Berberine, an isoquinoline alkaloid, inhibits streptozotocin-induced apoptosis in mouse pancreatic islets through down-regulating Bax/Bcl-2 gene expression ratio

Food Chemistry

Volumn 132, Issue 1, 2012, Pages 252-260

  Chueh, Wei Han ^a   Lin, Jin Yuarn ^a  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Bax Bcl 2 genes; Berberine; Primary pancreatic islets; Streptozotocin

Indexed keywords

CELL DEATH; GENE EXPRESSION REGULATION; GLUCOSE; MAMMALS; METABOLITES; NITROGEN COMPOUNDS; POLYMERASE CHAIN REACTION;

ANTI-APOPTOTIC EFFECTS; ANTI-INFLAMMATION; BERBERINE; CELL APOPTOSIS; EXPERIMENTAL MODELS; GENES EXPRESSION; IN-VITRO; ISOQUINOLINES; PANCREATIC ISLET; PANCREATIC ISLET CELLS; QUANTITATIVE POLYMERASE CHAIN REACTION; STREPTOZOTOCIN;

GENE EXPRESSION;

BERBERINE; PROTEIN BAX; PROTEIN BCL 2; STREPTOZOCIN; ISOQUINOLINE; ISOQUINOLINE DERIVATIVE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG EFFECT; GENE EXPRESSION; IN VITRO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; GENETICS; MALE; METABOLISM; PANCREAS ISLET; PROTO ONCOGENE;

MUS;

ANIMALS; APOPTOSIS; BERBERINE; DOWN-REGULATION; GENE EXPRESSION; GENES, BCL-2; ISLETS OF LANGERHANS; ISOQUINOLINES; MALE; MICE; STREPTOZOCIN;

EID: 84355161540     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2011.10.065     Document Type: Article

References (36)

