Selenium and asthma

Molecular Aspects of Medicine

Volumn 33, Issue 1, 2012, Pages 98-106

  Norton, Robert L ^a   Hoffmann, Peter R ^a  

^a UNIVERSITY OF HAWAII   (United States)

Author keywords

Allergic airway inflammation; Asthma; Immunity; Oxidative stress; Selenium; Selenoproteins

Indexed keywords

GLUTATHIONE PEROXIDASE; SELENIUM; SELENOPROTEIN; THIOREDOXIN REDUCTASE 1; THIOREDOXIN REDUCTASE 2;

ALLERGIC ASTHMA; ANTIOXIDANT ACTIVITY; ASTHMA; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CHILDHOOD ASTHMA; CONFERENCE PAPER; DIET SUPPLEMENTATION; DNA METHYLATION; HUMAN; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MATERNAL NUTRITION; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL; WHEEZING;

ANIMALS; ANTIOXIDANTS; ASTHMA; CELL DIFFERENTIATION; DISEASE MODELS, ANIMAL; HUMANS; LYMPHOCYTE ACTIVATION; MICE; SELENIUM; SELENOPROTEINS; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 84655162263     PISSN: 00982997     EISSN: 18729452     Source Type: Journal    
DOI: 10.1016/j.mam.2011.10.003     Document Type: Conference Paper

References (82)

