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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 1, 2012, Pages 579-585

The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways

(7) Yang, Tingting a Lu, Zhenyu b Meng, Li a Wei, Shanjian a Hong, Kui c Zhu, Weiming b Huang, Caiguo a

a SECOND MILITARY MEDICAL UNIVERSITY (China)

b OCEAN UNIVERSITY OF CHINA (China)

c WUHAN UNIVERSITY (China)

Author keywords

Apoptosis; Breast cancer; Cell cycle arrest; MAPK signaling pathway; Ophiobolin O

Indexed keywords

ANTINEOPLASTIC AGENT; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NATURAL PRODUCT; OPHIOBOLIN O; PROTEIN BAX; PROTEIN BCL 2; SERINE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ASPERGILLUS USTUS; BREAST CANCER; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL STRAIN MCF 7; CELL VIABILITY; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; MAP KINASE SIGNALING SYSTEM; MODELS, CHEMICAL; MODELS, MOLECULAR; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; SESTERTERPENES; TIME FACTORS;

ASPERGILLUS USTUS;

EID: 84655166546 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.10.079 Document Type: Article

Times cited : (52)

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