Cardiovascular characterization of pyrrolo[2,1-d][1,5]benzothiazepine derivatives binding selectively to the peripheral-type benzodiazepine receptor (PBR): From dual PBR affinity and calcium antagonist activity to novel and selective calcium entry blockers

Journal of Medicinal Chemistry

Volumn 39, Issue 15, 1996, Pages 2922-2938

  Campiani, Giuseppe ^a   Fiorini, Isabella ^a   De Filippis, Maria P ^a   Ciani, Silvia M ^a   Garofalo, Antonio ^a   Nacci, Vito ^a   Giorgi, Gianluca ^a   Sega, Alessandro ^a   Botta, Maurizio ^a   Chiarini, Alberto ^b   Budriesi, Roberta ^b   Bruni, Giancarlo ^a   Romeo, Maria R ^a   Manzoni, Cristina ^c   Mennini, Tiziana ^c  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4' CHLORODIAZEPAM; BENZODIAZEPINE DERIVATIVE; BENZODIAZEPINE RECEPTOR; CALCIUM ANTAGONIST; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; DILTIAZEM; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; NITRENDIPINE; PYRROLO[2,1 D][1,5]BENZOTHIAZEPINE DERIVATIVE; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR EFFECT; DRUG CONFORMATION; DRUG FORMULATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; GUINEA PIG; INOTROPISM; MALE; NONHUMAN; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ATRIAL FUNCTION; BINDING, COMPETITIVE; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CARDIOVASCULAR SYSTEM; CEREBRAL CORTEX; DEPRESSION, CHEMICAL; FEMALE; GUINEA PIGS; HEART RATE; MALE; MODELS, MOLECULAR; MYOCARDIAL CONTRACTION; MYOCARDIUM; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZEPINES;

EID: 8944259902     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960162z     Document Type: Article

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