-
1
-
-
13444274310
-
Gating of acetylcholine receptor channels: brownian motion across a broad transition state
-
Auerbach A (2005). Gating of acetylcholine receptor channels: brownian motion across a broad transition state. Proc Natl Acad Sci U S A 102, 1408-1412.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 1408-1412
-
-
Auerbach, A.1
-
2
-
-
36549084005
-
How to turn the reaction coordinate into time
-
Auerbach A (2007). How to turn the reaction coordinate into time. J Gen Physiol 130, 543-546.
-
(2007)
J Gen Physiol
, vol.130
, pp. 543-546
-
-
Auerbach, A.1
-
3
-
-
77949497067
-
The gating isomerization of neuromuscular acetylcholine receptors
-
Auerbach A (2010). The gating isomerization of neuromuscular acetylcholine receptors. J Physiol 588, 573-586.
-
(2010)
J Physiol
, vol.588
, pp. 573-586
-
-
Auerbach, A.1
-
4
-
-
49649099967
-
Gating at the mouth of the acetylcholine receptor channel: energetic consequences of mutations in the αM2-cap
-
Bafna PA, Purohit PG & Auerbach A (2008). Gating at the mouth of the acetylcholine receptor channel: energetic consequences of mutations in the αM2-cap. PLoS One 3, e2515.
-
(2008)
PLoS One
, vol.3
-
-
Bafna, P.A.1
Purohit, P.G.2
Auerbach, A.3
-
5
-
-
58149267953
-
X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation
-
Bocquet N, Nury H, Baaden M, Le Poupon C, Changeux JP, Delarue M & Corringer PJ (2009). X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation. Nature 457, 111-114.
-
(2009)
Nature
, vol.457
, pp. 111-114
-
-
Bocquet, N.1
Nury, H.2
Baaden, M.3
Le Poupon, C.4
Changeux, J.P.5
Delarue, M.6
Corringer, P.J.7
-
6
-
-
4344616080
-
Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel
-
Bouzat C, Gumilar F, Spitzmaul G, Wang HL, Rayes D, Hansen SB, Taylor P & Sine SM (2004). Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel. Nature 430, 896-900.
-
(2004)
Nature
, vol.430
, pp. 896-900
-
-
Bouzat, C.1
Gumilar, F.2
Spitzmaul, G.3
Wang, H.L.4
Rayes, D.5
Hansen, S.B.6
Taylor, P.7
Sine, S.M.8
-
7
-
-
78649817938
-
Subunit symmetry at the extracellular domain-transmembrane domain interface in acetylcholine receptor channel gating
-
Bruhova I & Auerbach A (2010). Subunit symmetry at the extracellular domain-transmembrane domain interface in acetylcholine receptor channel gating. J Biol Chem 285, 38898-38904.
-
(2010)
J Biol Chem
, vol.285
, pp. 38898-38904
-
-
Bruhova, I.1
Auerbach, A.2
-
8
-
-
34547691116
-
Conformational dynamics of the αM3 transmembrane helix during acetylcholine receptor channel gating
-
Cadugan DJ & Auerbach A (2007). Conformational dynamics of the αM3 transmembrane helix during acetylcholine receptor channel gating. Biophys J 93, 859-865.
-
(2007)
Biophys J
, vol.93
, pp. 859-865
-
-
Cadugan, D.J.1
Auerbach, A.2
-
9
-
-
77955693995
-
Linking the acetylcholine receptor-channel agonist-binding sites with the gate
-
Cadugan DJ & Auerbach A (2010). Linking the acetylcholine receptor-channel agonist-binding sites with the gate. Biophys J 99, 798-807.
-
(2010)
Biophys J
, vol.99
, pp. 798-807
-
-
Cadugan, D.J.1
Auerbach, A.2
-
10
-
-
11844258265
-
A speed limit for conformational change of an allosteric membrane protein
-
Chakrapani S & Auerbach A (2005). A speed limit for conformational change of an allosteric membrane protein. Proc Natl Acad Sci U S A 102, 87-92.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 87-92
-
-
Chakrapani, S.1
Auerbach, A.2
-
11
-
-
1842686239
-
Gating dynamics of the acetylcholine receptor extracellular domain
-
Chakrapani S, Bailey TD & Auerbach A (2004). Gating dynamics of the acetylcholine receptor extracellular domain. J Gen Physiol 123, 341-356.
-
(2004)
J Gen Physiol
, vol.123
, pp. 341-356
-
-
Chakrapani, S.1
Bailey, T.D.2
Auerbach, A.3
-
12
-
-
33749331062
-
Targeted molecular dynamics study of C-loop closure and channel gating in nicotinic receptors
-
Cheng X, Wang H, Grant B, Sine SM & McCammon JA (2006). Targeted molecular dynamics study of C-loop closure and channel gating in nicotinic receptors. PLoS Comput Biol 2, e134.
