krystkowiak, P.1    Gaura, V.2    Labalette, M.3    Rialland, A.4    Remy, P.5    Peschanski, M.6    Bachoud-Levi, A.C.7
  • 47
    • 2342475852 scopus 로고    scopus 로고
    • Rapid decline in motor symptoms in HD neural transplant patients prior to surgery
    • Lazic, S. E., and Barker, R. A. (2004). Rapid decline in motor symptoms in HD neural transplant patients prior to surgery. Brain Res. Bull. 63,83-84.
    • (2004) Brain Res. Bull , vol.63 , pp. 83-84
    • Lazic, S.E.1    Barker, R.A.2
  • 48
  • 50
    • 0030271245 scopus 로고    scopus 로고
    • DARPP-32-rich zones in grafts of lateral ganglionic eminence govern the extent of functional recovery in skilled paw reaching in an animal model of Huntington's disease
    • Nakao, N., Grasbon-Frodl, E. M., Widner, H., and Brundin, P. (1996). DARPP-32-rich zones in grafts of lateral ganglionic eminence govern the extent of functional recovery in skilled paw reaching in an animal model of Huntington's disease. Neuroscience 74, 959-970.
    • (1996) Neuroscience , vol.74 , pp. 959-970
    • Nakao, N.1    Grasbon-Frodl, E.M.2    Widner, H.3    Brundin, P.4
  • 51
    • 33747613561 scopus 로고    scopus 로고
    • Enriched environments, experience-dependent plasticity and disordersof thenervoussystem
    • Nithianantharajah, J., and Hannan, A. J. (2006). Enriched environments, experience-dependent plasticity and disordersof thenervoussystem. Nat. Rev. Neurosci. 7, 697-709.
    • (2006) Nat. Rev. Neurosci , vol.7 , pp. 697-709
    • Nithianantharajah, J.1    Hannan, A.J.2
  • 53
    • 0029011778 scopus 로고
    • Rationale for intrastriatal grafting of striatal neuroblasts in patients with Huntington's disease
    • Peschanski, M., Cesaro, P., and Hantraye, P. (1995). Rationale for intrastriatal grafting of striatal neuroblasts in patients with Huntington's disease. Neuroscience 68, 273-285.
    • (1995) Neuroscience , vol.68 , pp. 273-285
    • Peschanski, M.1    Cesaro, P.2    Hantraye, P.3
  • 55
    • 0030953742 scopus 로고    scopus 로고
    • Neuropsychological functioning following fetal striatal transplantation in Huntington's chorea: Three case presentations
    • Philpott, L. M., Kopyov, O. V., Lee, A. J., Jacques, S., Duma, C. M., Caine, S., Yang, M., and Eagle, K. S. (1997). Neuropsychological functioning following fetal striatal transplantation in Huntington's chorea: three case presentations. Cell Transplant. 6, 203-212.
    • (1997) Cell Transplant , vol.6 , pp. 203-212
    • Philpott, L.M.1    Kopyov, O.V.2    Lee, A.J.3    Jacques, S.4    Duma, C.M.5    Caine, S.6    Yang, M.7    Eagle, K.S.8
  • 59
    • 0029025103 scopus 로고
    • Embryonic striatal grafts reverse the disinhibitory effects of ibotenic acid lesions of the ventral striatum
    • Reading, P. J., and Dunnett, S. B. (1995). Embryonic striatal grafts reverse the disinhibitory effects of ibotenic acid lesions of the ventral striatum. Exp. Brain Res. 105, 76-86.
    • (1995) Exp. Brain Res , vol.105 , pp. 76-86
    • Reading, P.J.1    Dunnett, S.B.2
  • 61
    • 78650031174 scopus 로고    scopus 로고
    • Huntington's disease: From molecular pathogenesis to clinical treatment
    • Ross, C. A., and Tabrizi, S. J. (2011). Huntington's disease: from molecular pathogenesis to clinical treatment. Lancet Neurol. 10, 83-98.
    • (2011) Lancet Neurol , vol.10 , pp. 83-98
    • Ross, C.A.1    Tabrizi, S.J.2
  • 64
    • 0026787932 scopus 로고
    • Stereotactic technique and pathophysiological mechanisms of neurotransplantation in Huntington's chorea
    • Sramka, M., Rattaj, M., Molina, H., Vojtassak, J., Belan, V., and Ruzicky, E. (1992). Stereotactic technique and pathophysiological mechanisms of neurotransplantation in Huntington's chorea. Stereotact. Funct. Neurosurg. 58, 79-83.
