Caudatin induces cell cycle arrest and caspase-dependent apoptosis in HepG2 cell

Molecular Biology Reports

Volumn 39, Issue 1, 2012, Pages 131-138

  Fei, Hong Rong ^a   Chen, Hong Lei ^a   Xiao, Ting ^a   Chen, Geng ^a   Wang, Feng Ze ^a  

^a TAISHAN MEDICAL UNIVERSITY   (China)

Author keywords

Bcl 2; Caspase; Caudatin; Cell apoptosis; Hepatoma cell; MAPK

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; CAUDATIN; CYCLIN D1; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CELL STRAIN HEPG2; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; DOWN REGULATION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PROTEIN EXPRESSION; WESTERN BLOTTING;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CASPASES; CELL CYCLE CHECKPOINTS; CELL PROLIFERATION; CYNANCHUM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GLYCOSIDES; HEP G2 CELLS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PLANT ROOTS; PROTO-ONCOGENE PROTEINS C-BCL-2; STEROIDS; TETRAZOLIUM SALTS; THIAZOLES;

EID: 84855190795     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-011-0721-6     Document Type: Article

References (25)

1. DM Parkin F Bray J Ferlay P Pisani 2005 Global cancer statistics, 2002 CA Cancer J Clin 55 74 108 15761078 10.3322/canjclin.55.2.74 (Pubitemid 40372904)
2. Charette N, De Saeger C, Lannoy V, Horsmans Y, Leclercq I, Starkel P (2010) Salirasib inhibits the growth of hepatocarcinoma cell lines in vitro and tumor growth in vivo through ras and mTOR inhibition. Mol Cancer 9:256. doi: 10.1186/1476-4598-9-256
3. M Su X Wu HY Chung Y Li W Ye 2009 Antiproliferative activities of five Chinese medicinal herbs and active compounds in Elephantopus scaber Nat Prod Commun 4 1025 1030 19768977 1:CAS:528:DC%2BD1MXhtVOkurbE
4. Chang C, Zhu Y, Tang X, Tao W (2010) The anti-proliferative effects of norcantharidin on human HepG2 cells in cell culture. Mol Biol Rep. doi: 10.1007/s11033-010-0090-6
5. R Zhang Y Liu Y Wang Y Ye X Li 2007 Cytotoxic and apoptosis-inducing properties of auriculoside A in tumor cells Chem Biodivers 4 887 892 10.1002/cbdv.200790076 17511004 10.1002/cbdv.200790076 1:CAS:528: DC%2BD2sXmtFGrsb8%3D (Pubitemid 46930005)
6. YR Peng YB Li XD Liu Duan JA ZhangJF 2008 Apoptosis induced by caudatin in human hepatoma cell line SMMC7721 Chin J Nat Med 6 210 213 10.3724/SP.J.1009.2008.00210 1:CAS:528:DC%2BD1cXotV2ms7g%3D (Pubitemid 351802859)
7. JK Brunelle A Letai 2009 Control of mitochondrial apoptosis by the Bcl-2 family J Cell Sci 122 437 441 10.1242/jcs.031682 19193868 10.1242/jcs.031682 1:CAS:528:DC%2BD1MXjs1Wls7w%3D
8. J Zhu L Zhang X Jin X Han C Sun J Yan 2010 beta-Ionone-induced apoptosis in human osteosarcoma (U2os) cells occurs via a p53-dependent signaling pathway Mol Biol Rep 37 2653 2663 10.1007/s11033-009-9793-y 19757179 10.1007/s11033-009-9793-y 1:CAS:528:DC%2BC3cXosFCks7c%3D
9. MB Jarpe C Widmann C Knall TK Schlesinger S Gibson T Yujiri GR Fanger EW Gelfand GL Johnson 1998 Anti-apoptotic versus pro-apoptotic signal transduction: checkpoints and stop signs along the road to death Oncogene 17 1475 1482 10.1038/sj.onc.1202183 9779994 10.1038/sj.onc.1202183 1:CAS:528: DyaK1cXmsVyntbc%3D (Pubitemid 28458416)
10. MF Yuen JL Hou A Chutaputti 2009 Asia Pacific working party on prevention of hepatocellular carcinoma hepatocellular carcinoma in the Asia pacific region J Gastroenterol Hepatol 24 346 353 10.1111/j.1440-1746.2009.05784.x 19220670 10.1111/j.1440-1746.2009.05784.x
