The inhibitory effect of raloxifene on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells is mediated through a ROS/p38 MAPK/CREB pathway to the up-regulation of heme oxygenase-1 independent of estrogen receptor

Biochimie

Volumn 93, Issue 2, 2011, Pages 168-174

  Lee, Sin Ae ^a   Kim, Eun Ye ^a   Jeon, Woo Kwang ^a   Woo, Chang Hoon ^b   Choe, Jongseon ^a   Han, Sanghwa ^a   Kim, Byung Chul ^a  

^a Kangwon National University   (South Korea)

^b Yeungnam University College of Medicine   (South Korea)

Author keywords

Anti inflammatory; CREB; HO 1; p38 MAPK; Raloxifene; ROS

Indexed keywords

1,10 PHENANTHROLINE; ALLOPURINOL; BUTHIONINE SULFOXIMINE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FULVESTRANT; GLUTATHIONE; HEME OXYGENASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RALOXIFENE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; DRUG MECHANISM; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RNA INTERFERENCE; UPREGULATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; ENZYME INDUCTION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEME OXYGENASE-1; HYDROGEN PEROXIDE; IRON; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RALOXIFENE; REACTIVE OXYGEN SPECIES; RECEPTORS, ESTROGEN; SELECTIVE ESTROGEN RECEPTOR MODULATORS; SIGNAL TRANSDUCTION; UP-REGULATION; XANTHINE; XANTHINE OXIDASE;

EID: 78651290677     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2010.09.007     Document Type: Article

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