-
(2006)
PLoS Comput Biol
, vol.2
-
-
Cheng, X.1
Wang, H.2
Grant, B.3
Sine, S.M.4
McCammon, J.A.5
-
13
-
-
0036623799
-
Desensitization of diliganded mouse muscle nicotinic acetylcholine receptor channels
-
Elenes S & Auerbach A (2002). Desensitization of diliganded mouse muscle nicotinic acetylcholine receptor channels. J Physiol 541, 367-383.
-
(2002)
J Physiol
, vol.541
, pp. 367-383
-
-
Elenes, S.1
Auerbach, A.2
-
14
-
-
27144473613
-
Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations
-
Hansen SB, Sulzenbacher G, Huxford T, Marchot P, Taylor P & Bourne Y (2005). Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations. EMBO J 24, 3635-3646.
-
(2005)
EMBO J
, vol.24
, pp. 3635-3646
-
-
Hansen, S.B.1
Sulzenbacher, G.2
Huxford, T.3
Marchot, P.4
Taylor, P.5
Bourne, Y.6
-
15
-
-
79957953215
-
Principles of activation and permeation in an anion-selective Cys-loop receptor
-
Hibbs RE & Gouaux E (2011). Principles of activation and permeation in an anion-selective Cys-loop receptor. Nature 474, 54-60.
-
(2011)
Nature
, vol.474
, pp. 54-60
-
-
Hibbs, R.E.1
Gouaux, E.2
-
16
-
-
41149168686
-
X-ray structure of a prokaryotic pentameric ligand-gated ion channel
-
Hilf RJ & Dutzler R (2008). X-ray structure of a prokaryotic pentameric ligand-gated ion channel. Nature 452, 375-379.
-
(2008)
Nature
, vol.452
, pp. 375-379
-
-
Hilf, R.J.1
Dutzler, R.2
-
17
-
-
79951824109
-
Design and control of acetylcholine receptor conformational change
-
Jadey SV, Purohit P, Bruhova I, Gregg TM & Auerbach A (2011). Design and control of acetylcholine receptor conformational change. Proc Natl Acad Sci U S A 108, 4328-4333.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 4328-4333
-
-
Jadey, S.V.1
Purohit, P.2
Bruhova, I.3
Gregg, T.M.4
Auerbach, A.5
-
18
-
-
77950248091
-
Acetylcholine receptor channels activated by a single agonist molecule
-
Jha A & Auerbach A (2010). Acetylcholine receptor channels activated by a single agonist molecule. Biophys J 98, 1840-1846.
-
(2010)
Biophys J
, vol.98
, pp. 1840-1846
-
-
Jha, A.1
Auerbach, A.2
-
19
-
-
36549043834
-
Acetylcholine receptor gating at extracellular transmembrane domain interface: the cys-loop and M2-M3 linker
-
Jha A, Cadugan DJ, Purohit P & Auerbach A (2007). Acetylcholine receptor gating at extracellular transmembrane domain interface: the cys-loop and M2-M3 linker. J Gen Physiol 130, 547-558.
-
(2007)
J Gen Physiol
, vol.130
, pp. 547-558
-
-
Jha, A.1
Cadugan, D.J.2
Purohit, P.3
Auerbach, A.4
-
20
-
-
68049143193
-
Energy and structure of the M2 helix in acetylcholine receptor-channel gating
-
Jha A, Purohit P & Auerbach A (2009). Energy and structure of the M2 helix in acetylcholine receptor-channel gating. Biophys J 96, 4075-4084.
-
(2009)
Biophys J
, vol.96
, pp. 4075-4084
-
-
Jha, A.1
Purohit, P.2
Auerbach, A.3
-
22
-
-
58849151840
-
Structural rearrangements in loop F of the GABA receptor signal ligand binding, not channel activation
-
Khatri A, Sedelnikova A & Weiss DS (2009). Structural rearrangements in loop F of the GABA receptor signal ligand binding, not channel activation. Biophys J 96, 45-55.
-
(2009)
Biophys J
, vol.96
, pp. 45-55
-
-
Khatri, A.1
Sedelnikova, A.2
Weiss, D.S.3
-
23
-
-
49649102025
-
On the nature of partial agonism in the nicotinic receptor superfamily
-
Lape R, Colquhoun D & Sivilotti LG (2008). On the nature of partial agonism in the nicotinic receptor superfamily. Nature 454, 722-727.
-
(2008)
Nature
, vol.454
, pp. 722-727
-
-
Lape, R.1
Colquhoun, D.2
Sivilotti, L.G.3
-
24
-
-
70349967621
-
Modeling neuronal nicotinic and GABA receptors: important interface salt-links and protein dynamics
-
Law RJ & Lightstone FC (2009). Modeling neuronal nicotinic and GABA receptors: important interface salt-links and protein dynamics. Biophys J 97, 1586-1594.
