Synthesis of 1, 5-benzothiazepine derivatives bearing 2-phenoxy-quinoline moiety via 1, 3-diplolar cycloaddition reaction

Molecular Diversity

Volumn 15, Issue 4, 2011, Pages 963-970

  Dong, Zhi Qiang ^a   Liu, Fang Ming ^a   Xu, Feng ^b   Yuan, Zai Liang ^a  

^a HANGZHOU NORMAL UNIVERSITY   (China)

^b Zhejiang Transfar Co Ltd   (China)

Author keywords

1,2,4 Oxadiazole; 1,2,4 Triazole; 1,5 Benzothiazepine; 2 Phenoxy quinoline; Crystal structure

Indexed keywords

1 (4 CHLOROPHENYL) 3A (4 METHOXYPHENYL) 5 (2 PHENOXY QUINOLIN 3 YL) 4,5 DIHYDRO 3AH [1,2,4]OXADIAZOLO [5,4 D][1,5]BENZOTHIAZEPINE; 1 (4 CHLOROPHENYL) 5 (2 PHENOXY QUINOLIN 3 YL) 3A PHENYL 4,5 DIHYDRO 3AH [1,2,4]OXADIAZOLO[5,4 D][1,5]BENZOTHIAZEPINE; 1 (4 METHOXYPHENYL) 3A (4 CHLOROPHENYL) 5 (2 PHENOXY QUINOLIN 3 YL) 4,5 DIHYDRO 3AH [1,2,4]OXADIAZOLO[5,4 D][1,5]BENZOTHIAZEPINE; 1 (4 METHOXYPHENYL) 5 (2 PHENOXY QUINOLIN 3 YL) 3A PHENYL 4,5 DIHYDRO 3AH[1,2,4]OXADIAZOLO[5,4 D][1,5]BENZOTHIAZEPINE; 1,3A BIS(4 CHLOROPHENYL) 5 (2 PHENOXY QUINOLIN 3YL) 4,5 DIHYDRO 3AH [1,2,4]OXADIAZOLO[5,4 D][1,5]BENZOTHIAZEPINE; 1,3A BIS(4 METHOXYPHENYL) 5 (2 PHENOXY QUINOLIN 3 YL) 4,5 DIHYDRO 3AH [1,2,4]OXADIAZOLO[5,4 D][1,5]BENZOTHIAZEPINE; 3A (4 CHLOROPHENYL) 5 (2 PHENOXY QUINOLIN 3 YL) 1 (4 METHYLPHENYL) 4,5 DIHYDRO 3AH [1,2,4]OXADIAZOLO[5,4 D][1,5]BENZOTHIAZEPINE; 3A (4 CHLOROPHENYL) 5 (2 PHENOXY QUINOLIN 3 YL) 1 PHENYL 4,5 DIHYDRO 3AH [1,2,4]OXADIAZOLO[5,4 D][1,5]BENZOTHIAZEPINE; 3A (4 METHOXYPHENYL) 5 (2 PHENOXY QUINOLIN 3 YL) 1 (4 METHYLPHENYL) 4,5 DIHYDRO 3AH [1,2,4]OXADIAZOLO[5,4 D][1,5]BENZOTHIAZEPINE; 3A (4 METHOXYPHENYL) 5 (2 PHENOXY QUINOLIN 3 YL) 1 PHENYL 4,5 DIHYDRO 3AH [1,2,4]OXADIAZOLO[5,4 D][1,5]BENZOTHIAZEPINE; 5 (2 PHENOXY QUINOLIN 3 YL) 1,3A DIPHENYL 4,5 DIHYDRO 3AH [1,2,4]OXADIAZOLO[5,4 D][1,5]BENZOTHIAZEPINE; 5 (2 PHENOXY QUINOLIN 3 YL) 3A PHENYL 1 (4 METHYLPHENYL) 4,5 DIHYDRO 3AH [1,2,4]OXADIAZOLO[5,4 D][1,5]BENZOTHIAZEPINE; BENZOTHIAZEPINE DERIVATIVE; ETHYL 3 (4 CHLOROPHENYL) 3A (4 METHOXYPHENYL) 5 (2 PHENOXY QUINOLIN 3 YL) 3,3A,4,5 TETRAHEDRO[1,2,4]TRIAZOLO[3,4 D][1,5]BENZOTHIAZEPINE 1 CARBOXYLATE; ETHYL 3 (4 CHLOROPHENYL) 5 (2 PHENOXY QUINOLIN 3 YL) 3A DIPHENYL 3,3A,4,5 TETRAHEDRO[1,2,4]TRIAZOLO[3,4 D][1,5]BENZOTHIAZEPINE 1 CARBOXYLATE; ETHYL 3,3A BIS(4 CHLOROPHENYL) 5 (2 PHENOXY QUINOLIN 3 YL) 3,3A,4,5 TETRAHEDRO[1,2,4]TRIAZOLO[3,4 D][1,5]BENZOTHIAZEPINE 1 CARBOXYLATE; ETHYL 3A (4 CHLOROPHENYL) 5 (2 PHENOXY QUINOLIN 3 YL) 3 (4 METHYLPHENYL) 3,3A,4,5 TETRAHEDRO[1,2,4]TRIAZOLO[3,4 D][1,5]BENZOTHIAZEPINE 1 CARBOXYLATE; ETHYL 3A (4 CHLOROPHENYL) 5 (2 PHENOXY QUINOLIN 3 YL) 3 PHENYL 3,3A,4,5 TETRAHEDRO[1,2,4]TRIAZOLO[3,4 D][1,5]BENZOTHIAZEPINE 1 CARBOXYLATE; ETHYL 3A (4 METHOXYPHENYL) 5 (2 PHENOXY QUINOLIN 3 YL) 3 (4 METHYLPHENYL) 3,3A,4,5 TETRAHEDRO [1,2,4]TRIAZOLO[3,4 D][1,5]BENZOTHIAZEPINE 1 CARBOXYLATE; ETHYL 3A (4 METHOXYPHENYL) 5 (2 PHENOXY QUINOLIN 3 YL) 3 PHENYL 3,3A,4,5 TETRAHEDRO[1,2,4]TRIAZOLO[3,4 D][1,5]BENZOTHIAZEPINE 1 CARBOXYLATE; ETHYL 5 (2 PHENOXY QUINOLIN 3 YL) 3,3A DIPHENYL 3,3A,4,5 TETRAHEDRO[1,2,4]TRIAZOLO[3,4 D][1,5]BENZOTHIAZEPINE 1 CARBOXYLATE; ETHYL 5 (2 PHENOXY QUINOLIN 3 YL) 3A PHENYL 3 (4 METHYLPHENYL) 3,3A,4,5 TETRAHEDRO[1,2,4]TRIAZOLO[3,4 D][1,5]BENZOTHIAZEPINE 1 CARBOXYLATE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; CYCLOADDITION; DRUG SYNTHESIS; INFRARED SPECTROSCOPY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; ROOM TEMPERATURE; X RAY CRYSTALLOGRAPHY;

CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG DESIGN; OXADIAZOLES; QUINOLINES; THIAZEPINES; TRIAZOLES;

EID: 84855251686     PISSN: 13811991     EISSN: 1573501X     Source Type: Journal    
DOI: 10.1007/s11030-011-9328-z     Document Type: Article

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