Design and synthesis of novel β-diketo derivatives as HIV-1 integrase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 1, 2012, Pages 177-182

  Hu, Liming ^a   Zhang, Sulei ^a   He, Xianzhuo ^a   Luo, Zaigang ^a   Wang, Xiaoli ^a   Liu, Wei ^a   Qin, Xuemei ^a  

^a BEIJING UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

1,3 Diketo; HIV 1 Integrase; Inhibitor; Polyhydroxylated aromatics; Strand transfer

Indexed keywords

1 [1 (3 FLUOROBENZYL) 5 METHYL 1H 1,2,3 TRIAZOL 4 YL] 3 HYDROXY 3 (3,4,5 TRIHYDROXYPHENYL)PROP 2 EN 1 ONE; 1 [1 (3 FLUOROBENZYL) 5 METHYL 1H 1,2,3 TRIAZOL 4 YL] 3 HYDROXY 3 (3,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 [1 (3 FLUOROBENZYL) 5 METHYL 1H 1,2,3 TRIAZOL 4 YL] 3 HYDROXY 3 (4 HYDROXYPHENYL)PROP 2 EN 1 ONE; 1 [1 (3 FLUOROBENZYL) 5 METHYL 1H 1,2,3 TRIAZOL 4 YL] 3 HYDROXY 3 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 [1 (3 FLUOROBENZYL) 5 METHYL 1H 1,2,3 TRIAZOL 4 YL] 3 HYDROXY 3 PHENYL PROP 2 EN 1 ONE; 1 [1 (4 FLUOROBENZYL) 5 METHYL 1H 1,2,3 TRIAZOL 4 YL] 3 HYDROXY (3,4,5 TRIHYDROXYPHENYL)PROP 2 EN 1 ONE; 1 [1 (4 FLUOROBENZYL) 5 METHYL 1H 1,2,3 TRIAZOL 4 YL] 3 HYDROXY 3 (3,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 [1 (4 FLUOROBENZYL) 5 METHYL 1H 1,2,3 TRIAZOL 4 YL] 3 HYDROXY 3 (4 HYDROXYPHENYL)PROP 2 EN 1 ONE; 1 [1 (4 FLUOROBENZYL) 5 METHYL 1H 1,2,3 TRIAZOL 4 YL] 3 HYDROXY 3 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 [1 (4 FLUOROBENZYL) 5 METHYL 1H 1,2,3 TRIAZOL 4 YL] 3 HYDROXY 3 PHENYLPROP 2 EN 1 ONE; 1,3 DIKETONE; 3 (3,4 DIHYDROXYPHENYL) 1 [1 (3 FLUOROBENZYL) 5 METHYL 1H 1,2,3 TRIAZOL 4 YL] 3 HYDROXYPROP 2 EN 1 ONE; 3 (3,4 DIHYDROXYPHENYL) 1 [1 (4 FLUOROBENZYL) 5 METHYL 1H 1,2,3 TRIAZOL 4 YL] 3 HYDROXYPROP 2 EN 1 ONE; 3 (3,4 DIMETHOXYPHENYL) 1 [1 (3 FLUOROBENZYL) 5 METHYL 1H 1,2,3 TRIAZOL 4 YL] 3 HYDROXYPROP 2 EN 1 ONE; 3 (3,4 DIMETHOXYPHENYL) 1 [1 (4 FLUOROBENZYL) 5 METHYL 1H 1,2,3 TRIAZOL 4 YL] 3 HYDROXYPROP 2 EN 1 ONE; INTEGRASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIINTEGRASE ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG ISOLATION; DRUG PURIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; VIRUS REPLICATION; VIRUS TITRATION;

DRUG DESIGN; ENZYME ACTIVATION; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; KETO ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84855201210     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.11.014     Document Type: Article

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