Desensitization of diliganded mouse muscle nicotinic acetylcholine receptor channels

Journal of Physiology

Volumn 541, Issue 2, 2002, Pages 367-383

  Elenes, Sergio ^a   Auerbach, Anthony ^b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINIC RECEPTOR; ACETYLCHOLINE;

ACTION POTENTIAL AMPLITUDE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL KINETICS; CONFORMATION; CONTROLLED STUDY; DESENSITIZATION; DISSOCIATION CONSTANT; EMBRYO; HUMAN; HUMAN CELL; MOUSE; NEUROMUSCULAR SYNAPSE; NONHUMAN; PRIORITY JOURNAL; RATE CONSTANT; RECEPTOR OCCUPANCY; RECOVERY TIME CONSTANT; SINGLE CHANNEL PATCH CLAMP; ALPHA CHAIN; BETA CHAIN; CELL ADHESION; CHEMICAL REACTION; CONCENTRATION (PARAMETERS); ION CONDUCTANCE; MEMBRANE CHANNEL; MUSCLE FIBER MEMBRANE CONDUCTANCE; RECEPTOR DOWN REGULATION;

ANIMALS; CELL LINE; HUMANS; KIDNEY; KINETICS; LIGANDS; LINEAR MODELS; MEMBRANE POTENTIALS; MICE; PATCH-CLAMP TECHNIQUES; RECEPTORS, NICOTINIC; RECOMBINANT PROTEINS;

EID: 0036623799     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2001.016022     Document Type: Article

References (34)