-
(2009)
Biophys J
, vol.97
, pp. 1586-1594
-
-
Law, R.J.1
Lightstone, F.C.2
-
25
-
-
27744438169
-
Principal pathway coupling agonist binding to channel gating in nicotinic receptors
-
Lee WY & Sine SM (2005). Principal pathway coupling agonist binding to channel gating in nicotinic receptors. Nature 438, 243-247.
-
(2005)
Nature
, vol.438
, pp. 243-247
-
-
Lee, W.Y.1
Sine, S.M.2
-
26
-
-
0242268392
-
Conformation-dependent hydrophobic photolabeling of the nicotinic receptor: electrophysiology-coordinated photochemistry and mass spectrometry
-
Leite JF, Blanton MP, Shahgholi M, Dougherty DA & Lester HA (2003). Conformation-dependent hydrophobic photolabeling of the nicotinic receptor: electrophysiology-coordinated photochemistry and mass spectrometry. Proc Natl Acad Sci U S A 100, 13054-13059.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 13054-13059
-
-
Leite, J.F.1
Blanton, M.P.2
Shahgholi, M.3
Dougherty, D.A.4
Lester, H.A.5
-
27
-
-
0042355340
-
Agonist-induced conformational changes in the extracellular domain of α7 nicotinic acetylcholine receptors
-
Lyford LK, Sproul AD, Eddins D, McLaughlin JT & Rosenberg RL (2003). Agonist-induced conformational changes in the extracellular domain of α7 nicotinic acetylcholine receptors. Mol Pharmacol 64, 650-658.
-
(2003)
Mol Pharmacol
, vol.64
, pp. 650-658
-
-
Lyford, L.K.1
Sproul, A.D.2
Eddins, D.3
McLaughlin, J.T.4
Rosenberg, R.L.5
-
29
-
-
4644289077
-
Structural dynamics of the M4 transmembrane segment during acetylcholine receptor gating
-
Mitra A, Bailey TD & Auerbach AL (2004). Structural dynamics of the M4 transmembrane segment during acetylcholine receptor gating. Structure 12, 1909-1918.
-
(2004)
Structure
, vol.12
, pp. 1909-1918
-
-
Mitra, A.1
Bailey, T.D.2
Auerbach, A.L.3
-
30
-
-
27244454364
-
Dynamics of the acetylcholine receptor pore at the gating transition state
-
Mitra A, Cymes GD & Auerbach A (2005). Dynamics of the acetylcholine receptor pore at the gating transition state. Proc Natl Acad Sci U S A 102, 15069-15074.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 15069-15074
-
-
Mitra, A.1
Cymes, G.D.2
Auerbach, A.3
-
31
-
-
78651189765
-
On the nature of allosteric transitions: A plausible model
-
Monod J, Wyman J & Changeux JP (1965). On the nature of allosteric transitions: A plausible model. J Mol Biol 12, 88-118.
-
(1965)
J Mol Biol
, vol.12
, pp. 88-118
-
-
Monod, J.1
Wyman, J.2
Changeux, J.P.3
-
32
-
-
34247109679
-
An intersubunit trigger of channel gating in the muscle nicotinic receptor
-
Mukhtasimova N & Sine SM (2007). An intersubunit trigger of channel gating in the muscle nicotinic receptor. J Neurosci 27, 4110-4119.
-
(2007)
J Neurosci
, vol.27
, pp. 4110-4119
-
-
Mukhtasimova, N.1
Sine, S.M.2
-
33
-
-
0017905087
-
Local anaesthetics transiently block currents through single acetylcholine-receptor channels
-
Neher E & Steinbach JH (1978). Local anaesthetics transiently block currents through single acetylcholine-receptor channels. J Physiol 277, 153-176.
-
(1978)
J Physiol
, vol.277
, pp. 153-176
-
-
Neher, E.1
Steinbach, J.H.2
-
34
-
-
0037969585
-
191 segment is involved in GABA binding and channel gating
-
191 segment is involved in GABA binding and channel gating. J Biol Chem 278, 13166-13172.
-
(2003)
J Biol Chem
, vol.278
, pp. 13166-13172
-
-
Newell, J.G.1
Czajkowski, C.2
-
35
-
-
67650169910
-
Ligand-specific conformational changes in the α1 glycine receptor ligand-binding domain
-
Pless SA & Lynch JW (2009). Ligand-specific conformational changes in the α1 glycine receptor ligand-binding domain. J Biol Chem 284, 15847-15856.