11. D Xiao A Herman-Antosiewicz J Antosiewicz H Xiao M Brisson JS Lazo SV Singh 2005 Diallyl trisulfide-induced G(2)-M phase cell cycle arrest in human prostate cancer cells is caused by reactive oxygen species-dependent destruction and hyperphosphorylation of Cdc 25 C Oncogene 24 6256 6268 10.1038/sj.onc. 1208759 15940258 10.1038/sj.onc.1208759 1:CAS:528:DC%2BD2MXhtVSjt7jE (Pubitemid 43080049)
12. LF Alfonso KS Srivenugopal TV Arumugam TJ Abbruscato JA Weidanz GJ Bhat 2009 Aspirin inhibits camptothecin-induced p21CIP1 levels and potentiates apoptosis in human breast cancer cells Int J Oncol 34 597 608 19212664 1:CAS:528:DC%2BD1MXjs1Kgsrg%3D
13. SV Singh A Herman-Antosiewicz AV Singh KL Lew SK Srivastava R Kamath KD Brown L Zhang R Baskaran 2004 Sulforaphaneinduced G2/M phase cell cycle arrest involves checkpoint kinase 2 mediated phosphorylation of Cdc25C J Biol Chem 279 25813 25822 10.1074/jbc.M313538200 15073169 10.1074/jbc.M313538200 1:CAS:528:DC%2BD2cXksFygtbw%3D (Pubitemid 38756846)
14. S Lapenna A Giordano 2009 Cell cycle kinases as therapeutic targets for cancer Nat Rev Drug Discov 8 547 566 10.1038/nrd2907 19568282 10.1038/nrd2907 1:CAS:528:DC%2BD1MXnvFans78%3D
15. A Satyanarayana P Kaldis 2009 Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms Oncogene 28 2925 2939 10.1038/onc.2009.170 19561645 10.1038/onc.2009.170 1:CAS:528: DC%2BD1MXnslOjtrw%3D
16. HM Heath-Engel NC Chang GC Shore 2008 The endoplasmic reticulum in apoptosis and autophagy: role of the BCL-2 protein family Oncogene 27 6419 6433 10.1038/onc.2008.309 18955970 10.1038/onc.2008.309 1:CAS:528:DC%2BD1cXht12ltLjN
17. RJ Youle A Strasser 2008 The BCL-2 protein family: opposing activities that mediate cell death Nat Rev Mol Cell Biol 9 47 59 10.1038/nrm2308 18097445 10.1038/nrm2308 1:CAS:528:DC%2BD2sXhsVKrsrrP
18. S Kumar 2007 Caspase function in programmed cell death Cell Death Differ 14 32 43 10.1038/sj.cdd.4402060 17082813 10.1038/sj.cdd.4402060 1:CAS:528:DC%2BD28XhtlSqur%2FF (Pubitemid 44911892)
19. LA Allan PR Clarke 2009 Apoptosis and autophagy: regulation of caspase-9 by phosphorylation FEBS J 276 6063 6073 10.1111/j.1742-4658.2009.07330.x 19788417 10.1111/j.1742-4658.2009.07330.x 1:CAS:528:DC%2BD1MXhtlWrtLnJ
20. SI Yun HY Yoon YS Chung 2009 Glycogen synthase kinase-3beta regulates etoposide-induced apoptosis via Bcl-2 mediated caspase-3 activation in C3H10T1/2 cells Apoptosis 14 771 777 10.1007/s10495-009-0348-4 19408126 10.1007/s10495-009-0348-4 1:CAS:528:DC%2BD1MXlvFOms7k%3D
21. G Droga-Mazovec L Bojic A Petelin S Ivanova R Romih U Repnik GS Salvesen V Stoka V Turk B Turk 2008 Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues J Biol Chem 283 19140 19150 10.1074/jbc.M802513200 18469004 10.1074/jbc.M802513200 1:CAS:528:DC%2BD1cXnvVSjs78%3D
22. EF Wagner AR Nebreda 2009 Signal integration by JNK and p38 MAPK pathways in cancer development Nat Rev Cancer 9 537 549 10.1038/nrc2694 19629069 10.1038/nrc2694 1:CAS:528:DC%2BD1MXovFymu7w%3D
23. P Xie S Guo Y Fan H Zhang D Gu H Li 2009 Atrogin-1/MAFbx enhances simulated ischemia/reperfusion-induced apoptosis in cardiomyocytes through degradation of MAPK phosphatase-1 and sustained JNK activation J Biol Chem 284 5488 5496 10.1074/jbc.M806487200 19117950 10.1074/jbc.M806487200 1:CAS:528:DC%2BD1MXitFSntbs%3D
24. YS Chen HR Li M Lin G Chen BS Xie NL Xu LF Lin 2010 Livin abrogates apoptosis of SPC-A1 cell by regulating JNKI signaling pathway Mol Biol Rep 37 2241 2247 10.1007/s11033-009-9711-3 19690982 10.1007/s11033-009-9711-3 1:CAS:528:DC%2BC3cXotVWrsrc%3D
25. DM Milne DG Campbell FB Caudwell DW Meek 1994 Phosphorylation of the tumor suppressor protein p53 by mitogen-activated protein kinases J Biol Chem 269 9253 9260 7510706 1:CAS:528:DyaK2cXktVGqsLk%3D (Pubitemid 24209252)