Serum antibodies in first-degree relatives of patients with IBD: A marker of disease susceptibility? A follow-up pilot-study after 7 years

Digestion

Volumn 72, Issue 2-3, 2005, Pages 119-123

  Torok H P ^a,b   Glas, J ^a,b   Hollay, H C ^a,b   Gruber, R ^b   Osthoff, M ^b   Tonenchi, L ^a,b   Bruckl C ^a   Mussack, T ^a   Folwaczny, M ^a   Folwaczny, C ^a,b  

^a UNIVERSITY OF MUNICH   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Crohn's disease; Disease susceptibility; First degree relatives; Serum antibodies; Ulcerative colitis

Indexed keywords

CELL ANTIBODY; FUNGUS ANTIBODY; GOBLET CELL ANTIBODY; NEUTROPHIL CYTOPLASMIC ANTIBODY; PANCREAS CELL ANTIBODY; SACCHAROMYCES CEREVISIAE ANTIBODY; UNCLASSIFIED DRUG;

ADULT; AGED; ANTIBODY DETECTION; ARTICLE; BLOOD ANALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; CROHN DISEASE; DISEASE PREDISPOSITION; FEMALE; FOLLOW UP; GOBLET CELL; HUMAN; MALE; PANCREAS CELL; PRIORITY JOURNAL; RELATIVE; SERUM; ULCERATIVE COLITIS;

ADULT; AGED; ANTIBODIES; COLITIS, ULCERATIVE; CROHN DISEASE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW-UP STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; PILOT PROJECTS;

EID: 27144516402     PISSN: 00122823     EISSN: None     Source Type: Journal    
DOI: 10.1159/000088366     Document Type: Article

References (21)

1. Glas J, Török HP, Vilsmaier F, Herbinger KH, Hoelscher M, Folwaczny C: Anti-Saccharomyces cerevisiae antibodies in patients with inflammatory bowel disease and their first-degree relatives: potential clinical value. Digestion 2002;66:173-177.
2. Quinton JF, Sendid B, Reumaux D, Duthilleul P, Cortot A, Grandbastien B, et al: Anti-Saccharomyces cerevisiae mannan antibodies combined with antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease: prevalence and diagnostic role. Gut 1998;42:788-791.
3. Ruemmele FM, Targan SR, Levy G, Dubinsky M, Braun J, Seidman EG: Diagnostic accuracy of serological assays in pediatric inflammatory bowel disease. Gastroenterology 1998;115:822-829.
4. Cambridge G, Rampton DS, Stevens TR, McCarthy DA, Kamm M, Leaker B: Anti-neutrophil antibodies in inflammatory bowel disease: prevalence and diagnostic role. Gut 1992;33:668-674.
5. Colombel JF, Reumaux D, Duthilleul P, Noel LH, Gower-Rousseau C, Paris JC, Cortot A: Antineutrophil cytoplasmic autoantibodies in inflammatory bowel diseases. Gastroenterol Clin Biol 1992;16:656-660.
6. Shanahan F, Duerr RH, Rotter JI, Yang H, Sutherland LR, McElree C, et al: Neutrophil autoantibodies in ulcerative colitis: familial aggregation and genetic heterogeneity. Gastroenterology 1992;103:456-461.
7. Joossens S, Reinisch W, Vermeire S, Sendid B, Poulain D, Peeters M, et al: The value of serologic markers in indeterminate colitis: a prospective follow-up study. Gastroenterology 2002;122:1242-1247.
8. Hoffman IE, Demetter P, Peeters M, De Vos M, Mielants H, Veys EM, De Keyser F: Anti-Saccharomyces cerevisiae IgA antibodies are raised in ankylosing spondylitis and undifferentiated spondyloarthropathy. Ann Rheum Dis 2003;62:455-459.
9. Török HP, Glas J, Gruber R, Brumberger V, Strasser C, Kellner H, et al: Inflammatory bowel disease-specific autoantibodies in HLA-B27-associated spondyloarthropathies: increased prevalence of ASCA and pANCA. Digestion 2004;70:49-54.
10. Seibold F, Weber P, Jenss H, Wiedmann KH: Antibodies to a trypsin sensitive pancreatic antigen in chronic inflammatory bowel disease: specific markers for a subgroup of patients with Crohn's disease. Gut 1991;32:1192-1197.
11. Folwaczny C, Noehl N, Endres SP, Loeschke K, Fricke H: Antineutrophil and pancreatic autoantibodies in first-degree relatives of patients with inflammatory bowel disease. Scand J Gastroenterol 1998;33:523-528.
12. Folwaczny C, Noehl N, Tschop K, Endres SP, Heldwein W, Loeschke K, Fricke H: Goblet cell autoantibodies in patients with inflammatory bowel disease and their first-degree relatives. Gastroenterology 1997;113:101-106.
13. Folwaczny C, Noehl N, Endres SP, Loeschke K, Fricke H: Antineutrophil and pancreatic autoantibodies in first-degree relatives of patients with inflammatory bowel disease. Scand J Gastroenterol 1998;33:523-528.
14. Seibold F, Mork H, Tanza S, Muller A, Holzhuter C, Weber P, Scheurlen M: Pancreatic autoantibodies in Crohn's disease: a family study. Gut 1997;40:481-484.
15. Shanahan F: Antibody 'markers' in Crohn's disease: opportunity or overstatement? Gut 1997;40:557-558.
16. Folwaczny C, Loeschke K, Schnettler D, Jager G, Wiebecke B, Hoelscher M, et al.: Endothelial cell autoantibodies are a marker of disease susceptibility in inflammatory bowel disease but apparently not linked to persistent measles virus infection. Clin Immunol 2000;95:197-202.
17. Bansi DS, Lo S, Chapman RW, Fleming KA: Absence of antineutrophil cytoplasmic antibodies in relatives of UK patients with primary sclerosing cholangitis and ulcerative colitis. Eur J Gastroenterol Hepatol 1996;8:111-116.
18. Klebl FH, Bataille F, Bertea CR, Herfarth H, Hofstadter F, Scholmerich J, Regler G: Association of perinuclear antineutrophil cytoplasmic antibodies and anti-Saccharomyces cerevisiae antibodies with Vienna classification subtypes of Crohn's disease. Inflamm Bowel Dis 2003;9:302-307.
19. Klebl FH, Bataille F, Huy C, Hofstadter F, Scholmerich J, Rogler G: Association of antibodies to exocrine pancreas with subtypes of Crohn's disease. Eur J Gastroenterol Hepatol 2005;17:73-77.
20. Torok HP, Folwaczny C: Pancreatic autoantibodies in Crohn's disease: a feasible diagnostic tool? Eur J Gastroenterol Hepatol. 2005;17:37-39.
21. Lombardi G, Annese V, Piepoli A, Bovio P, Latiano A, Napolitano G, Perri F, Conoscitore P, Andriulli A: Antineutrophil cytoplasmic antibodies in inflammatory bowel disease: clinical role and review of the literature. Dis Colon Rectum 2000;43:999-1007.