1. M.K. Ahsan, H. Masutani, Y. Yamaguchi, Y.C. Kim, K. Nosaka, M. Matsuoka, Y. Nishinaka, M. Maeda, and J. Yodoi Loss of interleukin-2-dependency in HTLV-I-infected T cells on gene silencing of thioredoxin-binding protein-2 Oncogene 25 15 2006 2181 2191
2. F.E. Aldwell, M.A. Baird, C.E. Fitzpatrick, A.D. McLellan, M.L. Cross, M.R. Lambeth, and G.S. Buchan Oral vaccination of mice with lipid-encapsulated Mycobacterium bovis BCG: anatomical sites of bacterial replication and immune activity Immunol. Cell Biol. 83 5 2005 549 553 (Pubitemid 41805758)
3. K. Allan, and G. Devereux Diet and asthma: nutrition implications from prevention to treatment J. Am. Diet Assoc. 111 2 2011 258 268
4. M. Barnett, E. Bermingham, W. McNabb, S. Bassett, K. Armstrong, J. Rounce, and N. Roy Investigating micronutrients and epigenetic mechanisms in relation to inflammatory bowel disease Mutat. Res. 690 1-2 2010 71 80
5. J. Bleys, A. Navas-Acien, M. Laclaustra, R. Pastor-Barriuso, A. Menke, J. Ordovas, S. Stranges, and E. Guallar Serum selenium and peripheral arterial disease: results from the national health and nutrition examination survey, 2003-2004 Am. J. Epidemiol. 169 8 2009 996 1003
6. M.R. Bosl, K. Takaku, M. Oshima, S. Nishimura, and M.M. Taketo Early embryonic lethality caused by targeted disruption of the mouse selenocysteine tRNA gene (Trsp) Proc. Natl. Acad. Sci. USA 94 11 1997 5531 5534 (Pubitemid 27241803)
7. J. Bousquet Specific immunotherapy in asthma Allergy 54 Suppl. 56 1999 37 38 (Pubitemid 29462822)
8. P. Burney, J. Potts, J. Makowska, M. Kowalski, J. Phillips, L. Gnatiuc, S. Shaheen, G. Joos, P. Van Cauwenberge, T. van Zele, K. Verbruggen, Y. van Durme, I. Derudder, S. Wohrl, J. Godnic-Cvar, B. Salameh, L. Skadhauge, G. Thomsen, T. Zuberbier, K.C. Bergmann, L. Heinzerling, H. Renz, N. Al-Fakhri, B. Kosche, A. Hildenberg, N.G. Papadopoulos, P. Xepapadaki, K. Zannikos, M. Gjomarkaj, A. Bruno, E. Pace, S. Bonini, M. Bresciani, C. Gramiccioni, W. Fokkens, E.J. Weersink, K.H. Carlsen, E. Bakkeheim, C. Loureiro, C.M. Villanueva, C. Sanjuas, J.P. Zock, B. Lundback, and C. Janson A case-control study of the relation between plasma selenium and asthma in European populations: a GAL2EN project Allergy 63 7 2008 865 871 (Pubitemid 351832800)
9. M.F. Carneiro, C.R. Rhoden, S.L. Amantea, and F. Barbosa Jr. Low concentrations of selenium and zinc in nails are associated with childhood asthma Biol. Trace Elem. Res. 2011 10.1007/s12011-011- 9080-3 (Epub ahead of print)
10. X. Chen, T.O. Scholl, M.J. Leskiw, M.R. Donaldson, and T.P. Stein Association of glutathione peroxidase activity with insulin resistance and dietary fat intake during normal pregnancy J. Clin. Endocrinol. Metab. 88 12 2003 5963 5968 (Pubitemid 38033079)
11. R. Cox, and S. Goorha A study of the mechanism of selenite-induced hypomethylated DNA and differentiation of Friend erythroleukemic cells Carcinogenesis 7 12 1986 2015 2018
12. J.E. Curran, J.B. Jowett, K.S. Elliott, Y. Gao, K. Gluschenko, J. Wang, D.M. Abel Azim, G. Cai, M.C. Mahaney, A.G. Comuzzie, T.D. Dyer, K.R. Walder, P. Zimmet, J.W. MacCluer, G.R. Collier, A.H. Kissebah, and J. Blangero Genetic variation in selenoprotein S influences inflammatory response Nat. Genet. 37 11 2005 1234 1241 (Pubitemid 41568706)
13. A.R. Cyr, and F.E. Domann The redox basis of epigenetic modifications: from mechanisms to functional consequences Antioxid. Redox Signal. 15 2 2011 551 589
14. D.A. de Luis, O. Izaola, R. Aller, A. Armentia, and L. Cuellar Antioxidant and fat intake in patients with polinic asthma Med. Clin. (Barc) 121 17 2003 653 654 (Pubitemid 38236132)