-
(2009)
J Biol Chem
, vol.284
, pp. 15847-15856
-
-
Pless, S.A.1
Lynch, J.W.2
-
36
-
-
36549039473
-
Acetylcholine receptor gating at extracellular transmembrane domain interface: the "pre-M1" linker
-
Purohit P & Auerbach A (2007a). Acetylcholine receptor gating at extracellular transmembrane domain interface: the "pre-M1" linker. J Gen Physiol 130, 559-568.
-
(2007)
J Gen Physiol
, vol.130
, pp. 559-568
-
-
Purohit, P.1
Auerbach, A.2
-
37
-
-
36549080807
-
Acetylcholine receptor gating: movement in the α-subunit extracellular domain
-
Purohit P & Auerbach A (2007b). Acetylcholine receptor gating: movement in the α-subunit extracellular domain. J Gen Physiol 130, 569-579.
-
(2007)
J Gen Physiol
, vol.130
, pp. 569-579
-
-
Purohit, P.1
Auerbach, A.2
-
38
-
-
33744477329
-
Block of muscle nicotinic receptors by choline suggests that the activation and desensitization gates act as distinct molecular entities
-
Purohit Y & Grosman C (2006). Block of muscle nicotinic receptors by choline suggests that the activation and desensitization gates act as distinct molecular entities. J Gen Physiol 127, 703-717.
-
(2006)
J Gen Physiol
, vol.127
, pp. 703-717
-
-
Purohit, Y.1
Grosman, C.2
-
39
-
-
1542285356
-
Restoration of single-channel currents using the segmental k-means method based on hidden Markov modeling
-
Qin F (2004). Restoration of single-channel currents using the segmental k-means method based on hidden Markov modeling. Biophys J 86, 1488.
-
(2004)
Biophys J
, vol.86
, pp. 1488
-
-
Qin, F.1
-
40
-
-
0030956174
-
Maximum likelihood estimation of aggregated Markov processes
-
Qin F, Auerbach A & Sachs F (1997). Maximum likelihood estimation of aggregated Markov processes. Proc Biol Sci 264, 375-383.
-
(1997)
Proc Biol Sci
, vol.264
, pp. 375-383
-
-
Qin, F.1
Auerbach, A.2
Sachs, F.3
-
41
-
-
0033561222
-
A re-examination of adult mouse nicotinic acetylcholine receptor channel activation kinetics
-
Salamone FN, Zhou M & Auerbach A (1999). A re-examination of adult mouse nicotinic acetylcholine receptor channel activation kinetics. J Physiol 516, 315-330.
-
(1999)
J Physiol
, vol.516
, pp. 315-330
-
-
Salamone, F.N.1
Zhou, M.2
Auerbach, A.3
-
42
-
-
0036795364
-
Naturally occurring mutations at the acetylcholine receptor binding site independently alter ACh binding and channel gating
-
Sine SM, Shen XM, Wang HL, Ohno K, Lee WY, Tsujino A, Brengmann J, Bren N, Vajsar J & Engel AG (2002). Naturally occurring mutations at the acetylcholine receptor binding site independently alter ACh binding and channel gating. J Gen Physiol 120, 483-496.
-
(2002)
J Gen Physiol
, vol.120
, pp. 483-496
-
-
Sine, S.M.1
Shen, X.M.2
Wang, H.L.3
Ohno, K.4
Lee, W.Y.5
Tsujino, A.6
Brengmann, J.7
Bren, N.8
Vajsar, J.9
Engel, A.G.10
-
43
-
-
34548706524
-
Dynamics of heteropentameric nicotinic acetylcholine receptor: implications of the gating mechanism
-
Szarecka A, Xu Y & Tang P (2007). Dynamics of heteropentameric nicotinic acetylcholine receptor: implications of the gating mechanism. Proteins 68, 948-960.
-
(2007)
Proteins
, vol.68
, pp. 948-960
-
-
Szarecka, A.1
Xu, Y.2
Tang, P.3
-
45
-
-
13444271681
-
Refined structure of the nicotinic acetylcholine receptor at 4Å resolution
-
Unwin N (2005). Refined structure of the nicotinic acetylcholine receptor at 4Å resolution. J Mol Biol 346, 967-989.
-
(2005)
J Mol Biol
, vol.346
, pp. 967-989
-
-
Unwin, N.1
-
46
-
-
29244442919
-
A unified view of the role of electrostatic interactions in modulating the gating of Cys loop receptors
-
Xiu X, Hanek AP, Wang J, Lester HA & Dougherty DA (2005). A unified view of the role of electrostatic interactions in modulating the gating of Cys loop receptors. J Biol Chem 280, 41655-41666.
-
(2005)
J Biol Chem
, vol.280
, pp. 41655-41666
-
-
Xiu, X.1
Hanek, A.P.2
Wang, J.3
Lester, H.A.4
Dougherty, D.A.5
|