1. R. Aalinkeel, Z. Hu, B.B. Nair, D.E. Sykes, J.L. Reynolds, S.D. Mahajan, and S.A. Schwartz Genomic analysis highlights the role of the JAK-STAT signaling in the anti-proliferative effects of dietary flavonoids-'Ashwagandha' in prostate cancer cells Evidence-based Complementary and Alternative Medicine 7 2010 177 187
2. A.D. Bolzan, and M.S. Bianchi Genotoxicity of streptozotocin Mutation Research 512 2002 121 134 (Pubitemid 35441051)
3. H. Cheon, J.M. Cho, S. Kim, S.H. Baek, M.K. Lee, K.W. Kim, S.W. Yu, G. Solinas, S.S. Kim, and M.S. Lee Role of JNK activation in pancreatic β-cell death by streptozotocin Molecular and Cellular Endocrinology 321 2010 131 137
4. W.H. Chueh, and J.Y. Lin Berberine, an isoquinoline alkaloid in herbal plants, protects pancreatic islets and serum lipids in non-obese diabetic mice Journal of Agricultural and Food Chemistry 59 2011 8021 8027
5. G. Cui, X. Qin, Y. Zhang, Z. Gong, B. Ge, and Y.Q. Zang Berberine differentially modulates the activities of ERK, p38 MAPK, and JNK to suppress Th17 and Th1 T cell differentiation in type 1 diabetic mice Journal of Biological Chemistry 284 2009 28420 28429
6. M. de Groot, T.A. Schuurs, G.D. Leuvenink, and R. van Schilfgaarde Macrophage overgrowth affects neighboring nonovergrown encapsulated islets Journal of Surgical Research 115 2003 235 241 (Pubitemid 38021913)
7. Y. Gao, G.J. Parker, and G.W. Hart Streptozotocin-induced β-cell death is independent of its inhibition of O-GlcNAcase in pancreatic Min6 cells Archives of Biochemistry and Biophysics 383 2000 296 302
8. Y. Gu, Y. Zhang, X. Shi, X. Li, J. Hong, J. Chen, W. Gu, X. Lu, G. Xu, and G. Ning Effect of traditional Chinese medicine berberine on type 2 diabetes based on comprehensive metabonomics Talanta 81 2010 766 772
9. J.J. Haddad Redox and oxidant-mediated regulation of apoptosis signaling pathways: immuno-pharmaco-redox conception of oxidative siege versus cell death commitment International Immunopharmacology 4 2004 475 493 (Pubitemid 38501656)
10. V. Hadjivassiliou, M.H.L. Green, R.F.L. James, S.M. Swift, H.A. Clayton, and I.C. Green Insulin secretion, DNA damage, and apoptosis in human and rat islets of Langerhans following exposure to nitric oxide, peroxynitrite, and cytokines Nitric oxide 2 1998 429 441 (Pubitemid 29231176)
11. d mice Journal of Autoimmunity 10 1997 17 25 (Pubitemid 27110304)
12. M. Hosokawa, W. Dolci, and B. Thorens Differential sensitivity of GLUT1- and GLUT2-expressing β cells to streptozotocin Biochemical and Biophysical Research Communications 289 2001 1114 1117 (Pubitemid 34076306)
13. M. Ikram A review on the chemical and pharmacological aspects of genus Berberis Planta Medica 28 1975 353 358
14. H. Jaidane, F. Sane, J. Gharbi, M. Aouni, M.B. Romond, and D. Hober Coxsackievirus B4 and type 1 diabetes pathogenesis: contribution of animal models Diabetes/Metabolism Research and Reviews 25 2009 591 603
15. K.A. Kang, J.S. Kim, R. Zhang, M.J. Piao, D.O. Ko, Z.H. Wang, Y.J. Heo, D.B. Park, Y.H. Maeng, and J.W. Hyun Effect of KIOM-79 against mitochondrial damage induced by streptozotocin in pancreatic beta-cells Journal of Toxicology and Environmental Health, Part A 72 2009 1201 1208
16. H.Y. Kim, and K. Kim Protective effect of ginseng on cytokine-induced apoptosis in pancreatic β-cells Journal of Agricultural and Food Chemistry 55 2007 2816 2823 (Pubitemid 46668283)
17. C.L. Kuo, C.W. Chi, and T.Y. Liu The anti-inflammatory potential of berberine in vitro and in vivo Cancer Letters 203 2004 127 137
18. C.H. Liao, and J.Y. Lin Lotus (Nelumbo nucifera Gaertn) plumule polysaccharide protects the spleen and liver from spontaneous inflammation in non-obese diabetic mice by modulating pro-/anti-inflammatory cytokine gene expression Food Chemistry 129 2011 245 252
19. B.F. Li, Y.F. Liu, and Y. Cheng Silencing inducible nitric oxide synthase protects rat pancreatic islet Diabetes Research and Clinical Practice 89 2010 267 275
20. N. Li, L. Gu, L. Qu, J. Gong, Q. Li, W. Zhu, and J. Li Berberine attenuates pro-inflammatory cytokine-induced tight junction disruption in an in vitro model of intestinal epithelial cells European Journal of Pharmaceutical Sciences 40 2010 1 8
21. J.Y. Lin, C.Y. Li, and B.F. Lin Amaranthus spinosus L. inhibits spontaneous and dexamethasone-induced apoptosis in murine primary splenocytes Journal of Food and Drug Analysis 16 2008 52 61
22. W.C. Lin, and J.Y. Lin Five bitter compounds display different anti-inflammatory effects through modulating cytokine secretion using mouse primary splenocytes in vitro Journal of Agricultural and Food Chemistry 59 2011 184 192
23. W. Liu, X. Zhang, P. Liu, X. Shen, T. Lan, W. Li, Q. Jiang, X. Xie, and H. Huang Effects of berberine on matrix accumulation and NF-kappa B signal pathway in alloxan-induced diabetic mice with renal injury European Journal of Pharmacology 638 2010 150 155
24. K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method Methods 25 2001 402 408 (Pubitemid 34164012)
25. K. Motyl, and L.R. McCabe Streptozotocin, type 1 diabetes severity and bone Biological Procedures Online 11 2009 296 315
26. J.F. Ndisang Role of heme oxygenase in inflammation, insulin-signalling, diabetes and obesity Mediators of Inflammation 2010 2010 359732
27. G. Ning, J. Hong, Y. Bi, W. Gu, Y. Zhang, Z. Zhang, Y. Huang, W. Wang, and X. Li Progress in diabetes research in China Journal of Diabetes 1 2009 163 172
28. I. Nordentoft, P.B. Jeppesen, J. Hong, R. Abudula, and K. Hermansen Increased insulin sensitivity and changes in the expression on profile of key insulin regulatory genes and beta cell transcription factors in diabetic KKAy-mice after feeding with a soy bean protein rich diet high in isoflavone content Journal of Agricultural and Food Chemistry 56 2008 4377 4385 (Pubitemid 351999359)
29. J. Tang, Y. Feng, S. Tsao, N. Wang, R. Curtain, and Y. Wang Berberine and Coptidis Rhizoma as novel antineoplastic agents: A review of traditional use of biomedical investigations Journal of Ethnopharmacology 126 2009 5 17
30. C. Wang, J. Li, X. Lv, M. Zhang, Y. Song, L. Chen, and Y. Liu Ameliorative effect of berberine on endothelial dysfunction in diabetic rats induced by high-fat diet and streptozotocin European Journal of Pharmacology 620 2009 131 137
31. Z.Q. Wang, F.E. Lu, S.H. Leng, X.S. Fang, G. Chen, Z.S. Wang, L.P. Dong, and Z.Q. Yan Facilitating effects of berberine on rat pancreatic islets through modulating hepatic nuclear factor 4 alpha expression and glucokinase activity World Journal of Gastroenterology 14 2008 6004 6011
32. Z. Yang, M. Chen, J.D. Carter, J.D. Ellett, K.M. Smith, and J.L. Nadler Inflammation blockade improves pancreatic islet function Transplantation Proceedings 36 2004 2864 2865 (Pubitemid 40036857)
33. Y. Yu, L. Liu, X. Wang, X. Liu, X. Liu, L. Xie, and G. Wang Modulation of glucagon-like peptide-1 release by berberine: in vivo and in vitro studies Biochemical Pharmacology 79 2010 1000 1006
34. N. Zamzami, P. Marchetti, M. Castedo, C. Zanin, J.L. Vayssiere, P.X. Petit, and G. Kroemer Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo Journal of Experimental Medicine 181 1995 1661 1672
35. B. Zhang, M. Kang, Q. Xie, B. Xu, C. Sun, K. Chen, and Y. Wu Anthocyanins from Chinese bayberry extract protect β cells from oxidative stress-mediated injury via HO-1 upregulation Journal of Agricultural and Food Chemistry 59 2011 537 545
36. J.Y. Zhou, and S.W. Zhou Protective effect of berberine on antioxidant enzymes and positive transcription elongation factor b expression in diabetic rat liver Fitoterapia 82 2011 184 189