Differential sensitivity of GLUT1- and GLUT2-expressing β cells to streptozotocin

Biochemical and Biophysical Research Communications

Volumn 289, Issue 5, 2001, Pages 1114-1117

  Hosokawa, Masaya ^a   Dolci, Wanda ^a   Thorens, Bernard ^a  

^a University of Lausanne Departement de Pharmacologie et de Toxicologie   (Switzerland)

Author keywords

Diabetes; GLUT1; GLUT2; Insulin; Pancreatic islets; Streptozocin

Indexed keywords

GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 2; INSULIN; STREPTOZOCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG MECHANISM; HYPERGLYCEMIA; HYPOINSULINEMIA; INSULIN RELEASE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANIMALIA; MUS MUSCULUS;

EID: 0035930973     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.6145     Document Type: Article

References (13)

1. Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin
2. Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes
3. Major species differencs between humans and rodents in the susceptibility to pancreatic β cell-injury
4. STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells
5. Short term insulin treatment prevents the diabetogenic action of streptozotocin in rats
6. Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression
7. Streptozocin: A review of its pharmacology, efficacy, and toxicity
8. Uric acid nephrolithiasis and acute renal failure secondary to streptozotocin nephrotoxicity
9. Extent and persistence of streptozotocin-induced DNA damage and cell proliferation in rat kidney as determined by in vivo alkaline elution and BrdUrd labeling system
10. Acute renal failure and renal tubular squamous metaplasia following treatment with streptozotocin
11. Transgenic reexpression of Glut1 or Glut2 in pancreatic β cells rescues Glut2-null mice from early death and restores normal glucose-stimulated insulin secretion
12. Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and β-pancreatic islet cells
13. Early diabetes and abnormal postnatal pancreatic islet development in mice lacking GLUT2