15. G. Devereux, G. McNeill, G. Newman, S. Turner, L. Craig, S. Martindale, P. Helms, and A. Seaton Early childhood wheezing symptoms in relation to plasma selenium in pregnant mothers and neonates Clin. Exp. Allergy 37 7 2007 1000 1008 (Pubitemid 46955529)
16. A.M. Dittrich, H.A. Meyer, M. Krokowski, D. Quarcoo, B. Ahrens, S.M. Kube, M. Witzenrath, R.S. Esworthy, F.F. Chu, and E. Hamelmann Glutathione peroxidase-2 protects from allergen-induced airway inflammation in mice Eur. Respir. J. 35 5 2010 1148 1154
17. J.A. Dunstan, L. Breckler, J. Hale, H. Lehmann, P. Franklin, G. Lyons, S.Y. Ching, T.A. Mori, A. Barden, and S.L. Prescott Associations between antioxidant status, markers of oxidative stress and immune responses in allergic adults Clin. Exp. Allergy 36 8 2006 993 1000 (Pubitemid 44166618)
18. J.A. Dunstan, L. Breckler, J. Hale, H. Lehmann, P. Franklin, G. Lyons, S.Y. Ching, T.A. Mori, A. Barden, and S.L. Prescott Supplementation with vitamins C, E, beta-carotene and selenium has no effect on anti-oxidant status and immune responses in allergic adults: a randomized controlled trial Clin. Exp. Allergy 37 2 2007 180 187 (Pubitemid 46148275)
19. A. Flatt, N. Pearce, C.D. Thomson, M.R. Sears, M.F. Robinson, and R. Beasley Reduced selenium in asthmatic subjects in New Zealand Thorax 45 2 1990 95 99 (Pubitemid 20068002)
20. E.S. Ford, D.M. Mannino, and S.C. Redd Serum antioxidant concentrations among US adults with self-reported asthma. J. Asthma 41 2 2004 179 187 (Pubitemid 38507100)
21. V. Garcia-Larsen, S. Chinn, I.C. Arts, H. Amigo, and R.J. Rona Atopy, wheeze and bronchial responsiveness in young Chilean adults. Do dietary antioxidants matter? Allergy 62 6 2007 714 715 (Pubitemid 46763437)
22. F. Gazdik, J. Kadrabova, and K. Gazdikova Decreased consumption of corticosteroids after selenium supplementation in corticoid-dependent asthmatics Bratisl. Lek. Listy 103 1 2002 22 25
23. W. Ge, P.Z. Hu, Y. Huang, X.M. Wang, X.M. Zhang, Y.J. Sun, Z.S. Li, S.Y. Si, and Y.F. Sui The antitumor immune responses induced by nanoemulsion- encapsulated MAGE1-HSP70/SEA complex protein vaccine following different administration routes Oncol. Rep. 22 4 2009 915 920
24. A.V. Gett, F. Sallusto, A. Lanzavecchia, and J. Geginat T cell fitness determined by signal strength Nat. Immunol. 4 4 2003 355 360 (Pubitemid 36432318)
25. G. Grunig, M. Warnock, A.E. Wakil, R. Venkayya, F. Brombacher, D.M. Rennick, D. Sheppard, M. Mohrs, D.D. Donaldson, R.M. Locksley, and D.B. Corry Requirement for IL-13 independently of IL-4 in experimental asthma Science 282 5397 1998 2261 2263 (Pubitemid 29004075)
26. C.H. Guo, P.J. Liu, S. Hsia, C.J. Chuang, and P.C. Chen Role of certain trace minerals in oxidative stress, inflammation, CD4/CD8 lymphocyte ratios and lung function in asthmatic patients Ann. Clin. Biochem. 48 Pt 4 2011 344 351
27. L. Hasselmark, R. Malmgren, G. Unge, and O. Zetterstrom Lowered platelet glutathione peroxidase activity in patients with intrinsic asthma Allergy 45 7 1990 523 527 (Pubitemid 20329923)
28. D.L. Hatfield, and V.N. Gladyshev The Outcome of Selenium and Vitamin E Cancer Prevention Trial (SELECT) reveals the need for better understanding of selenium biology Mol. Interv. 9 1 2009 18 21
29. C.M. Hawrylowicz, and A. O'Garra Potential role of interleukin-10- secreting regulatory T cells in allergy and asthma Nat. Rev. Immunol. 5 4 2005 271 283 (Pubitemid 40516153)
30. + T cells in mice through a mechanism involving cellular free thiols J. Nutr. 140 6 2010 1155 1161
31. P.R. Hoffmann, C. Jourdan-Le Saux, F.W. Hoffmann, P.S. Chang, O. Bollt, Q. He, E.K. Tam, and M.J. Berry A role for dietary selenium and selenoproteins in allergic airway inflammation J. Immunol. 179 5 2007 3258 3267