1. AKK, G. & AUERBACH, A. (1996). Inorganic, monovalent cations compete with agonists for the transmitter binding site of nicotinic acetylcholine receptors. Biophysical Journal 70, 2652-2658.
2. AUERBACH, A. & AKK, G. (1998). Desensitization of mouse nicotinic acetylcholine receptor channels. A two-gate mechanism. Journal of General Physiology 112, 181-197.
3. AUERBACH, A. & LINGLE, C. J. (1986). Heterogeneous kinetic properties of acetylcholine receptor channels in Xenopus myocytes. Journal of Physiology 378, 119-140.
4. BREJC, K., VAN DIJK, W. J., KLAASSEN, R.V., SCHUURMANS, M., VAN DER OOST, J., SMIT, A. B. & SIXMA, T. K. (2001). Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors. Nature 411, 269-276.
5. CACHELIN, A. B. & COLQUHOUN, D. (1989). Desensitization of the acetylcholine receptor of frog end-plates measured in a Vaseline-gap voltage clamp. Journal of Physiology 415, 159-188.
6. COLQUHOUN, D. & HAWKES, A. G. (1977). Relaxation and fluctuations of membrane currents that flow through drug-operated channels. Proceedings of the Royal Society B 199, 231-262.
7. DILGER, J. P. & LIU, Y. (1992). Desensitization of acetylcholine receptors in BC3H-1 cells. Pflügers Archiv 420, 479-485.
8. EDELSTEIN, S. J., SCHAAD, O., HENRY, E., BERTRAND, D. & CHANGEUX, J. P. (1996). A kinetic mechanism for nicotinic acetylcholine receptors based on multiple allosteric transitions. Biological Cybernetics 75, 361-79.
9. FELTZ, A. & TRAUTMANN, A. (1982). Desensitization at the frog neuromuscular junction: a biphasic process. Journal of Physiology 322, 257-272.
10. FRANKE, C., PARNAS, H., HOVAV, G. & DUDEL, J. (1993). A molecular scheme for the reaction between acetylcholine and nicotinic channels. Biophysical Journal 64, 339-356.
11. GROSMAN, C. & AUERBACH, A. (2001). The dissociation of acetylcholine from open nicotinic receptor channels. Proceedings of the National Academy of Sciences of the USA 98, 14102-14107.
12. GROSMAN, C., ZHOU, M. & AUERBACH, A. (2000). Mapping the conformational wave of acetylcholine receptor channel gating. Nature 403, 773-6.
13. HEIDMANN, T. & CHANGEUX, J. P. (1979). Fast kinetic studies on the interaction of a fluorescent agonist with the membrane-bound acetylcholine receptor from Torpedo marmorata. European Journal of Biochemistry 94, 255-279.
14. HILLE, B. (2001). Ion Channels of Excitable Membranes. Sinauer Associates, Sunderland, MA, USA.
15. JACKSON, M. B. (1999). Ligand-gated channel: postsynaptic receptors and drug targets. Advances in Neurology 79, 511-524.
16. JAHN, K., MOHAMMADI, B., KRAMPFL, K., ABICHT, A., LOCHMULLER, H. & BUFLER, J. (2001). Deactivation and desensitization of mouse embryonic- and adult-type nicotinic receptor channel currents. Neuroscience Letters 307, 89-92.
17. KATZ, B. & THESLEFF, S. (1957). A study of the 'desensitization' produced by acetylcholine at the motor end-plate. Journal of Physiology 138, 63-80.
18. KIENKER, P. (1989). Equivalence of aggregated Markov models of ion-channel gating. Proceedings of the Royal Society B 236, 269-309.
19. MACONOCHIE, D. J. & STEINBACH, J. H. (1995). Block by acetylcholine of mouse muscle nicotinic receptors, stably expressed in fibroblasts. Journal of General Physiology 106, 113-147.
20. MACONOCHIE, D. J. & STEINBACH, J. H. (1998). The channel opening rate of adult- and fetal-type mouse muscle nicotinic receptors activated by acetylcholine. Journal of Physiology 506, 53-72.
21. MAGLEBY, K. L. & PALOTTA, B. S. (1981). A study of desensitization of acetylcholine receptors using nerve-released transmitter in the frog. Journal of Physiology 316, 225-250.
22. MAGLEBY, K. L. & STEVENS, C. F. (1972). A quantitative description of end-plate currents. Journal of Physiology 223, 173-197.
23. NARANJO, D. & BREHM, P. (1993). Modal shifts in acetylcholine receptor channel gating confer subunit-dependent desensitization. Science 260, 1811-1814.
24. PARADISO, K. & BREHM, P. (1998). Long-term desensitization of nicotinic acetylcholine receptors is regulated via protein kinase A-mediated phosphorylation. Journal of Neuroscience 18, 9227-9237.
25. QIN, F., AUERBACH, A. & SACHS, F. (1996). Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed events. Biophysical Journal 70, 264-280.
26. REITSTETTER, R., LUKAS, R. J. & GRUENER, R. (1999). Dependence of nicotinic acetylcholine receptor recovery from desensitization on the duration of agonist exposure. Journal of Pharmacology and Experimental Therapeutics 289, 656-660.
27. SAKMANN, B., PATLAK, J. & NEHER, E. (1980). Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist. Nature 286, 71-73.
28. SALAMONE, F. N., ZHOU, M. & AUERBACH, A. (1999). A re-examination of adult mouse nicotinic acetylcholine receptor channel activation kinetics. Journal of Physiology 516, 315-330.
29. SINE, S. M., CLAUDIO, T. & SIGWORTH, F. J. (1990). Activation of Torpedo acetylcholine receptors expressed in mouse fibroblasts. Single channel current kinetics reveal distinct agonist binding affinities. Journal of General Physiology 96, 395-437.
30. SINE, S. M., OHNO, K, BOUZAT, C., AUERBACH, A., MILONE, M., PRUITT, J. N. & ENGEL, A. G. (1995). Mutation of the acetylcholine receptor alpha subunit causes a slow-channel myasthenic syndrome by enhancing agonist binding affinity. Neuron 15, 229-239.
31. SINE, S. M. & STEINBACH, J. H. (1987). Activation of acetylcholine receptors on clonal mammalian BC3H-1 cells by high concentrations of agonist. Journal of Physiology 385, 325-359.
32. TOYOSHIMA, C. & UNWIN, N. (1988). Ion channel of acetylcholine receptor reconstructed from images of postsynaptic membranes. Nature 336, 247-250.
33. UNWIN, N. (1995). Acetylcholine receptor channel imaged in the open state. Nature 373, 37-43.
34. UNWIN, N. (2000). The Croonian Lecture (2000). Nicotinic acetylcholine receptor and the structural basis of fast synaptic transmission. Philosophical Transactions of the Royal Society B 355, 1813-1829.