    • (1992) Stereotact. Funct. Neurosurg , vol.58 , pp. 79-83
    • Sramka, M.1    Rattaj, M.2    Molina, H.3    Vojtassak, J.4    Belan, V.5    Ruzicky, E.6
  • 67
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
    • The Huntington's Disease Collaborative Research Group
    • The Huntington's Disease Collaborative Research Group. (1993). A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72, 971-983.
    • (1993) Cell , vol.72 , pp. 971-983
  • 71
    • 42549092746 scopus 로고    scopus 로고
    • Wheel running from a juvenile age delays onset of specific motor deficits but does not alter protein aggregate density in a mouse model of Huntington's disease
    • doi:10.1186/1471-2202-9-34
    • van Dellen, A., Cordery, P. M., Spires, T. L., Blakemore, C., and Hannan, A. J. (2008). Wheel running from a juvenile age delays onset of specific motor deficits but does not alter protein aggregate density in a mouse model of Huntington's disease. BMC Neurosci. 9, 34. doi:10.1186/1471-2202-9-34
    • (2008) BMC Neurosci , vol.9 , pp. 34
    • van Dellen, A.1    Cordery, P.M.2    Spires, T.L.3    Blakemore, C.4    Hannan, A.J.5
  • 73
    • 0034064954 scopus 로고    scopus 로고
    • Embryonicdonor age and dissection influences striatal graft development and functional integration in a rodent model of Huntington's disease
    • a
    • Watts, C., Brasted, P. J., and Dunnett, S.B.(2000a).Embryonicdonor age and dissection influences striatal graft development and functional integration in a rodent model of Huntington's disease. Exp. Neurol. 163,85-97.
    • (2000) Exp. Neurol , vol.163 , pp. 85-97
    • Watts, C.1    Brasted, P.J.2    Dunnett, S.B.3
  • 74
    • 0033949291 scopus 로고    scopus 로고
    • Volume and differentiation of striatal grafts in rats: Relationship to the number of cells implanted
    • b
    • Watts, C., McNamara, I. R., and Dunnett, S. B. (2000b). Volume and differentiation of striatal grafts in rats: relationship to the number of cells implanted. Cell Transplant. 9, 65-72.
    • (2000) Cell Transplant , vol.9 , pp. 65-72
    • Watts, C.1    McNamara, I.R.2    Dunnett, S.B.3
  • 75
    • 0028821648 scopus 로고
    • Intrastriatal cografts of autologous adrenal medulla and sural nerve in MPTPinduced parkinsonian macaques: Behavioral and anatomical assessment
    • Watts, R. L., Mandir, A. S., and Bakay, R. A. (1995). Intrastriatal cografts of autologous adrenal medulla and sural nerve in MPTPinduced parkinsonian macaques: behavioral and anatomical assessment. Cell Transplant. 4, 27-38.
    • (1995) Cell Transplant , vol.4 , pp. 27-38
    • Watts, R.L.1    Mandir, A.S.2    Bakay, R.A.3
  • 76
    • 0031257606 scopus 로고    scopus 로고
    • Effect of stereotaxic intrastriatal cografts of autologous adrenal medulla and peripheral nerve in Parkinson's disease: Two-year follow-up study
    • Watts, R. L., Subramanian, T., Freeman, A., Goetz, C. G., Penn, R. D., Stebbins, G. T., Kordower, J. H., and Bakay, R. A. (1997). Effect of stereotaxic intrastriatal cografts of autologous adrenal medulla and peripheral nerve in Parkinson's disease: two-year follow-up study. Exp. Neurol. 147, 510-517.
    • (1997) Exp. Neurol , vol.147 , pp. 510-517
    • Watts, R.L.1    Subramanian, T.2    Freeman, A.3    Goetz, C.G.4    Penn, R.D.5    Stebbins, G.T.6    Kordower, J.H.7    Bakay, R.A.8
  • 77
    • 0026603230 scopus 로고
    • Anatomy and connectivity of intrastriatal striatal transplants
    • Wictorin, K. (1992). Anatomy and connectivity of intrastriatal striatal transplants. Prog. Neurobiol. 38, 611-639.
    • (1992) Prog. Neurobiol , vol.38 , pp. 611-639
    • Wictorin, K.1


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