32. Z. Huang, A.H. Rose, and P.R. Hoffmann The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities Antioxid. Redox Signal. 2011 10.1089/ars.2011.4145 (Epub ahead of print)
33. E.S. Hwang, S.J. Szabo, P.L. Schwartzberg, and L.H. Glimcher T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3 Science 307 5708 2005 430 433 (Pubitemid 40139989)
34. R.K. Ikeda, M. Miller, J. Nayar, L. Walker, J.Y. Cho, K. McElwain, S. McElwain, E. Raz, and D.H. Broide Accumulation of peribronchial mast cells in a mouse model of ovalbumin allergen induced chronic airway inflammation: modulation by immunostimulatory DNA sequences J. Immunol. 171 9 2003 4860 4867 (Pubitemid 37310608)
35. S.H. Jackson, S. Devadas, J. Kwon, L.A. Pinto, and M.S. Williams T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation Nat. Immunol. 5 8 2004 818 827 (Pubitemid 39172975)
36. C.C. Johnson, F.M. Fordyce, and M.P. Rayman Symposium on 'Geographical and geological influences on nutrition': factors controlling the distribution of selenium in the environment and their impact on health and nutrition Proc. Nutr. Soc. 69 1 2010 119 132
37. J. Kadrabova, A. Mad'aric, Z. Kovacikova, F. Podivinsky, E. Ginter, and F. Gazdik Selenium status is decreased in patients with intrinsic asthma Biol. Trace Elem. Res. 52 3 1996 241 248 (Pubitemid 26231510)
38. M.L. Kapsenberg Dendritic-cell control of pathogen-driven T-cell polarization Nat. Rev. Immunol. 3 12 2003 984 993 (Pubitemid 37521540)
39. A. Kocyigit, F. Armutcu, A. Gurel, and B. Ermis Alterations in plasma essential trace elements selenium, manganese, zinc, copper, and iron concentrations and the possible role of these elements on oxidative status in patients with childhood asthma Biol. Trace Elem. Res. 97 1 2004 31 41 (Pubitemid 38177892)
40. G.V. Kryukov, S. Castellano, S.V. Novoselov, A.V. Lobanov, O. Zehtab, R. Guigo, and V.N. Gladyshev Characterization of mammalian selenoproteomes Science 300 5624 2003 1439 1443 (Pubitemid 36638165)
41. V.M. Labunskyy, B.C. Lee, D.E. Handy, J. Loscalzo, D.L. Hatfield, and V.N. Gladyshev Both maximal expression of selenoproteins and selenoprotein deficiency can promote development of type 2 diabetes-like phenotype in mice Antioxid. Redox Signal. 4 12 2011 2327 2336
42. Y.J. Li, H. Takizawa, A. Azuma, T. Kohyama, Y. Yamauchi, T. Kawada, S. Kudoh, and I. Sugawara The effects of oxidative stress induced by prolonged low- dose diesel exhaust particle exposure on the generation of allergic airway inflammation differ between BALB/c and C57BL/6 mice Immunopharmacol. Immunotoxicol. 31 2 2009 230 237
43. S.M. Lippman, E.A. Klein, P.J. Goodman, M.S. Lucia, I.M. Thompson, L.G. Ford, H.L. Parnes, L.M. Minasian, J.M. Gaziano, J.A. Hartline, J.K. Parsons, J.D. Bearden 3rd, E.D. Crawford, G.E. Goodman, J. Claudio, E. Winquist, E.D. Cook, D.D. Karp, P. Walther, M.M. Lieber, A.R. Kristal, A.K. Darke, K.B. Arnold, P.A. Ganz, R.M. Santella, D. Albanes, P.R. Taylor, J.L. Probstfield, T.J. Jagpal, J.J. Crowley, F.L. Meyskens Jr., L.H. Baker, and C.A. Coltman Jr. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT) JAMA 301 1 2009 39 51
44. R.M. Locksley Asthma and allergic inflammation Cell 140 6 2010 777 783
45. J. Lu, C. Berndt, and A. Holmgren Metabolism of selenium compounds catalyzed by the mammalian selenoprotein thioredoxin reductase Biochim. Biophys. Acta 1790 11 2009 1513 1519
46. L. Maddox, and D.A. Schwartz The pathophysiology of asthma Annu. Rev. Med. 53 2002 477 498 (Pubitemid 34177892)
