Dynamics of the acetylcholine receptor pore at the gating transition state

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 42, 2005, Pages 15069-15074

  Mitra, Ananya ^a   Cymes, Gisela D ^a,b   Auerbach, Anthony ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Ion channels; Phi value; Rate equilibrium free energy relationship (REFER) analysis

Indexed keywords

CHOLINERGIC RECEPTOR; COMPLEMENTARY DNA; ION CHANNEL; RECEPTOR SUBUNIT;

ANIMAL CELL; ARTICLE; ENERGY; EQUILIBRIUM CONSTANT; GENE EXPRESSION; KINETICS; MOLECULAR DYNAMICS; MOUSE; MUTAGENESIS; NEUROMUSCULAR SYNAPSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CELL LINE; HUMANS; ION CHANNEL GATING; MICE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PATCH-CLAMP TECHNIQUES; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN SUBUNITS; RECEPTORS, CHOLINERGIC; RECOMBINANT FUSION PROTEINS; THERMODYNAMICS;

ANIMALIA;

EID: 27244454364     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0505090102     Document Type: Article

References (36)

1. Auerbach, A. (2003) Sci. STKE 2003, re11.
2. Karlin, A. (2002) Nat. Rev. Neurosci. 3, 102-114.
3. Changeux, J. P. & Edelstein, S. J. (1998) Neuron 21, 959-980.
4. Tobimatsu, T., Fujita, Y., Fukuda, K., Tanaka, K., Mori, Y., Konno, T., Mishina, M. & Numa, S. (1987) FEBS Lett. 222, 56-62.
5. Miyazawa, A., Fujiyoshi, Y. & Unwin, N. (2003) Nature 423, 949-955.
6. Unwin, N. (1995) Nature 373, 37-43.
7. Akabas, M. H., Kaufmann, C., Archdeacon, P. & Karlin, A. (1994) Neuron 13, 919-927.
8. Panicker, S., Cruz, H., Arrabit, C. & Slesinger, P. A. (2002) J. Neurosci. 22, 1629-1639.
9. Wilson, G. G. & Karlin, A. (1998) Neuron 20, 1269-1281.
10. Kosolapov, A. V., Filatov, G. N. & White, M. M. (2000) J. Membr. Biol. 174, 191-197.
11. Filatov, G. N. & White, M. M. (1995) Mol. Pharmacol. 48, 379-384.
12. Labarca, C., Nowak, M. W., Zhang, H., Tang, L., Deshpande, P. & Lester, H. A. (1995) Nature 376, 514-516.
13. Kearney, P. C., Zhang, H., Zhong, W., Dougherty, D. A. & Lester, H. A. (1996) Neuron 17, 1221-1229.
14. Revah, F., Bertrand, D., Galzi, J. L., Devillers-Thiery, A., Mulle, C., Hussy, N., Bertrand, S., Ballivet, M. & Changeux, J. P. (1991) Nature 353, 846-849.
15. Grosman, C., Zhou, M. & Auerbach, A. (2000) Nature 403, 773-776.
16. Mitra, A., Bailey, T. D. & Auerbach, A. L. (2004) Structure (London) 12, 1909-1918.
17. Chakrapani, S., Bailey, T. D. & Auerbach, A. (2004) J. Gen. Physiol. 123, 341-356.
18. Cymes, G. D., Grosman, C. & Auerbach, A. (2002) Biochemistry 41, 5548-5555.
19. Fersht, A. R., Matouschek, A. & Serrano, L. (1992) J. Mol. Biol. 224, 771-782.
20. Auerbach, A. (2005) Proc. Natl. Acad. Sci. USA 102, 1408-1412.
21. Grosman, C. & Auerbach, A. (2000) J. Gen. Physiol. 115, 637-651.
22. Chakrapani, S. & Auerbach, A. (2005) Proc. Natl. Acad. Sci. USA 102, 87-92.
23. Zhou, Y., Pearson J. E. & Auerbach, A. (2005) Biophys. J 89, in press.
24. Zhou, M., Engel, A. G. & Auerbach, A. (1999) Proc. Natl. Acad. Sci. USA 96, 10466-10471.
25. Qin, F. (2004) Biophys. J. 86, 1488-1501.
26. Qin, F., Auerbach, A. & Sachs, F. (1997) Proc. R. Soc. London B 264, 375-383.
27. Elenes, S. & Auerbach, A. (2002) J. Physiol. 541, 367-383.
28. Unwin, N. (2005) J. Mol. Biol. 346, 967-989.
29. Grosman, C. (2003) Biochemistry 42, 14977-14987.
30. Magleby, K. L. & Stevens, C. F. (1972) J. Physiol. 223, 151-171.
31. Croxen, R., Newland, C., Beeson, D., Oosterhuis, H., Chauplannaz, G., Vincent, A. & Newsom-Davis, J. (1997) Hum. Mol. Genet 6, 767-774.
32. Grosman, C., Salamone, F. N., Sine, S. M. & Auerbach, A. (2000) J. Gen. Physiol. 116, 327-340.
33. Akk, G., Sine, S. & Auerbach, A. (1996) J. Physiol. 496, 185-196.
34. Chakrapani, S., Bailey, T. D. & Auerbach, A. (2003) J. Gen. Physiol. 122, 521-539.
35. Blanton, M. P. & Cohen, J. B. (1994) Biochemistry 33, 2859-2872.
36. Law, R. J., Forrest, L. R., Ranatunga, K. M., La Rocca, P., Tieleman, D. P. & Sansom, M. S. (2000) Proteins 39, 47-55.