47. J.P. McClung, C.A. Roneker, W. Mu, D.J. Lisk, P. Langlais, F. Liu, and X.G. Lei Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase Proc. Natl. Acad. Sci. USA 101 24 2004 8852 8857 (Pubitemid 38781575)
48. R.C. McKenzie, T.S. Rafferty, and G.J. Beckett Selenium: an essential element for immune function Immunol. Today 19 8 1998 342 345 (Pubitemid 28387000)
49. H.A. Meyer, A.M. Dittrich, and E. Hamelmann Different isoforms of glutathione peroxidase cause opposing effects during the development of allergic asthma in mice Antioxid. Redox Signal. 14 1 2010 169 170
50. A.L. Miller The etiologies, pathophysiology, and alternative/ complementary treatment of asthma Altern. Med. Rev. 6 1 2001 20 47 (Pubitemid 32194958)
51. N.L. Misso, K.A. Powers, R.L. Gillon, G.A. Stewart, and P.J. Thompson Reduced platelet glutathione peroxidase activity and serum selenium concentration in atopic asthmatic patients Clin. Exp. Allergy 26 7 1996 838 847 (Pubitemid 26266431)
52. K.M. Murphy, and S.L. Reiner The lineage decisions of helper T cells Nat. Rev. Immunol. 2 12 2002 933 944 (Pubitemid 37323214)
53. A.S. Niskar, D.C. Paschal, S.M. Kieszak, K.M. Flegal, B. Bowman, E.W. Gunter, J.L. Pirkle, C. Rubin, E.J. Sampson, and M. McGeehin Serum selenium levels in the US population: Third National Health and Nutrition Examination Survey, 1988-1994 Biol. Trace Elem. Res. 91 1 2003 1 10 (Pubitemid 36205201)
54. U. Nurmatov, G. Devereux, and A. Sheikh Nutrients and foods for the primary prevention of asthma and allergy: systematic review and meta-analysis J. Allergy Clin. Immunol. 127 3 2011 724 733 e721-730
55. O. Omland, Y. Deguchi, T. Sigsgaard, and J.C. Hansen Selenium serum and urine is associated to mild asthma and atopy. The SUS study J. Trace Elem. Med. Biol. 16 2 2002 123 127 (Pubitemid 34832021)
56. L.V. Papp, J. Lu, A. Holmgren, and K.K. Khanna From selenium to selenoproteins: synthesis, identity, and their role in human health Antioxid. Redox Signal. 9 7 2007 775 806 (Pubitemid 46919583)
57. C.S. Park, T.B. Kim, K.Y. Lee, K.A. Moon, Y.J. Bae, M.K. Jang, Y.S. Cho, and H.B. Moon Increased oxidative stress in the airway and development of allergic inflammation in a mouse model of asthma Ann. Allergy Asthma Immunol. 103 3 2009 238 247
58. L. Perrone, T.S. Devi, K. Hosoya, T. Terasaki, and L.P. Singh Thioredoxin interacting protein (TXNIP) induces inflammation through chromatin modification in retinal capillary endothelial cells under diabetic conditions J. Cell Physiol. 221 1 2009 262 272
59. J.D. Peterson, L.A. Herzenberg, K. Vasquez, and C. Waltenbaugh Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns Proc. Natl. Acad. Sci. USA 95 6 1998 3071 3076 (Pubitemid 28135856)
60. D. Qujeq, B. Hidari, K. Bijani, and H. Shirdel Glutathione peroxidase activity and serum selenium concentration in intrinsic asthmatic patients Clin. Chem. Lab. Med. 41 2 2003 200 202 (Pubitemid 36336711)
61. M.P. Rayman Dietary selenium: time to act BMJ 314 7078 1997 387 388 (Pubitemid 27067795)
62. M.A. Reeves, and P.R. Hoffmann The human selenoproteome: recent insights into functions and regulation Cell. Mol. Life Sci. 66 15 2009 2457 2478
63. M.A. Riedl, and A.E. Nel Importance of oxidative stress in the pathogenesis and treatment of asthma Curr. Opin. Allergy Clin. Immunol. 8 1 2008 49 56
64. E.V. Rothenberg, and J.A. Zhang T-cell identity and epigenetic memory Curr. Top. Microbiol. Immunol. 2011 10.1007/82-2011-168 (Epub ahead of print)
65. S. Sakaguchi, and F. Powrie Emerging challenges in regulatory T cell function and biology Science 317 5838 2007 627 629 (Pubitemid 47229955)
66. E. Schoenmakers, M. Agostini, C. Mitchell, N. Schoenmakers, L. Papp, O. Rajanayagam, R. Padidela, L. Ceron-Gutierrez, R. Doffinger, C. Prevosto, J. Luan, S. Montano, J. Lu, M. Castanet, N. Clemons, M. Groeneveld, P. Castets, M. Karbaschi, S. Aitken, A. Dixon, J. Williams, I. Campi, M. Blount, H. Burton, F. Muntoni, D. O'Donovan, A. Dean, A. Warren, C. Brierley, D. Baguley, P. Guicheney, R. Fitzgerald, A. Coles, H. Gaston, P. Todd, A. Holmgren, K.K. Khanna, M. Cooke, R. Semple, D. Halsall, N. Wareham, J. Schwabe, L. Grasso, P. Beck-Peccoz, A. Ogunko, M. Dattani, M. Gurnell, and K. Chatterjee Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans J. Clin. Invest. 120 12 2010 4220 4235
67. U. Schweizer, F. Streckfuss, P. Pelt, B.A. Carlson, D.L. Hatfield, J. Kohrle, and L. Schomburg Hepatically derived selenoprotein P is a key factor for kidney but not for brain selenium supply Biochem. J. 386 Pt 2 2005 221 226 (Pubitemid 40343779)
68. S.O. Shaheen, R.B. Newson, A.J. Henderson, P.M. Emmett, A. Sherriff, and M. Cooke Umbilical cord trace elements and minerals and risk of early childhood wheezing and eczema Eur. Respir. J. 24 2 2004 292 297 (Pubitemid 39139799)
69. S.O. Shaheen, R.B. Newson, M.P. Rayman, A.P. Wong, M.K. Tumilty, J.M. Phillips, J.F. Potts, F.J. Kelly, P.T. White, and P.G. Burney Randomised, double blind, placebo-controlled trial of selenium supplementation in adult asthma Thorax 62 6 2007 483 490 (Pubitemid 46910125)
70. R. Shaw, K. Woodman, J. Crane, C. Moyes, J. Kennedy, and N. Pearce Risk factors for asthma symptoms in Kawerau children N. Z. Med. J. 107 987 1994 387 391
71. R.K. Shrimali, R.D. Irons, B.A. Carlson, Y. Sano, V.N. Gladyshev, J.M. Park, and D.L. Hatfield Selenoproteins mediate T cell immunity through an antioxidant mechanism J. Biol. Chem. 283 29 2008 20181 20185
72. J.E. Squires, and M.J. Berry Eukaryotic selenoprotein synthesis: mechanistic insight incorporating new factors and new functions for old factors IUBMB Life 60 4 2008 232 235
73. B. Stockinger, and M. Veldhoen Differentiation and function of Th17 T cells Curr. Opin. Immunol. 19 3 2007 281 286 (Pubitemid 46687011)
74. J. Stone, L.J. Hinks, R. Beasley, S.T. Holgate, and B.A. Clayton Reduced selenium status of patients with asthma Clin. Sci. (Lond.) 77 5 1989 495 500 (Pubitemid 19257715)
75. C.D. Thomson Assessment of requirements for selenium and adequacy of selenium status: a review Eur. J. Clin. Nutr. 58 3 2004 391 402 (Pubitemid 38443698)
76. T. Usui, R. Nishikomori, A. Kitani, and W. Strober GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rbeta2 chain or T-bet Immunity 18 3 2003 415 428 (Pubitemid 36351520)
77. T. Usui, J.C. Preiss, Y. Kanno, Z.J. Yao, J.H. Bream, J.J. O'Shea, and W. Strober T- bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription J. Exp. Med. 203 3 2006 755 766
78. S. Verma, F.W. Hoffmann, M. Kumar, Z. Huang, K. Roe, E. Nguyen-Wu, A.S. Hashimoto, and P.R. Hoffmann Selenoprotein K knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses J. Immunol. 2011 186
79. K. Wingler, and R. Brigelius-Flohe Gastrointestinal glutathione peroxidase Biofactors 10 2-3 1999 245 249 (Pubitemid 29533836)
80. H.Y. Won, J.H. Sohn, H.J. Min, K. Lee, H.A. Woo, Y.S. Ho, J.W. Park, S.G. Rhee, and E.S. Hwang Glutathione peroxidase 1 deficiency attenuates allergen-induced airway inflammation by suppressing Th2 and Th17 cell development Antioxid. Redox Signal. 13 5 2010 575 587
81. Y. Xie, T.R. Bagby, M.S. Cohen, and M.L. Forrest Drug delivery to the lymphatic system: importance in future cancer diagnosis and therapies Expert Opin. Drug Deliv. 6 8 2009 785 792
82. H. Zeng, and G.F. Combs Jr. Selenium as an anticancer nutrient: roles in cell proliferation and tumor cell invasion J. Nutr. Biochem. 19 1 2008 1 7 (Pubitemid 350213396)